Isabella Cooper is among the top 3 guests on any type of health channel, of all time. She's right up there with Robert Lustig and Jason Fung. Absolutely fantastic (technically accurate) discussion. When she emphasised that understanding of mechanism is essential, I was immediately on-board and listening carefully.
21:17 Well, it's also because that idea of insulin resistance is understood in the context of JUST glucose regulation. That's it, right? And so, what's been shown quite nicely is the fact that where glucose is not being taken up, you know, mainly by muscle cells, let's say and therefore one would say you're insulin resistant, that's ONLY resistant to insulin getting that glucose out of the bloodstream. It's not, the rest of your body IS NOT resistant to the insulin and everything else it does.
I think that self selection is the most sensible thing with respect to diet. I fail to understand why commentators keep insisting on RCT when there are many populations who ‘religiously’ follow a particular way of eating (be that vegan, keto, carnivore, vegetarian etc.) I understand that often people adopt a way of eating because they have a disease in the first place. Thus, Case Series such as those done by Dr David Unwin in the UK are exceptionally valuable. We’ve all seen these emotionally charged TV documentaries where people cry their way through being forced to live on shakes for a month to test weight loss. Why not study instead people who are happily enough following a given way of eating to lose weight. Sure, it would make for less interesting TV but it would be far more realistic. There are many communities on platforms like Facebook that could be studied easily enough. Maybe a better use of research dollars!
A fascinating interview. Thank you so much. The more info we have from good studies the more validated the keto diet will have in general society for preventing disease. Please keep these coming. Two very clear minded people discussing facts is wonderful❤
Brilliant and beautiful. You should see her interview (3 part series) with Dr Robert Cywes. Goes into the intricate details of her study. The work and detail put into the study is mind blowing.
Listen to every word; do not listen at 1.5. Dr. Cooper's research is groundbreaking. She is taking us on a journey to better knowledge and increased health. Please follow up with more Bella interviews.
This has been a wonderful interview. So much science. And I knew a lot of it and was able to follow. I need to save this for a future view. Like watching a movie, I'm sure I will see something I didn't in the first go around. Thank You!!
I’m really excited about ketogenic therapy for mental illness but one warning - after being in ketosis and very strict about carbs for three months I had a high carb meal last week, then had a blood glucose spike close to 300 (and I’m not diabetic), had blurry vision and intense vomiting. I had to go to the ER where the doc told me to go off the diet for awhile. Be careful if you eat a ton of carbs after strict keto!!! Go in and out of keto gradually if you have too. Update/edit - my doc said I can try keto again as long as I take things slowly. This was just an example of my insulin production having to catch up with carb intake, not true insulin resistant. Just wanted to let other know to be more patient that I was. I really shocked my body.
@@joeberrouard3743 about 2 packs of lays cheese crackers (the only carbs I had in the house) I was unwisely trying to get out of keto fast because I felt like the early effects had worn off and I wanted to go off and start again. Also, my ketones had been very high (around 4-6mmol) in the weeks leading up to this so that might have been part of the problem - it was a big crash. Looks like about 75 carbs (I forgot I ate a cookie with 25 carbs too). I had been sticking to around 15-20 total carbs a day.
I believe this recent video on the Metabolic Mind channel addresses the issue: ua-cam.com/video/1Z_OMOfVEDY/v-deo.html TL;Dr: on keto diet the body adapts to the fact that it doesn't need to produce much insulin. This metabolic state looks very much like insulin resistance, except insulin levels stay low even during a glucose spike.
They came so close to mentioning the reciprocal inhibition of fat and glucose inside the cells, and how the complex cellular machinery, from the inside, allows or restricts the entry of glucose into the cells (aka, "Randle Cycle" ) based on current fuel saturation. These would be the actual gears behind the illusory concept they call "insulin resistance".
Please have a research on how GKI LEVEL and reversal of different metabolic Diseases such as Atherosclerosis, CKD, Stroke, Foot Ulcers, Retinopathy etc
Anytime I eat protein, take a hot shower, work out, or use red light, my ketones flatten. I guess my body just uses it all up instantly by becoming insulin sensitive. Then I need to wait about 4 hrs after eating to see my ketones rise again. Or about an hr after exercise or hot shower. Also some supplements also flatten my ketones. Like EAAs ans Nitric Oxide boosters. So basically I can't eat any protein until before bed if I want ketones during the day for mental clarity. Exogenous ketones only give me a spike for about an hr. So it's a complete waste of money. I'm wearing a ckm.
re Isabella’s comments (26:00). The arctic inuit peoples were also very keen to trap and eat any kind of bird they could possibly get their hands on…whenever they got the chance…anything from Auks, Fulmars, Ravens to enchanting little Snow Buntings!
It's hard to know sometimes, but some people find "hidden carbs" in sauces, dressings, baked goods, packaged keto foods, etc. Others find success adding fat, or MCT oil, or possibly even exogenous ketones. We wish you luck on your journey!
My favorite topic. Being in a constant fed ketogenic state from birth is how we evolved. I believe it is not only safe, but is required to be healthy. I have been trying to be in constant ketosis since 1998. It is serving me very well. The monkey wrench in this has been not realizing how bad seed oils are until a few years ago. Aninals do not need ketosis (small brain) except maybe a dolphin.
Doesn’t fat oxidation produce more reactive oxygen species (ROS) than carbohydrate metabolism? If so, one could argue that prolonged ketosis might shorten lifespan, especially if antioxidant intake from plants/fruit is insufficient.
Good question - I think excess carbs/fructose is also a process that produces more ROS , fructose at the very least creates more ROS from various pathways including affecting the mitochondria
@@dilettanter I would define excess as exceeding your fat threshold, where you no longer have the capacity to store carbs. It would be unfair to compare fat oxidation to carb metabolism in a metabolically deranged model. Could you please go more in-depth about the ROS created by fructose metabolism? I’d also like to mention that whole, natural foods containing fructose come with antioxidants. Thank you for joining the conversation and sharing your insight.
Fructose in natural form usually comes with fiber, so it blunts the shock and it's not unhealthy in normal doses. But one needs to be careful about fructose when stripped of fiber (eg. Fruit juice). Check Ricard Johnson for more info (eg. Nature Wants Us Fat book).
I'm not getting a word that she's saying at 27 : 40 , where she talks about the liver not using ketones for energy but using it for_____? If anybody can tell me that, I would appreciate it. Thank you
Is ketosis an all or nothing event, or is it a gradient. I found my ketone usually drop right after meal, but increase gradually to a maximum right before my next meal (I eat OMAD).
Ketosis is definitely a gradient based on many different factors. Someone can have a level of 0.4 in the morning and 2.0 in the afternoon or vice versa, or they could be a steady 1.0 all day. We will start to learn much more about ketone variability as we get more experience with CKMs in the near future.
He takes 111 pills a day to get nutrients like heme iron that he could get from animal meat, not to mention the other essential nutrients like B-12 etc. who wants to eat like that and take over 100 pills or can afford to? Absolutely ridiculous. I’d rather eat meat and enjoy my life.
111 pills is not necessary. He tries to put everything in it. AI making AI smarter combined with medicine may make it possible to live lots longer. He is just trying to not die. Collagen peptide is the only exception he makes.
@@jamiejaymee a lot of brands contain heavy metals. I would look for a brand that specifically says they are tested and contain low amounts. Have you tried an ultra low fiber diet to see how you bloating reacts?
Sorry you’re struggling with that. Have you tried an elimination diet? I had bloodwork done at quest for food sensitivities, felt better taking out those foods. Went carnivore for a year and really saw what different foods did to me. Pea protein can be hard for some people to digest due to several factors. Antinutrients-Pea protein contains certain compounds, such as phytic acid and lectins, which can interfere with nutrient absorption and may cause digestive discomfort like bloating or gas. Also, Fiber Content- Even though pea protein is processed to remove much of the fiber, some residual fiber can still be present, and for sensitive individuals, this can slow digestion and lead to discomfort. Also, Protein Structure- The body may find it harder to break down plant proteins compared to animal proteins due to differences in amino acid composition and the structure of the protein itself. Hope you find healing!
Maybe try a 30 day trial of carnivore? It’s the best elimination diet. I found out within DAYS that it was plants (fiber) that were responsible for my instant bloating after eating. Never ever feel that awful bloated feeling anymore.
I too was introduced to the Low fodmap diet in an effort to heal/ reduce my gut pain and excessive gas. I used the illumination protocol to experience relief, which mainly left me with animal proteins. When trying to re-introduce each plant or carb food in a very small amount, I had bad reactions. For the past 2 years I have remained pain and gas free eating a strict carnivore diet. During this time I have noticed many other health benefits including being able to wean myself off of anti anxiety drugs that I had been taking for over 3 decades. Keep an open mind and experiment with foods until you find what you can tolerate.
The only population that has traditionally eaten a keto diet, is the Inuit/Eskimo. However, that population lost the ability to go into ketosis fairly soon after settling in their Arctic/subArctic home. Or so I understand. What does this say about the long term consequences of being in ketosis? Presumably, early Inuit who could go into ketosis disappeared from the gene pool fairly quickly.
@@metabolicmind Thank you. Yes, she did but I don't recall her addressing the specific point that the Inuit population appears to have lost the ability to go into ketosis. Is this just the result of random genetic drift or was it selected for?
How can any of this be relevant when she admits that blood ketone monitoring does not tell how much ketone you are producing? Tests only show how much is spilling over into the blood and not being metabolized.
Isabella Cooper is among the top 3 guests on any type of health channel, of all time.
She's right up there with Robert Lustig and Jason Fung.
Absolutely fantastic (technically accurate) discussion. When she emphasised that understanding of mechanism is essential, I was immediately on-board and listening carefully.
Also, Ben Bikman, Nick Norowtiz
Incredible. Cooper, PhD, concisely presents hundreds of recent insights into metabolic health in less than an hour. Applause.
She is like a pleasant Bart Kay. She points out the shortcomings of other peoples arguments with a smile on her face.
🤣🤣🤣
21:49 "It's actually quite arguable, insulin's primary job is not regulating blood glucose, that is an acute job for an emergency situation "
I’m excited for when she says that haha I’m 6 min In
21:17 Well, it's also because that idea of insulin resistance is understood in the context of JUST glucose regulation. That's it, right? And so, what's been shown quite nicely is the fact that where glucose is not being taken up, you know, mainly by muscle cells, let's say and therefore one would say you're insulin resistant, that's ONLY resistant to insulin getting that glucose out of the bloodstream. It's not, the rest of your body IS NOT resistant to the insulin and everything else it does.
23:37 Glucose, first of all, EVERY CELL in your body that requires glucose CAN take up a fair amount of glucose WITHOUT insulin completely.
39:20 Which test would you do? Do the between 4 and 6 pm
Loaded with useful detail. Thank you both.
wow...great interview...she is SO SMART!!!!
I think that self selection is the most sensible thing with respect to diet. I fail to understand why commentators keep insisting on RCT when there are many populations who ‘religiously’ follow a particular way of eating (be that vegan, keto, carnivore, vegetarian etc.) I understand that often people adopt a way of eating because they have a disease in the first place. Thus, Case Series such as those done by Dr David Unwin in the UK are exceptionally valuable.
We’ve all seen these emotionally charged TV documentaries where people cry their way through being forced to live on shakes for a month to test weight loss. Why not study instead people who are happily enough following a given way of eating to lose weight. Sure, it would make for less interesting TV but it would be far more realistic. There are many communities on platforms like Facebook that could be studied easily enough. Maybe a better use of research dollars!
Fascinating science; just fascinating. We finally might be able to change some paradigms thanks to people like you! Thank you very very much!
Please write a book to bring this knowledge to the masses. Excellent initial foundation 🧠🧬
Dumb down co author for common man but all important information.
A fascinating interview. Thank you so much. The more info we have from good studies the more validated the keto diet will have in general society for preventing disease. Please keep these coming. Two very clear minded people discussing facts is wonderful❤
Brilliant and beautiful. You should see her interview (3 part series) with Dr Robert Cywes. Goes into the intricate details of her study. The work and detail put into the study is mind blowing.
Listen to every word; do not listen at 1.5. Dr. Cooper's research is groundbreaking. She is taking us on a journey to better knowledge and increased health. Please follow up with more Bella interviews.
We would love to have her back on. She's fantastic
This has been a wonderful interview. So much science. And I knew a lot of it and was able to follow. I need to save this for a future view. Like watching a movie, I'm sure I will see something I didn't in the first go around. Thank You!!
Glad it was helpful!
I’m really excited about ketogenic therapy for mental illness but one warning - after being in ketosis and very strict about carbs for three months I had a high carb meal last week, then had a blood glucose spike close to 300 (and I’m not diabetic), had blurry vision and intense vomiting. I had to go to the ER where the doc told me to go off the diet for awhile. Be careful if you eat a ton of carbs after strict keto!!! Go in and out of keto gradually if you have too.
Update/edit - my doc said I can try keto again as long as I take things slowly. This was just an example of my insulin production having to catch up with carb intake, not true insulin resistant. Just wanted to let other know to be more patient that I was. I really shocked my body.
Do you know about how many carbs you had?
@@joeberrouard3743 about 2 packs of lays cheese crackers (the only carbs I had in the house) I was unwisely trying to get out of keto fast because I felt like the early effects had worn off and I wanted to go off and start again. Also, my ketones had been very high (around 4-6mmol) in the weeks leading up to this so that might have been part of the problem - it was a big crash. Looks like about 75 carbs (I forgot I ate a cookie with 25 carbs too). I had been sticking to around 15-20 total carbs a day.
McDonald’s will do that
I believe this recent video on the Metabolic Mind channel addresses the issue:
ua-cam.com/video/1Z_OMOfVEDY/v-deo.html
TL;Dr: on keto diet the body adapts to the fact that it doesn't need to produce much insulin. This metabolic state looks very much like insulin resistance, except insulin levels stay low even during a glucose spike.
Thanks. Good to know.
Fascinating
They came so close to mentioning the reciprocal inhibition of fat and glucose inside the cells, and how the complex cellular machinery, from the inside, allows or restricts the entry of glucose into the cells (aka, "Randle Cycle" ) based on current fuel saturation. These would be the actual gears behind the illusory concept they call "insulin resistance".
Please have a research on how GKI LEVEL and reversal of different metabolic Diseases such as Atherosclerosis, CKD, Stroke, Foot Ulcers, Retinopathy etc
Hi drs, can you tell me what a keto rash looks like please? And is it on the face? Thanks
Heres an article that may help ketologic.com/blogs/articles/what-is-keto-rash
Anytime I eat protein, take a hot shower, work out, or use red light, my ketones flatten. I guess my body just uses it all up instantly by becoming insulin sensitive. Then I need to wait about 4 hrs after eating to see my ketones rise again. Or about an hr after exercise or hot shower. Also some supplements also flatten my ketones. Like EAAs ans Nitric Oxide boosters. So basically I can't eat any protein until before bed if I want ketones during the day for mental clarity. Exogenous ketones only give me a spike for about an hr. So it's a complete waste of money. I'm wearing a ckm.
re Isabella’s comments (26:00). The arctic inuit peoples were also very keen to trap and eat any kind of bird they could possibly get their hands on…whenever they got the chance…anything from Auks, Fulmars, Ravens to enchanting little Snow Buntings!
Thanks Bella
Yeah, I’m finding it very hard to get my ketones above .3-.5. Even at 5-10g of carbs. Need to figure out what is suppressing it.
It's hard to know sometimes, but some people find "hidden carbs" in sauces, dressings, baked goods, packaged keto foods, etc. Others find success adding fat, or MCT oil, or possibly even exogenous ketones. We wish you luck on your journey!
My favorite topic. Being in a constant fed ketogenic state from birth is how we evolved. I believe it is not only safe, but is required to be healthy. I have been trying to be in constant ketosis since 1998. It is serving me very well. The monkey wrench in this has been not realizing how bad seed oils are until a few years ago.
Aninals do not need ketosis (small brain) except maybe a dolphin.
Doesn’t fat oxidation produce more reactive oxygen species (ROS) than carbohydrate metabolism? If so, one could argue that prolonged ketosis might shorten lifespan, especially if antioxidant intake from plants/fruit is insufficient.
Good question - I think excess carbs/fructose is also a process that produces more ROS , fructose at the very least creates more ROS from various pathways including affecting the mitochondria
@@dilettanter I would define excess as exceeding your fat threshold, where you no longer have the capacity to store carbs. It would be unfair to compare fat oxidation to carb metabolism in a metabolically deranged model. Could you please go more in-depth about the ROS created by fructose metabolism? I’d also like to mention that whole, natural foods containing fructose come with antioxidants. Thank you for joining the conversation and sharing your insight.
Fructose in natural form usually comes with fiber, so it blunts the shock and it's not unhealthy in normal doses. But one needs to be careful about fructose when stripped of fiber (eg. Fruit juice). Check Ricard Johnson for more info (eg. Nature Wants Us Fat book).
I'm not getting a word that she's saying at 27 : 40 , where she talks about the liver not using ketones for energy but using it for_____? If anybody can tell me that, I would appreciate it. Thank you
cholesterol synthesis
Is ketosis an all or nothing event, or is it a gradient. I found my ketone usually drop right after meal, but increase gradually to a maximum right before my next meal (I eat OMAD).
Ketosis is definitely a gradient based on many different factors. Someone can have a level of 0.4 in the morning and 2.0 in the afternoon or vice versa, or they could be a steady 1.0 all day. We will start to learn much more about ketone variability as we get more experience with CKMs in the near future.
Bryan Johnson ranking as one of the highest longevity markers in the world uses pea proteine and is vegan.
He takes 111 pills a day to get nutrients like heme iron that he could get from animal meat, not to mention the other essential nutrients like B-12 etc. who wants to eat like that and take over 100 pills or can afford to? Absolutely ridiculous. I’d rather eat meat and enjoy my life.
He takes collagen peptides so no he’s not vegan.
The man looks unhealthy to me.
111 pills is not necessary. He tries to put everything in it. AI making AI smarter combined with medicine may make it possible to live lots longer. He is just trying to not die. Collagen peptide is the only exception he makes.
What's wrong with pea protein isolate? I've just ordered some as part of a fodmap diet to figure out why I'm so bloated all the time 😭
@@jamiejaymee a lot of brands contain heavy metals. I would look for a brand that specifically says they are tested and contain low amounts. Have you tried an ultra low fiber diet to see how you bloating reacts?
Potential heavy metals
Sorry you’re struggling with that. Have you tried an elimination diet? I had bloodwork done at quest for food sensitivities, felt better taking out those foods. Went carnivore for a year and really saw what different foods did to me. Pea protein can be hard for some people to digest due to several factors.
Antinutrients-Pea protein contains certain compounds, such as phytic acid and lectins, which can interfere with nutrient absorption and may cause digestive discomfort like bloating or gas.
Also, Fiber Content- Even though pea protein is processed to remove much of the fiber, some residual fiber can still be present, and for sensitive individuals, this can slow digestion and lead to discomfort.
Also, Protein Structure- The body may find it harder to break down plant proteins compared to animal proteins due to differences in amino acid composition and the structure of the protein itself.
Hope you find healing!
Maybe try a 30 day trial of carnivore? It’s the best elimination diet.
I found out within DAYS that it was plants (fiber) that were responsible for my instant bloating after eating. Never ever feel that awful bloated feeling anymore.
I too was introduced to the Low fodmap diet in an effort to heal/ reduce my gut pain and excessive gas. I used the illumination protocol to experience relief, which mainly left me with animal proteins. When trying to re-introduce each plant or carb food in a very small amount, I had bad reactions. For the past 2 years I have remained pain and gas free eating a strict carnivore diet. During this time I have noticed many other health benefits including being able to wean myself off of anti anxiety drugs that I had been taking for over 3 decades. Keep an open mind and experiment with foods until you find what you can tolerate.
The only population that has traditionally eaten a keto diet, is the Inuit/Eskimo. However, that population lost the ability to go into ketosis fairly soon after settling in their Arctic/subArctic home. Or so I understand. What does this say about the long term consequences of being in ketosis? Presumably, early Inuit who could go into ketosis disappeared from the gene pool fairly quickly.
Dr. Cooper provides an interesting discussion on the Inuit the interview
@@metabolicmind Thank you. Yes, she did but I don't recall her addressing the specific point that the Inuit population appears to have lost the ability to go into ketosis. Is this just the result of random genetic drift or was it selected for?
💯
What I want to know is...are those rings real?
How can any of this be relevant when she admits that blood ketone monitoring does not tell how much ketone you are producing? Tests only show how much is spilling over into the blood and not being metabolized.