Dude you are so amazing! You have no idea how much your videos have helped me as a pharmacy student. It has made pharmacology so simple. You deserved every good thing on this earth. Much love❤
Not a student, just trying to educate myself on antipsychotics after being prescribed for a few years, I had psychosis. Currently weaning off of olanzapine.
I'm on risperidone after psychosis in 2018 and 2019. I lowered my dose from 4 to 1 mg over the past 1.5 years. How's it going with you so far weaning off the olanzapine?
my life was for a long time ruined by antipsychotics. was prescribed them and although I suffer from major depressive disorder, I do not have schizophrenia, bipolar, or any sort of mood disorder. Because I already lack serotonin and dopamime due to my depression, this medication sedated me/turned me into a zombie, made me gain 15 lbs in a matter of 2 weeks, stripped me of my personality, confidence and creativity, & even after I went off of them, I could not get back to the girl I was before. I no longer was responding to any antidepressants that had worked in earlier years or stimulant medication that had helped in the past. I looked awful and became a different person. All I wanted to do was sleep. I was so severely depressed i could not function at work (yes, I was trying every class of antidepressants at this point). I was no longer myself and had become completely overcome by my mental illness. It got so bad that my therapist insisted I seek more comprehensive medical treatment. I admitted myself to the hospital and after many more trials of medications, I had to resort to electroconvulsive therapy. I am 23 years old. Although it has a terrible rep, this treatment saved my life. the reason I am writing this here is because I think antipsychotic medications are necessary for people who naturally go into manic states, suffer from schizophrenia or psychosis. however, I am writing this as an informative warning that these medications WILL change you, and WILL sedate you. for some this is necessary. however, if you are prescribed these because antidepressants alone are failing, I really hope you will do the research on how they work because I believe that for a depressed person, these meds can be extremely detrimental . I hope that those who need these meds find them helpful. However, for me the damage they did could only be repaired by literally shocking my brain out of it. Good luck to all and please know YOU ARE NOT ALONE.
Gracie xx thank you so much for telling us the truth..my friend is on aripiprazole for bipolar and she has been acting weird lately...i don't know how to handle the situation...now i ll just show your comment to her and maybe it ll help her get better
@@sanagoyal4119 becsuse my daughtersuddenely starting talking with herself and they prescribe her first Aripiprazole and now they put her on olanzapine,so plesse tell me,psychiatrist doctor snd nurses giving me lots of hope...can you tell me please?..Do these medicine really work?
This "meds" are cell poisons (study from 2023) and nerve poisons (many studies). The people you call ill are not ill they are a different species (study in human genetics 2024). By talking people into taking this drugs you make yourself guilty of a crime against humanity called "extermination".
Thank you for this simplified lecture. I watch your videos before reading textbooks or materials and it's always an easy read for me. Much love from Nigeria.
You are a legend. Words cannot describe how helpful and informative your videos are. They have been my saviors. God bless you! You deserve to be known and awarded for your concise knowledge!! 🤩
Thank You. This is exactly what I was looking for. I was wondering exactly how my medication actually works on my brain and I couldn't find it. Until now.
I am an avid #MentalHealthAwareness advocate and performer, and I love this so much. I travel the country trying to bring that awareness on stages, in classrooms, hospitals, and on my UA-cam channel, so I get excited when I see other advocates. 💙❤
thanks for this but just to note a MAJOR correction: psychosis is associated with increased dopamine presynaptic function in the nigrostriatal pathway (particularly the part that projects to the associative subdivision of the striatum) it is NOT the mesolimbic system
Neuroleptics are cell and nerve poisons. By promoting them as medicine this man makes himself guilty of the crime of "extermination" (one of the crimes against humanity that is listed by the Rome declaration).
I was misdiagnosed with schizophrenia. Been drug free for a long time and I am still suffering the disabilities caused by these medications. I cant express emotion and have slurred speach. The eay I walk changed. My hormones are all over the place. I exercise and hope for a better future. I feel like my a bird shose wings been clipped.
Most people will never experience extrapyramidal symptoms (EPS) so they have no idea how horrible they can be. There are many factors contributing to EPS but mainly a dysfunctional dopaminergic and acetylcholinergic neurological system play a role. There are so many hyperkinetic movement disorders like dystonia, dyskinesia, akinesia, akathisia, athetosis, ataxia, chorea, myoclonus, ballismus, tics, tremors, Tourette’s, spasms, RLS,etc.. it can make it very hard to distinguish. I sympathize for schizophrenics and people who need certain antipsychotics and other medications that exacerbate these movement disorders. Most these medications drastically deplete Dopamine which is one of the main reasons for these extrapyramidal side effects. Science has had more than enough time AND MZoNEY to develop a novel medication that should not cause this. Many schizophrenics need glutamate and dopamine regulation (not always “reduction”). There are several dopaminergic receptors and binding sites that can be antagonized and agonized therefore there is ZERO reason why there isn’t a proper neuroleptic to control psychiatric side effects while not exacerbating extrapyramidal side effects OR anhedonia! Dopamine agonists can do wonders for EPS and science was able to develop non-ergot agonists which are much much safer yet can’t develop an agonist that will not cause debilitating Dopamine withdrawl Syndrome? Come on that is ridiculousness there is no excuse for no development of one. Or how about an MAOI with no withdrawal? Nope, doesn’t exist 🤦♂️ 9-Methyl-β-carboline should be further examined as it appears to have incredible dopaminergic restoration properties. A study was done on rats that proved it. In layman’s terms scientists injected rats with synthetic neurotoxic compounds like 2,4,5-trihydroxyphenethylamine (6-OHDA) and 1-methyl-4-phenyl-pyridinium ion (MPP+) that selectively destroy tyrosine hydroxylase and dopaminergic neurons. So they essentially gave these rats Parkinson’s like symptoms. After a few weeks of 9-Methyl-β-carboline administration around 80% of the damaged neurons returned to normal determined by measurements of nicotinamide adenine dinucleotide dehydrogenase activity. Also the adamantane derivative called Bromantane and Pentadecapeptide BPC-157 play important roles. Yet no ongoing research is being done. 🤦♂️
Sorry for my english ... YOU Are SAYING that IT is POSSIBLE have an anti psychotic without side effects ??? Allucination depends ON high nonormal levels of dopamine in the BRAIN ??
Thanks for the quality of this video, and the concise, clear way these mechanisms are affecting us potentially! You are making it interesting both for patients and also purely on an intellectual and educational levels!
These videos are so helpful...you´re far better at explaining pharmacology than any of my college teachers!! You make it seem easy and cool.Thank you so much from Spain!!
Excellent explanation!! simple and easy graphics made to understand! As a psychology student, studying Schizophrenia this just made my day a whole lot easier! Thank you!
Remember 'Antipsychotics' can be 'hyperbolic' - which means that withdrawal needs to be approached more carefully at reduced doses. And remember that abrupt 'antipsychotic' drug withdrawal can result in 'Withdrawal Psychosis'.
I think the APs causing onset or worsening of negative symptoms is called “Neuroleptic-induced deficit syndrome”. I feel like this is something that needs to be talked more about!
Antipsychotics cause erectile dysfunction and loss of libido, emotions and motivation. Risperidal for me caused decreased quantity of sperm and no orgasm, premature ejaculation and erectile dysfunction. Now, after 4 years, Im on path to healing myself but strugle is so big.
Sir ur videos are simply amazing and ur way of teaching through animations is best CNS pharmacology will never be such easier without ur lectures keep going and best of luck
just to note that in 2010 it was found that there is no increase in the levels of dopamine in the nucleus acumbes, but rather in the nigrostriatal region that projects ventrally in both the striatum and the cutaneous nucleus, and this region is related to the positive symptoms of schizophrenia. Kegeles LS, Abi-Dargham A, Frankle WG, et al. Increased Synaptic Dopamine Function in Associative Regions of the Striatum in Schizophrenia. Archives of General Psychiatry. 2010;67(3):231. doi:10.1001/archgenpsychiatry.2010.10
Thank you so much, I was mixing my medications and your concise and clear way of explaining has helped me very much. I am new to your channel just subscribed.. Great explaining.
As a bipolar disorder patient and a former psychology major student. I just find some papers about the correlations between bipolar and obesity. Your video just explain very well.
Good video. Except, it is stated and implied from the neuronal diagram of serotonergic neurons synapsing with dopaminergic neurons that 5-HT binds to 5-HT2A receptors on dopaminergic neurons to decrease dopamine release. And that antagonism of these 5-HT2A receptors results in an increase in dopamine release. The problem with this theory is that 5-HT2A receptors are coupled to Gq/11 proteins, that when activated, stimulates phospholipase C activity, thus enhancing intracellular Ca2+ levels. This is a trigger for vesicular release of neurotransmitter. My question for you is, how do you explain activation of a Gq/11 coupled 5-HT2A receptors produces a decrease in dopamine release?
5HT2A antagonism increases dopamine rather than decreasing dopamine. It is believed that the antagonism mainly affects in the nigristriatal pathway without affecting the mesolimbic pathway. Thus.. the EPS side effects are relieved without exacerbating psychosis.. hope this clears your doubt.
*Hi ‘Speed Pharmacology’ Merci infiniment. Outstanding video. Question, your accent? I have five accents. Finnish, Swedish, English, German French and Thai. Accent in every language. How about you? Greetings from THAILAND* ua-cam.com/video/VOggAvPuLmM/v-deo.html
After they all sat and said we are putting the quetiapine up again and with that I have to give Lorazepam to .All this time myself and carers see what all these medications are doing .I lost I wanted to hurt myself because I feel like I am talking to a brick wall but they still refuse to listen now they are talking about having an adult protection meeting .This has got so bad with these people they do not care obviously its not their child whether grown or not when you think how people with health issues are treated and drugged it is so sad
Your videos are amazing and easy to understand but could you also add mnemonics.it will really help us to retain the drug names in our memory for longer period of time ✌️✌️😁
I think a great direction medical science could take would be to try to see if lifestyle modification could have the intended effects on these biological mechanisms, rather than trying to precisely target them with drugs. While these drugs work they come with many undesirable side effects, which is natural since they are so precise. It would be better to increase or decrease the activity of dopamine pathways as a result of activities that reform the whole brain-body system instead of just target isolated areas of the brain or body. I'm not sure if this is possible with something so damaging as psychosis but if it is then it would far more desirable.
What I find interesting about the newer class of (so called atypical) neuroleptics is their loose binding to D-receptors in contrast to the old typical ones. In exchange they have a very high affinity to 5HT (Serotonin) and guess where the body has the most of these receptors which are then antagonized? In the gut! So basically you loose your gut feeling...
What u just described can it be said about Olanzapine? Also what do u mean u lose gut feeling, like, that you cant feel anxiety in belly or? Also i heard that serotonin in gut its like a myth, its in brain.
@@RudisBoss no one claims seretonin is in the gut. the claim is that an unhealthy gut is linked to these mental disorders and seretonin and dopemeine have little to do with anything. its been disproven a long time ago that chemical imbalance is a myth. its nothing more then a lie to convince people they have an incurable disease and the only treatment is these drugs, they help very few people and cause worse side effects then the disorder. its mass genocide
(tmi but it’s medical talk so i’m sharing) i was put on olanzapine during an involuntary (and unnecessary) commitment in december, i was only on it for about a month total. i swear i SWEAR my bowel movements smell different sometimes. it’s very specific and didn’t happen until i was on the meds, it has continued despite being off of them for a few months. idk if my body is releasing certain molecules from the meds of if they changed my gut chemistry and now that’s just how that goes. either way i believe it to be a result of the medications
Smoking marijuana as a teenager caused me to have this problem. I was desperate for friends and they did it around me and I didn’t know any better. Deeply regret hanging around them. Would have been better off hanging out by myself all the time. Which is what I do now. Don’t. Smoke. At such a young age. And warn others! It will create a lifetime of issues and struggles that can be avoided by NOT smoking marijuana at a young age when your brain is still developing.
I am on a really low dose of aripiprazole and have been on high dose of risperidone from psychosis they both make me feel shit(currently on aripiprazole), lack of confidence I can get happy but is not a true happiness, also makes me lazy is this common?
You might want to add in your assignment how bad these drugs are to the brain long term. I suffer every day because of these awful drugs and these doctors that I put my trust in as a kid have totally fucked it up!!!!
Please also add the neurotoxic effect of neuroleptics and how psychiatrists often prescribe them wrong for MONEY and how pharmalobbies do chemical lobotomies and genocide claiming to help humans❤
@@HoldMeForeverantipsychotics are extreme neurotocix...it means that they are poisonous for your brain, since most of our life is dictated by our brain, once ur poisoned ur brain is not the same anymore 100s of things have changed to the worse and ur life isnt the same anymore. Im a victim myself and its basically a Pharma genocide
Can someone answer me. If D2 antagonist are used, won't it increase dopamine levels b/c D2 receptors are auto-receptors, and their inhibition will lead to increased levels of dopamine????
🚀 Elevate Your Pharm Game! 📚 Join Patreon for A+ Study Notes!
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Dude you are so amazing! You have no idea how much your videos have helped me as a pharmacy student. It has made pharmacology so simple. You deserved every good thing on this earth. Much love❤
Amen!!!
The Health System is Genius!
ua-cam.com/video/-Nd40Uy6tbQ/v-deo.html
Not a student, just trying to educate myself on antipsychotics after being prescribed for a few years, I had psychosis. Currently weaning off of olanzapine.
I'm on risperidone after psychosis in 2018 and 2019. I lowered my dose from 4 to 1 mg over the past 1.5 years. How's it going with you so far weaning off the olanzapine?
How are you doing? I've been on olanzapine for a couple years too. I'm trying to get off as well
Awesome that you are weaning off, I currently have minor form of PTSD, self diagnosed, and have been prescribed olanzapine, methex od etc.
@@rockit5288 you lowered your dose, or you and your health care provider worked together to lower your dose?
Yeayy, congrats. Hope you'll be okay!!
my life was for a long time ruined by antipsychotics. was prescribed them and although I suffer from major depressive disorder, I do not have schizophrenia, bipolar, or any sort of mood disorder. Because I already lack serotonin and dopamime due to my depression, this medication sedated me/turned me into a zombie, made me gain 15 lbs in a matter of 2 weeks, stripped me of my personality, confidence and creativity, & even after I went off of them, I could not get back to the girl I was before. I no longer was responding to any antidepressants that had worked in earlier years or stimulant medication that had helped in the past. I looked awful and became a different person. All I wanted to do was sleep. I was so severely depressed i could not function at work (yes, I was trying every class of antidepressants at this point). I was no longer myself and had become completely overcome by my mental illness. It got so bad that my therapist insisted I seek more comprehensive medical treatment. I admitted myself to the hospital and after many more trials of medications, I had to resort to electroconvulsive therapy. I am 23 years old. Although it has a terrible rep, this treatment saved my life. the reason I am writing this here is because I think antipsychotic medications are necessary for people who naturally go into manic states, suffer from schizophrenia or psychosis. however, I am writing this as an informative warning that these medications WILL change you, and WILL sedate you. for some this is necessary. however, if you are prescribed these because antidepressants alone are failing, I really hope you will do the research on how they work because I believe that for a depressed person, these meds can be extremely detrimental . I hope that those who need these meds find them helpful. However, for me the damage they did could only be repaired by literally shocking my brain out of it. Good luck to all and please know YOU ARE NOT ALONE.
Gracie xx thank you so much for telling us the truth..my friend is on aripiprazole for bipolar and she has been acting weird lately...i don't know how to handle the situation...now i ll just show your comment to her and maybe it ll help her get better
@@sanagoyal4119 can you tell me about electrocolvulsive thearpy?
@@sanagoyal4119 CAN you tell me,please,do they really work?
@@sanagoyal4119 becsuse my daughtersuddenely starting talking with herself and they prescribe her first Aripiprazole and now they put her on olanzapine,so plesse tell me,psychiatrist doctor snd nurses giving me lots of hope...can you tell me please?..Do these medicine really work?
@@sanagoyal4119 if they don't work,then what other treatment are possible?
I literally wasted 2 hours reading book before watching this video... I read my book after watching, I understood everything.
Same man. This video was wonderful.
😂 great iam too
Add a sticky note in the book with the link that would be awesome
Same here
Sameeee
What a elaboration in just 8 minutes. You have cleared many concepts. Thanks a lot.
من هذه اللحظة لن اضيع بعد الان اي لحظة في غير الطب والعلم و العبادة
والان ماذا حدث بعد 4 سنوات 🤔
I'm a student nurse, and this has made it so much easier than everything I've read!!
The Health System is Genius!
ua-cam.com/video/-Nd40Uy6tbQ/v-deo.html
This "meds" are cell poisons (study from 2023) and nerve poisons (many studies). The people you call ill are not ill they are a different species (study in human genetics 2024). By talking people into taking this drugs you make yourself guilty of a crime against humanity called "extermination".
You help murder and torture people for rasistic motives.
Thank you for this simplified lecture. I watch your videos before reading textbooks or materials and it's always an easy read for me. Much love from Nigeria.
Thank you for making this video to let us understand how the antipsychotic medications work
I must admit, this is a great video. You have allowed my brain to gain weight on neuroleptic and for that I’m grateful 🙏🏻
Finally I can inform my pd whats going on inside my head on a molecular level. Thank you so much.
You are poisoned. Neuroleptics work like rat poison.
You are a legend. Words cannot describe how helpful and informative your videos are. They have been my saviors. God bless you! You deserve to be known and awarded for your concise knowledge!! 🤩
Agreed 100 %
Thank You. This is exactly what I was looking for. I was wondering exactly how my medication actually works on my brain and I couldn't find it. Until now.
The Health System is Genius!
ua-cam.com/video/-Nd40Uy6tbQ/v-deo.html
I am an avid #MentalHealthAwareness advocate and performer, and I love this so much. I travel the country trying to bring that awareness on stages, in classrooms, hospitals, and on my UA-cam channel, so I get excited when I see other advocates. 💙❤
So very true nice 👍🏻
perfect timing....i dont usually subscribe to channels, but when i do, its speed pharmacology ...keep it up.. thank you for your work....youre a beast
My negative effect ba ang nozinan sa sperm cell
thanks for this but just to note a MAJOR correction: psychosis is associated with increased dopamine presynaptic function in the nigrostriatal pathway (particularly the part that projects to the associative subdivision of the striatum) it is NOT the mesolimbic system
Quetiapine saved me from major depression. Came off them for afew days and cried all day, very low. Back on them and well again.
I love you man. This is how one man helps another😘😁
Neuroleptics are cell and nerve poisons. By promoting them as medicine this man makes himself guilty of the crime of "extermination" (one of the crimes against humanity that is listed by the Rome declaration).
This was a very helpful video. Detailed however engaging. I have learned a lot in under 10 minutes 👏🏾 now I will study this so it sticks
I was misdiagnosed with schizophrenia. Been drug free for a long time and I am still suffering the disabilities caused by these medications. I cant express emotion and have slurred speach. The eay I walk changed. My hormones are all over the place. I exercise and hope for a better future. I feel like my a bird shose wings been clipped.
What drug was that and how long since you stopped?
How are you feeling now?
Hey I hope you're feeling better now
a perfect explanation of how cures could be worse than the disease
Definatley.
Is torture the reason for These devasting side effects. Why ja this called help?
@@clausmehl8731 it's considered "treatment" to make people so ill that they are driven to their death.
@@FutureBoyWonder I'm still right 😏
Chemical lobotomizers*
Most people will never experience extrapyramidal symptoms (EPS) so they have no idea how horrible they can be. There are many factors contributing to EPS but mainly a dysfunctional dopaminergic and acetylcholinergic neurological system play a role.
There are so many hyperkinetic movement disorders like dystonia, dyskinesia, akinesia, akathisia, athetosis, ataxia, chorea, myoclonus, ballismus, tics, tremors, Tourette’s, spasms, RLS,etc.. it can make it very hard to distinguish.
I sympathize for schizophrenics and people who need certain antipsychotics and other medications that exacerbate these movement disorders. Most these medications drastically deplete Dopamine which is one of the main reasons for these extrapyramidal side effects.
Science has had more than enough time AND MZoNEY to develop a novel medication that should not cause this. Many schizophrenics need glutamate and dopamine regulation (not always “reduction”). There are several dopaminergic receptors and binding sites that can be antagonized and agonized therefore there is ZERO reason why there isn’t a proper neuroleptic to control psychiatric side effects while not exacerbating extrapyramidal side effects OR anhedonia!
Dopamine agonists can do wonders for EPS and science was able to develop non-ergot agonists which are much much safer yet can’t develop an agonist that will not cause debilitating Dopamine withdrawl Syndrome? Come on that is ridiculousness there is no excuse for no development of one. Or how about an MAOI with no withdrawal? Nope, doesn’t exist 🤦♂️
9-Methyl-β-carboline should be further examined as it appears to have incredible dopaminergic restoration properties. A study was done on rats that proved it. In layman’s terms scientists injected rats with synthetic neurotoxic compounds like 2,4,5-trihydroxyphenethylamine (6-OHDA) and 1-methyl-4-phenyl-pyridinium ion (MPP+) that selectively destroy tyrosine hydroxylase and dopaminergic neurons. So they essentially gave these rats Parkinson’s like symptoms.
After a few weeks of 9-Methyl-β-carboline administration around 80% of the damaged neurons returned to normal determined by measurements of nicotinamide adenine dinucleotide dehydrogenase activity.
Also the adamantane derivative called Bromantane and Pentadecapeptide BPC-157 play important roles.
Yet no ongoing research is being done. 🤦♂️
Sorry for my english ...
YOU Are SAYING that IT is POSSIBLE have an anti psychotic without side effects ??? Allucination depends ON high nonormal levels of dopamine in the BRAIN ??
You clear my 5 yrs phobia of antipsychotics with single 8 min video.thank a lot🙂
Thanks for the quality of this video, and the concise, clear way these mechanisms are affecting us potentially! You are making it interesting both for patients and also purely on an intellectual and educational levels!
The Health System is Genius!
ua-cam.com/video/-Nd40Uy6tbQ/v-deo.html
"patients" uhm i guess the word ur looking for is lab rat ....?
Thanks alot sir🥰❤ you accomplished what my teacher couldn't do in 3 hours, in just 8 minutes. THANK YOU
YOUR VIDEOS ARE AMAZING! please post for every drug, i learn so much just by watching these short clips. THANK YOU!!! :)
I imagine if they did that it might be a few years before they finished posting….!!
And these are supposed to help people? Amazing, truly amazing. With friends like this, who needs enemies.
These videos are so helpful...you´re far better at explaining pharmacology than any of my college teachers!! You make it seem easy and cool.Thank you so much from Spain!!
Excellent explanation!! simple and easy graphics made to understand! As a psychology student, studying Schizophrenia this just made my day a whole lot easier! Thank you!
Read books by Dr. Abram Hoffer and Dr. Andrew Saul. Especially the booklet "Understanding Schizophrenia ".
Remember 'Antipsychotics' can be 'hyperbolic' - which means that withdrawal needs to be approached more carefully at reduced doses.
And remember that abrupt 'antipsychotic' drug withdrawal can result in 'Withdrawal Psychosis'.
Best explanation of antipsychotics so far 👍🏽👍🏽👍🏽
Love this-you made it very easy to understand what it’s doing to my brain 🧠
@Ken Personal LOL
Ii
j
.
I learned so much in your short video and made so much sense. Thank you.
I want to see this guy....made school easy for me.
Dude, your style of concept presentation is awesome. Keep up the great work!
Came to understand Quetiapine’s mechanism of action. I understand it now!! Thank you!
Excellent explanation, This is really helpful as I prepare for my final exams. Thanx alot
Thanks a lot. This video is the best among others that I have watched to understand the mechanism of action of the drugs.
I think the APs causing onset or worsening of negative symptoms is called “Neuroleptic-induced deficit syndrome”. I feel like this is something that needs to be talked more about!
These drugs made my son worse started as anxiety dr. Gave all kinds of meds and made him worse never seen anything like it
Antipsychotics cause erectile dysfunction and loss of libido, emotions and motivation. Risperidal for me caused decreased quantity of sperm and no orgasm, premature ejaculation and erectile dysfunction. Now, after 4 years, Im on path to healing myself but strugle is so big.
It was so nice and simplified.Now when I read the book it will all make sense. Thank you
Just wanted to say you r the best human I learned so much for my exam tomz shout out to you sir you have saved my life amen
Thanks for the video. Great help for 3rd year medical studies in Germany
wish i found your videos sooner!! please make a video about antiepileptics or drugs for parkinson's disease :)
Varporic acid for elispy
Sir ur videos are simply amazing and ur way of teaching through animations is best
CNS pharmacology will never be such easier without ur lectures
keep going and best of luck
The Health System is Genius!
ua-cam.com/video/-Nd40Uy6tbQ/v-deo.html
Thank you for such a clear explanation on this topic!
I am on antipsychotics. Was curious to know how they worked. Thanks.
Me too how long have you been on it??
@@Nancy-ow9wy 8 months. You?
@@raakbas1 since 2014 you can imagine
@@Nancy-ow9wy hope you are feeling better.
@@raakbas1 it's not easy
just to note that in 2010 it was found that there is no increase in the levels of dopamine in the nucleus acumbes, but rather in the nigrostriatal region that projects ventrally in both the striatum and the cutaneous nucleus, and this region is related to the positive symptoms of schizophrenia.
Kegeles LS, Abi-Dargham A, Frankle WG, et al. Increased Synaptic Dopamine Function in Associative Regions of the Striatum in Schizophrenia. Archives of General Psychiatry. 2010;67(3):231. doi:10.1001/archgenpsychiatry.2010.10
Thank you so much, I was mixing my medications and your concise and clear way of explaining has helped me very much. I am new to your channel just subscribed.. Great explaining.
As a bipolar disorder patient and a former psychology major student. I just find some papers about the correlations between bipolar and obesity. Your video just explain very well.
Oh wow
Neuronal insulin resistance. Get your 100% daily dosage of magnesium.
That was so simple even I could understand it. Thanks a loooooooot !
I take ziprasidone for psychosis and it works great for me. I feel like myself again
Please share your story and tell us how you are dealing with. Are you taking psychotherapy ?
Excellent 👍👍👍
Best video ever I found on UA-cam
The body and mind are such wonders
Excellent presentation, your work is appreciated worldwide
Thank you so very kindly for this video, you have no idea how much I personally appreciate it.
appreciate you stringing the neurotransmitters, pathways, and side effects. Very helpful! Thanks!
you are sent from heaven!!!thank you so much!
Clear and comprehensive review, thank u
U nailed it......u nailed it....im an anaesthetist...
Thank you so much. I really needed this. Doctors never reach anything. Congratulations.
Dude I love you. You have a gift for teaching
I was searching for this information. Thank you, it's amazing 🤩
Thanks a lot for this very clear lecture! Keep up the good work!
Good video. Except, it is stated and implied from the neuronal diagram of serotonergic neurons synapsing with dopaminergic neurons that 5-HT binds to 5-HT2A receptors on dopaminergic neurons to decrease dopamine release. And that antagonism of these 5-HT2A receptors results in an increase in dopamine release.
The problem with this theory is that 5-HT2A receptors are coupled to Gq/11 proteins, that when activated, stimulates phospholipase C activity, thus enhancing intracellular Ca2+ levels. This is a trigger for vesicular release of neurotransmitter.
My question for you is, how do you explain activation of a Gq/11 coupled 5-HT2A receptors produces a decrease in dopamine release?
Sorry bro can t help u with that one. I just take the stuff 🤞
5HT2A antagonism increases dopamine rather than decreasing dopamine. It is believed that the antagonism mainly affects in the nigristriatal pathway without affecting the mesolimbic pathway. Thus.. the EPS side effects are relieved without exacerbating psychosis.. hope this clears your doubt.
Many thanks to you. I have gained a lot of knowledge just watching this video. Hope you I video on the serotonin pathway. God bless you
جزاك الله خيرا ༶•┈┈⛧┈♛
*Hi ‘Speed Pharmacology’ Merci infiniment. Outstanding video. Question, your accent? I have five accents. Finnish, Swedish, English, German French and Thai. Accent in every language. How about you? Greetings from THAILAND* ua-cam.com/video/VOggAvPuLmM/v-deo.html
thanks for the quality and highly educative video. i love it
Thanks for making it simple, I really understand it now. 👌🏽
After they all sat and said we are putting the quetiapine up again and with that I
have to give Lorazepam to .All this time myself and carers see what all these medications are doing .I lost I wanted to hurt myself because I feel like I am talking to a brick wall but they still refuse to listen now they are talking about having an adult protection meeting .This has got so bad with these people they do not care obviously its not their child whether grown or not when you think how people with health issues are treated and drugged it is so sad
Your videos are amazing and easy to understand but could you also add mnemonics.it will really help us to retain the drug names in our memory for longer period of time ✌️✌️😁
Very helpful , pharma student from india
I think a great direction medical science could take would be to try to see if lifestyle modification could have the intended effects on these biological mechanisms, rather than trying to precisely target them with drugs. While these drugs work they come with many undesirable side effects, which is natural since they are so precise. It would be better to increase or decrease the activity of dopamine pathways as a result of activities that reform the whole brain-body system instead of just target isolated areas of the brain or body. I'm not sure if this is possible with something so damaging as psychosis but if it is then it would far more desirable.
Great video on antipsychotic medications. Thanks for sharing
Amazing video, this helped me understand the information so much more. Thank you!!
this video is pure gold! thank you so much
Superbly explained!!!
THANKS
EXTREMELY CLEAR
Very much helpful and time-befitting
What I find interesting about the newer class of (so called atypical) neuroleptics is their loose binding to D-receptors in contrast to the old typical ones. In exchange they have a very high affinity to 5HT (Serotonin) and guess where the body has the most of these receptors which are then antagonized? In the gut! So basically you loose your gut feeling...
What u just described can it be said about Olanzapine? Also what do u mean u lose gut feeling, like, that you cant feel anxiety in belly or? Also i heard that serotonin in gut its like a myth, its in brain.
@@RudisBoss no one claims seretonin is in the gut. the claim is that an unhealthy gut is linked to these mental disorders and seretonin and dopemeine have little to do with anything. its been disproven a long time ago that chemical imbalance is a myth. its nothing more then a lie to convince people they have an incurable disease and the only treatment is these drugs, they help very few people and cause worse side effects then the disorder. its mass genocide
(tmi but it’s medical talk so i’m sharing) i was put on olanzapine during an involuntary (and unnecessary) commitment in december, i was only on it for about a month total. i swear i SWEAR my bowel movements smell different sometimes. it’s very specific and didn’t happen until i was on the meds, it has continued despite being off of them for a few months. idk if my body is releasing certain molecules from the meds of if they changed my gut chemistry and now that’s just how that goes. either way i believe it to be a result of the medications
@@thewiggles3728 is vortioxetine effective for this?
Informative. Thank you. You really made this topic easier
Smoking marijuana as a teenager caused me to have this problem. I was desperate for friends and they did it around me and I didn’t know any better. Deeply regret hanging around them. Would have been better off hanging out by myself all the time. Which is what I do now.
Don’t. Smoke. At such a young age. And warn others!
It will create a lifetime of issues and struggles that can be avoided by NOT smoking marijuana at a young age when your brain is still developing.
Wow new favourite channel. So bummed I’m only finding it now!
I am on a really low dose of aripiprazole and have been on high dose of risperidone from psychosis they both make me feel shit(currently on aripiprazole), lack of confidence I can get happy but is not a true happiness, also makes me lazy is this common?
I love you man, you took pharma out of nightmare's list. big thanks
thank you for making pharmacology easy!
AMAZING video!! So clear and engaging. Thank you!
This help me in preparation of my pharmacology assignment, a lot of love & thanks 💙🌨
You might want to add in your assignment how bad these drugs are to the brain long term. I suffer every day because of these awful drugs and these doctors that I put my trust in as a kid have totally fucked it up!!!!
Please also add the neurotoxic effect of neuroleptics and how psychiatrists often prescribe them wrong for MONEY and how pharmalobbies do chemical lobotomies and genocide claiming to help humans❤
please add how they ruin peoples lifes and brains too :)
Very useful. Easily understandable... Keep doing more videos sir❤😇
Currently prescribed on Pimozide.
I would not take the medications.
I've been taking them for 10 years by force & I am fucked up now.
how so?
@@HoldMeForeverantipsychotics are extreme neurotocix...it means that they are poisonous for your brain, since most of our life is dictated by our brain, once ur poisoned ur brain is not the same anymore 100s of things have changed to the worse and ur life isnt the same anymore. Im a victim myself and its basically a Pharma genocide
Great stuff. so simple and straight forward. thanks a lot.
Extremely well explained and thanks
thank you so much...enjoyed it indeed. i believe i can hammer any question on anti-psychotics on my exam next week.
such an amazing video...thank you. Much appreciated!!!!
Very useful. Amazing videos. Greetings from Bulgaria!
Can someone answer me.
If D2 antagonist are used, won't it increase dopamine levels b/c D2 receptors are auto-receptors, and their inhibition will lead to increased levels of dopamine????
as always excellet knowledge and extraordinary explaining.