P53 is guardian of the genome / old man of the genome/ police man of the genome / care taker / gate keeper of the genome . The information which did not get from dr.sparsh gupta & dr.najeeb but i have found amazing & very effective information from your channel. It is why i have subscribed and followed your you tube channel. Thank you sir and i really love " i love pathology " channel..😊
I’m a week out from a huge pathology exam and I really wish I’d just studied from your videos from the beginning. I read all this info in a textbook and never retained it, and now it makes so much more sense to me. You break concepts up really well and you also keep it focused on the important stuff. Thank you!
U are a really wonderful teacher, making the basics so understandable in a simple way, thanks for taking all the efforts in making such wonderful presentations
Man i really have to thank you so much for your Video. Somehow we dont have anything that easy to understand in germany related to p53 Thanks a lot !!!!!
i already have subscribed to this channel and gave thumbs up to this channel/video. He will be fool who will not do this ... great work and proper guidance provided .... bravo....
Neoplasia was one of the hardest topics i've ever studied and thanks to your videos my concepts are very clear!! please keep uploading more videos on pathology it is indeed very very helpful!!❤❤❤
Well explained sir. Neoplasia is one chapter that scares me but you have made it more interesting. Your videos have made it more easy for me to go through the text and understand it in a clear way. No amount of paid online classes have made me understand neoplasia as well as these videos . Please keep posting regularly sir!! 🙂
Excellent presentation. You made this complex topic so simple that I should recommend that it should be used as a template by the Authors of Molecular pathology Books. Thanks a million, Amjad Ali Khan MD USA
I realise this is a very brief look at p53, so I'll leave out some of the simplifications, but I would say one thing needs to be corrected regarding the molecular weight. p53 was named because it ran on an SDS-PAGE gel at 53 kDa, not because its molecular weight is 53 kDa. Due to the fact that p53 is quite proline rich it is a more rigid structure with annoying "kinks" in it, and thus it migrates differently on SDS-PAGE. As I am sure you know, proteins don't necessarily migrate at their actual mass (and there are a plethora of reasons for this). p53 is around 44 kDa.
Very good job at outlining this topic - this is a perfect and easy to understand introduction to p53, so now I can go and delve deeper! I do wish you had explained a bit more as to what causes p53 inactivation and how, but all in all great video!
Thank you so much Sir for such a beautiful explanation. I wish you all the best, may you continue to educate lots of students like me. I study at Imperial College London and will tell my friends about your channel. Thank you!!!
very goodjob that explaining p53 also known as guardian of genome. But don't forget some virus can disable cell's p53 protein which means p53 can also protect cell from oncogen viruses like HPV.
Great explanation sir .Keep providing us lectures related to ias syllabus like nucleic acid topology, signal molecules, rna processing, ribozume technology, proteomics genomics ,rflp aflp etc. It would b of great help
You're the reason I'm passing exams with a clear concept instead of just writing what's in the book. Thankyou so much :)
😂🙌me too
Harsh truth
so cutee haripriya
me too
And 7 year later your videos are still saving lives👏 Thank you 🙏
Thank you😊 glad it still helps😊
5 years ago and still very helpful. I can now go into the exam hall in a few hours with more confidence. Thank you.
Thank you 😊 best wishes 😊
@@ilovepathologyVijayPatho Thank you
Thank you 😊 am glad it helps😊
P53 is guardian of the genome / old man of the genome/ police man of the genome / care taker / gate keeper of the genome .
The information which did not get from dr.sparsh gupta & dr.najeeb but i have found amazing & very effective information from your channel.
It is why i have subscribed and followed your you tube channel.
Thank you sir and i really love " i love pathology " channel..😊
Just 10 minutes lecture give alot of information is a miracle
Thanks sir
Our prayer always with your dedication and hardwork.
Thank you 😊
I’m a week out from a huge pathology exam and I really wish I’d just studied from your videos from the beginning. I read all this info in a textbook and never retained it, and now it makes so much more sense to me.
You break concepts up really well and you also keep it focused on the important stuff.
Thank you!
U are a really wonderful teacher, making the basics so understandable in a simple way, thanks for taking all the efforts in making such wonderful presentations
Thank you very much 😊.glad the video was of help 😊
Best wishes.
You are a really good teacher , thank you for all the time and energy put in to make these videos extremely clear and concise ♡♡ .
Marioara Protopapa thanks so much 😊
I was reading my book, but it makes no sense to me. You made it clearer! thank you so much!
I can relate
yass!!!
Man i really have to thank you so much for your Video. Somehow we dont have anything that easy to understand in germany related to p53
Thanks a lot !!!!!
Josef Boy Björn same hab nix gefunden
i already have subscribed to this channel and gave thumbs up to this channel/video. He will be fool who will not do this ... great work and proper guidance provided .... bravo....
You're a gem sir. Pls upload some more videos. I have my uni exams in 10 days and your videos on neoplasia are a saviour.
Keep it up, good luck :)
I love you. This is so well explained i'm in tears.
Neoplasia was one of the hardest topics i've ever studied and thanks to your videos my concepts are very clear!!
please keep uploading more videos on pathology it is indeed very very helpful!!❤❤❤
Thanks so much..glad these videos are helping 😊 do share with your friends
Thank you Sir , I am from Pakistan , u made this tough topic much easy to understand , love you
Wow ... Great video. Excellent, detailed yet simplified tuition. Thanks a lot
Thanks dude...i was searching for p53 explanation and ended up in your video with perfect explanation.....you helped me a lot.
One of the besttttt explanations I've come across. So systematic and made easy to grasp the concept. So grateful to have found this.
Thank you 😊
Best pathology tutorials site I have ever seen.. Really grateful to u .
Thank you.
I have my exam tomorrow n this video helped me to drill the concept really quick... ty ... great explanation...😎🤘
I'm super thankful that I found ur channel sir..
Well explained sir. Neoplasia is one chapter that scares me but you have made it more interesting. Your videos have made it more easy for me to go through the text and understand it in a clear way. No amount of paid online classes have made me understand neoplasia as well as these videos . Please keep posting regularly sir!! 🙂
Thanks for helping me understand it so easily. Textbooks are just overcomplicating everything.
Thanks to the author，I will finish my paper easily.
Just an amazing clear cut concept I have ever seen🤩
It was great.... 2moro is my exam nd this video worked for me a lot....
Excellent presentation. You made this complex topic so simple that I should recommend that it should be used as a template by the Authors of Molecular pathology Books. Thanks a million, Amjad Ali Khan MD USA
Thank you so much for making the concept clear and easy to understand
Keep up the good work! I love this video and it was very helpful in understanding. You are a great instructor.
I realise this is a very brief look at p53, so I'll leave out some of the simplifications, but I would say one thing needs to be corrected regarding the molecular weight. p53 was named because it ran on an SDS-PAGE gel at 53 kDa, not because its molecular weight is 53 kDa. Due to the fact that p53 is quite proline rich it is a more rigid structure with annoying "kinks" in it, and thus it migrates differently on SDS-PAGE. As I am sure you know, proteins don't necessarily migrate at their actual mass (and there are a plethora of reasons for this). p53 is around 44 kDa.
@johnny torres Probably a good thing if you attend KI. I should know, I taught some of the undergraduate labs that med students took! ;)
Thanks sir, really appreciate your hard work and hope to keep loving pathology. Lots of love from Afg🇦🇫
Very good job at outlining this topic - this is a perfect and easy to understand introduction to p53, so now I can go and delve deeper! I do wish you had explained a bit more as to what causes p53 inactivation and how, but all in all great video!
Thank you so much Sir for such a beautiful explanation. I wish you all the best, may you continue to educate lots of students like me. I study at Imperial College London and will tell my friends about your channel. Thank you!!!
Thank you 😊
Nicely illustrated about p53 gene regulation in tumor suppression
Me studying in PG . really u r explained very well and it's very helpfull to understand easily without confusing tq so much sir❤️
Thank you so much you made this concept so easy to understand. I was really struggling with this concept. Really helped with studying for my exam!
I m actually dealing a while with p53 but the Video is Great
You have made us love Pathology ❤️
Thank you so much sir for making Neoplasia too much easy and understandable😊🎉
Thank you from London. Great work.
Thank you for the amazing video sir! You explain things so simply!
very goodjob that explaining p53 also known as guardian of genome. But don't forget some virus can disable cell's p53 protein which means p53 can also protect cell from oncogen viruses like HPV.
U make all the concepts really easy to understand ... thank you so much sir!!
Thanks 😊 Glad you liked them
Beautifully explained!!
Thank you sir 😊
Loving this series of neoplasia... ❤❤ But I'm too late to reach hence regretting 😢
Good stuff and explanation! However I wish p53 videos also mention that it's part of the BAX/BAK pathway and Bcl2 as that can be a point of confusion.
Thank you so much for the video because I was very tired with p53
Thank u so much sir saw this video before going into exam.. got this question today
You are doing a great job. Please continue doing it, your videos are of great help. Thank you ❤️
Great teaching and illustrations thank you for teaching and sharing ❤❤❤❤❤
U're amazing sir.please keep it up
really a good art of teaching...Amazing...
You are doing great work sir... thank you so much ❤
great explanation and intro to the background of p53!
Thank you 😊
Pls do more videos ,its very helpful 🥺
wonderful illustration of role of p53 gene
Lovely video! Thanks man! Keep uploading more videos. Greetings from Gujarat.
SIR YOUR VIDEOS REALLY VERY HELPFUL
This was so helpful and clear, thank you!
Exellent videos regarding neoplasia ,injury etc .
But we require more videos regarding other pathological conceptual topics basis
Thank you
Sir, what book do you recommend for exam point of view for second year mbbs?
The concept is clear and easy to understand thanks to the author
Best teacher
i love your channel ......all videos are just amazing.......please upload some more videos of pathology
#Medico
Thanks:-)
Tqs so much for this very easy explanation
Hi. I have read an article where the P53 gene was mentioned. Could you please explain what is meant by mitochondrial translocation of the p53 gene?
Thanku sir a lot i really get concept from ur video thn i can make concept
These are so helpful and easy to understand :) THANK YOU!!!!
Now I got it completely 🕺
Such a great video!
P53!!!!! Yes!! Thats so cool! I am going to name my child Ilirian P53!
Wow so amazing and very clear ty so much ❤
i learned that the p21 actually stops the CDK2 and cyclin E and therefore stops the cell from entering into the S phase.
Sir kindly make more videos on general path so that our basic concepts will be clear
Thanks for posting this. It was very informative.
Thank you!!!! The information helped me a lot with my classes
I'm so glad that it helped
thank youu sooo much you arethe best in pathology :)
Yaqeen Yousef Thank you very much 😊
it's really really helpful .thank you
Great explanation sir .Keep providing us lectures related to ias syllabus like nucleic acid topology, signal molecules, rna processing, ribozume technology, proteomics genomics ,rflp aflp etc. It would b of great help
Thank you sir ..god bless ..you made it so easy to understand 😊
Great explanation !
amazing video! you kept it simple and not too complicated ! :)
Thank you so much! This was really helpfull and clear.
Thank you so much sir❣️
your lecture is just👌
Great video
Sir this video helps to learn a lot in short🙏🏆
Many thanks for you, you make it very easy
Thank you! The video is very clear!
Thanks for ur videos! I loved them, now i can do my essay easily hehe
the most helpful video! Thank u so much!
Great work bro
Really helpful. I'm impressed sir. Thank you so much🙂
this is a great time saving explanation
thanks alot
Very nice
Crisp and precise
Thank you so much for your efforts. Much appreciated!
Very helpful sir! Thank You :)
Great presentation
Thank you for your explanation sir...
Amazing explanation.. Thank you 😊