Strategies for Bone Medications with Dr. Benjamin Leder
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- Опубліковано 7 лют 2025
- Strategies for Bone Medications with Dr. Benjamin Leder
This video is a gift to you if you have questions on medication. It is filled with strategies for the sequencing and combining of bone health medications. Dr. Leder explains the need to have follow up medications to retain bone gains. He discusses using bone markers to determine status. If you wish to know which drugs have better impact on hips and/the spine...listen.
The last part is a Q & A format. OsteoBoston members had a multitude of great questions and Dr. Leder's answers were fabulous. This video is a gift to you if you have questions on medication.
Bio for Dr. Leder:
Dr. Benjamin Leder received his medical degree from Harvard Medical School and completed his Internal Medicine Residency and Endocrine Fellowship at Massachusetts General Hospital, where he has remained ever since. His current position is Professor of Medicine at Harvard Medical School.
Over the past two decades, Dr. Leder has been both an active clinician (serving as the Director of Endocrine Associates, a 16-physician practice focusing on metabolic bone disease) and principal clinical investigator of many studies. His NIH-funded research focuses on developing novel therapeutic approaches to the management of postmenopausal osteoporosis and other metabolic bone diseases.
This is the sad fact that I am glad he said “we are doing a horrible job in the treating and dealing with osteoporosis “ Shocking really
This was great. I am sorry I could not attend that evening, I had to watch my grandson. Thank you
When is best time to start Alendronate? At the start of osteoporosis when minor or when you’re a bit more advanced? 13:36
what about necrosis of the jaw with Prolia or Reclast?
Osteonecrosis of the jaw is a potential side effect for all of the osteoporosis drugs as is the a-typical fracture of the femur, especially, as the doctor said, the longer you've been on the drugs. ONJ also occurs in the general population at around a slightly lower rate. This is confirmed by trials that used a control group and placebo group. But doctors recommend getting major invasive dentistry done before starting any of the drugs to prevent the possibility of ONJ occurring.
I think it might be easier to understand if you all would stick with one name or the other instead of switching back and forth. For example, in one sentence you said Fosamax and then in the next you said alendronate. This happened for the other drugs as well. Very confusing, at least for me.
Me too!
I totally agree! It's hard enough to get your head around the pros and cons of each drug without the name confusion!
This was very informative, thank you very much! I was diagnosed with osteoporosis 6 months ago. Im 54, went through menopause at age 40. Wishing someone would've advised me to start HRT. My Dr. at UNMC wants to start me on Forteo, my t -score is -3.2. Do you think this sounds like a reasonable treatment? Im a very fit, active, 120 pound fitness instructor, so needless to say I was shocked when I got this diagnoses. They did all the bloodwork to rule out other possible causes. Have you by chance heard of the REMS Echolight scan?
we just had a program in Boston for Dr Zambito and Bush. They speak on a OsteoBoston video in April- look back at the UA-cam channel. I wish I had time to respond to everyone’s messages. but I will say I know it’s disappointing and hopefully you can learn some valuable ideas so that you can steward your progress in the way that you see fit. I wish you the best.
Check out Dr Doug Lucas program. Binge watch his UA-cam. Optimal Bone Health.
Answered alot of lingering questions for me.
VERY Helpful - Thank YOU!
I had 1 Prolia and I’m going to relay with Reclast I’ve cause I’m a gastric bypass patient. Would it be safe for me to get a lower dose of Reclast?
Once on fortes or Tymlos are you being monitored to see if the drug is working and is there is a baseline used before starting the drug?
What about Forteo, and HRT at the same time, with resistance and impact training. Then just remove Forteo at the appropriate time?
How much of a decrease would be seen??
Excellent.
I noticed Raloxifene has a RRR of 50% for vertebral fractures, but not so good for everything else. If one has osteoporosis for the spine, but not -penia everywhere else, why not just take Raloxifene?
Dr Leder - did you happen to attend the lecture @ the 2023 National Endo conference by Greek researchers on the efficacy of utilizing osteogenic loading technology (ie OsteoStrong sessions) to improve bone density as first line of defense, or in conjuction with pharmaceuticals?
N0
I.have to take my Dr's suggestion
Zometa infusions 3 infusions each for 3 years
Is it possible to make an appt with you for my osteoporosis? I live in Nebraska but willing to travel to get a 2nd opinion. Or is there a Dr you can recommend in my area? Thank you!
Great!
Dr Britt in Seattle is the most world rebound osteoporosis specialist. She's says the jaw issue isn't so rare. Atypical bone breaks are harder to heal than regular breaks. I'm thinking of not taking the medications.
Kidney issues not take Reclast?
Increase heart attacks or strokes with Evenity that is quite scary and I guess since I already have CAD I would not be able to take Evenity.
This doctor focuses on 'novel approaches' to treatment? Is treatment with these scary drugs novel or creative? Also, he doesn't really get into the side effects and quality of life impact of drugs that are not a cure.
I enjoy your presentations but PLEASE buy a better microphone.
Do you see new patients ?? Help!!!
I see you now. Sorry
What about zometa infusions. I haven't heard that mentioned. I was offered that after trying 3 years 6 infusions. Now after 7 yrs taking anastrozole + calcium vit D3, osteoporosis has worsened. Dr says I need to retake zometa infusions for 3 years with 3 infusions over once a year.
What about Forteo, and HRT at the same time, with resistance and impact training. Then just remove Forteo at the appropriate time?
How much of a decrease would be seen??