I need to live as long as possible to care for my disabled child. As of now I can't forsee him being able to care for himself. I plan to do that to the best of my ability through healthy lifestyle choices, not by relying on anything outside myself, while continuing to train him into self sufficiency. It's all i can do.
@kellyb3198 I'm happy to read that your family is on keto. That will help. Taking care of the Microbiome will also help. In some cases, FMT (Fecal Microbiota Transplant) has been extremely helpful. I will pray for you and your family
Your caring innate motherly instinct to care for your kid is the strongest factor and real physiological secret that will make you live the length of life you need.
I have a similar situation. I have been taking all the “longevity supplements” for near two years now, and started my Rapamycin therapy this month. I also started carnivore diet 6 months ago. I feel better than ever. I am 65, feel like 20s though. Anyhow, this video I feel misled. We are talking about extremely low doses and take once a week (I take 6mg per week). The possible side effects he is taking about is out of question here.
Thank you, Ben, for this concise direct summary on Rapamycin. I was skeptical of Rapamycin when I first learned of it as it was praised to no end for longevity. A quick check, however, showed that its primary use was suppressing the immune system for organ transplant recipients, primarily by inhibiting MTOR. If inhibiting MTOR is the primary means that Rapamycin confers some longevity benefits, fasting can achieve the same. Autophagy likely confers most of the benefits of taking Rapamycin. Autophagy can be attained by fasting without the need to take Rapamycin. That was my conclusion. Your going even farther than the above has helped reinforce and expand my understanding of Rapamycin. Thank you.
I reference you so often that autocorrect, when I type Dr. , suggests Chaffee, Bikman and Bright. You've such a clarity of thought it's refreshing. Thanks Prof 🫡👍
Dr. Bikman, the longevity community doesn't view protein as harmful. We prioritize muscle mass and health through regular exercise and adequate protein intake alongside rapamycin. The issue with rapamycin research is the lack of pharmaceutical funding due to its inability to be patented, which is why independent researchers are advancing this field. While rapamycin may suppress immune function in high doses (as seen in transplant patients), there's evidence that it can reset the immune system in lower, carefully timed doses. This has been observed in studies showing improved vaccine responses after short-term rapamycin use. Though much remains unknown, its ability to recalibrate the immune system is a promising area of study.
Thanks again, Dr. Bikman. The more I learn about metabolic health, the more I am convinced in the anthropological view that we must eat as we have evolved. It seems to me that modern society has drifted too far into the pharmacological intervention paradigm. This lecture proves the point to me once again.
Again food is medicine and knowledge is power. This short lecture on MTOR is quite enlightening. I've been chasing the answers to healthy longevity for 3 years now and the MTOR discussions were never this clear. Thank you for the cited references so I can read and study this subject at a deeper level. Dr. Longo at UCLA does not discuss MTOR in h I s research that brought about tge Mimicking Fasting Diet. I have used his meals in tge past, but never got the results suggested in eating that food. My carnivore lifestyle has made all the difference.
IMO, you have achieved immortality, not only through your children, but also through the excellence of your lectures, that’s how anyone achieves immortality, ie, through the excellence of his/her work.
Thank you for this informative video! You have validated my plan to just keep eating low carb, resistance training and intermittent fasting and I will save my money by not taking more meds!
Just wanted to mention that in another video with Ken Berry, hesitation to recommend fasting to older folks. This point is valid. I'm 55, and used a lot of actual fasting (not intermittent fasting), to lose weight. I felt better and clear headed during these fasts, and I indeed lose significant weight. I also lost significant muscle. Currently on healthy keto-vore, and aggressive resistance training to put muscle back on. Thank you, and really appreciate all you do.
Good point we will know in 50 years if Peter wins the centanarian decathalon.Robert C has a different training strategy and is 10 years closer to the finish. I'm not sure if I want to win that one
Some drugs have a nonlinear dose-response relationship. Tylenol is harmless in low doses and suddenly becomes very poisonous once you take enough to burn through all the glutathione in your liver. Nicotine is stimulating in low doses and sedative in higher doses. Rapamycin advocates claim that the immune suppression only shows up in high doses of the drug. I haven't seen research one way or the other on that, but I feel like you're ignoring an important point of their argument by not addressing that assertion.
Great lecture in that I understand the functions of Rapamycin much better. Also I believe mTOR has been changed to Mechanistic Target Of Rapamycin, changing the Mammalian part for reasons I can't remember.
I have similar philosophy in that I see my children and grandchildren as my immortality. However, I want to live long enough to play a beneficial and active role in my children’s, grandchildren’s, and great-grandchildren’s lives. So I’m still considering rapamycin, in lower doses.
It does seem like there’s some confusion here about the dosing of rapamycin for longevity. SUSTAINED levels of rapamycin in the body do suppress the immune system (great for organ transplantation). But short duration spikes of rapamycin do not have this effect and seem to (more research needed) strengthen the immune system. Many people interested in longevity do only one or two courses of rapamycin (e.g. 6mg of rapamycin, once per week, for two months) to see benefits…often IN COMBINATION with fasting and/or ketosis. Both fasting and rapamycin use can reduce insulin sensitivity, protein synthesis, testosterone production, and overall reproductive vigor (in the short term), but with the right dose and duration, may have profound long-term health effects. I’m also curious to learn more about the other benefits of rapamycin not directly related to mTor (e.g. antifungal properties)
T A most valuable part of this discuss was why Animal results are a poor predictor of mechanisms within hominoids. I had a discussion with a heart surgeon who said stents were sometimes coated with it. However one working hypothesis is that MtorC1 and MtorC2 are addressed differently by low dosing:: ""Cellular processes: mTORC1 is more involved in cell growth and proliferation, while mTORC2 is more involved in cell survival and cytoskeletal organization.""
@@benbikman no thank you for your service ouTside acAdemia. I am truly disgusted with the way the medical community has handled diabetes (I II and eye.5 :). 15+ yrs on gen II sulfonyereas probably gave me irreversible insulin resistance. Pound for pound pancreas and kidneys do more than the brain, but lipids (not just RBC glycation) seem to be the rate limiting factor in targeting Affect. I honestly think low tech stuff like intermittent fasting, and psyllium fiber might have done enough for me in the early years since ACE II and HMG-COA inhibitors are a joke. IN addition to your lecture series am a big Fan of Jason Fung, Ken Sikharis, Paul Mason; since like you i believe they are SHOWing me their truth and not just parroting information.
Longevity use of rapamycin is based on intermittent use once individuals have entered middle age. i.e. MTOR is temporarily interrupted, hopefully also disrupting degenerative processes like cancer. So yes, it's not appropriate during reproductive years. Insulin resistance is an important factor - yes, possibly more important than any supplement.
Animal evidence suggests that taking rapamycin once you're already old still extends lifespan and healthspan a substantial amount. So the obvious thing to do is wait until you're starting to feel age weighing on you and then try rapamycin to see if it helps.
Yes, possibly because mTOR can be over-expressed in older humans. Not addressing this and the dosing schedules used for anti-aging use make this lecture much less nuanced than it purports to be.
A couple of years ago, I was very sceptical to the idea that protein restriction would be good fo longevity. All it took for me was to see in the charts of basic cellular metabolic pathways that mTOR is not only activated by amino-acids but also by Akt (through some steps in between) which is part of the insulin-pathway in the cell. So my hypothesis was exactly what Ben Bikman says, that insulin matters more and that a chronic hyperinsulinaemia is the actual problem. Nice to get actual confirmation of my bias ;-).
Hello - thank you for the dozens of amazing videos -- I've learned quite a bit and I never hesitate to recommend them for information on the topic of which you are obviously the expert. However, in this case I'm disappointed that you've jettisoned your usual rigor for fuzzy if not misleading information. Although your video is titled "Rapamycin and Longevity", you are not discussing the protocol used for this purpose. First of all, the topic under discussion is the four-syllable RAPA-MYCIN not RAPA-MAYA-CIN - not a huge deal, but if you're going to make a video, you may as well call it what it is. More importantly, you know very well you can't go around uttering phrases like "using rapamycin"! I don't hear you say in your other videos if you "have insulin" then X happens -- you are going to talking about a specific amount of the compound and a specific velocity that the compound changes over time -- so please give the same treatment to this topic. It's well documented that the effect of chronic/continual dosing of rapamycin as used on-label intentionally for immune suppression is completely different than the effect of pulsatile dosage (in my case one dose every 2 weeks - usually 7-14 days) when used for its hopeful health and longevity benefits. Specifically it doesn't act as an systemic immune suppressant to any great degree, inhibit MTORC2, or seem to inhibit muscle growth. (It seems to have the opposite effect - improving the efficacy of vaccines in older adults, etc., and no reported loss of muscle hypertrophy or strength.) As for side-effects using the protocol, there are very few. (Cold sores for a day or two in a small percentage of users - which I've never experienced.) I think its not hyperbole to say that occasional rampamycin use is much safer than casual use of either antibiotics or even NSAIDs like Tylenol, of which there are many deaths every year. Regarding risk - I'm not a risk-taker, and I find the possible-risk (almost zero) to possible-reward (possibly some benefits) to be quite acceptable. As you know, absence of evidence is not evidence of absence - as you rightly say, doing longevity trials on humans is near impossible, but given rapamycin's effect on the simplest organisms on the planet all the way up to mammals like mice, there's a decent chance that the mechanisms of actions extend to humans, although we can expect the effect size to be much smaller. You can also be assured that those of us taking rapamycin are fully aware of our labs such as lipids, triglycerides, A1C or real-time glucose levels, fasting insulin, etc., and are doing "all the things" for health first before reaching for rapamycin - certainly not in lieu proper diet, fasting (if it's your thing), aerobic & strength conditioning, and sleep. It's also not fair to omit other resources here, such as Matt Kaeberlein's companion animal project (so we'll get results from dogs soon) as well as www.rapamycin.news where you can interact with the many thousands of people that are actually taking rapamycin rather than guessing about side-effects, etc.
How does the protein, MIBK get involved with the MTOR protein and isn’t there like a see-saw effect between those two proteins? That is, when one of these proteins is activated, the other one is not or creates a lower effect. Do these two proteins have opposite effects?
Thank you Dr. Bilkman for presenting this about rapamycin. I have been considering it. I want to know if and how dosing changes risk. The dosing for organ transplant patients is daily for life, but in my understanding, one only has to take rapamycin for a few weeks to have benefit, that daily doses used in immune suppression do not increase lifespan, but greatly limited dosing does extreme life in older, but not younger, mice.
Wow! Great lecture. As suggestions: please do not extend the length of the video and slides might be helpful. Again, thank you for an excellent lecture.
Can you really reverse Insulin resistance with ketogenic or carnivore diet? Or just control the insulin and glucose levels in blood? Reversing IR should make it possible to eat regular diet again with some carbs of course avoiding standard american diet and junk food. Being, coming back to be a completely insulin sensitive person.
It is absolutely possible. But If you have retained it you still should have a fasting Times and controled carbs. When I worked in Africa, only rich people had Diabetes. The poor could Not afford meat. They drank only tea im the morning and worked the whole day through. In the evening they are one very big mal of carbs: Stiff porridge, rice or beans. They we're very slim, but muscular and had no chronic diseases.
"Can you really reverse Insulin resistance with ketogenic or carnivore diet?" You can normalize your insulin and that is what matters. "Or just control the insulin and glucose levels in blood?" Why "just"? "Reversing IR should make it possible to eat regular diet again" Why would anyone do such a ridiculous nonsense?
My doc put me on this. I took two pills and felt like it was actively killing me. My hair fell out in handfuls and I felt terrible. Sheesh. Never again.
Hi good morning one question I can’t find the answer for it I am type two diabetic I am using CGM my glucose set point increase from 5mmol to 13 mmol constant for some reason it like to stay at that level if I bring it down by fasting or insulin it will go back to around 13 mmol? So what I learn cause is the cure . Now brain override the glucose controls because of vessculites issue brain 🧠 not getting enough glucose it increases the glucose gradient GLUT -2 ? I hope you understand the cause of diabetes and obesity Thanks
With diabetes, your cells are filled with carbs so you need some time tio get rid of it. Eating keto or carnivore, you may experience somehow higher blood sugar levels , because your cells are not deppendent in carbs anymore.
Your religion teaches that Adam's sin was okay. But that command was given before the sin. Adam and Eve were only going to die if they ate of that tree in the middle of garden. Had they not disobeyed, they would never have died. So humans were meant to live forever. We die now because we inherited sin from Adam and Eve. God set in place the realization of his original purpose when he made the prophecy in Genesis 3:15. Jesus will crush Satan in the head which means a death blow. Jesus was struck in the heel when he died on the stake but it was not a permanent death blow because he was resurrected. Humans were originally created to live forever right here on earth. If Adam had never sinned would he have ever died? No.
In science it is important to hear all sides and listen to critique. I just listened to your lecture, and I am not impressed. To claim that rapamycin inhibits the immune response is not giving the listener the whole picture. Yes, rapamycin, in HIGH doses administered on a daily basis, is used to inhibit the immune response after an organ transplant, but for longevity much, much lower doses are used intermittently, and it strengthens our immune system. In other words, it has a hormeses effect and by challenging the immune system with a low dose makes it bounce back stronger than before. One of the primary reasons rapamycin improves live span is that it helps prevent many of the diseases that kills us such as cancer (rapamycin is now FDA approved to treating breast cancer), heart disease, and many others by lowering systemic inflammation and boosting our immune response. I agree that no human double blind placebo studies have been done since the length and cost of such a study makes it impossible, but in every other animal study (not all conducted in a sterile environment - that is incorrect) the animals increased their average life span and lived healthier. No other molecule has achieved that result again and again, in practically every mammal studied. There is no advantage starting a rapamycin regime for health span and longevity at a young age. It has the same effect if started in mid to late middle age, late 40's - 60. Very few of us plan to have children at such an age so a minor effect on sperm count is irrelevant. Further, the effect on muscle synthesis using low dose, intermittent rapamycin is so minor that only a professional body builder would care. The studies you mention all use much higher doses than those used by the longevity community, but yet you draw conclusions from them - even those studies that are 15 years old.
Personally, I believe I will live as long as God Almighty grants me to live by His grace. People eat and drink things they ought not to and do things as well that affect their health thereby shortening their life span. Then again, not much we buy to eat contain things that are toxic to our bodies. Is it any wonder some have so many health problems that can shorten their lives! God has set our life span and folks do things to shorten it. If you're able to grow your own fruits and vegetables do so for the good of your health. People never took drugs to extend they're life spans.
The reason is carnivore are always in ketosis and their blood fasting insulin is lower which the body didn't get a chance to store fats. On the other hand vegan don't eat fats, when we combine fats with carbohydrate then metabolism of carbohydrate produce alpha melonic acid which inhibit fats metabolism. So vegan don't eats fats to store in adipose tissue thay why they are both leaner.
As a Bible believing Christian, I thank you for bringing creation in the space. Too many doctors bring up the evolution theory only, and it creates a sense of confusion as to what we should eat using the evolutionary precepts of food and mankind......there is so much room for all whole foods which God made, and He said it was good.....
I bet a 100 Singapore Dollars that your next video would be titled "HGH"or at least included in the title Prof Ben. And "C : 15" in the one right after that. Another 100 Singapore Dollars there.
He is right about it being more important to have a healthy, fulfilling life, rather than a long life and being miserable. That’s why vampires are always miserable! 😅
Dear Dr. Bikman, I love your channel because it's informative and I believe accurate. I am always wary because of your religion. When you bring your religion into this discussion, you lose credibility with me, and to extrapolate, with others too. How can you adhere to science in all other areas save this? You talk about the creation theory as being valid, what is the evidence, that you've been brainwashed and indoctrinated since birth, like all Mormons? This tangent that you went off on today, away from valid science, is a deal breaker. Now you've leveled yourself or maybe gone beneath other channels where the science isn't always reliable.
I noticed 20+ years ago that nearly everyone who is interested in living to 150 y.o. are upper class white men. For the most part, women are accepting of mortality. I need to get the heck out of the way for newer, better people. How arrogant it would be for me to think the world needs me for 150 years. Truth is it never needed me at all. I love life, but if Mom would have rolled over that night....i might not have been there. And the world would have been fine.
We believe in One and the only one God or creator Not God as Jesus, who is the son of god or the Trinity belief I'm a Muslim I have a UA-cam channel to translate what you say to arabic
Jesus Christ is the way the truth and the life. No one gets to the Father except through Jesus. Jesus Christ is God. Mohammed knew that he himself needed to be saved as well more than 600 years after Jesus was sacrificed for the sins of mankind. The quran is false doctrine. The writers of the quran are false teachers of satan himself. Please study the life and sacrifice of Jesus Christ, and compare that with your mohammed.
I need to live as long as possible to care for my disabled child. As of now I can't forsee him being able to care for himself. I plan to do that to the best of my ability through healthy lifestyle choices, not by relying on anything outside myself, while continuing to train him into self sufficiency. It's all i can do.
Start keto for your child
@@Roberto-cg2gr my child is already keto, actually carnivore by most standards.
@kellyb3198
I'm happy to read that your family is on keto. That will help.
Taking care of the Microbiome will also help. In some cases, FMT (Fecal Microbiota Transplant) has been extremely helpful.
I will pray for you and your family
Your caring innate motherly instinct to care for your kid is the strongest factor and real physiological secret that will make you live the length of life you need.
I have a similar situation. I have been taking all the “longevity supplements” for near two years now, and started my Rapamycin therapy this month. I also started carnivore diet 6 months ago. I feel better than ever. I am 65, feel like 20s though. Anyhow, this video I feel misled. We are talking about extremely low doses and take once a week (I take 6mg per week). The possible side effects he is taking about is out of question here.
Glad someone credible is tackling this! Thanks Dr Bikman.
Thank you, Ben, for this concise direct summary on Rapamycin.
I was skeptical of Rapamycin when I first learned of it as it was praised to no end for longevity. A quick check, however, showed that its primary use was suppressing the immune system for organ transplant recipients, primarily by inhibiting MTOR.
If inhibiting MTOR is the primary means that Rapamycin confers some longevity benefits, fasting can achieve the same. Autophagy likely confers most of the benefits of taking Rapamycin. Autophagy can be attained by fasting without the need to take Rapamycin. That was my conclusion.
Your going even farther than the above has helped reinforce and expand my understanding of Rapamycin. Thank you.
bravo
I reference you so often that autocorrect, when I type Dr. , suggests Chaffee, Bikman and Bright.
You've such a clarity of thought it's refreshing.
Thanks Prof 🫡👍
Me too…I tell everyone I know…
Dr. Bikman, the longevity community doesn't view protein as harmful. We prioritize muscle mass and health through regular exercise and adequate protein intake alongside rapamycin. The issue with rapamycin research is the lack of pharmaceutical funding due to its inability to be patented, which is why independent researchers are advancing this field.
While rapamycin may suppress immune function in high doses (as seen in transplant patients), there's evidence that it can reset the immune system in lower, carefully timed doses. This has been observed in studies showing improved vaccine responses after short-term rapamycin use. Though much remains unknown, its ability to recalibrate the immune system is a promising area of study.
Yes, all the above. His criticism sounds ill informed when he doesn't differentiate between immunosuppressive vs other dosing regimens.
@@NickWestgate Well it seems at least two listeners actually have a brain and question the good doctor! Thank you szghasem and Nick.
Dr Bikman does not see protein as harmful.
Thanks again, Dr. Bikman. The more I learn about metabolic health, the more I am convinced in the anthropological view that we must eat as we have evolved. It seems to me that modern society has drifted too far into the pharmacological intervention paradigm. This lecture proves the point to me once again.
Thank you so much!
I'm so happy to be part of the growing "parallel society ", which educate them self ,and become healthy, strong&smart 💪🥰
Again food is medicine and knowledge is power. This short lecture on MTOR is quite enlightening. I've been chasing the answers to healthy longevity for 3 years now and the MTOR discussions were never this clear. Thank you for the cited references so I can read and study this subject at a deeper level. Dr. Longo at UCLA does not discuss MTOR in h I s research that brought about tge Mimicking Fasting Diet. I have used his meals in tge past, but never got the results suggested in eating that food. My carnivore lifestyle has made all the difference.
IMO, you have achieved immortality, not only through your children, but also through the excellence of your lectures, that’s how anyone achieves immortality, ie, through the excellence of his/her work.
1. Thumbs up. 2. Watch post. Thanks Ben.
Rapamycin is slow suicide
Ben is making a good point. You want to live longer? Then bring your insulin down through fasting, lifestyle change, and exercise.
Thank you for this informative video! You have validated my plan to just keep eating low carb, resistance training and intermittent fasting and I will save my money by not taking more meds!
WOW, just wow! The knowledge gained is so appreciated!
Just wanted to mention that in another video with Ken Berry, hesitation to recommend fasting to older folks. This point is valid. I'm 55, and used a lot of actual fasting (not intermittent fasting), to lose weight. I felt better and clear headed during these fasts, and I indeed lose significant weight. I also lost significant muscle. Currently on healthy keto-vore, and aggressive resistance training to put muscle back on. Thank you, and really appreciate all you do.
Peter Attia uses rapamycin, which indicates that I definitely should not use it.
HAAAHAHHAHAHAAAAA!
With ya.
🤣🤣
😂
Good point we will know in 50 years if Peter wins the centanarian decathalon.Robert C has a different training strategy and is 10 years closer to the finish. I'm not sure if I want to win that one
Peter Attia still thinks statins are a good idea too
Some drugs have a nonlinear dose-response relationship. Tylenol is harmless in low doses and suddenly becomes very poisonous once you take enough to burn through all the glutathione in your liver. Nicotine is stimulating in low doses and sedative in higher doses.
Rapamycin advocates claim that the immune suppression only shows up in high doses of the drug. I haven't seen research one way or the other on that, but I feel like you're ignoring an important point of their argument by not addressing that assertion.
I am really thankful for your time and kindness to share this information with us.
Wonderful! Another fantastic lecture, Ben. Thank you.
Superb teacher.
They say that the dose for transplant is too high compared with the small dose for longevity.
My understanding also.
Your lectures will also be forever goodness in all of us.... thank you ❤️🙏
Great lecture in that I understand the functions of Rapamycin much better. Also I believe mTOR has been changed to Mechanistic Target Of Rapamycin, changing the Mammalian part for reasons I can't remember.
Another mind blowing topic thanks for your generosity .
I have similar philosophy in that I see my children and grandchildren as my immortality. However, I want to live long enough to play a beneficial and active role in my children’s, grandchildren’s, and great-grandchildren’s lives.
So I’m still considering rapamycin, in lower doses.
Worked for Wyeth and knew well this compound...glad it is still being studied! Thanks
Once again, thank you!
Absolutely love your content
You are an inspiration!
It does seem like there’s some confusion here about the dosing of rapamycin for longevity. SUSTAINED levels of rapamycin in the body do suppress the immune system (great for organ transplantation). But short duration spikes of rapamycin do not have this effect and seem to (more research needed) strengthen the immune system.
Many people interested in longevity do only one or two courses of rapamycin (e.g. 6mg of rapamycin, once per week, for two months) to see benefits…often IN COMBINATION with fasting and/or ketosis.
Both fasting and rapamycin use can reduce insulin sensitivity, protein synthesis, testosterone production, and overall reproductive vigor (in the short term), but with the right dose and duration, may have profound long-term health effects.
I’m also curious to learn more about the other benefits of rapamycin not directly related to mTor (e.g. antifungal properties)
T A most valuable part of this discuss was why Animal results are a poor predictor of mechanisms within hominoids.
I had a discussion with a heart surgeon who said stents were sometimes coated with it.
However one working hypothesis is that MtorC1 and MtorC2 are addressed differently by low dosing:: ""Cellular processes: mTORC1 is more involved in cell growth and proliferation, while mTORC2 is more involved in cell survival and cytoskeletal organization.""
Thank you for the kind gift. I do not expect such things, but I do notice and appreciate them. Thanks.
@@benbikman no thank you for your service ouTside acAdemia. I am truly disgusted with the way the medical community has handled diabetes (I II and eye.5 :). 15+ yrs on gen II sulfonyereas probably gave me irreversible insulin resistance. Pound for pound pancreas and kidneys do more than the brain, but lipids (not just RBC glycation) seem to be the rate limiting factor in targeting Affect. I honestly think low tech stuff like intermittent fasting, and psyllium fiber might have done enough for me in the early years since ACE II and HMG-COA inhibitors are a joke.
IN addition to your lecture series am a big Fan of Jason Fung, Ken Sikharis, Paul Mason; since like you i believe they are SHOWing me their truth and not just parroting information.
Longevity use of rapamycin is based on intermittent use once individuals have entered middle age. i.e. MTOR is temporarily interrupted, hopefully also disrupting degenerative processes like cancer. So yes, it's not appropriate during reproductive years. Insulin resistance is an important factor - yes, possibly more important than any supplement.
Why not just interrupt a shitty diet?
Thank you,Dr. Buckman! Once again you've educated me in an area I've been wondering about.
I did not see the study you said you would post on higher protein consumption in the elderly reduced mortality?
Nice overview, well done
Excellent. This talk tied together many loose ends for me.
Great talk, Prof! Thank you so much for the knowledge.
@insuliniq I couldn't find a link in the show notes to the study showing the correlation between animal protein consumption and longevity?
Excellent lecture, thank you 🙏
Animal evidence suggests that taking rapamycin once you're already old still extends lifespan and healthspan a substantial amount. So the obvious thing to do is wait until you're starting to feel age weighing on you and then try rapamycin to see if it helps.
Yes, possibly because mTOR can be over-expressed in older humans. Not addressing this and the dosing schedules used for anti-aging use make this lecture much less nuanced than it purports to be.
@@NickWestgatemy thoughts also
A couple of years ago, I was very sceptical to the idea that protein restriction would be good fo longevity.
All it took for me was to see in the charts of basic cellular metabolic pathways that mTOR is not only activated by amino-acids but also by Akt (through some steps in between) which is part of the insulin-pathway in the cell.
So my hypothesis was exactly what Ben Bikman says, that insulin matters more and that a chronic hyperinsulinaemia is the actual problem.
Nice to get actual confirmation of my bias ;-).
Well said, thanks for sharing, look forward for future updates.
great information
Great information as usual Dr Bickman
excellent teaching
Hello - thank you for the dozens of amazing videos -- I've learned quite a bit and I never hesitate to recommend them for information on the topic of which you are obviously the expert.
However, in this case I'm disappointed that you've jettisoned your usual rigor for fuzzy if not misleading information. Although your video is titled "Rapamycin and Longevity", you are not discussing the protocol used for this purpose.
First of all, the topic under discussion is the four-syllable RAPA-MYCIN not RAPA-MAYA-CIN - not a huge deal, but if you're going to make a video, you may as well call it what it is.
More importantly, you know very well you can't go around uttering phrases like "using rapamycin"!
I don't hear you say in your other videos if you "have insulin" then X happens -- you are going to talking about a specific amount of the compound and a specific velocity that the compound changes over time -- so please give the same treatment to this topic.
It's well documented that the effect of chronic/continual dosing of rapamycin as used on-label intentionally for immune suppression is completely different than the effect of pulsatile dosage (in my case one dose every 2 weeks - usually 7-14 days) when used for its hopeful health and longevity benefits. Specifically it doesn't act as an systemic immune suppressant to any great degree, inhibit MTORC2, or seem to inhibit muscle growth. (It seems to have the opposite effect - improving the efficacy of vaccines in older adults, etc., and no reported loss of muscle hypertrophy or strength.)
As for side-effects using the protocol, there are very few. (Cold sores for a day or two in a small percentage of users - which I've never experienced.) I think its not hyperbole to say that occasional rampamycin use is much safer than casual use of either antibiotics or even NSAIDs like Tylenol, of which there are many deaths every year.
Regarding risk - I'm not a risk-taker, and I find the possible-risk (almost zero) to possible-reward (possibly some benefits) to be quite acceptable. As you know, absence of evidence is not evidence of absence - as you rightly say, doing longevity trials on humans is near impossible, but given rapamycin's effect on the simplest organisms on the planet all the way up to mammals like mice, there's a decent chance that the mechanisms of actions extend to humans, although we can expect the effect size to be much smaller.
You can also be assured that those of us taking rapamycin are fully aware of our labs such as lipids, triglycerides, A1C or real-time glucose levels, fasting insulin, etc., and are doing "all the things" for health first before reaching for rapamycin - certainly not in lieu proper diet, fasting (if it's your thing), aerobic & strength conditioning, and sleep.
It's also not fair to omit other resources here, such as Matt Kaeberlein's companion animal project (so we'll get results from dogs soon) as well as www.rapamycin.news where you can interact with the many thousands of people that are actually taking rapamycin rather than guessing about side-effects, etc.
Thanks Ben
Thank you sir!
superb content
How does the protein, MIBK get involved with the MTOR protein and isn’t there like a see-saw effect between those two proteins? That is, when one of these proteins is activated, the other one is not or creates a lower effect. Do these two proteins have opposite effects?
Great topic!
Thank you Dr. Bilkman for presenting this about rapamycin. I have been considering it. I want to know if and how dosing changes risk. The dosing for organ transplant patients is daily for life, but in my understanding, one only has to take rapamycin for a few weeks to have benefit, that daily doses used in immune suppression do not increase lifespan, but greatly limited dosing does extreme life in older, but not younger, mice.
Please for more info about Igf1
Excellent !
Again love your information keep it up 😊
Thanks Professor Ben 🎉
Adam and Eve is not a theory. It's a belief.
Wow! Great lecture. As suggestions: please do not extend the length of the video and slides might be helpful. Again, thank you for an excellent lecture.
Can you really reverse Insulin resistance with ketogenic or carnivore diet? Or just control the insulin and glucose levels in blood? Reversing IR should make it possible to eat regular diet again with some carbs of course avoiding standard american diet and junk food. Being, coming back to be a completely insulin sensitive person.
It is absolutely possible.
But If you have retained it you still should have a fasting Times and controled carbs.
When I worked in Africa, only rich people had Diabetes.
The poor could Not afford meat.
They drank only tea im the morning and worked the whole day through.
In the evening they are one very big mal of carbs:
Stiff porridge, rice or beans.
They we're very slim, but muscular and had no chronic diseases.
@@johannesherbst3632 Thanks'
"Can you really reverse Insulin resistance with ketogenic or carnivore diet?"
You can normalize your insulin and that is what matters.
"Or just control the insulin and glucose levels in blood?"
Why "just"?
"Reversing IR should make it possible to eat regular diet again"
Why would anyone do such a ridiculous nonsense?
Thank you!
Awesome Dr Ben 👍👍💪
What is too low insulin level
Thanks!
Dan, this is unexpected but certainly appreciated. You’re kind. Thank you.
What if you used Rapamycin only to speed up Autophagy during fasting once a month?
Can you please comment on PATHOPHYSIOLOGY OF Lp(a) AND ASCVD.
Fantastic.
Thanks
Thank you, Carol. Not expected, but appreciated. Thanks.
My doc put me on this. I took two pills and felt like it was actively killing me. My hair fell out in handfuls and I felt terrible. Sheesh. Never again.
Hi good morning one question I can’t find the answer for it
I am type two diabetic I am using CGM my glucose set point increase from 5mmol to 13 mmol constant for some reason it like to stay at that level if I bring it down by fasting or insulin it will go back to around 13 mmol? So what I learn cause is the cure . Now brain override the glucose controls because of vessculites issue brain 🧠 not getting enough glucose it increases the glucose gradient GLUT -2 ? I hope you understand the cause of diabetes and obesity
Thanks
With diabetes, your cells are filled with carbs so you need some time tio get rid of it.
Eating keto or carnivore, you may experience somehow higher blood sugar levels , because your cells are not deppendent in carbs anymore.
What insulin level can you say that you are in Autophagy? How about Glucose to ketone index?
I remember that it is fasting Insulin below about 5, even down to 2.
But I think it is more a marker for metabolic flexibility.
@@johannesherbst3632
Hope there will be published research
Never take a supplement to affect only one element of a pathway
throwing shade on Attia.
Fantastic
Fast regularly
Your religion teaches that Adam's sin was okay. But that command was given before the sin. Adam and Eve were only going to die if they ate of that tree in the middle of garden. Had they not disobeyed, they would never have died. So humans were meant to live forever. We die now because we inherited sin from Adam and Eve. God set in place the realization of his original purpose when he made the prophecy in Genesis 3:15. Jesus will crush Satan in the head which means a death blow. Jesus was struck in the heel when he died on the stake but it was not a permanent death blow because he was resurrected. Humans were originally created to live forever right here on earth. If Adam had never sinned would he have ever died? No.
That tangent was really disappointing 😑 otherwise, good points
awesome
In science it is important to hear all sides and listen to critique. I just listened to your lecture, and I am not impressed. To claim that rapamycin inhibits the immune response is not giving the listener the whole picture. Yes, rapamycin, in HIGH doses administered on a daily basis, is used to inhibit the immune response after an organ transplant, but for longevity much, much lower doses are used intermittently, and it strengthens our immune system. In other words, it has a hormeses effect and by challenging the immune system with a low dose makes it bounce back stronger than before. One of the primary reasons rapamycin improves live span is that it helps prevent many of the diseases that kills us such as cancer (rapamycin is now FDA approved to treating breast cancer), heart disease, and many others by lowering systemic inflammation and boosting our immune response. I agree that no human double blind placebo studies have been done since the length and cost of such a study makes it impossible, but in every other animal study (not all conducted in a sterile environment - that is incorrect) the animals increased their average life span and lived healthier. No other molecule has achieved that result again and again, in practically every mammal studied. There is no advantage starting a rapamycin regime for health span and longevity at a young age. It has the same effect if started in mid to late middle age, late 40's - 60. Very few of us plan to have children at such an age so a minor effect on sperm count is irrelevant. Further, the effect on muscle synthesis using low dose, intermittent rapamycin is so minor that only a professional body builder would care. The studies you mention all use much higher doses than those used by the longevity community, but yet you draw conclusions from them - even those studies that are 15 years old.
My understanding is that the theory of evolution is more akin to the theory of gravity.
Personally, I believe I will live as long as God Almighty grants me to live by His grace. People eat and drink things they ought not to and do things as well that affect their health thereby shortening their life span. Then again, not much we buy to eat contain things that are toxic to our bodies. Is it any wonder some have so many health problems that can shorten their lives! God has set our life span and folks do things to shorten it. If you're able to grow your own fruits and vegetables do so for the good of your health. People never took drugs to extend they're life spans.
Love listening to your podcasts. Sounds like a hell no to me. Fasting is king.
Ahhhhhh! A bee hit my bottom! Now my bottom's big!!
Professor, am I hearing you say, you’re against birth control, sterilization?
I am not sure evolution and religion are equally valid... at least from a scientific standpoint
explains why Carnivores and Vegans are lean - one gets almost no carbs and the other is 100% carbs (all their fats and proteins are in Carbs)
The reason is carnivore are always in ketosis and their blood fasting insulin is lower which the body didn't get a chance to store fats.
On the other hand vegan don't eat fats, when we combine fats with carbohydrate then metabolism of carbohydrate produce alpha melonic acid which inhibit fats metabolism. So vegan don't eats fats to store in adipose tissue thay why they are both leaner.
As a Bible believing Christian, I thank you for bringing creation in the space. Too many doctors bring up the evolution theory only, and it creates a sense of confusion as to what we should eat using the evolutionary precepts of food and mankind......there is so much room for all whole foods which God made, and He said it was good.....
First 100 views! My lucky day!
I bet a 100 Singapore Dollars that your next video would be titled "HGH"or at least included in the title Prof Ben. And "C : 15" in the one right after that. Another 100 Singapore Dollars there.
He is right about it being more important to have a healthy, fulfilling life, rather than a long life and being miserable. That’s why vampires are always miserable! 😅
❤❤❤
Dear Dr. Bikman, I love your channel because it's informative and I believe accurate. I am always wary because of your religion. When you bring your religion into this discussion, you lose credibility with me, and to extrapolate, with others too. How can you adhere to science in all other areas save this? You talk about the creation theory as being valid, what is the evidence, that you've been brainwashed and indoctrinated since birth, like all Mormons? This tangent that you went off on today, away from valid science, is a deal breaker. Now you've leveled yourself or maybe gone beneath other channels where the science isn't always reliable.
If it's a "deal breaker" feel free to try and find someone else with more knowledge than Professor Bikman.
Don't bring religion into a scientific discussion.
I noticed 20+ years ago that nearly everyone who is interested in living to 150 y.o. are upper class white men. For the most part, women are accepting of mortality.
I need to get the heck out of the way for newer, better people. How arrogant it would be for me to think the world needs me for 150 years. Truth is it never needed me at all. I love life, but if Mom would have rolled over that night....i might not have been there. And the world would have been fine.
One large meat meal a day= lots of protein and lots of autophagy, all in the same day.😂
Evolution is not a theory. Lost me at religion. Complete bollocks.
What the hell is Rapamycin?
Start by defining your subjects.
It's explained in the show notes. Or, there's Google ...
Religion is not a theory. That is probably the most ridiculous statement that you have ever made.
No he is correct. I might add It is not only a theory but its probability is extremely low.
We believe in One and the only one God or creator
Not God as Jesus, who is the son of god or the Trinity belief
I'm a Muslim
I have a UA-cam channel to translate what you say to arabic
Jesus Christ is the way the truth and the life. No one gets to the Father except through Jesus. Jesus Christ is God. Mohammed knew that he himself needed to be saved as well more than 600 years after Jesus was sacrificed for the sins of mankind. The quran is false doctrine. The writers of the quran are false teachers of satan himself. Please study the life and sacrifice of Jesus Christ, and compare that with your mohammed.