What Causes Fatty Liver? | Alan Flanagan | The Proof Clips EP
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- Опубліковано 12 гру 2023
- Join Alan Flanagan in this intriguing clip of The Proof Podcast, where we delve into the hidden connections between diet and liver health, including important insights into fatty liver. Discover studies and expert insights that reveal surprising aspects of everyday nutrition. This clip offers a unique perspective on how subtle lifestyle choices can impact liver health, including the development of conditions like fatty liver.
Whether you're a health enthusiast or simply curious about the science behind nutrition, this clip is a must-watch. It's packed with useful information and thought-provoking discussions, perfect for anyone looking to deepen their understanding of health and well-being, especially about liver health.
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I love when Alan Flanagan is on...but could we cut in some data graphics when he is quoting numbers? it would be so helpful for those of us who have stronger visual processing and memory ❤
Great idea!
Where can I watch the full interview?
Excellent
Cheers!
Can Alan Flanagan tell us how the research on deuterium factors into metabolic health?
The research points to sat fats having less heavy hydrogen therefore less likely to gum up mitichondrial function.
How can we make any sort of informed decision on what to eat if we don't consider the deuterium research?
We all want to make the right decision when it comes to what to eat but it is becoming so convoluted and contradictory.
Keep up the good work ❤
Start with your conscience where sentient animals are involved. Think "Empath" and change your diet accordingly. Soon you'll see positive changes in your mental and physical health. You will gain wisdom and intelligence as you eat whole plants and live a peaceful long life.
Can ceramides used topically get absorbed and contribute to fatty liver ?
I do not believe so, they are too large in a skin formulation to penetrate the skin barrier. They sit on top of the skin
My primary care patients get remission of NAFLD quickest on low carb diet no matter of saturated fats intake. They eat less UPF so also less refined carbs and added PUFas and more leafy greens at the same time. Possibly because higher fat content they have better control over appetite and ultimately have lower caloric intake throughout the day. Best results with those patients who avoid fructose. I measure it witch liver enzymes, TG and ultrasound with elastography. Focal fat in the liver is gone within 7-10 days of strict LCH.
If saturated is the main cause then why patients on keto diet have lower prevalence of NAFLD? It seems like dr Johnson’s explanation seems to work better in real life scenario. We treat individual patients , not average, randomised patient from the study. Every patient is different and may require different approach.
A clean vegan keto diet has shown to be helpful in treating some patients with certain cancers.
@@chiyerano it is possible. But it is nearly impossible to prove it. Both ethically and practically. And also to many confounders because it is very hard to find homogeneous group of patients with same cancer that is metabolically identical. Even if it is the case then there is other individual factors that play role. And so it is in whole clinical nutrition. Most of the studies show some patients that respond to diet very well and those that don’t respond at all. Then on average there is positive or negative net effect.
If you actually care to know, ask yourself by what process the liver transports stored fat out of the liver, and what part of that is rate limiting. Spoiler: it’s ApoB. And ApoB synthesis is inhibited by insulin… which is elevated for basically everyone with NAFLD. (For people with truly terrible diets, they’re likely choline deficient too.) So cutting carbs isn’t the whole story, you also need caloric restriction and a reasonable diet that’s not so heavy in fatty acids the liver can’t keep up, but it’s a good start. Consider adding intermittent fasting to the protocol.
@@jackthompson6296 I didn’t mentioned that but intermittent fasting is in protocol. Activity directly after meal as well to further lower insulin spike. Patient with high insulin are more likely to have ApoB. Low insulin levels correlate well with low ApoB. So I don’t know how high insulin and insulin resistance cause inhibit ApoB synthesis. By lowering insulin by this protocols NAFLD gets better and because of this insulin sensitivity gets better, lipid profile with ApoB gets better. This tendency is quite consistent throughout most of my patients.
@@jackthompson6296 insulin resistance in hepatocite lowers degradation rate of ApoB and that’s why there is more ApoB in circulation. Hyperinsulinemia that cause insulin resistance is the problem and we should address it in the first place.
I'm having a hard time understanding what he's saying 😕
He thinksj 3 things that increase liver fat are too much saturated fat, too much sugar, and oveating in general.
@@gb7168 thanks 😊
@@gabymalembe thanks 😊
@gb7168 Yes,too technical 😆
Over eating on saturated fat causes fatty liver. Fat has 9 calories per gram while protein and carbohydrates have 4 calories per gram. So he is saying people are over eating on fat (9 calories per gram).
If your focus is being evidence-based, why do you consult naturopaths (your prenatal supplement podcast ad) and regularly engage with them (ND Nagra) to discuss research? I've loved listening to the podcast over the years but never see this mentioned.
I thought the same thing. I decided to do some fact checking on Nagras claims and they do check out. He didnt make claims not supported by the studies he was referencing.
I dont know who the guy is, but what he said (in the episode) seems to be pretty well supported.
@@LinusBerglund Yep and he has a microbiology degree. I don’t get why you’d mystify your scientific credentials with naturopathy. Maybe regulation in Canada is way different. Tbf, that’s the only example of a naturopath recently.
Naturopaths tend to be not very evidence based but I think we just judge people as individuals not as monoliths and Nagra is very evidence based. There are also completely unhinged MDs so you can't just approve/discard people based on a degree.
if you are eating a high saturated fat (relative to PUFA), but are not in caloric excess, then you are fine.
No, most people would have higher atherogenic lipoproteins from doing this. And would be less insulin sensitive
No. Table 3 here lists isocaloric studies investigating saturated fat and it has a negative effect even under isocaloric conditions. www.ncbi.nlm.nih.gov/pmc/articles/PMC5749316/
Processed sugar is not good for you. Sugar found in whole natural foods are not as bad but…
Processed vegetable and seed oils are just poison. Olive oil and coconut oil excluded.
Saturated fat… in itself isn’t harmful. But I think the amount of saturated fats ingested is the issue. Along with what we are eating the saturated fat with. I believe that if we eat a high saturated fat content along with carbs we setting up a dangerous environment.
We all need to just focus on eating a natural amount of natural foods. Eat some plants, eat some meat, drink some water, get some sunshine and be more active throughout the day. We’re over complicating things with all this nutrition dogma. It’s great to have knowledge of nutrition and how our body functions… but on the other hand most people are just so dang confused about what to eat that the stress of trying to eat healthy is just wrecking them. Also what works for one may not work for others due to numerous reasons. So though we are all human our diets will vary depending on several factors. We all need certain nutrients but to what degree varies… so nutrition is personal and should be specific to your needs and health. The one thing most everyone can agree on is that processed foods are not cool. So stay away from them as best as you can. Sending everyone love. ❤
Plant based saturated fat in its naturally occurring forms is fine in the presence of fiber and is the safest way to have saturated fat in a diet. Animal fat contains trans fats which we all know are the worst fats to eat.
I love your response and follow your suggestions, which have been serving me well throughout life. I am an omnivore who eats whole foods. I avoid ultra-processed foods and added sugar; I drink plenty of water, and I move my body. For reference, I am 54, postmenopausal x5 years, 115 lbs with zero belly fat. I am active, happy, and medication-free with optimal labs. ❤
The problem is not saturated fats. It's extra fats (seed oils) devoid of protein and mostly in highly processed foods. People are not getting sick from steak or milk. You guys are chasing the wrong problem. Walk through a grocery store and check which foods have pufas added. That will give you the answer to societal disease or obesity.
The problem is people who ignore the large body of peer reviewed research because you are incapable of understanding it.
It is good to know that saturated fats cause more liver fat.
But it was also explained, the main problem is energy excess, not the type of fat or sugar.
Seed oils are fine when used in a salad or to sautee, just don't eat too much food that you can easily overeat. That is normally already prepared foods and those contain a lot of oils. This is the reason people think oils are bad in the first place.
To be clear it’s extra calories that are the problem. Fat deposition just doesn’t happen if you don’t overeat
Steak is fine if it's from WILD GAME MEAT and is very lean and low in animal fat and a person isn't allergic to it. Animal fat naturally contains trans fats. People actually DO get sick from eating milk and it's products. Dairy IS a common ALLERGEN. Some people are also allergic to the meat of land animals so you may want to check where you are getting your information on this.
@@MichaelHorstmannsome people develop metabolic disease like fatty liver when their overall body fat level is just a little higher than normal. Others don’t develop it unless their overall body fat level is severely above normal. This tells us that caloric excess is not the entire explanation. To a great extent, the differences in where people put their fat (healthy subcutaneous vs intrahepatic) appears to be genetic. However, nutrition appears to play a role based on studies like the ones presented in this video.