DNA replication in prokaryotes 2 | Prokaryotic DNA replication elongation

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  • Опубліковано 18 гру 2024

КОМЕНТАРІ • 281

  • @Manisha-mf2qe
    @Manisha-mf2qe 2 роки тому +12

    Thanku Bhagwan ji💓🌼😇🌈🤗🙏Thanku sir🙏😇🌈🤗💓🌼

  • @sofiaelectra1918
    @sofiaelectra1918 4 роки тому +90

    Instead of only pointing out the minor mistakes in this video, you could also praise this man for explaining difficult subjects so easy for us to understand. Keep up the good work and we will keep the A grade at the biochemistry!!

  • @pratikonkar8360
    @pratikonkar8360 Рік тому +3

    Your video's are very knowledgeable as you go deep into the concepts and mechanisms. Love to watch and gain knowledge from your videos.

  • @rachanadaschaudhury1647
    @rachanadaschaudhury1647 6 років тому +18

    Lucid explanation. But there is a small correction I would like to add. The direction of the last primer of lagging strand will be reversed(i.e., 5'--> 3'). :)

  • @shido4206
    @shido4206 4 роки тому +4

    with your explanation, this mind blowing topic become so easy to understand...thank u for such great content to reply on.!!!

    • @shomusbiologyofficial
      @shomusbiologyofficial  4 роки тому +1

      You're welcome. Glad to hear that you're getting benefit from my lectures

  • @komal24373
    @komal24373 Рік тому +2

    Can't believe it is 7 years old video, 😮so much detailed explanation ❤❤ thanks sir

  • @srish2536
    @srish2536 3 роки тому

    Aatma tript ho jati h aapse pdne ke baad🙏You are a gem❤️

  • @joshcaldwell3
    @joshcaldwell3 9 років тому +2

    Excellent video! You posted it in just the perfect time too. I'm studying for my Biochem final exam right now, and this has been super helpful to visualize everything!

  • @snehalvaidya9714
    @snehalvaidya9714 4 роки тому +1

    Your explanation is far more better then my professors....good job keep it up

  • @nilufarafreen4559
    @nilufarafreen4559 7 років тому

    ur videos r too helpful for me...when i hv confusion about any topic..i alwys search ur videos....ur speaking is also very fine...u alwys use easy words in ur sentence

  • @LS-om4bb
    @LS-om4bb 4 роки тому +3

    This has helped me a lot.Such a great initiative to clear out the doubts of many who are struggling like me.

  • @nandhiniperumalsamy6961
    @nandhiniperumalsamy6961 3 роки тому

    Thanku so much brother...u r a best soul...I don't have a best teacher like you....

  • @acpangel
    @acpangel 10 місяців тому +2

    you are a genius sir

  • @ОбычныйПерсонаж
    @ОбычныйПерсонаж 6 років тому

    I found one mistake, but in common your lessons are helping me a lot (right now) to pass the exams for the magister program. Thank you so much for your hard work!! I found all I needed and even more. Priceless material if you're tired of reading books (temporarily), and there is a need of human touch :)

  • @barborak6419
    @barborak6419 8 років тому +60

    I don't think that is correct... in the second part of the video the primer in the loop…when you imagine you straighten the loop out... than the primers in both chains will be in the same direction….or…leading strand is 5‘ (on the left) - 3´(on the right) so lagging strand is 3‘ (on the left) than on the end of the loop it should be 5‘ ....but primer on it starts also with 5‘…Still thanks for your videos, your teaching helps me a lot!

    • @imrocknreeling
      @imrocknreeling 6 років тому +4

      Barbora K the part which is incorrect i agree, but the idea is making a loop only in the direction of 5'-3' which justifies the loop formation. Don't bother about the rest loop, the dna polymerase only select the same direction primer. If you're not satisfied with it watch the video which describes it. I was also confused because of this one. But now I've got it.

    • @shrutisoni8744
      @shrutisoni8744 5 років тому +2

      Major confusion is created

    • @akashmishra1285
      @akashmishra1285 5 років тому

      Yes u r correct in this video the direction of primers in the lagging strand is altered

    • @rupahansda173
      @rupahansda173 5 років тому

      I'm also agree with you after looping both replication direction will be same

  • @bhargabjyotibaruah9765
    @bhargabjyotibaruah9765 4 роки тому +2

    Thank you sire. You are the real gem for all life science students. Lots of love and respect from assam.

    • @shomusbiologyofficial
      @shomusbiologyofficial  4 роки тому +1

      Glad to hear that you're getting benefit from my lectures. Please subscribe and share

  • @kaoutharnajim567
    @kaoutharnajim567 7 років тому +4

    Perfect Sir!! You resolve a huge problem I had nerver understanding how the process goes, and now I understand it! Thank you, Thank you, Thank you!
    May Allah bless you, secure your knowledge and your simple yet complete teaching methode!

    • @shomusbiologyofficial
      @shomusbiologyofficial  7 років тому

      +Kaouthar Najim thank you. Glad you liked my lectures

    • @KajalSharma-jd4un
      @KajalSharma-jd4un 6 років тому

      Meko nhi aaya smj..!! Plss help mee...! Mera test h nd yeh ques aane hi vaala h for sure...! Help me..!

    • @subhabrataghosh3565
      @subhabrataghosh3565 6 років тому

      sir i think there is some thing wrong in this lecture please rectify....:)

  • @shubhamaggarwal3801
    @shubhamaggarwal3801 3 роки тому +1

    Thank you so much sir for such a informative video ...i was always afraid of this topic , but you made it like a childhood story

  • @malihauddin5037
    @malihauddin5037 4 роки тому +3

    it is soo well explained!!
    Great explanation as always from Shomu Sir!
    I hope I master this concept and answer all the questiona from this topic

    • @shomusbiologyofficial
      @shomusbiologyofficial  4 роки тому +1

      You're welcome. Glad to hear that you're getting benefit from my lectures. Please subscribe and share

  • @gayanashaji225
    @gayanashaji225 6 років тому +10

    First part of the video initiation was helpful...But the elongation part is not clear

  • @pallavisagare2895
    @pallavisagare2895 2 роки тому +1

    U made it easier to understand much more 😀❤thank you.....

  • @dfgange2558
    @dfgange2558 Рік тому +1

    Thank u very much sir ...
    Ur teaching method just amazing....👍👌

  • @dolanbiswas1350
    @dolanbiswas1350 4 роки тому +1

    Thank you so much sir
    This is so helpful..
    Lots of love and respect from Kolkata
    Sir there is just no doubt after seeing your lectures..

    • @shomusbiologyofficial
      @shomusbiologyofficial  4 роки тому

      You're welcome. Glad to hear that you're getting benefit from my lectures

  • @omniabadr602
    @omniabadr602 7 років тому +1

    Many thanks for all your great videos. your explain is wonderful and that attractive me to watch and watch without stopping.

  • @Sankalanersankalan
    @Sankalanersankalan 3 роки тому

    Boss তুমি সেরা! ❤️❤️

  • @Wanderer789-v8o
    @Wanderer789-v8o 7 років тому +16

    The direction of the addition of primer is wrong in the lagging strand.
    Primers are added as soon as the helicase unwinds and multiple primers are added to that strand from the region of unwinding
    .......correction required.

    • @bogdanbogdanovich140
      @bogdanbogdanovich140 5 років тому

      No the direction is correct.

    • @kuldeepgupta8521
      @kuldeepgupta8521 5 років тому

      @@bogdanbogdanovich140 after the formation of loop the direction of dna synthesis is still 3 prime to 5 prime that is incorrect. see the video again.

    • @bogdanbogdanovich140
      @bogdanbogdanovich140 5 років тому

      @@kuldeepgupta8521 I'm afraid you don't understand that prime ends are actual ends and not directions. Technically it is correct.

    • @palakkhandelwal8487
      @palakkhandelwal8487 4 роки тому

      No, in the video it is wrong totally

    • @delyespadon40
      @delyespadon40 2 роки тому

      @@bogdanbogdanovich140 i agree with you

  • @pankajmaurya7416
    @pankajmaurya7416 8 років тому +9

    sir plz check the legging strand and primer direction on this and dna direction also

  • @garimachouhan816
    @garimachouhan816 6 років тому

    Directionality of legging strand is not right explained..but over all perfect..helped me to solve a lot of problems...thx u sir

  • @withayshwarya6926
    @withayshwarya6926 8 місяців тому +1

    sir thank you for such a detailed explaination.

  • @nisharai6892
    @nisharai6892 4 роки тому +2

    Sir... Thanku frm core of my heart💝✨

  • @sadafrafeeq2250
    @sadafrafeeq2250 Рік тому +1

    Well explained sir, I like your videos 😀

  • @suchanasain1425
    @suchanasain1425 7 років тому +10

    frstly, formation of loop isn't clear to me still. n secondly, primers r removed by RNase H n den d gap is fulfilled by DNA pol 1 . dis portion isn't clear.

    • @srijonibose7630
      @srijonibose7630 4 роки тому

      Primers are removed by DNA pol 1 by it's 5'-3' exonuclease activity.

  • @anweshasarkar18
    @anweshasarkar18 4 роки тому +1

    This video is so so good and really helpful.

    • @shomusbiologyofficial
      @shomusbiologyofficial  4 роки тому +1

      You're welcome. Glad to hear that you're getting benefit from my lectures

  • @Itachiuchiha77365
    @Itachiuchiha77365 4 роки тому +3

    But thanks for this video because I was totally blank in my class after this but you have cleared me a lot

  • @jyotsnathakur1048
    @jyotsnathakur1048 3 роки тому +1

    You explained it so nicely 🥺thankyou sir

    • @shomusbiologyofficial
      @shomusbiologyofficial  3 роки тому +1

      You're welcome. Glad to hear that you're getting benefit from my lectures

  • @jayasrivastava495
    @jayasrivastava495 4 роки тому +1

    very very informative video

  • @sakshiChoudhary-nm5du
    @sakshiChoudhary-nm5du 3 роки тому +1

    Sir circular dna mai bhi loop bnega but kese ,? Pehle breakdown krna hoga dna ko

  • @kavalimadhavi6704
    @kavalimadhavi6704 3 роки тому +1

    Thank you for clearing our concepts sir...

    • @shomusbiologyofficial
      @shomusbiologyofficial  3 роки тому

      You're welcome. Glad to hear that you're getting benefit from my lectures

  • @reshmaba3311
    @reshmaba3311 Рік тому +1

    Tnqq sirr it's very useful 😍

  • @vandanakv7856
    @vandanakv7856 2 роки тому +1

    Even difficult topics are explained in simplified manner🤗👍good.

  • @starvini9386
    @starvini9386 10 місяців тому +1

    excellent thank you sir

  • @tiyashascorner5951
    @tiyashascorner5951 5 років тому +2

    Excellent sir,i have to read the book only, once after watching these videos...too good to understand ,thnku

  • @nirmalparmar1726
    @nirmalparmar1726 6 років тому +6

    DNA is circular in PROKARYOTES
    So how primer will bind at terminal site

  • @riyagupta390
    @riyagupta390 6 років тому +1

    Why DNA polymerase can't go in 3'-5'direction? Is there anything in it's structure?

  • @SuPRiyAsInGh-mS
    @SuPRiyAsInGh-mS 4 роки тому +1

    Well explained sir ....Thank u

  • @rojangaikwad3879
    @rojangaikwad3879 6 років тому

    most beautiful video sir

  • @prekshadepani959
    @prekshadepani959 8 років тому +1

    your videos is very helpful f or my study ....thank you so much

  • @solmazmorovati3086
    @solmazmorovati3086 8 років тому +1

    Is it true that there are leading and lagging direction at both strands?I mean in total we have a leading and lagging direction at leading strand & another leading and lagging direction at lagging strands?

  • @q-rioustv654
    @q-rioustv654 3 роки тому

    It is so easy to understand.... Thank you sir

  • @biotalksolution
    @biotalksolution 6 років тому +2

    Outstanding

  • @gunjanpatidar8403
    @gunjanpatidar8403 4 роки тому +1

    nice explanation sir
    thankyou sir

  • @monikasihag8809
    @monikasihag8809 4 роки тому +1

    nice sir very helpful

  • @Chowdhury_sayan
    @Chowdhury_sayan 8 років тому

    Thanq dada.. I think ur 2nd diagram lagging stand loop is more perfect than first 1...

  • @bts_rollercosterlifepurplearmy

    I just wanna be honest...
    At the same time you make it easy to understand as well as confusing ( in the loop formation and replication direction ) ...

  • @sahilsheoran1202
    @sahilsheoran1202 7 років тому +2

    thank u sir yesterday i got my result & i clear molecular biology paper with good marks thank u very much sir your videos are very helpful & i am doing M.Sc. Biochemistry

  • @santhiya.vviswanathan2696
    @santhiya.vviswanathan2696 3 роки тому

    Thank you sir for ur teaching

  • @AvinashSharma-w5z
    @AvinashSharma-w5z Рік тому +2

    thnk u so much sir & u r so cute😊

  • @Mohdirfan-ku6nu
    @Mohdirfan-ku6nu 4 роки тому +2

    thanku so much sir..now my all doubt clear about elongation process in DNA replication

  • @alokanandamukherjee2649
    @alokanandamukherjee2649 5 років тому +1

    Very nice sir

  • @hrapaoyumai7755
    @hrapaoyumai7755 Рік тому +1

    Very understandable

  • @prabalkakati6486
    @prabalkakati6486 5 років тому +1

    Formation of loop in the strand is not clear to me, and the direction of the lagging stand is wrong as you described,
    But rest of the videos I watched are very easy to understand

  • @satishT23
    @satishT23 4 роки тому +1

    Thank you for the lessons 🙏❤️

  • @54shamamairam38
    @54shamamairam38 5 років тому

    Very helpful vid ,thnkuu sirrr

  • @n.dcreations2805
    @n.dcreations2805 5 років тому +1

    Superb

  • @anamikaseduspace4448
    @anamikaseduspace4448 5 років тому

    I think primer in the lagging strand is not drawn in correct direction. its little bit confusing.. will u plz clear it?

  • @MohdDanish-vg7qe
    @MohdDanish-vg7qe 7 років тому +2

    Firstly I would like to thanks for all your videos but I have a little bit problem in formation of loop on lagging strand plzzz u explain it clearly if u do I am thankful to you...

  • @ektabijarnia8592
    @ektabijarnia8592 6 років тому +2

    direction of primer in lagging strand not clear

  • @cynousitlhou6626
    @cynousitlhou6626 5 років тому +1

    I love your tutorial sir

  • @aparnasv7920
    @aparnasv7920 3 роки тому

    Because of the some writings seen in the bottom of the video, I can't see the figure clearly. Anyway good information you are great your videos are really helping me for my exams . Thankyou Sir

    • @haritham334
      @haritham334 3 роки тому

      Turn off captions in settings

  • @-academykharian6471
    @-academykharian6471 2 роки тому +1

    Dono strand ki polarity same kese ker dii Aap ny?

  • @___cook_eat_repeat____
    @___cook_eat_repeat____ 2 роки тому

    Sir please make a new video on this topic again , coz now u have more technology by which you will make it more easy to understand for us.

  • @sunalpathania6392
    @sunalpathania6392 2 роки тому

    you have made similar videos on same topic so which one should we watch , the latest on or the earlier ones ???

  • @sushreeswagatikaswain4552
    @sushreeswagatikaswain4552 6 років тому +1

    Sir, I can't understand clearly about the looping in lagging strand

  • @biotalksolution
    @biotalksolution 6 років тому +1

    Mindblowing

  • @madhusmitapollai5464
    @madhusmitapollai5464 8 років тому +1

    thnk u so much sir for these videos its really helpful

  • @biotalksolution
    @biotalksolution 6 років тому +1

    Very helpful

  • @sudevpalamangalam7769
    @sudevpalamangalam7769 7 років тому

    Superb sir....thank u sooomuch

  • @tanvidhanorkar5625
    @tanvidhanorkar5625 4 роки тому

    Sir, I have one question as in Ecoli there is circular DNA and already there is 3' hydroxyl group then why we add primer?

  • @nandinidas1567
    @nandinidas1567 6 років тому

    You are just awsm... thank you very much

  • @KhushbooYadav-vv1kc
    @KhushbooYadav-vv1kc 4 роки тому +1

    Thank you so much sir

  • @ahasanulshah249
    @ahasanulshah249 5 років тому +1

    Very nice

  • @anisheshdas362
    @anisheshdas362 2 роки тому +1

    Thank you

  • @biotalksolution
    @biotalksolution 6 років тому +1

    Superbbbb

  • @ashnachhetri758
    @ashnachhetri758 6 років тому

    Really nice👍...but one thing is a bit confusing dat is d dirctn of d arrows of the primers...

  • @lethaldynamite8844
    @lethaldynamite8844 6 років тому +3

    Thank you. There are some mistakes, hope i will do it correctly in my exams.

  • @AsgarAli-ke1bt
    @AsgarAli-ke1bt 5 років тому

    Sir i have a confusion that loop will not formed over becoz bacterial dna is circular so lagging strand will remain circular ,secondly okazaki experiment does not support loop formation...pls make clear my concept

  • @nigamgupta7492
    @nigamgupta7492 Рік тому

    Sir you did a mistake
    In lagging strand the primer is added in complement strand of 5' end .
    Means at 5' end of the ssDNA the primer 5' to 3' is added

  • @prateekpanda4224
    @prateekpanda4224 5 років тому

    Liked the way u explain bro 👌👌👌

  • @jayalekshmir7276
    @jayalekshmir7276 Рік тому +1

    Thank u sirr❤️

  • @gulshanthakur3555
    @gulshanthakur3555 4 роки тому

    How leading and lagging strands can form in same direction ???? Direction of primer is opposite to leading strand primer ???
    I am able to understand this sir.. otherwise you are fantastic

  • @miraclevibration5844
    @miraclevibration5844 6 років тому +1

    ThAnkyoU brother you helped me a lot.....

  • @aguardsjohnson8942
    @aguardsjohnson8942 7 років тому

    Perfect Sir!

  • @AmitGupta-od9rt
    @AmitGupta-od9rt 8 років тому

    thank you so much sir this video helps me a lot many confusion were cleared but sir can you tell me what was the direction problem in lagging strand because i confuse there please reply

  • @taynapasi4486
    @taynapasi4486 6 років тому +1

    everything is good but ...i think some may also need written notes of the whole described process of u sir...like i do..😄😄😄

    • @tabassumparween4551
      @tabassumparween4551 6 років тому

      Try to make notes on your own...it will help you more to remember the process..

  • @firojalam-3778
    @firojalam-3778 7 років тому +2

    Bro...I didn't get well about the looping of lagging strand......

    • @mol_biologist30
      @mol_biologist30 4 роки тому

      Rewatch the video and Copy down the notes on this Chapter given in the description box. It'll be clear to you I think

  • @neerajaneelam3847
    @neerajaneelam3847 8 років тому

    you are amazing... thank you

  • @prithwirajkundu2512
    @prithwirajkundu2512 7 років тому

    the direction of the primer in the end of the lagging strand before the formation of the loop is not correct i guess..please correct that

  • @SHIVANIBTBIOT
    @SHIVANIBTBIOT 5 років тому +4

    Sir your reaction at 11:29 🤣🤣🤣🤣🙏🙏🙏🙏🙏

  • @tsogojohane2794
    @tsogojohane2794 8 років тому

    love your videos, they are always helpful:)

  • @ummulbanin9845
    @ummulbanin9845 4 роки тому +1

    Thanku shomu sir