SOS Response and DNA Repair

The SOS response is a global response to DNA damage in which the cell cycle is arrested and DNA repair and mutagenesis are induced. The system involves the RecA protein.The RecA protein, stimulated by single-stranded DNA, is involved in the inactivation of the LexA thereby inducing the response. It is an error-prone repair system that is attributed to mutagenesis.
SOS genes include lexA, recA, uvrA, uvrB, and uvrD.
Source : en.wikipedia.org/wiki/SOS_res...

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Hussain Biology
Sir pls make a video lacture on expression of lac operon in merozygotes. all that constitutive and inducible phentotype.
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Glad it was helpful!

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Much more concise than Shomu's Biology. I like that you get right into it as opposed to taking forever to introduce a new topic.

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Thanks Shruti for appreciation...
And the Photoreactivation video is here:
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[@virendrapatel550]

nice. I have a question. Can you tell me how the cell regulates the preparation of uvrC and uvrD proteins and uvrA protein as they all come under the same promoter?

[@hussainbiology]

I have not read any specific regulation for uvrC ,D, and A proteins but i can say the majority of gene expression is controlled via DNA methylation and for these genes to be regulated it must be the CpG islands present on the genes that on/off the expression of any gene by Methylation of CpG islands.

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It is uvr ABC Excinuclease.....operates the NER mechanism...

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EXCELLENTTTTTT

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vry nice

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Surely.... thanks

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thank you for helping but next time please slow down when you are speaking wish you the best

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sir can u explain the new concept of primpol mechansism in dsb repair, it would be of great help

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can you please make a video on homologous recombination

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nuvvu

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hi sir can you please make a video on recombinational dna repair ??

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Very nice explanation, but pls go little slow, and sound is not so clear.

[@hussainbiology]

thanks for appreciation..... and i will definitely be slow in future videos

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Can you please refer a book for this particular topic ?

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Live 100. Not much, but the most n absolute explanation than shomu

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[@hussainbiology]

Yes Nazish , i am from Kashmir.. Greetings....😊

[@nazishamin2548]

Yes i am also from kashmir , the accent of your speaking made me recognise that you are a kashmiri too 😊.

[@nazishamin2548]

Nothing like that its my exam tomorrow and i am from srinagar brother.

[@hussainbiology]

@@nazishamin2548 All the best dear...

[@varshajetty1131]

Is it "Translesion " or "translation" DNA synthesis?

[@hussainbiology]

at 2:54 It is Translesion synthesis
The Translesion synthesis is a DNA damage tolerance process that allows the DNA replication machinery to replicate past DNA lesions such as thymine dimers or AP sites.It involves switching out regular DNA polymerases for specialized translesion polymerases (i.e. DNA polymerase IV or V, from the Y Polymerase family), often with larger active sites that can facilitate the insertion of bases opposite damaged nucleotides.

[@affra.b946]

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[@poupouill21]

That's not an operon it is a regulon since it's not on the same gene

[@hussainbiology]

It is a type of Regulon , which falls under the group of operons........ i hope this makes sense

[@hussainbiology]

It is a type of Regulon , which falls under the group of operons........ i hope this makes sense

[@sinthy8447]

A bit slowly... Would be better! Thanks anyway!!!

[@renutailors4634]

Sir kya ye topic jo aap upload krte ho csir net ke liye h

[@hussainbiology]

G Poonam , all are for CSIR NET

[@arivinmech4391]

What is sos genes

[@hussainbiology]

Any genes which help at the time of urgency

[@RehanKhanNISER]

thora shi se bolta ye nakli foreign accent boht ganda lgta hai...by the way video was nice and helpfull
i have exam in an hour.

[@hussainbiology]

Apologies........Will stick towards my real accent.

[@RehanKhanNISER]

@@mominayasmin6941 I don't even remember I commented this 😂😂

[@vaibhavabhi1250]

Sir, Is topic pr video in hindi m bnaya

[@Alam9838.]

The spelling are mistake in translation

[@gooddoctor6434]

He pointing to the moon, and you r looking to his finger:-)

[@anushkasupakar3305]

So how does it make SOS repair a direct reversal repair mechanism? Since it is the last resort for the cell to repair extensive damages.

[@hussainbiology]

this happens to occur in bacteria as a global response mechanism.

[@anushkasupakar3305]

@@hussainbiology Okay so all the direct reversal mechanism occur only in prokaryotes right?

[@hussainbiology]

@@anushkasupakar3305 Na na....It occurs in Mammmals too.
Like Photolyases have vast diversity found within bacteria , fungi, plants and in animals too.
Furthermore direct reversals in mammals by MGMT protein
✓ AlKb mediated direct reversal in E.Coli.

[@anushkasupakar3305]

@@hussainbiology thank you for the clarification! Thanks a lot. Take care!

[@hussainbiology]

@@anushkasupakar3305 you are welcome...Keep sharing and supporting

[@vijayalakshmi-wx7yg]

SOS full from enti sir

[@hussainbiology]

save our souls... an emergency signal used in Morse Code during emergency

[@vijayalakshmi-wx7yg]

@@hussainbiology thank you sir

[@hussainbiology]

@@vijayalakshmi-wx7yg you are welcome