Hormone Receptor Upregulation and Downregulation
Вставка
- Опубліковано 26 жов 2022
- This video shows Dr. Evan Matthews describing how hormone receptor upregulation and downregulation can impact hormone activity. This video is part of a series of videos that will cover the endocrine system as it relates to exercise physiology, health, and fitness. The playlist to that series is listed below.
Endocrine System Playlist
• Endocrine System and E...
Exercise Physiology Teaching Current Edition Playlist
• Introduction to Exerci...
Videos in the Endocrine System Playlist to check out:
Endocrine System Purpose - Hormones as Chemical Communication
• Endocrine System Purpo...
Types of Hormones
• Types of Hormones
Hormone Release - Negative Feedback Loop
• Hormone Release - Nega...
Hormone Receptor Upregulation and Downregulation
• Hormone Receptor Upreg...
Overview of Acute Hormone Responses to Aerobic Exercise
• Overview of Acute Horm...
Hormonal Control of Exercise Metabolism
• Hormonal Control of Ex...
Blood Glucose Control and Supply to Skeletal Muscle During Exercise
• Blood Glucose Control ...
Endocrine Control of Blood Volume and Electrolytes During Rest and Exercise
• Endocrine Control of B...
Endocrine Control of Cardiac Output and Hematocrit
• Endocrine Control of C...
Endocrine Control of Hunger and Satiety - Appetite Regulation
• Endocrine Control of H...
Endocrine Control of Muscle Hypertrophy
• Endocrine Influence on...
Link to Dr. Evan Matthews website.
sites.google.com/site/evanmat... - Наука та технологія
Androgenic receptors down regulate or up regulate, there are many mix reviews pls put light on It
Hey, Evan! Great vid. Can you talk about ways to naturally optimize/improve the amount + sensitivity of these receptors?
The only way I'm aware of to up regulate receptors is to decrease the hormonal signal for long enough for the body to adapt. That isn't helpful when attempting to increase a hormone effect though as you would have to experience a lack of hormone effect for a while before gaining up regulated receptors. There are likely receptor specific mechanisms I'm unaware of though.
Thanks for the video. Do we have any idea how endocrine disrupters can dock on receptors and displace or block our endogenous hormones? Any idea about EDC binding affinity vs endogenous hormones?
Sorry. I don't have any information on that.
We can increase hormone availability by supplementation but how can we increase receptors in the body to get high response?
Interesting question. The only way I'm aware of to up regulate receptors is to decrease the hormonal signal for long enough for the body to adapt. That isn't helpful when attempting to increase a hormone effect though as you would have to experience a lack of hormone effect for awhile before gaining up regulated receptors. There are likely receptor specific mechanisms I'm unaware of though.
Does the same principle work for neurotransmitters?
To my knowledge, all receptors can up and down regulate. That includes both hormonal and neurotransmitter receptors.
Does this also count for people adding hormones (oestrogens for instance) and the way they react to it? (Menopause)
Hi @ankavangemert934. I cannot speak on specific hormones on exactly what would happen because it is complicated and not my area of specialty. However, yes, in general high levels of endogenous or exogenous hormone delivery in the body will likely lead to down regulation of hormone receptors in tissues who do not require that level of hormone for maintenance of its normal function.
@@VivoPhys thank you! And so quick!
I took finasteride for hair loss and it ruined my sexuality. Stopped taking the drug 6 months ago and can't feel sexual arousal and have ED. Some say its an epigenetic change. some say our receptors are up or downregulated. How can my body go back to homeostasis?
Sorry. You should consult with your medical professional on this.
@@VivoPhys the thing is doctors don't believe Post finasteride syndrome is real. Do you think 5 alfa reductase inhibitors can ruin a person life? Tinnitus, dry skin and hair, depression, anxiety, suic1de thoughts, erectile disfunction, insomnia, anhedonia, inability to feel sexual arousal, genital numbness, inability to feel love, brain fog and genital changes like wrinkles and bigger veins. Not only finasteride does that but saw palmetto which is a natural 5 ar blocker.
@@VivoPhys blood tests are normal in Post finasteride syndrome patients. So doctors can't do nothing...
@@IgrwOwsame man, I’m sorry for this response
Sorry. I don't know anything about this. I hope you are on your way to figuring things out.
What’s the essence of up regulation and down regulation?
Is it for homeostasis?
Essentially, yes. It is another means for the body to control hormone action and homeostasis.
In order to maintain homeostasis the body needs to control the level of hormone action. It can do this by releasing more or less hormone into the bloodstream, or by up or down-regulating the number of receptors on the cells. Because the hormones released into the bloodstream are delivered to the whole body, up and down regulation allows individual cells/tissues to control the level of hormone action they receive. For instance, if the body releases high quantities of norepinephrine into the blood because it is needed within one area of the body, another area of the body that does not need that much norepinephrine can down regulate its receptors over time so it is not negatively affected by the high levels of circulating norepinephrine. It provides some tissue level control of hormone actions because hormone release is a body wide level of control. In the end it is to maintain homeostasis throughout the body and in individual tissues.