Gene Silencing by Micro RNA - Medical Animation
Вставка
- Опубліковано 16 тра 2015
- MicroRNAs are a class of small, non-coding RNA molecules that regulate gene expression by inactivating messengerRNA (mRNA) and have a big impact on many biological processes. This medical 3D animation shows the biogenesis and function of microRNA within the cell. The goal of the project was to arouse interest by presenting the topic of gene silencing in a simplified and visually appealing way. It was part of my master`s graduation project where I had the opportunity to combine my two different studies Information Design and Molecular Biology.
For schools and universities: If you want to embed the video on your site, please write my website www.katharinapetsche.com as a credit under the video. Thank you!
Companies: If you want to use this video commercially, please get in contact: mail@katharinapetsche.com
CREDITS:
Concept, Design, Animation: Katharina Petsche www.katharinapetsche.com
Narrator: Steve Crilley
Music: "Mutations" by Small Collin www.smallcolin.com - Наука та технологія
Boy, did this information become suddenly far more relevant today. Appreciate the factual information.
This is microRNA (miRNA), not messenger RNA (mRNA) that’s in the vaccine. There’s lots of different types of RNA including ribosomal RNA (rRNA), transfer RNA (tRNA), and more: en.m.wikipedia.org/wiki/List_of_RNAs.
But it would definitely be cool if microRNA was able to be used clinically. (The COVID vaccine is messenger RNA, mRNA).
@@greenbeancasserole6646 many of the technical terms got explained though.
@@greenbeancasserole6646 wikipedia is biased.
@@epstein_isnt_dead7726 yo, this is basic biology taught in schools now. You don't need a college degree to remember that there are different types of RNA. And no, Wikipedia is not like CNN. Wikipedia is pretty accurate about science stuff. It literally cites the pubmed articles. CNN manufactures consent based on what people who control power want. The main source they use is "people are saying" and "scientists are telling us."
@@greenbeancasserole6646 Wikipedia need for money made it vulnerable.. a need to be wary is warranted
We are indeed fearfully and wonderfully made.
There were an awful lot of very fortunate evolutionary steps along the way to get us to where we are.
@@jaco7675 “very fortunate” doesn’t even begin to describe the improbability.
@@benmilesg I know. I was being facetious. We are truly amazingly created.
@@jaco7675 haha cool, I didn’t catch that. God Bless
Indeed!!!!!!
Best cell animation I have ever seen.
It will be nice to see the effect of COVID vaccines to RNA
This animation is amazing and you should definitely make a series of these covering other important topics. What a great little crash course on the key points of miRNA this was!
I'm a Mechanic and this is fascinating. It's another world within a cell. Hopefully now that we know how it works. Man will not mess with it without fully understanding it for the sake of Money and Greed.
the vidéo appears today on my UA-cam suggestion,but the vidéo is 7 years old ,it's like a response from the past to show us what the so called vaccine is about,have a nice year
And hopefully as a mechanic, you don't charge customers for unnecessary repairs for the sake of money and greed.
@@benplus2053 this is true sadly
Lol this is not mRNA, it's miRNA. Nothing to do with current vaccines or whatever.
LOL you got to be kidding right?
This is absolutely fantastic, not only is the information very easy to absorb, but the animation style and overall design is amazing! As a lot of comments have said before me, I very much encourage you to make more scientific animations like this!
Thank you, that's great to hear! I would really love to create more animations like this one! But this detailed 3D style takes a long time - so at the moment it is difficult. However I am thinking about alternative ways to create science animations, so that I can produce them in less time. I will keep you updated :)
Awesome! I'm so glad to hear you'll be making more science stuffs :D (Btw your animation was something of which i kept referring to whilst working on a University assignment, helped so much!)
The first time in my life i heard about this and it amazingly explains all the cells diversity in our bodies.
Thanks so much, I'm an old man and haven't time to learn any other way but this way. The video is absolutely amazing. I've already seen many videos on cells and they are more magical than the Santa Clause I once believed in. The world is far more mysterious that I could have imagined.
Well, damn! Me Too! 68 and more inquisitive than ever! I'll tell you who is good at explaining things (but not with graphics like this) is Zack Murphy, "the Ninja Nerd". There's a really cool vid on the Electron Transport Chain too. The Universe just fascinates me... I've no need of any supernatural make-believe at all. (yeah, I know it's an old vid...)
The Universe uses click-clack logic to produce a really wonderful place - even though (imo) its only simple click-clack mechanisms at heart.
@@BR-hi6yt Just when we think we know such things, nature proves us wrong. Maybe it'll be clack-click, everything opposite to what we thought. But for me I don't spend time wondering such things. To peel the onion and find the next mystery is enough for me if each mystery completely changes everything I thought I knew. It doesn't matter if the magician explains every trick if his next one is beyond our comprehension. Nature has done that so far.
@@MichaelHarrisIreland I'm over the "you can never know or understand the universe". I studied physics, QM, math, philosophy, and shit-hard programming. I am 100% convinced now and no person gets near convincing me otherwise:
Its a sort-of computery thing that uses simple 0s and 1s (quantum states) to produce fantastic computer-y results. Even intelligence is just 0s and 1s. Simple things evolve to incredible complexity but its fundamental mechanism is click-clack. DNA is that. There is no program running it all apart from a very very basic one that evolved (itself). Sure there's a small program running quarks and photons etc - but the rest of it looks afetr itself via evolution (what works persists).
We are probably in a black hole in a holographic cosmos. Its working on computer-like principles at heart. But most people tell me its not that and there is some magic around that we will never comprehend. The Universe doesn't need any magic to be as wonderful as it is imo. I'm so happy here and pleased with what its evolved.
I know you don't believe me - so why am I even writing this? - trying to spread truth I guess. It helps us because then we know where we came form and all that good stuff that confuses so many people.
@@BR-hi6yt So many people thought we were at the end of science and knowledge to find we were not. Even if what you say is true it doesn't matter if it continues to elude us as to what it produces. It's like saying: "We're all going to die anyway so what's the point". The point is we want to stay right to end to find out for definite, to leave no stone unturned, to know without any doubt. I obviously hope this never materialises.
I am fearfully and wonderfully made
Just as the BIBLE DECLARES!!! GLORY TO ALMIGHTY GOD/ JESUS CHRIST AMEN 🙏
Just wonderful...no reason to not like it...detailed description, vivid animation... Awesome
It was really hard for me to study this mechanism by reading a book. But you made it so clear & easy for me to understand as well as memorized. Thanks a Lot! Worth A Big Hats Off! :)
+Ashen Lankathilaka Thank you, I am happy that it helped you understanding this topic! :)
It's true, this video disclaims miRNA way more clearly than articles I've read
What book do you read?
This is amazing Katharina. A very big thank you for making it so easy to understand.
Wow! The Gain of Function possibilities! Imagine the future for this patented technology!
If anyone is wondering that fantastic beat you hear at the end it is: Move This by Techtronic circa 1992
This is so interesting and instructive! Totally beyond topic for what I'm supposed to be studying as a first year nurse student, but it really strengthens my understanding of DNA and RNA, to better comprehend what I'm studying, fill in the gaps in the literature I have. For every new thing I learn, so many new questions arise ♥ Props for the beautiful animations with just the right amount of jiggling to feel the chaotic activity without it being disturbing to take the knowledge in!
Thanks for this simple yet informative video. Great work!
Only wish more videos like this were there,,,,this is how people can understand cell biology
Great animation and explanation of this important molecule,wish you the best!
This is the best animation for molecular biology I have ever seen!!
this video helped me understand in few minitues what i have been struggling to understand in a long while..More vids will be appreciated .thanks
I feel compelled to react as well - videos like these are breathtaking and great for grasping the concept of mRNA. What is unusual is that almost every screen breeds more questions - like no other topic! Especially my questions are about those parts that get discarded along the way - why is it cut? Why was it discarded? What happens to the discarded mRNA part? What happens to those carrying it? How do these proteins move (seeing they have no obvious propulsion mechanism) and how do they know where to take the mRNA strand from and where to paste it? What happens when the person moves or shakes or is massaged by a vibrating instrument? It is mindblowing.
Good questions! I got some theory to your question on how proteins carry the mRNA and where to paste it...programming. These proteins have no brains so it has to be programmed from outside. What do you think?
@@mariao.k.6634 well the movement could be just polarity in many general situations, but then finding the actual place is more complicated.
The most of the answers to your questions could be chemical interactions, and most of the molecules in the cells aren't discarded but simply used and re-shaped in more chemical reactions
thank you so much, katharina, for this video! it was hard for me to understand the generation of miRNA for my course, and not many videos were helpful except yours! thanks again!!
Best basic presentation on this subject I've seen.
Great video. For some reason, I wasn't taught about this subject in high school biology in 1975.
Every time I see things like this I am fascinated and in awe of how complex we are... weather we were made by a higher power, or randomly converged in perfect circumstances, I appreciate our existence.
Random might be too strong a word, there are principles that were probably forged the beginnings of things, those principles could be different in alternate universes if those exist. It's even possible that they be different in different regions of our universe because it is so vast.
This was just out of the world.....
Superb Kath....
Plz make plenty of vids...
Beautifully explained. Thank you for this👏🏻
I was born with perfect DNA and need no ex-peri-mental gene-therapy to change what doesn't need changing.
Ex- as in 'out of, from,'
-peri - as in 'fairy,'
-mental as in 'of the mind, mad.'
Tell them again, the_smoking man.
They can't get it through their dense brains, that not everyone needs, or wants to be modified.
Wise comment!
@@annmyann437 exactly! 🎯
@@annmyann437 but some people were born men ... and they wish to compete as women at the Olympics ... Chinese just dressed theirs up and for some reason the Olympic committees did not bother to check.
bruh, this is unreal! and that happens in every single cell of the body 🤯
probably the best animation on this topic
Fabulous animation!!! Great work!
This animation is amazing, thank you so much for sharing it!
Beautiful!
An amazing way to teach and learn
This video was too beautiful and nicely illustrated I hope you more videos of this kind.
one of the most beautiful video about biology on the website !!! REALLY!!!! congratulation!
Wow, that's so great to hear! Thank you :)
Seriously impressive, well-structured video! THe information was presented very clearly and concisely. Thanks!
Katharina, you are a SCIENCE GODDESS. Like other viewers, I've had a lot of trouble visualizing this process, and even more trouble pinning down a succinct, clear explication of it on the internet. You're doing fantastic work! THANK YOU.
Thank you, Alexandra for this great feedback! So happy to hear that it helped you :)
Thank you, Katharina. So complex, So amazing.
Thank you Katharina, great work.
Very well organised and structured video. Animations were clear and concise and there was enough information in this video to have a good understanding of microRNAs.
+Jessica Jean Thank you!
2020 this is so relevant
Many years have passed, now it is December 2021. Tell me, any diseases are already being treated with this technology? As far as I know, all subjects died from krispr kas, because of autoimmune diseases caused by these experiments. Tell me, is this technology used anywhere other than covid vaccines?
@@100nirosta iRNA can be engineered to silence specific genes (reverse genetics) so it's mainly used for studying gene function rather than a treatment itself
@@KatharinaPetsche please add Indonesia language
Love this video! You are golden!!!
This is AWESOME!!! Mind-blowing. Thanks.
Awesome work with the video. Kudos, well appreciated!
Excellent video and explanation!! 🤗
Instantly cleared my concepts..well done and thanks a lot 😇😇
excellent educational material - thank you for sharing!
The quality of everything is top notch! How long does it take you to make a video like this?
😍😍😍😍😍
Congrats for this magnificent work! Hope you are by now an excelent scientific
I was looking for a video that can make easy the understanding of the miRNA for my students. Et voilà.
The visual effects are really great ! it is a monstruous work. You deserve a lot a thanks and respect for the days of work necessary for this 5 minutes of video. Thanks !
Thank you for this great feedback! It was a lot of work but since it helps so many people to understand the topic I think it was worth it :)
This is beautiful!
This video is awesomely made! Thanks for the animation - you're talented!
thank you :)
Thanks for this very clear concept ❤
I love it ,amazing, imaginative.
Can you do a video on how the covid 💉 MRNA will affect the body.
Hi friend, mRNA and miRNA are not the same thing. Here the miRNA is part of the complex that breaks the mRNA to stop a protein from being produced, so the miRNA are the focus of this video :)
This video is about micro RNA not messenger RNA.
micro RNA is in the first virus, messenger RNA is in the shots. The virus has made my arm and leg muscles grow slightly bigger 2 years on. Hopefully it didn't silence any cancer suppressing genes.
My gosh, you saved me, this is the best video I found in the matter, thank you so much!
A great work went into the animations!
One of the best videos on this. Thank you!
thank you, that is great to hear! :)
true
such an awesome video! saved me from having to look at my notes over and over again! thank you!!
trust me , you really gotta make more videos. this has to be the best one
Fascinating explanation and animation. Thanks a lot!
Thank you so much for this! I finally understood the miRNA mechanism because of this both explanatory and visually great video!
The big takeaway I got from this video is the difference between micoRNAs and messenger RNAs. Thanks to the post by Ms. Petshce. Still not trusting the jab though.
Clear explanation and graphics. Thank you for this video
This is awesome - great job!! Thanks!
please upload more videos ma'am..it was so beautifully explained.
that is best video on this topic. thank you
This video helped me a lot. Thank you so much and keep going making such good videos
The billions of interactions that go unnoticed within the body...
Taken for granted until the day something stops.
the video says disregulation can cause cancer and heart disease. But they are messing with the complex system. Can it cause disregulation in the body, did they test it? NO they didn't!
Beautifully presented and explained. You have made it so easy to understand - well done!
Nice animation video! This helps a lot to understanding gene silencing mechanism by miRNA :)
Thank you, that's so great to hear!
This was amazing. Thank you so much!!
this is unbelievably good. wow thank you so much.
6 years ago
What program did you use to make this and how did it take? It's spectacular!
excellent video. very well explained. great job!
Excellent animation! Please make more :))
So important to understand now that we have mRNA vaccines. I would like to know what prompts the micro RNA to silence some genes and not others?
Thats what we will find out in this trials that we are going through now.
Some sort of programming; I'd expect.
Quite impressive! I learned my cell biology 40 years ago and its great to see how far we have gotten in understanding M-RNA, protein transcription and gene blocking. My children (and my husband, autosomal dominant disease) have a disease called CADASIL which causes progressive dementia. The CADASIL gene as been well defined. However, as far as I know there is no current CADASIL research being done. I don't know if this specific gene/chromosomal defect is amenable to gene therapy, but I would certainly love to find out.
Umm I think that's called herpes lol
Iz qwiz! Go back to school
@@steviemichelle7271 then what you called it?
@@izqwiz1746 How did you get herpes from CADASIL
I was asking many question while I was reading. I got Many answers from yours vedio. I really appreciate that!!
WoW! This is so beautiful! Thank you!
Fantástico, melhor animação que já vi.... Amei demais.
Oi vc poderia resumir o que é falado no vídeo? O Rna é bom ou ruim? Obrigada
@@nonick_23 De uma forma geral e bem resumida o vídeo fala sobre um regulador, esse regulador é o microRNA, ele é um tipo de RNA pequeno que atua como regulador pós transcricional... ou seja, um gene é transcrito em RNA mensageiro e o microRNA atuará nesse RNA mensageiro (por isso pós transcricional). O microRNA vai se ligar a esse RNA mensageiro e na maioria das vezes ele vai impedir a tradução do RNA mensageiro em proteínas.
É uma das formas do organismo controlar funções como fagocitose, carcinogênese, apoptose, hematopoese, diferenciação e regulação da proliferação celular.
De uma forma geral os microRNAs são muito importantes para o organismo, ele pode controlar funções dentro da própria célula que o produz ou ir pra fora dessa célula e atuar em células vizinhas próximas ou em outros órgãos, é bem estudado em vários tipos de câncer, por exemplo:
Um microRNA-x é o responsável por impedir a tradução de uma proteína que é importante pra proliferação de um câncer, se esse microRNA está reduzido no organismo aquela proteína não tem mais um regulador, não tem mais quem a impeça de ser produzida, então haverá um aumento em sua produção e isso pode contribuir para o aparecimento de determinado câncer, ou para a velocidade de proliferação de um câncer já existente.
Não sei se expliquei de uma forma que deu para entender, ou se sua dúvida era em relação a outra coisa.
Qualquer dúvida, estou a disposição.
@@talitasouzasiqueira8418 oi muito obrigada, sim vc explicou muito bem, consegui entender 👍🏼👍🏼
@@nonick_23 😊
Very nice presentation.. how does the mRNA they giving people nowadays in shots go with this ?
This isn't mRNA(messenger rna) in the vaccines. This is miRNA(micro rna) a different form of nucleic acid. It's kinda like saying water and hydrogen peroxide are the same thing.
@@thefbat5847 Is it possible that scientists could be dishonest about what exactly they are injecting in people, much like they have been dishonest about everything thing else over the past 2 years?
@@kalyddessalines769 I understand that public health communication has been politicised and has been damaged massively. But for one moment think about all the people who've put their hard work and effort to try and make our world a better place. Spent years of their lives trying to studying hard science and engineering just so they can come up with innovative ideas to help humanity improve their day to day living. I'm a biochemical specialist and I know and understand why you would say what you've said but it still sucks that all the scientists are lumped together when it comes to negative things.
@@thefbat5847 Good scientists need to be debunking bad scientists. When we literally were told for 2 years that cloth masks can be effective against viruses when ALL SCIENTISTS knew (since forever) that the micron size of a virus through a piece of cloth would be like a bicyclist travelling through a train tunnel. But yet the top scientists in the world pretended to be dumb for the last two years. Even high-school drop-outs knew that they couldn't throw a piece of cloth over their face to work in a paint shop or to remove asbestos, but yet under the guise of "follow the science" we were all duped to believe cloth masks "could help" against viruses. World top scientists told us to use chain-link fences to keep out mosquitoes.
@@kalyddessalines769 The scientist are top for a reason, they're also politicians. At the start of the pandemic it was indeed very confusing on what to do because specialists in each of their specific specialisation were not part of the conversation when the government decided to implement certain rules. I agree that we need more data, a more clear rationale and better reason to make it clear why certain changes are implemented by the government. A single layer mask is indeed useless as you mentioned but a good mask does create a layer of dirt that acts as a barrier for brownian diffusion. But ya it ofcourse was not communicated by the government as they don't seem there care about what scientists think either as much as the general public.
Great video for all levels of knowledge!
thank you fo being able to create this!!
Real question. What is the materialistic mechanism that is proposed by which random mutation and natural selection could have evolved all of these interdependent proteins/functions and logical control systems that appear to all be necessary and fully functional in order for a cell to live?
How could a cell develop, in small incremental step wise fashion, the different proteins involved that have to work together perfectly or they system breaks down, but they must evolve separately, in sync (from not being there to being semi function or fully functional, across different "domains" (like in the DNA code, and being a part of and integrated into the existing transcription process without breaking what is supposedly already there and working) and if it was able to work without it, why would it ever need to be "evolved" or "added" in the first place? and how would mindless evolution "know" in any sense sentient or other wise, what to add to accomplish what this does for complex life to exist?
This seems utterly thought out and designed to work within in the overall system and it appears that the overall system is completely dependent on it being fully functional from the beginning in order to function at all.
I know that evolution is the study of things that give every appearance of being designed, but are "not" designed by a designer, but at what point do we stop and think that maybe it really is designed by a mind?
What am I missing here that easily explains why this is a strictly un-guided materialistic process?
Nicely explained and fabulous animation ⭐⭐⭐⭐⭐💯
thank you very much! :)
Great work and quite impressive explanation
I highly appreciate it 👍🏻👍🏻👍🏻👍🏻
Absolutely amazing! Complicated topic made simple!
It's a nice video and it is easily accessible by students like us nice work and we need much more videos like this for various fields of molecular biology, biotechnology as well as CANCER BIOLOGY which is my special interest
ua-cam.com/video/2nYvS11NDRc/v-deo.html
the video is amazing! thank you so much!
Awesome job on the 3D work for the animation! It was also a great study supplement for an up coming exam I have! What program are you rendering these animations with?
Wonderful explanation and animation! Thank you!
And remember it all came from random star dust which came from nothing.
Right?
Just adding this to update from 666 comments!
most beautiful anime and explanation ever seen
love from india !!
keep doing these type of vid
Very clear and informative video, thanks!
More videos like this please!
looks like a bunch of chewed gum building things. The graphics are great but life is so complex I want to blow my head off. Great video
Zoophilia Consultant omfg lol
ua-cam.com/video/zU7Lww-sBPg/v-deo.html
@@nickkrug8157 Thanks for posting Nick. Tour is such an important cautionary tale. Dumbfounding how someone with so much scientific bona-fides can be so filled with a lust for religious comfort that they blindly step outside the scientific method (to claim objective knowledge of what's impossible), without ever noticing they have done so. Religion truly poisons everything...
@zoophilieConsultant how are you doing today?
Said very well!
this is the best explainatory video I've even seen. Thank you so much. 🌹🌹🌹🌹
Thank you for this awesome feedback! :)
Loved the animation!