Mismatch repair

This DNA repair lecture explains the mechanism of mismatch repair using methyl mismatch machinery.
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[@anisaishaq-balogun9982]

9years after, still very relevant. Thanks for saving us during examinations 😅 and explaining so simply ❤

[@shomusbiologyofficial]

All the best for future

[@pluviophile6063]

Bruhh I’ll cry…so grateful to Almighty that I flounder your channel😭❤️

[@shomusbiologyofficial]

All the best

[@Bahar1370]

you are a gift to future doctors of this world thanks for making us better

[@navidnami4455]

I,m in my exam period and u became my best friend...thanks alot.

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I was stupid forgot the login password. I would love any assistance you can offer me.

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@Boden Raylan instablaster :)

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[@dominicazariah9092]

@Boden Raylan No problem :)

[@pavizz4075]

Sir iam from kerala.. Ur lectures are superb.... Explanation is..perfect

[@shomusbiologyofficial]

Thank you. Glad you liked my lectures

[@didimoseprimal3509]

Yo malayali

[@fatemaalihabib8237]

you are a great teacher, you make every purpose for every process so clear and comprehensive. Make more videos like these, its great help.

[@anaherrera4805]

I Love the way you explain everything! Thank you for your help
You are blessed

[@absksa8184]

I love your video man .. keep sharing your knowledge please .. many thanks and love from Bristol-UK, Abdul

[@111656hila]

you are an angel in our bad time :) thank you!

[@laddugopal8137]

As it is your video is outstanding. This video is uploaded very early but still it's working is fresh and Waooooo👨‍🏫👌👍

[@shomusbiologyofficial]

Thank you. Glad you liked my lectures. Please subscribe and share

[@peachlife5118]

I lost my notes on this topic.. thank you soooo much for the work you do!!!

[@majdmohamad30]

Man that was reeeally awesome ❤ it helped me a lot, thank you very much

[@grethelmeza4803]

thank you so much ! Gracias !! your video helped me a lot ! thank you all the way from mexico !!

[@shomusbiologyofficial]

+Grethel Meza thank you. Glad you liked my lectures and

[@mobenkane2075]

Excellent,I also watched the base mismatch repair and nucleotide excision repair videos ,,, great illustrations...

[@miraclevibration5844]

Thanks a lot ....bro!! your so helpful and even your making biology more favorite

[@prarthubidkar1135]

Great thanks Sir.... I watches only u r videos..... Bcaz it is too simple and in detailed..... Thnx a lot
.no lectures as like u

[@shomusbiologyofficial]

You're welcome. Glad to hear that you are getting benefit from the videos

[@farishtanezomuddin2856]

this is a very helpful video. Thank you !

[@shynakaushal853]

You are doing a great work sir...Lots of respect and gratitude for you 💓

[@shomusbiologyofficial]

You're welcome. Glad to hear that you're getting benefit from my lectures

[@anjalibhusari2831]

Thank you for your videos...they are very helpful

[@chx99]

Thanks so much. Your explanations are so clear! :D

[@shomusbiologyofficial]

You're welcome

[@pakhisingh6378]

Sir you are doing a grt job keep it up its very helpful

[@karabeebaishya2060]

Sir , I am very happy by getting your videos. U are just amazing..my concepts are clear after listening your videos.thank you very much sir.🙏🙏🙏🙏🙏

[@shomusbiologyofficial]

Glad to hear that you're getting benefit from my lectures

[@shivleengill4976]

Appreciate your work and efforts tx man

[@apurvadhole5262]

thank u sooo much for giving us this knowledge.....it will definitely help me in my upcoming exams....:-)

[@salmasiddiq7521]

Thanks a lot😊😊😊😊😊. As student I hv watched lots of ur videos especially they helped for my seminars and exam

[@shomusbiologyofficial]

Glad to hear that you are getting benefit from the videos. Please subscribe and share

[@gasperkosmac7672]

If it wasn't for you I'd be in a very bad situation. Thanks a lot I wish you all the best.

[@rayanbhattacharya5549]

shomu da ... puro aguuun porale tohh ... bhai bhai bhai bhai bhai

[@tulasibiswal2666]

Just love your explanation and after watch ur lecture it is easy to understand thank you

[@shomusbiologyofficial]

You're welcome

[@akanshanarayan5900]

This is so helpful. Thank you so much :)

[@shomusbiologyofficial]

+akansha narayan you're welcome

[@cadendias3323]

I believe this is the mechanism used in prokaryotes not eukaryotes. Eukaryotic cells are theorised to use nicks made in the newly synthesised strands for this recognition to occur

[@surakshajkumar5771]

all ur videos are soooo helpfull ... i lov listening to ur teaching.... u really nw how to teach... and in nucleotide excision repair u havent mentioned about uvr A forming complex with uvr B .... other than that evrthngs just too gud... thankyou !!

[@shomusbiologyofficial]

+suraksha jkumar thank you. Glad you liked my lectures

[@doctorvimalkatarmal4704]

thanks somu bro.. it's easy and helpful...
u are intelligent

[@shomusbiologyofficial]

You're welcome. Glad to hear that you're getting benefit from my lectures

[@doctorvimalkatarmal4704]

@@shomusbiologyofficial.. ☺☺ keep sharing knowledge... god bless u bro☺

[@prativadevi2892]

Thank you sir.your vedios helps up in our bed time

[@tshakma3903]

You are saviour, appreciate your hardwork. Your lectures are really helpful. Thanks alot dude

[@shomusbiologyofficial]

Thank you for appreciating my efforts

[@mariashahid8871]

You are just superb.. No words

[@shomusbiologyofficial]

Thank you

[@quratjaan5165]

Crystal clear understanding .

[@shomusbiologyofficial]

You're welcome

[@abusayeem1482]

Splendid brother💙💙

[@shomusbiologyofficial]

Thank you

[@boazomido2373]

Hello you are doing a great job, your videos are so helpful, however, I think polymerase III will be recruited, not polymerase I at 14.50 in the repair process. Kindly clarify

[@shimafanimoghaddam7886]

Thanks a lot from Norway! This is so helpful.

[@shomusbiologyofficial]

Thank you. Glad you liked my lectures

[@MrVicinator]

Thanks, you really really helped me a lot!

[@hakandelilbasi2635]

U teach very well thank u:))

[@laxminamishra7126]

Thank you so much for making mutation easy❤️

[@shomusbiologyofficial]

You're welcome. Glad to hear that you're getting benefit from my lectures

[@ayeshairfan2695]

Very nice explanation thank you

[@shomusbiologyofficial]

You're welcome. Glad to hear that you're getting benefit from my lectures

[@junkmail8883]

Cheers man, very helpful

[@meghasvibe6497]

I hv exam period.. ur videos r helping me lot.. . 😍

[@shomusbiologyofficial]

You're welcome

[@aniruddhg.r]

Thank you so much sir for the explanation!! But, the part where you say helicase or UvrD cleaves the DNA is bit wrong I think. Helicase is required to open the 2 stands of DNA and it is accompanied by exonuclease 1 to cleave the oligonucleotide.

[@jichupang5659]

This video is amazing but I I have a question. For the step that the segment that contains the mismatch is cleaved out, is the UvrD helicase doing the job, or is there another exonuclease presented in the process? Thank you!

[@lewiswalker5554]

Yes, uvrD removes the incised region of DNA containing the lesion by breaking hydrogen bonds between the parent and daughter strands, so an exonuclease is not required. (Although the excised DNA may later be degraded by a ubiquitous exonuclease that is not specific to the mismatch repair pathway)

[@shatakshisingh4709]

It’s DNA polymerase III that fills the gap(acc. to Watson). Other than that your video is a life saver 😁😁

[@shomusbiologyofficial]

You're welcome

[@beegaluanjali739]

Thanks a lot for your vedio it will help me a lots

[@sutopasingha290]

can you please make a full video on axis formation in Drosophila it will be very helpful :)

[@1DangerRose]

i don't why every word you say make sense to all the words in my chapter that i was trying ages ago to understand 😀

[@shomusbiologyofficial]

+Undeadkitty c'v thank you for watching

[@anands272]

Excellent explanation ❤

[@shomusbiologyofficial]

Thank you

[@dasjohn1813]

Excellent explanation sir.

[@shomusbiologyofficial]

You're welcome

[@krishanumahindar652]

Very good lecture sir..thank you..

[@shomusbiologyofficial]

You're welcome

[@inspirationtalk7429]

Iam owe to sir a lot..🙏🙏literally appritiable..

[@shomusbiologyofficial]

Glad to hear that you're getting benefit from my lectures

[@shaikhalarab8662]

You helped me alot freind

[@thokchomnaochaa9039]

Sir... U have explained very nicely...but i have one doubt.which dna pol will come....dna pol I or dna pol III?

[@phanitej3122]

thank u very much for ur lecture... bt plz explain about the basic difference between methyl mismstch repair and base exision repair.... only mutS mutL and mutH r participating in methyl mismatch repair unlike in base exision repair... dats it??? plz explain....

[@biswajitpeyada7320]

Outstanding daada ❤️❤️

[@shomusbiologyofficial]

Thank you

[@alejarojasgo]

Very helpful, but I have found that MutH binds at hemimethylated sites along the daughter DNA and that at the end works Pol III not Pol I

[@heerachoudhary2885]

Thank u so much sir
U are great

[@shomusbiologyofficial]

You're welcome

[@rajlaxmiprasad7087]

Helpful sir thank you.

[@shomusbiologyofficial]

You're welcome

[@aratisahoo6254]

Life saviour ❤️

[@shomusbiologyofficial]

Thank you

[@toybajan85]

Really helpful

[@shomusbiologyofficial]

You're welcome

[@Clarawinfred96]

nice job

[@farsana3555]

Video is superb but more time is utilised for explanation

[@amirulfaez8437]

well explained

[@ritubhura7448]

Sir,,why not DNA pol.lll is used here ,, instead of DNA pol l

[@bibhubhusanchaki7642]

excellent...

[@tan4640]

Can this method repair dystrophin gene which causes DMD or BMD?

[@AsmaKhan-fh9on]

I think DNA polymerase III in prokaryotes and DNA€ in eukaryotes will work.

[@nithins3875]

This is awesome 🥰🥰🥰

[@shomusbiologyofficial]

You're welcome

[@dipanghosh9996]

what is the importance of dna replicatio.? pls tell me

[@khadijabegum4333]

Sir can I get the materials

[@M_5787]

Thankyou so much sir 😊🙏

[@shomusbiologyofficial]

You're welcome

[@kalyanlohar476]

Thank you Sir ....Thank you.. 👌👌💞👍🤗🙂

[@shomusbiologyofficial]

You're welcome

[@mulukentekle7181]

waw thanks a lot

[@jiayapcrysix7929]

Excellent !

[@carnage2k4]

No, it was horrible... I'm not kidding, complete nonsense video.

[@ramathanga268]

very much useful easily understandable thank you

[@sanaashfaq1290]

DNApolymerase I or III in 2nd last step ?

[@arpitasahoo5698]

Thank u so much sir

[@shomusbiologyofficial]

You're welcome

[@parvathalumadgula4976]

Mut L attach non methylated strand or methylated strand??

[@radhikaradhika3330]

Thank you sir

[@shomusbiologyofficial]

You're welcome

[@shivam781]

Amazing amazing amazing

[@shomusbiologyofficial]

Thank you

[@merikhatoon4707]

Make a video about epigenetic....

[@anitasingh7161]

thank u sir

[@marlenagwardys9716]

Is this about E.Coli ?

[@MARCOSGAMING100kill]

hi sir can you please make a video on lac operon and trp operon translation if you can than it will be helpful to me

[@shomusbiologyofficial]

+Manas Roy it's already made. Please check.

[@bdffmonster....1735]

Tqsm sir❤

[@shomusbiologyofficial]

You're welcome

[@54shamamairam38]

Very clear

[@shomusbiologyofficial]

You're welcome

[@Weirdaf_27]

Am here after 9 yrs.

[@shomusbiologyofficial]

You're welcome

[@pragyanpriyadarshini5856]

Me too 😁

[@haseenabegum7760]

So nice

[@shomusbiologyofficial]

You're welcome

[@prakritijha4050]

Ty😊

[@dnadatadive]

this is for prkaryotes any thing for eukaryotes

[@ahmadrashwan5231]

EXCELLLENT

[@shomusbiologyofficial]

Thank you

[@gajerajaydip994]

great...

[@bessbestmithra8268]

Thanq ..u r a saviour

[@shomusbiologyofficial]

You're welcome

[@Anisa-kx3pt]

Can cell uses all the repair mechanism to repair the damage

[@shomusbiologyofficial]

Yes

[@rathprasenjit07]

Pol I or III??? will fill

[@babluhrangkhawl4699]

👍