Dude you are so amazing! You have no idea how much your videos have helped me as a pharmacy student. It has made pharmacology so simple. You deserved every good thing on this earth. Much love❤
Not a student, just trying to educate myself on antipsychotics after being prescribed for a few years, I had psychosis. Currently weaning off of olanzapine.
I'm on risperidone after psychosis in 2018 and 2019. I lowered my dose from 4 to 1 mg over the past 1.5 years. How's it going with you so far weaning off the olanzapine?
This "meds" are cell poisons (study from 2023) and nerve poisons (many studies). The people you call ill are not ill they are a different species (study in human genetics 2024). By talking people into taking this drugs you make yourself guilty of a crime against humanity called "extermination".
my life was for a long time ruined by antipsychotics. was prescribed them and although I suffer from major depressive disorder, I do not have schizophrenia, bipolar, or any sort of mood disorder. Because I already lack serotonin and dopamime due to my depression, this medication sedated me/turned me into a zombie, made me gain 15 lbs in a matter of 2 weeks, stripped me of my personality, confidence and creativity, & even after I went off of them, I could not get back to the girl I was before. I no longer was responding to any antidepressants that had worked in earlier years or stimulant medication that had helped in the past. I looked awful and became a different person. All I wanted to do was sleep. I was so severely depressed i could not function at work (yes, I was trying every class of antidepressants at this point). I was no longer myself and had become completely overcome by my mental illness. It got so bad that my therapist insisted I seek more comprehensive medical treatment. I admitted myself to the hospital and after many more trials of medications, I had to resort to electroconvulsive therapy. I am 23 years old. Although it has a terrible rep, this treatment saved my life. the reason I am writing this here is because I think antipsychotic medications are necessary for people who naturally go into manic states, suffer from schizophrenia or psychosis. however, I am writing this as an informative warning that these medications WILL change you, and WILL sedate you. for some this is necessary. however, if you are prescribed these because antidepressants alone are failing, I really hope you will do the research on how they work because I believe that for a depressed person, these meds can be extremely detrimental . I hope that those who need these meds find them helpful. However, for me the damage they did could only be repaired by literally shocking my brain out of it. Good luck to all and please know YOU ARE NOT ALONE.
Gracie xx thank you so much for telling us the truth..my friend is on aripiprazole for bipolar and she has been acting weird lately...i don't know how to handle the situation...now i ll just show your comment to her and maybe it ll help her get better
@@sanagoyal4119 becsuse my daughtersuddenely starting talking with herself and they prescribe her first Aripiprazole and now they put her on olanzapine,so plesse tell me,psychiatrist doctor snd nurses giving me lots of hope...can you tell me please?..Do these medicine really work?
Thank you for this simplified lecture. I watch your videos before reading textbooks or materials and it's always an easy read for me. Much love from Nigeria.
Your video made weeks of agonizing studying so simplistic and easy to understand! The pictorials are very helpful as a visual for understanding and memorization. Thank you sooo very much for making my study life that much easier!
You are a legend. Words cannot describe how helpful and informative your videos are. They have been my saviors. God bless you! You deserve to be known and awarded for your concise knowledge!! 🤩
Neuroleptics are cell and nerve poisons. By promoting them as medicine this man makes himself guilty of the crime of "extermination" (one of the crimes against humanity that is listed by the Rome declaration).
Thank You. This is exactly what I was looking for. I was wondering exactly how my medication actually works on my brain and I couldn't find it. Until now.
I am an avid #MentalHealthAwareness advocate and performer, and I love this so much. I travel the country trying to bring that awareness on stages, in classrooms, hospitals, and on my UA-cam channel, so I get excited when I see other advocates. 💙❤
Thanks for the quality of this video, and the concise, clear way these mechanisms are affecting us potentially! You are making it interesting both for patients and also purely on an intellectual and educational levels!
I was misdiagnosed with schizophrenia. Been drug free for a long time and I am still suffering the disabilities caused by these medications. I cant express emotion and have slurred speach. The eay I walk changed. My hormones are all over the place. I exercise and hope for a better future. I feel like my a bird shose wings been clipped.
Excellent explanation!! simple and easy graphics made to understand! As a psychology student, studying Schizophrenia this just made my day a whole lot easier! Thank you!
thanks for this but just to note a MAJOR correction: psychosis is associated with increased dopamine presynaptic function in the nigrostriatal pathway (particularly the part that projects to the associative subdivision of the striatum) it is NOT the mesolimbic system
These videos are so helpful...you´re far better at explaining pharmacology than any of my college teachers!! You make it seem easy and cool.Thank you so much from Spain!!
Most people will never experience extrapyramidal symptoms (EPS) so they have no idea how horrible they can be. There are many factors contributing to EPS but mainly a dysfunctional dopaminergic and acetylcholinergic neurological system play a role. There are so many hyperkinetic movement disorders like dystonia, dyskinesia, akinesia, akathisia, athetosis, ataxia, chorea, myoclonus, ballismus, tics, tremors, Tourette’s, spasms, RLS,etc.. it can make it very hard to distinguish. I sympathize for schizophrenics and people who need certain antipsychotics and other medications that exacerbate these movement disorders. Most these medications drastically deplete Dopamine which is one of the main reasons for these extrapyramidal side effects. Science has had more than enough time AND MZoNEY to develop a novel medication that should not cause this. Many schizophrenics need glutamate and dopamine regulation (not always “reduction”). There are several dopaminergic receptors and binding sites that can be antagonized and agonized therefore there is ZERO reason why there isn’t a proper neuroleptic to control psychiatric side effects while not exacerbating extrapyramidal side effects OR anhedonia! Dopamine agonists can do wonders for EPS and science was able to develop non-ergot agonists which are much much safer yet can’t develop an agonist that will not cause debilitating Dopamine withdrawl Syndrome? Come on that is ridiculousness there is no excuse for no development of one. Or how about an MAOI with no withdrawal? Nope, doesn’t exist 🤦♂️ 9-Methyl-β-carboline should be further examined as it appears to have incredible dopaminergic restoration properties. A study was done on rats that proved it. In layman’s terms scientists injected rats with synthetic neurotoxic compounds like 2,4,5-trihydroxyphenethylamine (6-OHDA) and 1-methyl-4-phenyl-pyridinium ion (MPP+) that selectively destroy tyrosine hydroxylase and dopaminergic neurons. So they essentially gave these rats Parkinson’s like symptoms. After a few weeks of 9-Methyl-β-carboline administration around 80% of the damaged neurons returned to normal determined by measurements of nicotinamide adenine dinucleotide dehydrogenase activity. Also the adamantane derivative called Bromantane and Pentadecapeptide BPC-157 play important roles. Yet no ongoing research is being done. 🤦♂️
Sorry for my english ... YOU Are SAYING that IT is POSSIBLE have an anti psychotic without side effects ??? Allucination depends ON high nonormal levels of dopamine in the BRAIN ??
This is sadly mostly the case. There was interesting research in Australia about TMS (Transcranial Magnetic Stimulation) from Professoe Snyder, which found out that we could simulate Savant like strengths to normal people. The research didn't continue. This is different from what you're talking about, but it's one of many examples. There is also no research about how different medications could help create cocktails for different diseases. It's been progression slowly with A.I. though. The problem with research is that most institutes that do it are either private or privately funded. Most breakthroughs are state supported, and if research isn't profitable but needed, no one will invest in it. It's a sad truth of capitalism.
Sir ur videos are simply amazing and ur way of teaching through animations is best CNS pharmacology will never be such easier without ur lectures keep going and best of luck
I am on a really low dose of aripiprazole and have been on high dose of risperidone from psychosis they both make me feel shit(currently on aripiprazole), lack of confidence I can get happy but is not a true happiness, also makes me lazy is this common?
I think a great direction medical science could take would be to try to see if lifestyle modification could have the intended effects on these biological mechanisms, rather than trying to precisely target them with drugs. While these drugs work they come with many undesirable side effects, which is natural since they are so precise. It would be better to increase or decrease the activity of dopamine pathways as a result of activities that reform the whole brain-body system instead of just target isolated areas of the brain or body. I'm not sure if this is possible with something so damaging as psychosis but if it is then it would far more desirable.
yes but then the (mis)educated could not exploit the suffering of others. Psychiatry is powerful due to it's control over not only 'mental health' but many brain disorders and criminal insanity. It's a bit like only having a 'physical health' which covers all bodily systems and morality.
Thank you so much, I was mixing my medications and your concise and clear way of explaining has helped me very much. I am new to your channel just subscribed.. Great explaining.
*Hi ‘Speed Pharmacology’ Merci infiniment. Outstanding video. Question, your accent? I have five accents. Finnish, Swedish, English, German French and Thai. Accent in every language. How about you? Greetings from THAILAND* ua-cam.com/video/VOggAvPuLmM/v-deo.html
Remember 'Antipsychotics' can be 'hyperbolic' - which means that withdrawal needs to be approached more carefully at reduced doses. And remember that abrupt 'antipsychotic' drug withdrawal can result in 'Withdrawal Psychosis'.
just to note that in 2010 it was found that there is no increase in the levels of dopamine in the nucleus acumbes, but rather in the nigrostriatal region that projects ventrally in both the striatum and the cutaneous nucleus, and this region is related to the positive symptoms of schizophrenia. Kegeles LS, Abi-Dargham A, Frankle WG, et al. Increased Synaptic Dopamine Function in Associative Regions of the Striatum in Schizophrenia. Archives of General Psychiatry. 2010;67(3):231. doi:10.1001/archgenpsychiatry.2010.10
I think the APs causing onset or worsening of negative symptoms is called “Neuroleptic-induced deficit syndrome”. I feel like this is something that needs to be talked more about!
Nice video. I like the fact that you went into specific dopamine receptor selectivity and the different dopaminergic pathways that can be implicated. Subscribed to your channel. :)
Good video. Except, it is stated and implied from the neuronal diagram of serotonergic neurons synapsing with dopaminergic neurons that 5-HT binds to 5-HT2A receptors on dopaminergic neurons to decrease dopamine release. And that antagonism of these 5-HT2A receptors results in an increase in dopamine release. The problem with this theory is that 5-HT2A receptors are coupled to Gq/11 proteins, that when activated, stimulates phospholipase C activity, thus enhancing intracellular Ca2+ levels. This is a trigger for vesicular release of neurotransmitter. My question for you is, how do you explain activation of a Gq/11 coupled 5-HT2A receptors produces a decrease in dopamine release?
5HT2A antagonism increases dopamine rather than decreasing dopamine. It is believed that the antagonism mainly affects in the nigristriatal pathway without affecting the mesolimbic pathway. Thus.. the EPS side effects are relieved without exacerbating psychosis.. hope this clears your doubt.
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Dude you are so amazing! You have no idea how much your videos have helped me as a pharmacy student. It has made pharmacology so simple. You deserved every good thing on this earth. Much love❤
Amen!!!
The Health System is Genius!
ua-cam.com/video/-Nd40Uy6tbQ/v-deo.html
I literally wasted 2 hours reading book before watching this video... I read my book after watching, I understood everything.
Same man. This video was wonderful.
😂 great iam too
Add a sticky note in the book with the link that would be awesome
Same here
Sameeee
What a elaboration in just 8 minutes. You have cleared many concepts. Thanks a lot.
Not a student, just trying to educate myself on antipsychotics after being prescribed for a few years, I had psychosis. Currently weaning off of olanzapine.
I'm on risperidone after psychosis in 2018 and 2019. I lowered my dose from 4 to 1 mg over the past 1.5 years. How's it going with you so far weaning off the olanzapine?
How are you doing? I've been on olanzapine for a couple years too. I'm trying to get off as well
Awesome that you are weaning off, I currently have minor form of PTSD, self diagnosed, and have been prescribed olanzapine, methex od etc.
@@rockit5288 you lowered your dose, or you and your health care provider worked together to lower your dose?
Yeayy, congrats. Hope you'll be okay!!
I'm a student nurse, and this has made it so much easier than everything I've read!!
The Health System is Genius!
ua-cam.com/video/-Nd40Uy6tbQ/v-deo.html
This "meds" are cell poisons (study from 2023) and nerve poisons (many studies). The people you call ill are not ill they are a different species (study in human genetics 2024). By talking people into taking this drugs you make yourself guilty of a crime against humanity called "extermination".
You help murder and torture people for rasistic motives.
my life was for a long time ruined by antipsychotics. was prescribed them and although I suffer from major depressive disorder, I do not have schizophrenia, bipolar, or any sort of mood disorder. Because I already lack serotonin and dopamime due to my depression, this medication sedated me/turned me into a zombie, made me gain 15 lbs in a matter of 2 weeks, stripped me of my personality, confidence and creativity, & even after I went off of them, I could not get back to the girl I was before. I no longer was responding to any antidepressants that had worked in earlier years or stimulant medication that had helped in the past. I looked awful and became a different person. All I wanted to do was sleep. I was so severely depressed i could not function at work (yes, I was trying every class of antidepressants at this point). I was no longer myself and had become completely overcome by my mental illness. It got so bad that my therapist insisted I seek more comprehensive medical treatment. I admitted myself to the hospital and after many more trials of medications, I had to resort to electroconvulsive therapy. I am 23 years old. Although it has a terrible rep, this treatment saved my life. the reason I am writing this here is because I think antipsychotic medications are necessary for people who naturally go into manic states, suffer from schizophrenia or psychosis. however, I am writing this as an informative warning that these medications WILL change you, and WILL sedate you. for some this is necessary. however, if you are prescribed these because antidepressants alone are failing, I really hope you will do the research on how they work because I believe that for a depressed person, these meds can be extremely detrimental . I hope that those who need these meds find them helpful. However, for me the damage they did could only be repaired by literally shocking my brain out of it. Good luck to all and please know YOU ARE NOT ALONE.
Gracie xx thank you so much for telling us the truth..my friend is on aripiprazole for bipolar and she has been acting weird lately...i don't know how to handle the situation...now i ll just show your comment to her and maybe it ll help her get better
@@sanagoyal4119 can you tell me about electrocolvulsive thearpy?
@@sanagoyal4119 CAN you tell me,please,do they really work?
@@sanagoyal4119 becsuse my daughtersuddenely starting talking with herself and they prescribe her first Aripiprazole and now they put her on olanzapine,so plesse tell me,psychiatrist doctor snd nurses giving me lots of hope...can you tell me please?..Do these medicine really work?
@@sanagoyal4119 if they don't work,then what other treatment are possible?
I was taught antipsychotics today and our lecturer said almost all that was said in this video.
Watching this video reinforced my understanding
Thank you for this simplified lecture. I watch your videos before reading textbooks or materials and it's always an easy read for me. Much love from Nigeria.
من هذه اللحظة لن اضيع بعد الان اي لحظة في غير الطب والعلم و العبادة
والان ماذا حدث بعد 4 سنوات 🤔
الله يكرمك ويوفقك أخي الكريم ❤
I must admit, this is a great video. You have allowed my brain to gain weight on neuroleptic and for that I’m grateful 🙏🏻
Your video made weeks of agonizing studying so simplistic and easy to understand! The pictorials are very helpful as a visual for understanding and memorization. Thank you sooo very much for making my study life that much easier!
perfect timing....i dont usually subscribe to channels, but when i do, its speed pharmacology ...keep it up.. thank you for your work....youre a beast
My negative effect ba ang nozinan sa sperm cell
Finally I can inform my pd whats going on inside my head on a molecular level. Thank you so much.
You are poisoned. Neuroleptics work like rat poison.
You are a legend. Words cannot describe how helpful and informative your videos are. They have been my saviors. God bless you! You deserve to be known and awarded for your concise knowledge!! 🤩
Agreed 100 %
Thanks!
I love you man. This is how one man helps another😘😁
Neuroleptics are cell and nerve poisons. By promoting them as medicine this man makes himself guilty of the crime of "extermination" (one of the crimes against humanity that is listed by the Rome declaration).
You clear my 5 yrs phobia of antipsychotics with single 8 min video.thank a lot🙂
Thank You. This is exactly what I was looking for. I was wondering exactly how my medication actually works on my brain and I couldn't find it. Until now.
The Health System is Genius!
ua-cam.com/video/-Nd40Uy6tbQ/v-deo.html
I am an avid #MentalHealthAwareness advocate and performer, and I love this so much. I travel the country trying to bring that awareness on stages, in classrooms, hospitals, and on my UA-cam channel, so I get excited when I see other advocates. 💙❤
So very true nice 👍🏻
Thanks alot sir🥰❤ you accomplished what my teacher couldn't do in 3 hours, in just 8 minutes. THANK YOU
YOUR VIDEOS ARE AMAZING! please post for every drug, i learn so much just by watching these short clips. THANK YOU!!! :)
I imagine if they did that it might be a few years before they finished posting….!!
Thank you for making this video to let us understand how the antipsychotic medications work
Thanks for the quality of this video, and the concise, clear way these mechanisms are affecting us potentially! You are making it interesting both for patients and also purely on an intellectual and educational levels!
The Health System is Genius!
ua-cam.com/video/-Nd40Uy6tbQ/v-deo.html
"patients" uhm i guess the word ur looking for is lab rat ....?
And these are supposed to help people? Amazing, truly amazing. With friends like this, who needs enemies.
This was a very helpful video. Detailed however engaging. I have learned a lot in under 10 minutes 👏🏾 now I will study this so it sticks
Nursing student here. This helped me a lot . Thank you good sir.
Dude, your style of concept presentation is awesome. Keep up the great work!
I was misdiagnosed with schizophrenia. Been drug free for a long time and I am still suffering the disabilities caused by these medications. I cant express emotion and have slurred speach. The eay I walk changed. My hormones are all over the place. I exercise and hope for a better future. I feel like my a bird shose wings been clipped.
What drug was that and how long since you stopped?
How are you feeling now?
Hey I hope you're feeling better now
Me too😢😢😢
Excellent explanation!! simple and easy graphics made to understand! As a psychology student, studying Schizophrenia this just made my day a whole lot easier! Thank you!
Read books by Dr. Abram Hoffer and Dr. Andrew Saul. Especially the booklet "Understanding Schizophrenia ".
Danke!
Thank you!
Love this-you made it very easy to understand what it’s doing to my brain 🧠
@Ken Personal LOL
Ii
j
.
thanks for this but just to note a MAJOR correction: psychosis is associated with increased dopamine presynaptic function in the nigrostriatal pathway (particularly the part that projects to the associative subdivision of the striatum) it is NOT the mesolimbic system
I was about to say that.
Best explanation of antipsychotics so far 👍🏽👍🏽👍🏽
Quetiapine saved me from major depression. Came off them for afew days and cried all day, very low. Back on them and well again.
I want to see this guy....made school easy for me.
I learned so much in your short video and made so much sense. Thank you.
These videos are so helpful...you´re far better at explaining pharmacology than any of my college teachers!! You make it seem easy and cool.Thank you so much from Spain!!
a perfect explanation of how cures could be worse than the disease
Definatley.
Is torture the reason for These devasting side effects. Why ja this called help?
@@clausmehl8731 it's considered "treatment" to make people so ill that they are driven to their death.
@@FutureBoyWonder I'm still right 😏
Chemical lobotomizers*
Thanks a lot. This video is the best among others that I have watched to understand the mechanism of action of the drugs.
Came to understand Quetiapine’s mechanism of action. I understand it now!! Thank you!
Most people will never experience extrapyramidal symptoms (EPS) so they have no idea how horrible they can be. There are many factors contributing to EPS but mainly a dysfunctional dopaminergic and acetylcholinergic neurological system play a role.
There are so many hyperkinetic movement disorders like dystonia, dyskinesia, akinesia, akathisia, athetosis, ataxia, chorea, myoclonus, ballismus, tics, tremors, Tourette’s, spasms, RLS,etc.. it can make it very hard to distinguish.
I sympathize for schizophrenics and people who need certain antipsychotics and other medications that exacerbate these movement disorders. Most these medications drastically deplete Dopamine which is one of the main reasons for these extrapyramidal side effects.
Science has had more than enough time AND MZoNEY to develop a novel medication that should not cause this. Many schizophrenics need glutamate and dopamine regulation (not always “reduction”). There are several dopaminergic receptors and binding sites that can be antagonized and agonized therefore there is ZERO reason why there isn’t a proper neuroleptic to control psychiatric side effects while not exacerbating extrapyramidal side effects OR anhedonia!
Dopamine agonists can do wonders for EPS and science was able to develop non-ergot agonists which are much much safer yet can’t develop an agonist that will not cause debilitating Dopamine withdrawl Syndrome? Come on that is ridiculousness there is no excuse for no development of one. Or how about an MAOI with no withdrawal? Nope, doesn’t exist 🤦♂️
9-Methyl-β-carboline should be further examined as it appears to have incredible dopaminergic restoration properties. A study was done on rats that proved it. In layman’s terms scientists injected rats with synthetic neurotoxic compounds like 2,4,5-trihydroxyphenethylamine (6-OHDA) and 1-methyl-4-phenyl-pyridinium ion (MPP+) that selectively destroy tyrosine hydroxylase and dopaminergic neurons. So they essentially gave these rats Parkinson’s like symptoms.
After a few weeks of 9-Methyl-β-carboline administration around 80% of the damaged neurons returned to normal determined by measurements of nicotinamide adenine dinucleotide dehydrogenase activity.
Also the adamantane derivative called Bromantane and Pentadecapeptide BPC-157 play important roles.
Yet no ongoing research is being done. 🤦♂️
Sorry for my english ...
YOU Are SAYING that IT is POSSIBLE have an anti psychotic without side effects ??? Allucination depends ON high nonormal levels of dopamine in the BRAIN ??
This is sadly mostly the case. There was interesting research in Australia about TMS (Transcranial Magnetic Stimulation) from Professoe Snyder, which found out that we could simulate Savant like strengths to normal people. The research didn't continue. This is different from what you're talking about, but it's one of many examples. There is also no research about how different medications could help create cocktails for different diseases. It's been progression slowly with A.I. though. The problem with research is that most institutes that do it are either private or privately funded. Most breakthroughs are state supported, and if research isn't profitable but needed, no one will invest in it. It's a sad truth of capitalism.
@@antonellapergliamiciThat's essentially what he is saying, yes.
Sir ur videos are simply amazing and ur way of teaching through animations is best
CNS pharmacology will never be such easier without ur lectures
keep going and best of luck
The Health System is Genius!
ua-cam.com/video/-Nd40Uy6tbQ/v-deo.html
It was so nice and simplified.Now when I read the book it will all make sense. Thank you
The body and mind are such wonders
Excellent 👍👍👍
Best video ever I found on UA-cam
Excellent explanation, This is really helpful as I prepare for my final exams. Thanx alot
I was searching for this information. Thank you, it's amazing 🤩
you are sent from heaven!!!thank you so much!
That was so simple even I could understand it. Thanks a loooooooot !
I am on a really low dose of aripiprazole and have been on high dose of risperidone from psychosis they both make me feel shit(currently on aripiprazole), lack of confidence I can get happy but is not a true happiness, also makes me lazy is this common?
Just wanted to say you r the best human I learned so much for my exam tomz shout out to you sir you have saved my life amen
Thank you for such a clear explanation on this topic!
Dude I love you. You have a gift for teaching
Thank you so very kindly for this video, you have no idea how much I personally appreciate it.
Clear and comprehensive review, thank u
I think a great direction medical science could take would be to try to see if lifestyle modification could have the intended effects on these biological mechanisms, rather than trying to precisely target them with drugs. While these drugs work they come with many undesirable side effects, which is natural since they are so precise. It would be better to increase or decrease the activity of dopamine pathways as a result of activities that reform the whole brain-body system instead of just target isolated areas of the brain or body. I'm not sure if this is possible with something so damaging as psychosis but if it is then it would far more desirable.
yes but then the (mis)educated could not exploit the suffering of others. Psychiatry is powerful due to it's control over not only 'mental health' but many brain disorders and criminal insanity. It's a bit like only having a 'physical health' which covers all bodily systems and morality.
Thanks for the video. Great help for 3rd year medical studies in Germany
Superbly explained!!!
Thank you so much, I was mixing my medications and your concise and clear way of explaining has helped me very much. I am new to your channel just subscribed.. Great explaining.
جزاك الله خيرا ༶•┈┈⛧┈♛
*Hi ‘Speed Pharmacology’ Merci infiniment. Outstanding video. Question, your accent? I have five accents. Finnish, Swedish, English, German French and Thai. Accent in every language. How about you? Greetings from THAILAND* ua-cam.com/video/VOggAvPuLmM/v-deo.html
Excellent presentation, your work is appreciated worldwide
Great video on antipsychotic medications. Thanks for sharing
Thanks a lot for this very clear lecture! Keep up the good work!
this video is pure gold! thank you so much
Remember 'Antipsychotics' can be 'hyperbolic' - which means that withdrawal needs to be approached more carefully at reduced doses.
And remember that abrupt 'antipsychotic' drug withdrawal can result in 'Withdrawal Psychosis'.
That's healing for you, job well done eh.
wish i found your videos sooner!! please make a video about antiepileptics or drugs for parkinson's disease :)
Varporic acid for elispy
thanks for the quality and highly educative video. i love it
I am on antipsychotics. Was curious to know how they worked. Thanks.
Me too how long have you been on it??
@@Nancy-ow9wy 8 months. You?
@@raakbas1 since 2014 you can imagine
@@Nancy-ow9wy hope you are feeling better.
@@raakbas1 it's not easy
This video is so amazing 🥺
Great video! what about amisulpride?
just to note that in 2010 it was found that there is no increase in the levels of dopamine in the nucleus acumbes, but rather in the nigrostriatal region that projects ventrally in both the striatum and the cutaneous nucleus, and this region is related to the positive symptoms of schizophrenia.
Kegeles LS, Abi-Dargham A, Frankle WG, et al. Increased Synaptic Dopamine Function in Associative Regions of the Striatum in Schizophrenia. Archives of General Psychiatry. 2010;67(3):231. doi:10.1001/archgenpsychiatry.2010.10
THANKS
EXTREMELY CLEAR
Wow new favourite channel. So bummed I’m only finding it now!
I think the APs causing onset or worsening of negative symptoms is called “Neuroleptic-induced deficit syndrome”. I feel like this is something that needs to be talked more about!
appreciate you stringing the neurotransmitters, pathways, and side effects. Very helpful! Thanks!
thank you for making pharmacology easy!
Many thanks to you. I have gained a lot of knowledge just watching this video. Hope you I video on the serotonin pathway. God bless you
U nailed it......u nailed it....im an anaesthetist...
I love you man, you took pharma out of nightmare's list. big thanks
These drugs made my son worse started as anxiety dr. Gave all kinds of meds and made him worse never seen anything like it
Very much helpful and time-befitting
Amazing video, this helped me understand the information so much more. Thank you!!
Very useful. Easily understandable... Keep doing more videos sir❤😇
AMAZING video!! So clear and engaging. Thank you!
Extremely well explained and thanks
Informative. Thank you. You really made this topic easier
as always excellet knowledge and extraordinary explaining.
Your videos are legendary. Such an underrated channel. I watch your content for fun!
such an amazing video...thank you. Much appreciated!!!!
Nice video. I like the fact that you went into specific dopamine receptor selectivity and the different dopaminergic pathways that can be implicated. Subscribed to your channel. :)
Thanks for making it simple, I really understand it now. 👌🏽
Thank you so much. I really needed this. Doctors never reach anything. Congratulations.
Good job done mate👊
Good video. Except, it is stated and implied from the neuronal diagram of serotonergic neurons synapsing with dopaminergic neurons that 5-HT binds to 5-HT2A receptors on dopaminergic neurons to decrease dopamine release. And that antagonism of these 5-HT2A receptors results in an increase in dopamine release.
The problem with this theory is that 5-HT2A receptors are coupled to Gq/11 proteins, that when activated, stimulates phospholipase C activity, thus enhancing intracellular Ca2+ levels. This is a trigger for vesicular release of neurotransmitter.
My question for you is, how do you explain activation of a Gq/11 coupled 5-HT2A receptors produces a decrease in dopamine release?
Sorry bro can t help u with that one. I just take the stuff 🤞
5HT2A antagonism increases dopamine rather than decreasing dopamine. It is believed that the antagonism mainly affects in the nigristriatal pathway without affecting the mesolimbic pathway. Thus.. the EPS side effects are relieved without exacerbating psychosis.. hope this clears your doubt.
Very useful. Amazing videos. Greetings from Bulgaria!
Thank you so much, sir.
ur videos are so help ful for me , thank u so much 😊😊😊☺
Very helpful thank you very much ❤️
Great lectures 👍🏻