NEOPLASIA 3: TUMOR SUPPRESSOR GENES: Retinoblastoma Gene, Knudson's Two Hit Hypothesis.

[@satadruray9787]

Absolutely brilliant sir. As a practicing surgical oncologist since more than 25 years, as also a teaching faculty in a medical college, I really appreciate the clarity and lucidity of your excellent presentation. Thank you so much.

[@nirmalnemane3566]

Sir Pls do not get inactive. Pls continue ur proliferative potential of spreading knowledge.
This type of mutation in u is welcome sir.
Pls do continue generating such interesting videos

[@ilovepathologyVijayPatho]

😂 😂 👌 👍 thank you 😊

[@mjayreign6699]

Fr you’re amazing I can’t even shouttttt!!!!

[@iamjaya3179]

Its never a boring subject if u have a great teacher

[@drabdul86]

Randomly came here and WOW , u have made difficult topic capable of understanding , Thanks

[@Albaraaf]

You explanations of complicated topics makes it so much easy to understand and comprehend the topics that are discussed in dozens of pages. I've been always looking forward for your tutorials. THANK YOU SO MUCH for all the effort.

[@ilovepathologyVijayPatho]

Albaraa Alfaraidi thanks for those kind words :-)

[@albert1as]

Is there any notes available and is it helpful in university exam ? Please let me know

[@A.B001]

I am viewing your videos to cover neoplasia sir..i hope it's enough for theory exams, coz it's genuinely not easy to convey so much content in such an easy and informative way.
Thank you so much sir...

[@ilovepathologyVijayPatho]

@@A.B001 Hopefully it helps in understanding concepts.. Using this you can approach to solving question..
Though this is not very comprehensive

[@drnirmalraut]

never understood retinoblastoma gene this better

[@crazyrobin5]

Haha.. That's the problem sir.. We being an oncologist... Just are entangled with the trials... Basics and core fundamentals, I feel are given the least weightage.. 🙏

[@dhritimadas6357]

Easy to understand... concept clear ....
Respect & love from core of my heart

[@shifapathan8386]

Finally understanding the topic..tons of pages made soo easy thank you sir..

[@ilovepathologyVijayPatho]

😊 thank you

[@Aestheticbeeee]

Your explanation is mind-blowing. Very useful thanks alooottt

[@debigdogk9563]

Great teaching and illustrations thank you for teaching and sharing ❤❤❤❤❤

[@brandonjackson2730]

This is absolutely fantastic! Very well explained thank you sir.

[@leonardunganai8589]

I couldn’t be more grateful🙏🏽🙏🏽🙏🏽😩😩

[@venkateshwarlugangishetty8853]

Your explanations r making my preparation very easy.
Thanks a lot sir 😊😊

[@patiencechepkorir5596]

Aaah people are missing out on content 🤩

[@dikshadinker4313]

Understand LOH after years of reading cancer. Thank you!

[@madhupreethi7072]

Crystal clear topics ...tq...excepting more videos from hematology

[@ranan2682]

very useful video thx from the heart

[@mangalthorat7951]

Thanks alot..Very informative and easy to understand video on this topic.It helped me a lot .

[@coolmitochondria4467]

thank you so much for this, you are a lifesaver

[@aggieruiru1999]

Your make everything so simple to understand , thank you Sir

[@tinyhunter2419]

Thank you sir for this beautiful explanation. Please do a video series on wbc malignancies

[@SuperAirbus123]

Thank you sir..
It helped me a lot..😌😌

[@maryam00005]

Thank you sooooo much ... robbins is a piece of cake cuz of you

[@nahiralejandra91]

Your content is so good I don’t even skip the ads.

[@poornimakadam1330]

Beautiful explanation

[@zeelbaraiya7916]

Thank you Sir🙌🏻

[@Varshneymicrobes]

The gene for retinoblastoma is transmitted along with a gene for esterase D to which it is closely linked. However, either of the two alleles for esterase D can be transmitted with either allele for retinoblastoma. How do you know that retinoblastoma is not the direct effect of the esterase D genotype?
Please give explanation....

[@amruthb8524]

very good explanation, , thank you sir

[@oviya7715]

Good explanation easy to understand useful for my exams

[@saramohammadi8578]

Thanks a lot, I was struggling a lot with this concept for my cancer biology exam :)

[@saurabh_sahani]

10000% solid concept

[@kavishasoni9127]

Sir I m very grateful ..very nice explaination

[@pallavis9533]

Finally understood the topic ❤️ Thank you sir.

[@UNNIMAYAVP]

Clear explanation.❤

[@ilovepathologyVijayPatho]

@@UNNIMAYAVP thank you 😊

[@Artsylove4]

Thank you so much sir!!!

[@biotopper5390]

I love the way you teach sir .. god bless you with still more knowledge 💖...
If possible plz upload more videos tqvm sir

[@DoraDora-z7c]

Sir, what is loss of function mutations for RB protein ? Can you please make a video on this topic 😢

[@randsa2588]

Thank you doctor 🌸 i call this simplicity 👌🏻

[@immdhil1814]

I love these ❤️

[@subhamkarmakar3320]

Awesome content 🔥

[@thashreen3537]

Thank u soo much sir!

[@sangeetachoudhury2411]

Great explanation....Thanks for helping

[@ilovepathologyVijayPatho]

You are most welcome

[@RESHMAPNAIR-ii5hl]

Great explanation.... Too good.... Robbins can be made so simple?

[@visallinivasanthan1523]

Thank u so much ...it was very useful 👏🏼

[@geethabalamurugan9641]

A plenty of thanks sir.... waiting for systematic pathology videos

[@ilovepathologyVijayPatho]

Very soon

[@faheemullah7592]

Conceptual approach 👌

[@nileshlifesciences9601]

Very well explained

[@kanugulatejasri369]

Thankyou so much sir

[@drneelz]

Very happy to the vedio..you made easy for me as preparing for oncosurgery

[@ashwini16k]

Awesome. ❤

[@safaaalesawi7437]

Very good thanks

[@jeyshreechandrashekar8936]

very helpful

[@abijeyarajan2173]

Clear explanation and easy to grasp the information 🙏🏼

[@mokgadimaloba6936]

Thank you so much for this

[@benazirnowshath9002]

Excellent explanation sir! 👏

[@archanasingh3587]

Super explanation

[@bayraktararda]

Your explanations are very good but if you speak more slowly it will be better to understand

[@sarahmina1442]

Thank you!
Why is the retinoblastoma unilateral in 60% of cases? Since there are ×2 hits (in both chromosomes) it should be bilateral. (Affects both retinas).

[@rukhsarshaikh8322]

Thank you so much..
It really helpful

[@noorusamaa9931]

YOU’RE THE BEST! Thankyou so much

[@geethatamilselvan4619]

Very useful... thank u so much sir ..

[@poonampayal6737]

Thank you but please make more videos

[@jaymakwana1776]

Really helpful video. Thank you😊

[@yasinkhan644]

Well played !! Thank you

[@animsegoviasanchez4364]

3:15
RB

[@athirasivanand4756]

Excellent video

[@sumitgurjar818]

Beautiful explanation..

[@osagiodagbonegbon8735]

Thanks for this

[@ravipriya2012]

Excellent explanation.thankyou sir

[@komancikartal]

thank u, great explanation

[@Stressed_PhD_0831]

Great job!, thanks!

[@medicalknowledge7950]

Very useful 👍

[@silasrotich5436]

Excellent!

[@dr.dharmilshah]

Too good 🙌

[@nahidhaboub3316]

You are amazing thank you sir thank you very much

[@terquisefog4264]

Great explanation thank you

[@Jagannadhpeela]

good presentation

[@Dr_Shkar]

May I know your specific references, for example for the pictures, please?

[@smanna25]

Excellent

[@athirasivanand4756]

Very helpful

[@wasim1880]

How normal cell divided? If RB gene is inhibit the cell to go S phase of cell cycle.??

[@rabbianadeem9101]

Which book do u follow?

[@ilovepathologyVijayPatho]

Robbins Pathology
Also Rubins

[@kanishjain9390]

So wonderful . Thank you. You can also checkout my article in pediatriconcall on the same topic

[@anandsingh4071]

which is more common inherited or acquired retinoblastoma??

[@mahfuzajebun5968]

Awesome. Thanks a lot

[@ilovepathologyVijayPatho]

Thanks. Glad you liked it. Any suggestions are welcome.

[@JahangirAlam-qm7kn]

Thank you

[@tamilanda2678]

Wishes from madurai medical college😇

[@atulyanair6828]

Can you share the notes also?

[@ilovepathologyVijayPatho]

Most of the content is available on www.ilovepathology.com 😊

[@spek2554]

What happens if you eat food containing cancer cells or tumor?

[@naveeddar8542]

U r ossm sir

[@alamielizabeth]

Gracias

[@Xyz-p2s4g]

Awesome

[@rashidakhatoon4541]

Thankew you so much

[@Interestingworld4567]

Thanks 💚😊

[@kirstenw4622]

p53 will have an altered function if it only has one functional allele right?

[@igbinobanelsonosahon9176]

No it won't! It will have an altered function only if both allele are affected! Remember the Two hit hypothesis

[@marwanmohamed387]

no
p53 is unique it doesnt follow the 2 hit hopothesis

[@aranosaur]

thank you saar

[@cindya2760]

Thanks

[@abdallah6755]

thanks a lot

[@MasayoMusic]

Thank you.