Pyroluria: The Most Common Biochemical Disorder You've Never Heard Of

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  • Опубліковано 8 лис 2024

КОМЕНТАРІ • 77

  • @Bhakta_Mark
    @Bhakta_Mark 9 місяців тому +17

    In my experience I was told I had high HPL (pyroluria) and ended up taking lots of zinc picolinate. I didnt understand that all the zinc I was taking was pushing out my high copper stores and giving me some very serious side efects including explosive anger eventualy I discoverd HTMA and mineral balancing and how to do it properly. I highly recomend any one with pyroluria has a HTMA and consults with someone experienced in mineral balancing. Thanks for you chanel felix.

    • @thebentzenable
      @thebentzenable 7 місяців тому +2

      Me too, I did the same and got explosive anger 🙈🙈

    • @blissfulbaboon
      @blissfulbaboon 2 місяці тому

      Like who?

  • @ari-jv
    @ari-jv Рік тому +20

    This is one of the best videos covering pyroluria on UA-cam. It’s such a mysterious disorder

  • @Jana_PalmTree
    @Jana_PalmTree Рік тому +19

    Thank you so much. I’m 45 and just discovered pyroluria in a book: Depression Free, Naturally! I have been searching for 20 years. I’m 45 and my daughter 23. I believe we both have it. My daughter is very reactive to treatments, want this to help her so much. We already have a genetic mutation called Loeys-Dietz Syndrome. She has Autism Spectrum Disorder, OCD, digestive problems, nervous system problems. Subscribed to your channel. Looking forward to your other videos. We don’t tolerate stress or have energy. We don’t have money to work with a provider. Only state insurance which won’t cover this kind of care so I’m always learning all I can. We eat so well but slowly get worse. Waiting for the pyroluria protocol to arrive in mail as described in book. It’s been used extensively with patients at an addiction recovery center who get screened for pyroluria so I hope we can tolerate it. It is more than the 2 main nutrients and we’re already on general supplements. Need to learn more on copper.

    • @Shasha8674
      @Shasha8674 Рік тому

      Gluten may hurt the gut lining so less nutrients absorb. Hair test shows good minerals/heavy metal levels. Coenzymated B vitamins/Zn/Mg/fish oil/Vit C/lecithin/evening primrose oil/Nature's plus-Source of life multiple/Vit B12 methylcobalamin under the tongue with folate/coenzyme Q10/rhodiola/Vit E/Vit A/Vit D3/sunlight/Vit K2/Krill oil/5000mcg of biotin and more may help people. Gluten is in wheat/barley/rye...oats/corn/rice. Rice is low in gluten. Wild rice has no gluten...is a grass. Nuts not sold in the shell/meat basting/some spices/air/lotions/food with a label/gluten free food and more may have hidden gluten. LDN may help block low amounts of gluten. Orthobiotic probiotic before a meal and HCl and enzymes with meals may help. When I was detoxing Copper I was very smart, but could not detox it forever. God bless

    • @inittiela4934
      @inittiela4934 Рік тому +8

      You should for sure consider copper overload especially because it was highly correlated to autism spectrum.

    • @animeshchandra4505
      @animeshchandra4505 2 місяці тому +1

      Hey any update?

    • @Jana_PalmTree
      @Jana_PalmTree 2 місяці тому

      @@animeshchandra4505 We definitely have pyroluria and benefit from ongoing supplementation. Keeping vitamin B6 (we use p5p form) and zinc coming into our bodies throughout the day has greatly improved our stress endurance. I used to feel frazzled most of the time, now when I do I usually realize I didn’t take my supplements. We sleep better too. Now our good diet and general supplementation helps us feel good. Since last year we have moved to a better home (couldn’t handle the stress of moving before!) My daughter was able to talk to more people, fell in love, and just gave birth a few weeks ago to a healthy boy!

    • @Jana_PalmTree
      @Jana_PalmTree 2 місяці тому +1

      @@inittiela4934 yes, the pyroluria protocol keeps nutrients coming in that allows the body to let go of excess copper. So important. Mental health has improved for both of us.

  • @annettediberardino6628
    @annettediberardino6628 11 місяців тому +8

    i have studied this condition as my son has elevated pyrroles. It is related to heavy metals in particular aluminium toxicity and poor methylation (elevated homocysteine levels).

  • @Joan11ify
    @Joan11ify Рік тому +12

    Great video! Thank you for this!
    Pyrroles are metabolites of Heme degradation, which are supposed to be eliminated via liver/gallbladder/feces. If this pathway is dysfunctional they get excreted via kidneys/Urine, which is why when pyrroles can be detected in the urine one is considered to have Pyroluria (pyrroles in the urine).

    • @QUINTUSMAXIMUS
      @QUINTUSMAXIMUS Рік тому +1

      I wonder if there is a way to fix this because my GI doctors don't diagnose this. I read you just have to take B6 and zinc for the rest of your life.

    • @Joan11ify
      @Joan11ify Рік тому +9

      @@QUINTUSMAXIMUS Pyroluria is essentially a symptom of oxidative stress in the body. Improving liver and gallbladder function can do a lot to help reduce Pyroluria. Also there are often root-causes that needs to be addressed to reduce the oxidative stress (parasites, mold, Heavy metal toxicity, poor gut microbiome, too much EMF exposure, hidden blood infections like Lyme, Babesia, Mycoplasma etc..)

    • @violetfem1808
      @violetfem1808 Рік тому

      @@Joan11ify Very interesting! I'm starting to look into this bc I've already been positive for the B6 deficiency issues & severe brain fog/clarity issues. 🤔

    • @ceptember.
      @ceptember. 3 місяці тому

      How do you know this?

  • @l.c838
    @l.c838 Рік тому +10

    Thank you for such an informative video. It’s good to be reminded that the entire body must be in balance before healing can take place. Thanks again! 🙏

  • @karilockremwellness8123
    @karilockremwellness8123 Рік тому +6

    I am studying on this currently. Thank you for this video!

  • @lowlylisalisa
    @lowlylisalisa Рік тому +9

    Thanks for the video Felix! Any chance you also have Gilbert’s Syndrome or chronic elevated levels of bilirubin? I read one article that was linking the two and yes you are correct, always more than just one issue we are dealing with. Whole body approach is best while tackling these nutrient deficiencies 😊

    • @sailorbob74133
      @sailorbob74133 9 місяців тому +2

      I have Gilbert's and after some research found that some other people with it suffer from fatigue and intermittent brain fog and that NAC is supposed to help with it.

  • @gradylang8032
    @gradylang8032 Рік тому +3

    Person with Gilbert’s syndrome here, I keep seeing information supposing a link between GS and Pyroluria. Would love to see a video on Gilbert’s since it’s such a tricky condition to balance nutrients with

  • @ava.artemis
    @ava.artemis 4 місяці тому +4

    Trudy Scott has a lot of great info on this on her website. I’m certain I have it and a carnivore diet is finally getting me in balance after 35 years of struggle. I’ve had insulin resistance, massive estrogen dominance, chronic systemic infections, MCAS, MTHFR, swollen lymph nodes for 30 years… MCAS made me so sensitive to supplements I couldn’t take them and I just get them via red meat and organs, the most nutrient dense foods on the planet, with all of the cofactors they need so I don’t create more imbalances through supplementing. I don’t plan to do it forever, and it may not be for everyone, but I do think it’s about the best way to balance nutrient deficiencies and metabolic-hormonal dysfunction. I do take small extra doses of P5P, zinc, vit c, and glutathione. I’d like to get tested to see how that’s really working, but I’m feeling better all the time and testing is expensive.

  • @edyt.8761
    @edyt.8761 Рік тому +1

    Felix THANK you for explaining this issue very, very well. Years back i mentioned this to my doctor and he began addressing the H pylori infection.

  • @BizKit167
    @BizKit167 Рік тому +8

    I have pyroluria. And also under methylation. I really want to know if there's a connection between these two conditions.

    • @felix-harder
      @felix-harder  Рік тому +10

      This is normal. Most people have more than one biochemical issue. I will have a video on the walsh protocol soon, where I go over this in more detail.

  • @TheRagbags1
    @TheRagbags1 Рік тому +3

    Wow ! Wonderful explanation, they ( NHS gastroenterologist!) took me in for 6 weeks , thought I had Porphyria!!

  • @sodamncutestud2
    @sodamncutestud2 Рік тому +5

    I have this! Confirmed via testing 8 years ago !

  • @Freddie1M
    @Freddie1M Рік тому +10

    With all these metabolic disorders we can have, say pyroluria for example, the recommendation is to start taking zinc and B6, but how long are we supposed to do this for? Forever? Until we feel better? And if we come off them how do we know it won't just come back?
    It's just so confusing fixing metabolic issues because you can so easily overtime create another metabolic issue through supplementation creating a different imbalance/toxicity somewhere.
    I don't want to live my life thinking about how to manage supplements and when I need to come off them.
    You always emphasise that one solution doesn't work for everyone in all the metabolic disorders you mention on your channel, every solution therefore seems so volatile and impermanent. I've nearly gotten to the point where I'll just give up as there's just too much to consider.
    Also I may be able to fix one metabolic disorder but not realise I have another one, and then later realise I do, try and fix that one, but then reverse all the hard work to fix the first one.
    It would be nice to have a one solution for all, are you sure there isn't one? And if there isn't one how can we feel confident in any of the protocols we follow in the long term?
    If not possible what I would ideally like is to have an AI assistant who can monitor all my nutrient deficiency's perfectly and simultaneously create one single supplement which is the perfect solution for the deficiencies/toxicities at the time. That way I am not going to be taking too much B6 long term for example, the AI will automatically adjust the supplement stack to reduce the B6 dosage so I don't have to think about it. That would be far more reliable than having to constantly guess around with what dosage I should be taking and constantly having to think about it.
    That's the way I feel about it, I'd just like some advice on how to get over this way of thinking really because I find it all too daunting to even start improving my health.

    • @Padraigp
      @Padraigp 5 місяців тому +2

      No theres no one solution for all. As you say its complex. Thats why you need to get tested. To see which issue you actually have. I had a gitmain d deficiency so I started taking vitamin d what I didnt know is i had a magnesium deficiency as well and taking vitamin d made that worse which I disnt realise...then one day I took calcium and have a full body spasm convulsion because if you have low mag and take cal the imbalance is too much for the body. Magnesium sorted it out and my water is very high calcium so I have to take magnesium to balance that out ..if I lived somewhere the water didn't have so much calcium I might not need it as much. Unfortunately normal blood tests do not show magnesium deficiency. You need to go to a person who can get proper tests which are insanely expensive...I couldn't afford the test 400 euro. So I just took the magnesium and felt the effect which was amazing. I had heart palpitations and they got better in two days gone. When I stopped taking magnesium they came back. But if you can afford the testing get it done. Who does this I dont know.

    • @RigoUnreal
      @RigoUnreal Місяць тому +1

      I also have it and i think you need it for ever, at least some form of a good combination that is fitting your needs. I read somewhere that people with this condition can in a time frame of 2 weeks get symptoms again if stopping the protocol, not sure if that is true tho.

  • @Shasha8674
    @Shasha8674 Рік тому +2

    Stress uses up Zn/B vitamins and progesterone. Hair test to see good mineral levels/heavy metal levels may help and restore low minerals/detox heavy metals.

  • @angelataylor2049
    @angelataylor2049 9 місяців тому +1

    What is the best diet?

  • @QUINTUSMAXIMUS
    @QUINTUSMAXIMUS Рік тому +4

    From what I understand, only a few doctors test for this. It's not through the Walsh Institute. You have to find doctors online who consult and order the tests from places like DHA labs. It's not very convenient, to be honest.

    • @felix-harder
      @felix-harder  Рік тому +1

      Yes, you are right. Most walsh practitioners use DHA labs. They dont rely on the ranges the lab defines as "normal" though. So yeah, it's pretty complex.

  • @user-hp6ls8qy6d
    @user-hp6ls8qy6d Рік тому +2

    I'm pretty sure I have this. There are tests online for the symptoms I had yes for almost all of them!
    My scalp gets inflamed and my hair goes thin.

    • @tlkendall29
      @tlkendall29 2 місяці тому

      I’ve had this as well and none of the dr.’s I went to and explained my symptoms knew what was wrong with me…they were like oh..I’ve never heard of this and I felt like a crazy person…this took me on a 15 year journey in self diagnosing and treating myself…so frustrating but also made me realize most dr’s are clueless unless it’s the usual virus, allergy, broken bone etc

  • @xanxus8272
    @xanxus8272 Рік тому +2

    According to KEAC:
    "Malvaria (HPL) or mauve factor is often mistakenly referred to as kryptopyrrole (KP) or pyrroluria. This is due to studies incorrectly classifying mauve factor and KPU as the same substance, owing to similarities in the chemical structure. Mauve factor or hydroxyl-haemopyrrolin-2-one (HPL) is produced from hydroxylactam or haemopyrrole and not of kryptopyrrole. Therefore the terms pyrroluria and kryptopyrrole should not be used interchangeably to refer to mauve factor or malvaria."

  • @CandycaneBeyond
    @CandycaneBeyond 10 місяців тому +2

    Is there any correlation with Hemochromatosis ?

  • @tommyortiz6623
    @tommyortiz6623 Рік тому

    Hello! Have you heard of Oligoscan? How accurate is this compared to hair analysis?

  • @random55912
    @random55912 4 дні тому

    I have 5,3mg/g and it say from 6 its elevated. How.much does it change by stress etc? Maybe I wasnt stressed and it often is higher or i was stressed and its normally lower. Do I have the condition or not?
    I have a very good dream recall, normally it shouldn correlate with HPU?!

  • @maetompkins8360
    @maetompkins8360 Рік тому +2

    What’s the best form of Zinc?

    • @felix-harder
      @felix-harder  Рік тому +3

      Most people will say picolinate but it practice it varies form person to person. I talk about this in more detail here: ua-cam.com/video/WmrygiojKUc/v-deo.html

  • @tesssins3239
    @tesssins3239 7 місяців тому

    thanks a lot for your video!

  • @SuperAmazingAnt
    @SuperAmazingAnt 5 місяців тому

    What supplements you take now btw

  • @rm6857
    @rm6857 5 місяців тому

    is there any theory behind this? is it just bad metabolic mutation, or has it some benefits for survival in some conditions?

  • @keren1126
    @keren1126 9 місяців тому

    Which of the tests did you do with Keac? Was it the HPU or KPU test? And was it the 24 hour urine test, or the morning sample?

    • @felix-harder
      @felix-harder  8 місяців тому +1

      24 hour HPU urine test

    • @keren1126
      @keren1126 8 місяців тому

      @@felix-harder thank you for replying. Do you understand the difference between the HPU and the KPU test with Keac? I am struggling to make sense of it.
      Also, do you know anything about the Pyroluria test with Biovis? I looked at the Biovis example report, and the measurement units are different to other Pyroluria tests I have looked at.

  • @robwembley
    @robwembley Рік тому

    Thank You !

  • @meggi8048
    @meggi8048 Рік тому

    i have this, but i also have low copper (low coeruloplasmin and even hair tests show lownormal copper) and high mangan. weirdly.

  • @mojjt
    @mojjt 4 місяці тому

    Is it necessary to stop taking vitamins before doing pyrroluria test?

    • @danahumphrey5044
      @danahumphrey5044 3 місяці тому +1

      yes, I was told to go off supplements for a couple of weeks for my first test. Also, the pyrroles are very sensitive to heat and light and degrade quickly. So the test may not be accurate. Most practitioners dont just rely on the pyrrole urine test. You get blood tests serum copper, plasma zinc and ceruloplasmin and then adding a HTMA also if you have someone to interpret would give you the whole picture.

  • @dr.salomemasghati9937
    @dr.salomemasghati9937 Рік тому

    What type of zinc is recommended to treat - zinc orotate, monomethionine, citrate or bisglycinate?

    • @julia1234
      @julia1234 7 місяців тому

      Zinc piccolate is most bioavailable for the body

  • @Dan-oi4kt
    @Dan-oi4kt 10 місяців тому +1

    B6, zinc, vitamin c and magnesium.

  • @isa-manuelaalbrecht2951
    @isa-manuelaalbrecht2951 11 місяців тому +1

    All about metabolic issues....ther's nothing else then metabolic imbalances..😊😁😆🤩

  • @anurruti
    @anurruti Рік тому +2

    If pryoluria does not have an easy fix like taking heightened doses of Zn and VitB6 and other nutrients, how then the lives of some people you know of changed (and you hint postiviely)? What did they do that their lives changed positively?

    • @felix-harder
      @felix-harder  Рік тому +6

      By focusing on other nutrient deficiencies and imbalances and trying to bring all the major nutrient back into balance. More on this here: ua-cam.com/video/cvajPUiDrdA/v-deo.html

    • @anurruti
      @anurruti Рік тому +1

      @@felix-harder Thanks I'll check the video.

    • @irenaw2504
      @irenaw2504 5 місяців тому

      Thanks for the video! What about people who match all the symptoms but the test result is negative? ​@@felix-harder

  • @a.b.4052
    @a.b.4052 Рік тому +1

    So how did you get better if pyroluria treatments didnt work?

    • @felix-harder
      @felix-harder  Рік тому +2

      I checked my other nutrient deficiencies besides zinc and b6 (ua-cam.com/video/q7hJ5M0H_4k/v-deo.html) and also found out that copper toxicity was my main problem (also have a video on that).

    • @a.b.4052
      @a.b.4052 Рік тому +2

      @@felix-harder I have severe copper toxicity also from the pyroluria. Have you found 100% health restoration? Can you please link me to your copper video that shows your protocol to lower the copper? High P-5-P is causing me to dump copper and it is not pleasant at all.

  • @Darren-c6u
    @Darren-c6u 9 місяців тому

  • @sugarpuddin
    @sugarpuddin Рік тому +1

    Body fat has an enzyme that converts testosterones into estrogens. More body fat can mean more estrogens.

    • @kara3396
      @kara3396 9 місяців тому +1

      True, I remember feeling like a solid steel when I was shreded.

    • @sugarpuddin
      @sugarpuddin 9 місяців тому

      @@kara3396 A patient has two drugs to turn off the estrogen whilst they get back into shape:
      Arimidex or Femera. Of the two, Femera is the best as the dose is only 1mg every other day, (Arimidex is 1mg per day) These drugs turn off the production of estrogens; and as a result, testosterone's increase. The American medicine doesn't seem to understand hormones. Another interesting ancillary medicine is Proviron.

  • @jddavisism
    @jddavisism 11 місяців тому +1

    felix needs more sun!

  • @denesfodor8497
    @denesfodor8497 Рік тому +1

    You are not serious without scientific references.

  • @rookmanikaur6170
    @rookmanikaur6170 Рік тому +3

    Hi Felix, I have been following your channel for a while in hopes that you would discuss alopecia universalis but so far I have not heard anything about this. My son is diagnosed with this horrible diagnosis, which has robbed him of his dignity. He has isolated himself socially for the past five years and rarely interacts with anyone except me or his Dad. Do you know anything about this disorder? There has been coverage in the press recently, but that’s not an option long term and he does not want to rely on prescription medications which will impact his liver and kidneys. If you or any of your followers know of a cure of some kind would you please contact me. I’m desperate to help my only son find a way forward in his life.

    • @maija-liisapiittari9618
      @maija-liisapiittari9618 3 місяці тому

      Dr Eric Berg could have an answer to this condition, some vitamins or....