Methylene Blue: Dosing Expert Pharmacist Dr. Newville
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- Опубліковано 24 кві 2024
- 🧠 In today’s video Dr. Dane Newville will discuss the dosing of Methylene Blue.
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Ok so been using it for 6 months. I used 2 drops for 3 weeks cycled off for a week. Huge improvement in autoimmune symptoms and my skin condition dramatically improved. I know do 6 drops at one time once a week. Plus using a drop directly on a skin wart and currently 90% of it removed.
Wow and that’s no where near therapeutic levels!
@@UseYourManners123 exactly 💯.
What is your source?
Thank you, I bought it for a skin condition (tsw) and wasn't sure what dosage to start with so I will try the same
@@tahio0081 TSW is tough af. I'm like 1.5 years into it and while I'm mostly functional at this point my legs are still bad. Will post a quick list of what I've been doing: I use taurine + glycine (antioxidant, anti-inflammatory, collagen synthesis, gut health etc.) + red light therapy + 3-4 days water fasts every month; mostly animal-based diet (may or may not suit you). I also feel like vitamins A + E in somewhat high doses mostly helps me even though people are fearmongering about it but every time I quit retinol it gets worse. Dexpanthenol spray without any additives (like the one against sunburns) was the only thing my skin tolerated, some mosturizers even "dermatologically tested" crap caused aggravations. Spent gallons of those sprays, now use them less often. There are times it gets worse for no reason even in spots that you thought already healed long ago. Hair drier at max setting to combat the itch if it gets unbearable
PEOPLE*** Start with 1 or 2 drops and see how you feel. NEVER take a large dose to start something new. Plenty of people are helped with MUCH lower doses than what this guy is recommending.
You are absolutely correct. It depends on how well your electron transport chain is functioning in your mitochondria. If you don't have problems with your electron transport chain, then it doesn't take much methylene blue to be way too much. I took 20 drops at once and it shut down my energy because I'm a fairly healthy person who exercises and has a clean lifestyle and diet
The drops per ml varies so if you don't know what it is just count the total drops. It was 400 for my one oz jar that I filled with mb powder and filtered water. I put a gram in there so each drop is 2.5mg. It would be better for most people to dilute it more but for me fewer drops makes it easier to deal with.
Lol who's there. I still think that just using a small syringe (like 2ml I'm using) is quicker and easier than counting drops and get rids of any discrepancies. I even taped the 1ml range just so I don't have to spend CALORIES on THINKING (well actually black lines on a syringe are hard to see when its filled with MB) If you know that your solution is 1% math gets very simple like he explained @1:09
Much needed video. Thanks. When I started 8 months ago, I had to do all these calculations by myself. No youtuber gave the exact drop numbers somehow. and the numbers of drops looked to big, I had to calculate everything 3 times to make sure im not doing any mistake.
Because it is really lots of MB to drops, I use 1/4 teaspoon or 1 teaspoon measurement spoons instead of droppers. I did the calculations of their volumes.
I get powder MB and I do my own 1% solution btw. more economic.
Can you share the link for the MB powder that you purchase? Please and thank you
Thank you for your time!!
Let me guess - you are talking about the therapeutic dose against acute poisoning. For my brain fog, two drops three times daily is more than I need.
I thought the 0.5mg/kg through 4mg/kg was an IV dosage and the oral dose was up to ~15mg/day. Can the higher dose orally affect your gut flora since MB has an antibiotic effect?
EXCELLENT information!! A BIG Thank you!! Very clear and concise!
Glad it was helpful!
Thank you.
very healthy and active but always lethargic and foggy for the last couple years since covid or at least since i started working from home. been using about 10 drops for a week. nothing noticeable on teeth or urine so probably not near a high dose but I have seen improvement in my productivity and recall. I do notice an energy increase so I probably wont take it after 5 or 6 pm. Its a steady energy and focus not a jolt like an espresso or energy drink
Can you guide me on what to buy as far as bottles so I can make bottles that have numbers on them so I can explain this to my family how to take them as simply as possible. Ty!!! All this math hurts my head. 😅
I take 5-10 drops per day which works well for my Lymes induced brain fog and fatigue
Good video, well done
Thank you very much!
Do we need to eat tyrosin and histamin free diet while using MB?
Whats the deal with l tyrosine and MB thanks*
Dave, why do I see exact same size bottles of 99% methylene blue and bottles of 1% methylene blue, for basically the same price.?
I see no explanation as to why one bottle claims to be 99% methylene blue and another identical bottle claims to be 1% methylene blue
I have asked this question of other channels with no answer. What is the interaction of methylene blue with nitric oxide at the cellular level? Thanks.
According to some youtubers and professionals, MB clears out the NO from the body. which is supposed to be a good thing. The initial headache when starting the MB is considered the NO cleaning. I had lots of headache when i increase the dose, but after a week or so it went away.
@@bediha That is what I have found also. The problem with clearing NO is that proper amounts of NO are critical for body function. One such example is arterial expansion. I found my blood pressure increased dramatically to a dangerous level when I was taking methylene blue.
You have likely not received an answer because it is layered and not definitive, we have strong evidence of methylene blue and its interaction with NO pathways, in fact this knowledge is used in acute settings for emergent issues in hospitals. But it is not so cut in dry. We will be putting together a video on this exact subject in the next few weeks. Thanks for the question!
@@Dr.DaneNewvilleRPh You, sir, are a gentleman and a scholar.
Following. Would really like the answer for this also as my BP shot up to 222/180.
MB blocks Nitric Oxide?
I heard it does from reliable sources, but nothing like researching yourself!
Yes, that's why I bought it, needed a nitric oxide inhibitor
@@tahio0081why do you need to inhibit NO?
Sounds like one should probably buy powder and maybe set up a solution with a bit higher dose.
I use to do this over ten years ago, MB powder was ridiculously inexpensive, and a couple of years before that, some brave souls were getting it from pet stores, as fish medication (relatively pure, but yuck!) But I don't think it's profitable that way, so more vendors are selling it pre-mixed, at strengths like 1% talked about here.
That's what I do. I mix my own solution from MB powder as a 2% solution. So, each drop is 1 mg of MB, and a dropper full (about 3/4 is all it will draw up) is about 15 drops/mg of MB. I take that about once or twice per day (15-30 mg per day) with very good results.
Just got some today , trying it now in some water. Mine says 10 drops and it tastes kind of bad lol
So? It's not sugar, it's not supposed to taste like kool aid. Lol
I put it in an empty gelcap, the cap dissolves in about 15 seconds so do it quickly and hold it over the sink.
So I'm curious, how would this apply to the MB I have. I use Meraki Brand which is 100% pure USP/Pharmaceutical grade. they say on the bottle that each drop is 250 mcg so I've slowly worked up to 12 drops now once a day, but I know from working out the math that I would need to bump it up to 20 drops for it to be 5mg I think, which seems to be a pretty standard dose most take. I do it 5 days on two days off on the weekend. Was just curious what you thought about that, applying the info you provided in this video. all the best
250 MCG = 25mg
12 drops is 300mg daily
I think that is a full 4mg/kg dose if you were about 75 kg. Someone correct me if I am wrong.
How have you found the benefits?
@@bettycooper369 actually no 250 mcg = .25mg not 25mg
@@bettycooper369 that's a pretty low weight for an average American male! I'd say 90kg, and maybe even that's low!
@@bettycooper369No this is not correct. 250mcg = 0.25mg. OP is correct in his/her calculations that 20 drops equal 5mg. That’s still only a percent or so of the therapeutic dose in the literature, basically a homeopathic/placebo dose.
@@bettycooper369Wrong, 250mcg = 0.25mg. The OP is right, 20 drops equal 5mg.
I am super confused. I thought the dosage was X mg/Kg of body weight for the whole drop. of the 1% solution???
So I weighed one of my drops and it is 50mg, so at say 3mg/Kg of 100 Kg I would take 6 drops. But you're saying in that 300mg of liquid only 1% of that is the actual MB dose I'm getting? I'm only getting a 3mg dose of MB not 300mg?
3mg is fine. 1mg is usually what’s used to actually treat methemoglobinemia. 5 is considered toxic, over 7 is literally just poisoning yourself, and there’s no antidote for methylene blue poisoning.
How about alkohol and cbd, as MB is a MAO inhibitor? Any dangers?
Also interested in hearing the answer to this question
@@fannarkaribergvinsson2917 pretty safe. Only worry about antidepressants, and even then serotonin syndrome is more of an issue than MAOI. CBD is a cannabinoid, different set of neurotransmitters, Alcohol effects GABA mainly, although taking a high dose with a home-made or exotic craft brew might present tyramine issues. Basically a possible blood pressure spike.
Sounds like an impractical ammount to use. I plan to increase the dose a bit but I see results with just one drop on an empty stomach. Increased blood flow & pumps when exercising mainly.
Out of curiosity, what's your age?
@@deama15 I am 60 and feel an increase in energy , clarity with just 5 drops...
@@alexandrelevy3916 Yeah as I suspected. I tried taking about 50mg worth of MB (custom made) and didn't really feel a difference. I think this stuff works best if you're older or have a problem already, I'm too young for it, but I'll keep in mind for the future and probably will cycle it in/out once a year.
What do you mean by pumps?
@@UseYourManners123 Blood flow to muscles causing a nice defined look after workouts
Is methylene blue synthetic?
has been described as "the first fully synthetic drug used in medicine." Methylene blue was first prepared in 1876. It was used as a blue dye long before that, maybe centuries. It's a whole lot less processed than most synthetics
So im 73 kg. So I need 36 drops a day? I took 20 drops in a glass of water and it tasted awful. I found a bottle on Amazon for $5 for 1 ounce. It says it has 60 doses. 1% usp. But I’m weary as it has a name called Shanghai but a French address as the owner maker.
real methyene blue is so cheap, there's not much reason to fake it. Plus, if it turns your tongue blue and your urine greenish, you know it's real.
If a guy that is 100 kilos needs 100 drops..then u need 73 drops if u are 73kilos... Am i wrong?
I took ten drops of 1%. Developed a headache and ringing in my ears. I think I don’t need 800 drops. 1-3 drops per day is fine.
Everybody responds a little differently, understanding that and being conservative in your approach is never a bad idea!
I take six drops of 1% USP. Works out to 3mg. Not much, but with higher doses ketchup taste weird. Maybe I just had bad ketchup. Not sure.
You should not be eating ketchup or anything containing tomatoes when taking this product. It interacts with anything high in tyrosine, so do not drink tea, coffe, take anything with chocolate, tomatoes, fermented foods, anything high nitrite ie cheeses, cured meats etc when taking this or you will get negative reactions and probably more health issues.
try putting it in empty gelcap to avoid the taste, just beware it dissolves quickly.
Watch the tyramines that chocolate binge could give you a stroke
Can someone tell me the best dose for 180 pounds would be
Just start with 2 drops and see how you feel. He's describing a therapeutic dose, most don't need that much.
@sandyjones1014 I'm definitely wanting a therapeutic dose. From my research I'd be around 20 - 30 MG for a light therapeutic dose. Anything above 30 starts messing with gut bacteria
@@royalbroman9467anything over 5mg is toxic. 🤦♂️ where are y’all getting this information. Methylene blue in high doses can poison you and there’s no treatment for it.
There are 98.57843 drops per teaspoon.
So instead of "100 drops" you could just use 1 teaspoon in your theoretical example.
Can't you just get a slin pin from CVS and use it? No courting, just fill it up to the ml point.
We keep reading that we shouldn't use MB daily.
Whats the reason just curious I started taking it daily thanksss*
@@Intwodeep902 I'm not sure exactly why not to take it every day, but maybe because it's a monoamine oxidase inhibitor that can possibly cause serotonin toxiicity. MAOI's are like an SSRI substitute and for some reason the medical nazis have decided not to use MAOI's much anymore for what they used to use it for, I guess. Maybe because they're just following orders. There's a bengreenfieldlife webpage the says "Dosing: My friend Dr. John Lieurance suggests 0.5-1 mg per kilogram of body weight per day, 2 to 4 days per week." and that you can download his book "Methylene Blue & Metabolic Medicine" for free. I haven't read his book, but I think I've also heard someone in a different video say that you shouldn't take it every day also.
@@Intwodeep902 It's an MAOI which is like an SSRI and it can cause serotonin toxicity. Dr. John Lieurance suggests 0.5-1 mg per kilogram of body weight per day, 2 to 4 days per week. UA-cam has blocked my previous attempts to answer you. I don't know why.
@@Intwodeep902 Because it can cause serotonin toxicity. Be careful with it, it's a real drug.
@@keepingup2952 ok cool check out oral bpc157 to help with the serotonin syndrome
I only weigh 41 kg
This guy doesn't understand the biochemistry involved. Methylene blue does the opposite of what is supposed to do when you have too much for a specific person. It'll shut down your electron transport train instead of enhancing it. With mehtylene blue, it is very specific to the person and the most effective dose is very small for healthier people.
So everyone is basically on homeopathic/placebo doses of MB… 😐
That dude is one with math.. just sayin
a low dose gave me high blood pressure
Interesting 😮
@@bluesky7704 my blood pressure is down in normal range now - no more lisonipril
Same, and I can't figure out why. I am NOT taking any other medications at all. Just 2 drops in the morning and 2 drops in the evening of MB and my BP went to 222/180. Thought I was going to have a stroke and had to start taking BP meds. I think the key is to take it with nitric oxide. I'm trying to research that now. I really want to be able to take MB for all the great benefits.
That a lot of math.. I don’t know about this guy
Give it time. Thank you for watching our video.
I dissolve one gram of MB powder in 100 mls of water. That is a 1% solution. I take 4 mls of MB liquid daily. My dropper has mls marked on the side so I take four of those. There is 10 milligrams per ml so that means I am taking 40 milligrams of MB per day.
Thanks
It helps @@bugsy1254
He didn’t even need to look at his notes for the math 😱
Thanks for vid. I’m all new to this I’m 50 good shape zero meds. I want to keep it that way. I’m wondering if I should use it and how often
Maybe people shouldn’t be experimenting with ingesting synthetic chemicals. No one knows the long term downstream effects.
I would agree that there is not an abundance of literature relating daily methylene blue consumption and long term effects. Something that should be considered before starting any long term supplementation. Thank you for the comment.
It has been described as "the first fully synthetic drug used in medicine." Methylene blue was first prepared in 1876. that's a whole lot of therapeutic use. One would think any indications of long-term "abuse" would have been found and mentioned in the literature. And this will never be thoroughly investigated, because it's much too cheap and long-term studies are much too expensive. I mean, the "aspirin" you take is synthetic. It was originally derived from a plant, but what you get in a bottle is synthetic. Although feel free to abstain for the rest of your life. If it was good medication God would gift it like a present wrapped in a bow, right?
it's an organic dye that's been around since the late 1800's. It cures malaria and was the very first drug approved by the FDA.
I am super confused. I thought the dosage was X mg/Kg of body weight for the whole drop. of the 1% solution???
So I weighed one of my drops and it is 50mg, so at say 3mg/Kg of 100 Kg I would take 6 drops. But you're saying in that 300mg of liquid only 1% of that is the actual MB dose I'm getting? I'm only getting a 3mg dose of MB not 300mg?
yes!!!! Get a dropper with markings (1mL anyways), and you're going to want to take a full dropper's worth at least. Don't weigh a drop, that doesn't work. You would only take a couple of drops or so if it was like 95+% pure, or more likely you would use a few milligrams of nearly pure powder put in a drink. 1% solution is much much more dilute.
@@squirlmy Thanks, I figured it out. I was taking super low doses. Thanks again!
@@squirlmy Not sure where my original reply went, but yah, thanks for that. I did dig into it more. The confusing part is the studies use mg/Kg but the measurements are in ml. Super confusing but yes I figured it out and I was taking very small dosage. So my dropper does 0.5 mg of MB per drop. It was my confusion thinking the 1% solution is what they were using in studies. The 1% is from labs requiring that dilution for use in staining slides in the lab.