How to best do lifespan studies - The Longevist Q4 2023

Each quarter, The Longevist, an endeavour spurred out of VitaDAO, showcases preprint reserach publications to spotlight the most groundbreaking longevity studies each quarter. The papers are selected by their editorial team utilises a combination of social listening tools, AI, and an expansive network to forge a shortlist of preprint contenders. Our expert panel of Longevist Curators then vote in a quarterly battle royale to establish the cream of the crop.
In this video, we’ll take a look at the key findings from each paper taking us from reproductive aging, to sleep health and senescence to how to best conduct lifespan studies - have we been doing it all wrong?
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TIMESTAMPS:
Intro - 00:00
Paper 1 - 00:35
Paper 2 - 03:15
Paper 3 - 04:00
References:
Exceptional longevity of mammalian ovarian and oocyte macromolecules throughout the reproductive lifespan Ewa K. Bomba-Warczak, Karen M. Velez, Luhan T Zhou, Christelle Guillermier, Seby Edassery, Matthew Steinhauser, Jeffrey N. Savas, Francesca E. Duncan bioRxiv 2023.10.18.562852; doi: doi.org/10.1101/2023.10.18.56...
Chronically disrupted sleep induces senescence in the visceral adipose tissue of C57BL/6 mice
Daria Timonina, Genesis V Hormazabal, Indra Heckenbach, Edward Anderton, Lauren Haky, Ariel Floro, Rebeccah Riley, Ryan Kwok, Stella Breslin, Harris Ingle, Ritesh Tiwari, Olga Bielska, Morten Scheibye-Knudsen, Herbert Kasler, Judith Campisi, Marius Walter, Eric Verdin
bioRxiv 2023.10.17.562803; doi: doi.org/10.1101/2023.10.17.56...
The impact of short-lived controls on the interpretation of lifespan experiments and progress in geroscience
Kamil Pabis, Diogo Barardo, Jan Gruber, Olga Sirbu, Kumar Selvarajoo, Matt Kaeberlein, Brian K. Kennedy
bioRxiv 2023.10.08.561459; doi: doi.org/10.1101/2023.10.08.56...
Please note that The Sheekey Science Show is distinct from Eleanor Sheekey's teaching and research roles at the University of Cambridge. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed.
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[@TheSheekeyScienceShow]

Find out more about The Longevist here - www.longevist.xyz/sheekey
x.com/longevist_xyz

[@OliverArataKun]

The best literature review as always. I'm proud of being your student 😊

[@ChessMasterNate]

There are some mutations in humans that allow people with these to sleep shorter but be fully rested. It would be interesting to see if analogous mutations might protect from the senescent cell increase in fat tissue, or if that reduced sleep still comes at a cost.
Also, sleep that is shorter but undisturbed (at least until the end of the sleep period) could have differing effects than sleep that is repeatedly disturbed each night.
I would be interested in seeing if the mice can recover from say a quarter of their lives sleep-deprived, or whether it is permanent damage, and if that differs depending on the stage of life where the disturbances occurred.
Can fasting effect things?
Lots of things to look at here.

[@MyFirstHandle]

Hello, I'm also trying to live a long life and staying healthy but I want to share more about my experiences about how it impacted the social environment to where I live and my unlikely neighbors. They have a different mindset which is envy and jealousy. Moreover: prejudice towards agelessness and my other backgrounds. I continued eating healthy but the store stops sending me vegetables there so I decide to find elsewhere. It looks like my main priority is privacy so I can continue with my longevity research. I'm getting older but I'm seen as a kid really. I just found a lifestyle that really simulates the halting of my aging but just a claim I still age a little bit because I see aging scars forming out of nowhere on my face probably stress from the people's negative environment I think? It's just confusing really. I had no priorities about romance, I just want to be alone. I even see them getting older over time, so it probably angers them.

[@peterz53]

Thanks you. Always been skeptical about translating magnitude of lifespan effects from short lived animals to much longer lived humans. Good for exploring mechanisms and generating hypothesis but magnitude? Probably not so much. Good that steps are being taken. Much more excited about researchers identifying pathways responsible for exceptional longevity, like in bats, mole rats, bowhead whales and how that might be applied to humans (and my dogs).

[@curingaging]

Great video!

[@howrandy]

do u have any research on klotho protein or gene,...???