Could omega-3 prevent dementia? | Axel Montagne, Ph.D.
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- Опубліковано 4 чер 2024
- People with high levels of omega-3 DHA are ~50% less likely to develop Alzheimer's disease compared to people with low levels. Disruption of brain DHA transport via the MFSD2A transporter causes blood-brain barrier breakdown. Furthermore, where we lose pericytes - which are important for dementia prevention - overlaps with the loss of DHA transporters.
In this clip, Dr. Axel Montagne discusses how the brain transport of omega-3 DHA may be important for the prevention and possibly as a therapy for dementia.
Watch the full interview featuring Dr. Axel Montagne:
• Axel Montagne, PhD, on...
Timestamps:
00:00:00 - Introduction
00:00:30 - Loss of omega-3 transport
00:02:14 - Reduced glucose transport in brain
00:04:30 - Inhibition of VCAM1 (adhesion protein)
00:08:11 - Fibrinogen in the brain
Interview published on Feb 28, 2023
#Omega3 #Alzheimers #brain - Наука та технологія
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Show notes and full episode available at:
www.foundmyfitness.com/episodes/axel-montagne
When I take Omega-3, I start remembering little things from my past, they keep popping up in my thoughts. Once I remembered that when I was learning music in the 60's, I remembered a music I bought and it even triggered the smell of the paper. All kings of thoughts and activities from my past keep coming up when I take Omega-3.
That’s awesome!
Excellent video participation by both parties.
Excellent episode again with the informed interviewer style of interaction and key question development and examination
Iv been taking high doses of EPA and dha for around 6 weeks or so. 2+grams a day. I have noticed a considerable improvement in my mental health and depression.
sadly it’s very expensive in the UK. the highest potency I can find is the Seven seas brands and 3caps a day for a month is around £35-40.
You can import it from countries like China, India etc.
here it is cheap, $7 for 60 capsule of 1000 mg.
@@praveenka8468 yes the fish oil part isn’t that expensive. it’s the quantity’s of EPA DHA that are. the good quality stuff containing worthwhile amounts around 2g are expensive. A lot of brands claim 1000mg but when you read the ingredients it’s epa 0.25g dha 0.10 and so on…
Love you both!
Thank you
thank you so much maam,i really appreciate your content,,greetings from INDIA ❤️✌🏻
TY
Thanks Rhonda. : )
Fascinating clip as usual with lots of useful information. I think I will bump up my EPA & DHA levels from 2 to 3 grams daily.
Be careful. Omega 3 has downsides too. Human body is very complex this type of research is very interesting but doesn't answer all questions. I play it safe, I take one large Omega 3 gel cap every other day. I hedge my bets. Taking one Omega 3 every other day for life is A LOT MORE than what people that don't take the supplement take. And if I ate more fish I could probably do away with the supplement
@@OctavioRichetta I've taken ounces of fish oil in one day through a smoothie (which doesn't taste bad, actually, fructose in limits, has a place) with no adverse effects. If you are low, you are low and you don't want to be low. I likely go through 1.5 to 2 liters of fish oil in a year and find that buying 500ml bottles gives the best bang for the buck, but you can buy 2lt bottles of human grade fish oils for dogs online with the same DHA/EPA ratios per 5g as high end for $ 40 Canadian through Amazon.
Not saying that's the best choice for everyone, but that's what I do. I wouldn't waste time taking months to get back to par if there is brain fog, just cut the carbs and guzzle some fish oil and the brain fog is gone. The body will take the excess and convert it to ketones or triglycerides or burn it off, it knows what to do, I would worry more about not enough than too much.
@@OctavioRichetta It is very difficult to 'overdose' on Omega-3 EPA/DHA/ALA. If you are concerned, then take an Omega Index Test. Simple.
would be interesting to know whether simple plasma donation as we get older could reduce proteins like VCAM1. Work by Conboy Lab suggests that components of older plasma may be more important that young plasma impying that a lot can be done simply by reducing these elevated proteins can resent gene expression to younger phenotype. Dialing in the frequency and volume of plasma donation has not been done, but normal blood banks in US will allow for 800 mls every 4 weeks, which allows for turning over at least 3 plasma volumes every year.
Great video, but unfortunately there's no indication of what the RDA of EPA or DHA is?
Could nattokinase or serrapeptase help get rid of the fibrin in the brain?
Any suggestions on how to find quality fish oil capsules that don’t contain rancid oil (I heard that omega 3s are very unstable and the processing into capsules renders them pretty much useless) or pollutants like toxins and heavy metals? Does any company do regular (not just once) controls of their product and publish the results? It’s frustrating that there is no regulation of the supplement industry in the U.S.
I would look into Performance Lab (a supplement company which is based in the UK, I think, but sells products in the U.S.A.). They sell an Omega 3 product that might interest you.
David Tomen, who calls himself "Nootropics Expert", has a website with many articles on it, including some that talk about best ways to get Omega 3's, and he seems to be a big fan of these 2 supplement companies: DoubleWood and Performance Lab. Mr. Tomen has many informative articles at his website, and has a UA-cam channel also. He responds to questions and comments from the public, in a way that seems quite generous to me.
Personally, I've bought Omega 3 supplements from Performance Lab, and am very happy with them. They are not cheap! (in price). But they are not fish based; their website explains it better than I can do here. BTW, I always let liquid filled pills dissolve in my mouth, and taste the contents (to be sure of the quality), unless they are particularly noxious. That's if I have any doubt about the quality of the ingredients. If it's rancid, spit it out!
I suppose a person could also use their nose, also, to test for freshness. Let the pills come to room temperature. Cut open and smell. But for possibly rancidity, I trust my sense of taste more for that.
Good luck!
I don't know, at this particular moment, if Performance Lab officially (formally) does "Third Party Testing" of their Omega 3 supplement. But I suppose you could always ask them directly, or explore on their website (or other sources online), to find out if their quality control measures are satisfactory for you. To see if any documentation, or lab results, could be provided.
Additional Note:
About the Omega 3 supplement from Performance Lab, David Tomen recommends taking 6 of those liquid gel caps per day (to get at least 1,000 mgs of DHA per day). 3 at a time, with a meal, is what he recommends. One of the detailed articles at his website is titled "What I Take" , RE: the supplements that he himself personally takes. (And why.) Thus, between looking at his website, and listening to/watching his UA-cam videos, you can get an idea of the way he thinks.
Nordic Naturals
Here in the Netherlands it's Arctic Blue. Very very low oxidation number (totox=5). Some different forms available. I have here capsules:
1200 mg fish oil
400 mg EPA
250 mg DHA.
A cheaper way is cod liver in own oil, 120 g in total. I have one can per week, after opening immediately 1/3, remaining 2 x 1/3 is frozen in and taken over the week.
Don't take huge amounts because you might get too much vitamin A.
@@MrXerxes Agreed, these are the best.
I'm confused about how much Omega 3 one should take in a day. Anyone out there know? Currently I'm taking one 1200mg gel per day.
I take the same 3-3x a day along with turmeric 1x a day, don't know strength off hand
I saw a recent study that indicated higher omega 3 levels were associated with increased risk of prostate cancer. Please share your thoughts on that. I want to help my brain but not increase risk of prostate cancer.
Here’s some discussion. ua-cam.com/video/LncobFcnYlg/v-deo.html
Bottom line is that the evidence is overall fairly poor that omega-3 in any way promotes prostate cancer…
Obviously it is more than one variable
So how much DHA do you need?
When you say people who have high levels of Omega-3 DHA are almost 50% lss likeley to develop Alzheierms.. I have one question:
Is that regardsless of Apoe e4?
What supplement (brand/product) is a good quality to take to boost DHA etc?
Canned sardines give you so much more
I wish I liked SArdines. I totally don't like eating seafood, I have to have a capsule.@@humboldtharry1289
Finding a good Omega 3 supplement that works is hard. My nutritionist friend @kennethopdahl recommended testing my Omega 3 levels with Zinzino. My levels were super low before taking Zinzino's Balance oil. After 4 months they improved dramatically. I feel much better. I would recommend contacting @kennethopdahl if you're still interested, details on his UA-cam account.
A good, cheaper way is cod liver in own oil. It hardly has any taste upon opening, but you know how to keep it once opened.
I have one can per week, after opening immediately 1/3 is consumed, the remaining part is divided over 2 small containers and frozen in and taken over the week.
Don't take much more because you might get too much vitamin A, which is not healthy.
Does NMN help prevent this?
Check out this video with David Sinclair: NMN, Resveratrol and Alzheimer’s ua-cam.com/video/0n6fmXkLgcA/v-deo.html
Least graceful thumbnail
Are omega 3 supplements rancid and do they cause oxidative stress like omega 6? What happens if I cook them in food?
How about flaxseed daily?
That's another form of omega 3, ALA, which is not bad, but doesn't have the benefits that EPA and DHA bring. Your body will try to convert it, but that happens only in small amounts (4-6%).
@@rredding ua-cam.com/video/ATm6C4al9iU/v-deo.html
@@rredding ua-cam.com/video/NI7_QekdVoI/v-deo.html
Does this mean that we can say dementia is a chronic omega-3 deficiency, in the same way that scurvy is a chronic vitamin C deficiency?
I don't think so b/c other factors also play a role in dementia.
No definitely not
These docs blame saturated fat - ua-cam.com/video/dVOSitvTqLw/v-deo.html
It helps feed the brain what it needs, however I believe it's more about high glucose that attacks the brain
I don't believe so but great question 👍🏻
How calcium can prevent your hair growing fast
I am sure glad the brand I take is not rancid. Stop buying your supplements at a box store
What brands are best?
The amount of times i've read this question. There never is an answer to it though, it's as if it's some great secret that needs to be protected. 🙄@@debbieking6664