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NEOPLASIA 2: HALLMARKS OF CANCER : Protooncogenes, Oncogenes & Oncoproteins
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- Опубліковано 7 гру 2016
- In this video i have discussed 8 hallmarks of cancer and also about the role of oncogenes and oncoproteins in cancer
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Hallmarks of cancer
8 fundamental changes
Protooncogenes , oncogenes & Oncoproteins
Role of Oncogenes in cancer
Definition
A disorder of cell growth
Triggered by a series of acquired mutations
Affecting a single cell and its clonal progeny
HALLMARKS OF CANCER
1. Self sufficiency in the growth Signals
2. Insensitivity to antigrowth/ growth inhibitory signals
3.Evasion of Apoptosis
4. Limitless Replicative Potential
5. Sustained Angiogenesis
6. The Ability to invade and Metastasize
7. Reprogramming Energy Metabolism
8. Evasion of Immune System
enablers
9. Genomic Instability
10.Tumor promoting inflammation
SELF SUFFICIENCY IN GROWTH SIGNALS
Oncogenes: They promote unregulated proliferation/Autonomous cell growth
(Self sufficiency in growth signals)
The unmutated counterparts of Oncogenes are “proto oncogenes”
Growth factors: Cancer cells develop growth self sufficiency ( Synthesize self responsive growth factors)
Eg: a. PDGF - Glioblastomas
b. TGF-α - Sarcomas
c. FGF - Breast ca
2. Growth factor receptors:Cancer cells encode for growth factro receptors.
a. EGF-receptor family: ERB-B1 (overexpression) Squamous cell carcinoma
b. CSF-1 receptor: FMS (point mutation) - Leukemia
c. PGDF receptor: PGDF-R (overexpression) - Gliomas
3. Signal transduction proteins - Receive growth promoting signals.
Eg. RAS family (point mutation) - Ca colon, lung. Pancreas
4. Nuclear regulatory proteins: Transcriptional activators
Eg: C-MYC (translocated) - Burkitt lymphoma
N-MYC (Amplification) - Ca lung,
5. Cell cycle regulatory proteins:
Eg: Cyclin D (Translocation) Ca breast, Ca esophagus
CDK4 (Amplification) Melanoma
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Please watch: "WARBURG EFFECT: Hallmark of CANCER. What, Why & How?"
• NEOPLASIA 6: WARBURG E...
~-~~-~~~-~~-~
Amazing amazing stuff! Love how you summarise Robbins so well so that it saves me time going through it.
Never saw a more detailed video making Robbins so easy. Thank you so much!!! Please make more such videos
ua-cam.com/video/1PkFC8X6Ie0/v-deo.html
as a lung cancer patient with back ground in science, I find your presentation simple, easy to understand and well presented. thank you very much
Why did u stop making videos
Thank you so much for making Robbins easier to understand.
Where can i find other topics like i love pathology videos to understand genral pathology from robbins.
May i express my gratitude - for making it so much easy to understand, in a simple THANK YOU? Because Thank you so much!
Good job sir. We need more of your videos please...
Great teaching and illustrations thank you for teaching and sharing ❤❤❤❤❤
I watch this three times and I think I understand it pretty well now
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Your videos are really helpful. Please post more videos
Thank you so much, understanding of neoplasia has been made easier.
Okay ...This is bestest explanation 😃
Plz make video on Genetic disease pathology.
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Thanks for making us able to deal with patho.....
Sir love your explanations.... Please make more videos
Good explaination..easily understood😊
Thank you sir you made robbins easy
Even from sri lanka medical students following your videos
Please upload more videos specifically in general pathology 🙏🙏
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In dentistry all receptors, receptor factors are compulsory ?
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please be a little louder great content but voice is sleepy
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Carlos Poblete Jara ..what I just suggested to be a bit louder like apoptosis one . content is very useful...I scored really well.because of this exam
Very use ful, excellent
Apki awaj itni soyi hui Ku h 😫😫😫 yr sb bdiya h tda ache se btao please
Sure. Thanks 😊 will sound better next time 👍👍
Sorry but tda sa ache se .. apse hi yad kia h mne p53 sir bht bdiya khi Ni mila ita sahi p53 pr tda or thankyou
Awful sound quality