How Dolly the Sheep was cloned

Dolly was the first cloned sheep. This is an explanation of how it was done. Read more here: www.understandinganimalresear... and www.animalresearch.info/en/me...
This presentation was originally made in a flash file format in around 2010. This film was restored and uploaded in 2021.

[@stevenhutt2904]

Ask the doctor if he ever cloned himself.

[@animalevidence]

You could ask them yourself!🙂

[@PrivateerJimmy]

​@@Izmology.lmao! you can just pick such nicks?

[@YOUTUBE-ADMlN]

This is old news. Why would a doctor clone himself? When he can clone a super doctor with another old tech crispr.
I'm sure X-Men tech exists as well but we normies won't know about it but for sure be paying for it.

[@SmilingDahliaFlower-wz6ld]

😂😂😂

[@Cherry-pu4mx]

He certainly tried

[@Izmology.]

They've obviously cloned humans

[@FallacyUnknown]

Yup

[@cavesinger5441]

Thank you so much for this informative video! I used it and your references as the basis for my research for my assignment. Unlike the module that the school has provided, this one is way too easy to understand. Once again, Thank you Very Much!

[@animalevidence]

Thank you, glad to be of use.

[@krystleirvin6733]

Wow learn something but I already forgot so I will watch it again.

[@HumanBeanbag]

Rest in peace, Dolly. You are missed 😢

[@niraxlevi9930]

By the time they cloned dolly they didn't know about the reprogrammation of somatic cells into pluripotent cells so how did they succeed to do it ? I think it was discovered just recently in 2012 by gurdon and yamanaka so was it accidental ?

[@animalevidence]

Good question. I'm afraid I don't know the answer. I vaguely remember they made hundreds of attempts before being successful, so a degree of luck, but as they had set out to clone, I don't think it was accidental.

[@younghannibal7434]

Great video

[@animalevidence]

Glad you enjoyed it

[@amindeshmukh2958]

Thank you it helped me a lot in my class thank you again ☺️😃

[@animalevidence]

You are very welcome

[@letitbe3625]

Chutiya schoool jata hai drop out kar school se

[@iliaanjin7333]

How did the enucleated ovum undergo the multiplication without having a nucleus to express the necessary genes to do so?

[@mairead3361]

The cell culture from sheep 1 (white faced sheep) had been fused with sheep 2 (black faced sheep) and with it its nucleus. The offspring sheep had a white face proving that it was a clone of sheep 1, meaning that it had the exact genetic information
The genes (sheep 1) were expressed from the mothers embryonic signalling (sheep 2)
Sheep 2 was just used for its embryo (cell signalling and cell differentiation)
Sheep 3 was used for gestation
Sheep 1 was the only sheep that contributed genetically (hence Dolly is a clone)

[@EmoBoiLink]

Anyone know how they solved the rapid aging problem? And if it had anything to do with the pituitary gland.

[@user-tx7in5ug8i]

finally a video that is simple and makes it make sesne

[@igotjiminsjam4142]

Thank you mam

[@footballbranthan2396]

I have a question why use the egg from sheep 2 to insert cells from sheep 1 why not insert shells into sheep 1's egg itself?

[@3th4n_ol26]

In the video, they say they did this so they could tell if the offspring was a clone, as the offspring should have a different colour face to the surrogate.
There were probably other reasons, too, though.

[@silkybiswal4874]

There is a process called transgenic where we fuse two different cell of different organism .so basically its a experiment where a donor and recepient are used to see the results of forming cell

[@akshantrapaliwal7096]

From this I will made my whole clone army them will rule the world

[@blackballskaiser6423]

Clone wars

[@cigdemcetin303]

I dont get it. where does the centrosome come from?egg cells dont have a centrosome.can someone explain pls

[@alexabiber1023]

No

[@yorgunsavasci4529]

insane

[@kawaragi7529]

can you explain? is dolly the sheep 1?

[@animalevidence]

Hello, no dolly is sheep 2, Dolly is the cloned animal

[@jasonstout8582]

Isn't this more closely related to IVF than "cloning"?

[@user-nz3ll5fi1t]

While they indeed implanted the egg into the surrogate sheep via IVF, the lamb that was born (dolly) was completely genetically identical to the older dolly whose DNA they extracted and implanted into the donor egg, so for lack of a better word, they did “clone” her

[@sdfjsd]

Wait what about mitochondrial DNA? How was the mitochondrial DNA cloned?

[@animalevidence]

I think the mitochondrial DNA came from the 'host' cell, the one receiving the donor DNA

[@sdfjsd]

@@animalevidence Well, then it's not an exact clone then. Mitochondrial DNA has some genes that can cause phenotypes, na?

[@animalevidence]

@@sdfjsd Yes

[@srishtisaini7174]

Means there is two ✌2⃣ parent involve in it not 3

[@srishtisaini7174]

Is it right

[@kafkaesque999]

There are 3 parents involved in the production of Dolly;
sheep-1: Donor of the nucleus
sheep-2: Donor of the enucleated egg cell
sheep-3: The surrogate mother who nourished and developed the zygote, eventually giving birth to Dolly.

[@jade4r4]

❤❤❤❤❤❤❤❤

[@math_hw]

Wait this means a cat can be born from a dog

[@evaatsydney7541]

LOL 😭

[@capybaraponque611]

no, that's not what it means

[@diala1602]

طلاب السادس شونكم وي النعجة دوللي