Jeff Volek, PhD, RD | Exploring the Keto-Adapted Phenotype: Focus on Muscle | Ep.49
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- Опубліковано 21 вер 2024
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In this episode of The Metabolic Link, recorded at Metabolic Health Summit 2024, we share Dr. Jeff Volek's full presentation where he takes a deep dive into the "Keto-Adapted Phenotype" with a focus on muscle. Dr. Volek, a leading expert in low-carbohydrate and ketogenic diets, shares groundbreaking research on how ketones impact muscle function and performance. Dr. Volek explores the intricate ways ketones influence muscle glycogen metabolism, ketone production in skeletal muscle, and even heart function.
Dr. Volek unpacks underappreciated aspects of ketosis, such as how muscle glycogen can be preserved and replenished without the need for high carbohydrate intake, the role of ketones in cardiac health, and how skeletal muscles may play a part in ketone metabolism. This thought-provoking episode not only challenges conventional ideas about energy and performance but also offers insights for athletes, health professionals, and anyone interested in optimizing metabolic health.
Tune in for a compelling discussion on the evolving science of ketosis and muscle!
About Dr. Volek
Dr. Volek is a registered dietitian and professor in the Department of Human Sciences at The Ohio State University. For the last 25 years, he has performed translational research on how humans adapt to ketogenic diets with a dual focus on clinical and performance applications of nutritional ketosis. His scholarly work includes more than 350 peer-reviewed scientific manuscripts and five books. Dr. Volek is the Chief Science Officer and Co-Founder of Virta Health, the first clinically proven treatment to safely and sustainably reverse type 2 diabetes at scale without medications or surgery. Dr. Volek has a Bachelor of Science in dietetics from Michigan State University, and a Master of Science in exercise physiology and Doctorate in kinesiology and nutrition from Pennsylvania State University.
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In every episode of The Metabolic Link, we'll uncover the very latest research on metabolic health and therapy. If you like this episode, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in!
I so enjoy listening to Volek talk about his research excellent information keep up the good work
This lecture was very interesting and informative, unlike the in video ads.
Nice to see the callouts on some of the open questions in FAO/ketogenic metabolism. Curious that he went back to Owen and Reichard's work but didn't touch on acetone, up to 70 or 80 percent of which is utilized throughout the body, not merely exhaled as so often taught.
The question of compartmentalized NAD metabolism (AcAc from liver, conversion to BOHB in muscle) is fascinating and has been nagging ever since I first heard him talk about it after the FASTER study. And what about that 8-fold increase in Hmgcs2? Muscle and astrocytes pose a similar paradox: expression of both the rate limiting enzyme of ketogenesis (Hmgcs2) and the rate limiting enzyme for ketolysis (SCOT). Synthesizing ketones from acetyl-CoA and then turning around and breaking the ketones back down to acetyl-CoA? The export of BOHB would make some sense of this if the mechanism revolves around NAD homeostasis. Verrry interesting.
Thanks for sharing the video. Ignore the complainers - yes there are ads, but yes also this content was shared FREE. ❤
Thank you for your comment and for watching! We appreciate the support, our sponsors do help us make this kind of content possible :)
dude. some of this guy's papers helped me tremendously in my low-carb lecture to my stroke department. wild. he's definitely a legend.
fantastic presentation.
We're so glad you enjoyed it!
I could definitely do without the annoying ad interruptions in the middle of the researcher’s speech. Very distracting. It’s a complex talk, and the interruptions are not helpful in understanding the topic.
We appreciate your feedback. Our sponsors allow us to make this type of content available to watch for free on UA-cam. If you'd like to watch this episode without the ads, we do have that version available on our medical education platform along with other exclusive content: membership.metabolicinitiative.com
@MetabolicHealthSummit it is waaay too many add reads, it's ridiculous. One or two max.
Gotta make money
Great Presentation! But seriously, too many adverts :(
Glad you enjoyed the lecture. Thanks for the feedback. The sponsors who support our podcast allow us to make this type of content available for free.
@@MetabolicHealthSummit I cut the ads out. Sound off, or scroll on, or make coffee. I have no idea what the ads were. But they DO give me time to put the kettle on.
We need more scientists as him, great talk.
Good information, but way to many ads!
Thanks for the feedback.
Jeff Volek is such a solid resercher. Nice to see a the heir of Stephen Phinney.
Keep up the good job.
We agree!
❤❤
Very interesting ❤ thank you
Thanks for watching!
Where are the research references?
Match 2 much advertising - especially when thinking that I have paid for UA-cam Premium or something..
Awsome...
I have got aprecious information,...
Thank you .......❤
Interesting stuff but the number of built in ads is frankly ridiculous. This caused me to stop viewing mid way through.
Thanks for the feedback. Our sponsors allow us to make this type of content available to watch for free on UA-cam. If you'd like to watch this episode without the ads, we do have that version available on our medical education platform along with other exclusive content: membership.metabolicinitiative.com
If you are long term fat adapted eg 3 years would doing 4 or 5 hours cardio in the middle of a 48-hour weekly fast for a number of weeks upregulate glycogen re synthesis via gluconeogenesis or would it down regulate glycogen use during this exercise?
Thank you for this information. Very Low Carb and/or Nutritional Ketosis Diets (NKD) have been used since at least 1922 (and earlier) to control Type 2 diabetes, reduce insulin requirements for Type 1 diabetics, and reduce epileptic seizures. More recently, NKDs have been used to prevent, delay onset, and/or mitigate other pathologies. Presumably, some diabetics and/or epileptics have been in or close to nutritional ketosis for several years (10, 20, or more).
Given this 100-year history, do you know of any longitudinal, multi-year population observational studies (or clinical studies) of diabetic and/or epileptic (or other) groups that document the positive and/or negative long-term health impacts of NKDs for 5, 10, or 15+ years? The longest study I have found so far is 24-weeks, not long enough to identify some situations.
Thank you.
How does the body know how much glycogen it has stored?
Too many ads.
You can always watch our videos without ads when you become a member of our medical education platform: membership.metabolicinitiative.com
I agree! But it gives me time to put the kettle on. Ho ho!
I'm an OLD KETO LADY gradually turning 69 years of flab and brain fog into something better. 72 next birthday. Yay! I'm OLD but NEW to UA-cam. I want to add my voice to the KETO community...before I die! Look, I KNOW it is JUST ANOTHER VOICE. N = 1. But we can all add up to something significant (to counterweight the bad science/vested interests out there). We should ALL subscribe to folk like Jeff Volek (it's free to subscribe, after all). Google takes note of the numbers. Perhaps governments will too? (this Metabolic Health Summit channel has ads and sells things, so I (probably) won't subscribe here - but maybe Jeff Volek has a channel with nothing on sale except know-how?) Let me know!
What the Heck. How on Gods green earth can The Metabolic Health Summit allow Puff to push in ads for her crap in their channel.
Really sad to see Poff now doing commercials. She needs to be separate from sponsors to maintain her independence.
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Hernandez Helen Davis Amy Moore Helen
Perez John Robinson Amy Walker Lisa
great lecture, but this large female head appearing on the screen to advertise is just disturbing. you gotta change that to something better. at the least, use a medium shot, not this large close up.
35:50 ... man! I was paying for NAD+ supplementation awhile back. Didn't know keto diet was producing it endogenously the whole time. : /