How Does Type 2 Diabetes Develop | The Twin Cycle Hypothesis | Roy Taylor | The Proof EP

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Dive into The Proof, Episode 287 ‒ A Scientific Analysis: Roy Taylor on Type 2 Diabetes, Twin Cycle Hypothesis, Insulin Resistance, & more
In this insightful episode of The Proof, Roy Taylor, a renowned expert in diabetes and metabolism, deviates from traditional discussions to address pressing scientific questions, bringing evidence-based insights to the forefront.
This segment particularly delves into:
- The scientific basis of the Twin Cycle Hypothesis and its implications for understanding Type 2 Diabetes
- Comprehensive analysis of the body's metabolism, focusing on insulin resistance and the impact of excess glucose on diabetes progression
- Evaluating the critical functions of the liver and pancreas in the regulation of blood sugar and fat
- Unraveling the complex relationship between dietary habits, insulin production, and organ health to provide a comprehensive understanding of the root causes of diabetes
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[@gstlynx]

Excellent interviewer and interviewee.

[@limitisillusion7]

The question to me then is this: Are there any active people who perhaps lift weights as part of that activity who are of a healthy weight and still develop diabetes? Or is exercise, particularly strength training, the path to avoid this problem?

[@jaymayhoi]

nice graph presentation!

[@TheProofWithSimonHill]

Glad you liked it!

[@chrisconklin2981]

It seems that something is being left out regarding muscle insulin resistance. Roy Tylor mentions that either a muscle cell is insulin resistant or it is not. He does not explain what causes that resistance. According to the NIH: "Lipids stored in skeletal muscle cells are known as intramyocellular lipid (IMCL). Disorders involving IMCL and its causative factor, circulatory free fatty acids (FFAs), induce a toxic state and ultimately result in insulin resistance (IR) in muscle tissue". The way I see it IMCL fat accumulation happens in muscles before the the liver is involved.

[@FightBackAgainstDiabetes]

*You Did Not Choose To Be Classified As Diabetic, But You Can Choose To Fight Back Against Diabetes* 💪

[@KarlKrassnitzer-mm8wb]

This hypophisis seems to fit to a bunch of type 2 diabetes phanotypes.

[@madcircle7311]

Hey Simon Hill, any plans on making a video with a nephrologist on kidney disease?

[@TheProofWithSimonHill]

Yes on our list