Pharmacokinetics | Drug Clearance

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  • Опубліковано 2 січ 2025

КОМЕНТАРІ • 111

  • @iamlethibe
    @iamlethibe Рік тому +27

    Thank you so much! You are helping thousands graduate and be contributing health professionals to society. This is big. My heart is grateful.

  • @taoficmakaya1727
    @taoficmakaya1727 2 роки тому +31

    We love you prof. Zach❤️❤️❤️❤️❤️❤️

    • @sammillan653
      @sammillan653 Рік тому +1

      This guy is absolutely amazing !!!

  • @khalilahd.
    @khalilahd. 2 роки тому +11

    You’re the best Zach! Thanks for this 🙏🏽

  • @nini2535
    @nini2535 2 роки тому +108

    Can you please do the rest of the pharmacology lessons this days please 🥺 .. I have exams after 2 weeks and your videos help a lot and facilitate the whole situation professor ! .. may Allah bless you and your beloved ones 🤍

  • @dryusuf4950
    @dryusuf4950 2 роки тому +8

    Big thank you to Prof Murphy and the team. I used the neurology playlist as a foundation for my part 1 residency exams in neurology. In addition to it I reviewed other topics covered on the channel. It was the best decision. I passed the exam and hopefully will start residency soon. My appreciation and respect to the team.

  • @novaexx6587
    @novaexx6587 2 роки тому +6

    I was literally trying to study this yesterday.. thank you so much for all your videos, they are genuinely life savers!

  • @wanpissulupin8165
    @wanpissulupin8165 2 роки тому +7

    You are really gifted. I've been following your lectures since you started.
    👍

  • @mohammedisak4645
    @mohammedisak4645 2 роки тому +7

    Masha Allah I'm from Somalia🇸🇴 We proud of You Me and My friends For your Hardworking Thank you For Your Helping us With Out you I'm sure that i can't know something About Medicine.
    Thank you.

  • @elidonmarku591
    @elidonmarku591 2 роки тому +2

    Your videos are more effective than reading the medical books

  • @22.Satty.
    @22.Satty. 2 роки тому +12

    You make every subject of medicine my favorite you are just magical sir, thanks a lot 🙏

  • @Itszarakagha
    @Itszarakagha 2 роки тому +4

    Please upload more than one video at least 2 to 3 videos of pharma per week 🙏

  • @mrsamandabernier
    @mrsamandabernier 2 роки тому +3

    Loving this series

  • @onyiukechidinma5598
    @onyiukechidinma5598 Рік тому

    We just started pharmacology course in school, this is the first video I'm watching on it and I am so happy because it has killed every single fear I had about pharm. Thank you ninja nerd

  • @saradurdiakova4000
    @saradurdiakova4000 2 роки тому +2

    even tho this came up after my pharmacology exam, its so nice to see more pharma for another students!!!

  • @vinayakkapatral4246
    @vinayakkapatral4246 2 роки тому +1

    Zack … your lectures are inspiring me to go back to school.
    Wonderful! Where were you? When I was in Grad school?
    Excellent! Just excellent!

  • @zaidkhan-yc3fd
    @zaidkhan-yc3fd 2 роки тому +4

    Thanks for a very helpful lectures. 💕

  • @Timtam973
    @Timtam973 7 місяців тому +2

    You are delivering the most helpful and very educational material. Thank you on behalf of all! Let's support this channel by subscribing, liking, commenting! So worth!

  • @samanehnikhal8578
    @samanehnikhal8578 11 місяців тому +1

    This video helped me to understand the topic which was always difficult for me. Thank you ninja nerd

  • @enricazamolo7086
    @enricazamolo7086 Рік тому +1

    I wish you were my teacher!! Thank you for all your help!

  • @muhammadsulaiman6023
    @muhammadsulaiman6023 2 роки тому +1

    Zach you are really a hero.

  • @malikihamski4265
    @malikihamski4265 2 роки тому +1

    You are great teacher forever...one love from Tanzania

  • @crypto_radio9653
    @crypto_radio9653 Рік тому +1

    You made this so much more clear than my professor! You rock :)

  • @TimUlang-wl6pd
    @TimUlang-wl6pd Рік тому +1

    Thank you so much for helping us out on basic pharmacology
    You’re magical prof: Zach Murphy ❤❤

  • @derrickphiri955
    @derrickphiri955 2 роки тому +1

    Definitely here to watch...about ⌚

  • @selo5124
    @selo5124 2 місяці тому +2

    The first question (at 18:36) is actually really smart. Kidney disorders can either increase (e.g. glomerulonephritis, diabetic nephropathy) or decrease glomerular capillary permeability. But, if the condition was associated with increased clearance (increased glomerular capillary permeability), there would probably be no need for dialysis => there likely is decreased clearance.

  • @BaoTran-ls7oy
    @BaoTran-ls7oy 3 місяці тому

    Thank you very much, I can see that you put a lot of passion into teaching these topics!

  • @atiqullahomerzai7937
    @atiqullahomerzai7937 2 роки тому +2

    Thank you so much Zach❤️❤️
    Please do the next video about Diabetes Drugs🙏🙏

  • @kanakraj4847
    @kanakraj4847 2 роки тому +1

    Thank you so much, love from India 😊😊

  • @alawiaomer2739
    @alawiaomer2739 2 роки тому +1

    I LOVE YOU NINJA NERD ❤️❤️❤️❤️❤️❤️

  • @shreyashnarade7566
    @shreyashnarade7566 2 роки тому +7

    Can't wait to see this but I'm now only in 2nd year 🤣😁

  • @sawantiparang6660
    @sawantiparang6660 2 роки тому +3

    Please teach us dynamic,,cholinergic,adenergic also sir
    Love from India 🇮🇳

  • @Self-Health-Evangelist
    @Self-Health-Evangelist Рік тому

    Thank you for your time and effort

  • @Demothones
    @Demothones 2 роки тому +1

    I don’t have tests or anything. I just find pharmacology very interesting.

  • @giantalentti3774
    @giantalentti3774 15 днів тому

    This is so helpful!! thank you!!!!

  • @PerfusionPrime
    @PerfusionPrime 2 роки тому +1

    Thank you ninja nerd

  • @sandemichael7242
    @sandemichael7242 Рік тому

    We love you so much professor you are our life saving machine we do appreciate your wonderful work sir 🙏🙏

  • @Jessica-by7us
    @Jessica-by7us 2 роки тому +2

    I love all your videos! My educator in icu refers us to your videos, I use them for university, clear and detailed enough. Thank you so much! 🙏🙏🙏🙏 lifesaver hahah
    Curious, are you NP or phd?

  • @mosesnchimunya8136
    @mosesnchimunya8136 2 роки тому +1

    Powerful lesson, kindly make videos on anasthetic drugs as well, kindly waiting

  • @MoonMm-zr4uf
    @MoonMm-zr4uf 7 місяців тому

    This is amazing ! Thank you soooo muchhhhhh you are the bestttttttt!❤❤❤❤❤

  • @claraishungry501
    @claraishungry501 Місяць тому

    amazing as usual

  • @minutemovienight9094
    @minutemovienight9094 6 місяців тому

    Thankyou so much Nija Nerd!

  • @RobotChitti-j7g
    @RobotChitti-j7g Місяць тому

    Thank you sir god bless you ❤❤

  • @mishkalmujjalla8286
    @mishkalmujjalla8286 2 роки тому +1

    Thanks a lot 🙏 💓 💗

  • @shebasanimations
    @shebasanimations 2 роки тому

    Thank you Ninja nerd😭

  • @Zetsuke4
    @Zetsuke4 2 роки тому +1

    Perfectly said and easy to understand

  • @karenishness1
    @karenishness1 2 роки тому +1

    Have you done episodes on parasitic infection?

  • @rehanaqamar2608
    @rehanaqamar2608 2 роки тому

    We r proud of u...sir. from pakistan

  • @kizitosenkabirwa955
    @kizitosenkabirwa955 Рік тому

    you the best sir thanks for making us pass God bless you

  • @willenova
    @willenova 2 роки тому +1

    my bro Vmax making a comeback

  • @thanzeelp3515
    @thanzeelp3515 2 роки тому

    Ninja is dope !

  • @jaymjay2313
    @jaymjay2313 Рік тому

    Never understand pharmacokinetics during my years at uni..u just clear my confusion on this...I will enroll if offer online pharmacology courses..keep up with good work 👏

  • @john.the.beloved
    @john.the.beloved 2 роки тому +1

    Timely!

  • @rakeshshah1074
    @rakeshshah1074 2 роки тому +1

    U r amazing sir

  • @elidonmarku591
    @elidonmarku591 2 роки тому +1

    Please are you going to do more videos about pharmacology

  • @benkhelifnesrine5623
    @benkhelifnesrine5623 Рік тому

    Thank you so much, it is so helping

  • @Hu7eyfe
    @Hu7eyfe Рік тому +1

    Regarding the first question, wouldn't undergoing dialysis compensate for the pharmacokinetic alterations of the drug caused by the renal impairment, eventually leading to no change in half-life and necessary dosage?

    • @Kenny5867
      @Kenny5867 Рік тому +1

      I swear I had the same thoughts but I also think it’ll depend on if the drug is dialyzable or Non dialyzable. Anyone with a better idea?

  • @HamnaAbbasi-sl6mv
    @HamnaAbbasi-sl6mv Рік тому

    Sir kindly teach the various compartment models of drugs as well

  • @AlisonFoelsche
    @AlisonFoelsche Рік тому

    so helpful thank you!!!

  • @cumarcalicumar8299
    @cumarcalicumar8299 2 роки тому +1

    thanks sir

  • @dishanthsrideva7196
    @dishanthsrideva7196 2 роки тому +1

    "What the frig, kabaam, done roasted" 😉🙏 thanks zach and ninja nerd team

  • @coey6744
    @coey6744 2 роки тому +1

    May I know where can we find more exercises like in the video? Thanks !!!

  • @fawadkhan8171
    @fawadkhan8171 Рік тому

    You are the best

  • @niyadeo7970
    @niyadeo7970 Рік тому

    Amazing!

  • @sensational6991
    @sensational6991 10 місяців тому

    Thank You soo much bruv!

  • @sawantiparang6660
    @sawantiparang6660 2 роки тому +1

    Wow,,,,,,,,amazing

  • @rajkumar01035
    @rajkumar01035 2 роки тому +1

    Zack kindly Make a video on Etiopathogenesis and immunehistochemistry on lukemias and lymphomas .. These 2 topic Are so confusing While we Are diagonstic a patient

  • @bijoyt.thomas5518
    @bijoyt.thomas5518 2 роки тому +1

    I like the drug Ninja ......

  • @ahmedmaher8400
    @ahmedmaher8400 Рік тому

    Great sir

  • @blackfoxmp5
    @blackfoxmp5 2 роки тому +3

    60 hours (t 1/2 = 5) would best approximate the half life of the Drug Ninja since over 96% of the drug is cleared. At 48 hours, roughly 94% of the drug is removed. How is 48 hours considered a steady state when that is less than 95%? Enjoyed the video, nonetheless!

  • @TimUlang-wl6pd
    @TimUlang-wl6pd Рік тому

    Launch for us more videos on parasympathomimetic sir ❤❤

  • @AsharSsozi1962
    @AsharSsozi1962 2 роки тому +1

    C Is my answer

  • @niloofarkh4779
    @niloofarkh4779 Рік тому +1

    thank u

  • @PharmaDstudent
    @PharmaDstudent 8 місяців тому

    you are hero

  • @Dr.BelloAliyu
    @Dr.BelloAliyu 2 роки тому +1

    🔥🔥🔥

  • @aayushbatra1147
    @aayushbatra1147 Рік тому

    Love❤❤❤❤❤❤

  • @niloofarkh4779
    @niloofarkh4779 Рік тому

    amazing

  • @dler5360
    @dler5360 Рік тому

    you explain it like you were the one who discovered it, wow

  • @larishsa8816
    @larishsa8816 Місяць тому

    Hi Zach, I read in Lippincott that zero-order kinetics is non-linear, and first-order kinetics is linear. Can you confirm?

    • @jasrakhan8974
      @jasrakhan8974 Місяць тому

      Zero-order kinetics is non-linear because the rate of elimination does not change proportionally with the drug concentration. As a result, small increases in dose can lead to disproportionate increases in drug concentration in the body.
      • Example: Phenytoin and ethanol at high concentrations.

  • @amirabbasbaharfar2328
    @amirabbasbaharfar2328 Рік тому

    Done.✅

  • @elijahwall8139
    @elijahwall8139 Рік тому

    "I got you boo"🤣❤

  • @Frank_Castle_Nair
    @Frank_Castle_Nair Рік тому

    The whole comment section: Thanking zach for helping them with their studies.
    Me who came to check how soon I can take a drug test. 😐

  • @mustafamark5394
    @mustafamark5394 Рік тому

    Ninja ur Cool af 😎💞

  • @TimUlang-wl6pd
    @TimUlang-wl6pd Рік тому

    Launch for us more videos on parasympathomimetic sir

  • @shahdanish1884
    @shahdanish1884 Рік тому

    Zach education

  • @alnoorsunesara2378
    @alnoorsunesara2378 10 місяців тому

    Why do some drugs follow zero order elimination?
    Is it because of chemistry or other factors?

  • @omarila3659
    @omarila3659 2 роки тому +1

    ❤️❤️

  • @mutakamartin7549
    @mutakamartin7549 Рік тому

    Thanks for the video, however, something needs to be cleared up here. if they say a drug follows nonlinear kinetics it means Zero order kinetics. some one may be confused by the explanation

  • @sobanjobukunmi1574
    @sobanjobukunmi1574 Рік тому

    If she’s suffering from renal disease, doesn’t that mean that more of the drug will be eliminated in turn increasing clearance and decreasing half life?

  • @gloriyaghosh7467
    @gloriyaghosh7467 Рік тому +1

    why are zero order kinetics called non linear kinetics even though their graph is linear

  • @07katrodiyaman45
    @07katrodiyaman45 9 місяців тому

    good

  • @dailydoseofmedicinee
    @dailydoseofmedicinee 2 роки тому +1

    👋

  • @passntesam3346
    @passntesam3346 Рік тому

    ❤❤❤❤❤

  • @zezomed3749
    @zezomed3749 Рік тому

    Thannnnnnkksssss

  • @nasseryassin2269
    @nasseryassin2269 Рік тому

    14:45 when he says “rate of eliminationl” , put it on 1.25 and it’s gonna sound like Eminem in his song “I’m not a afraid”.

  • @adnansofi2364
    @adnansofi2364 11 місяців тому +2

    I think for your question no 1 option B will be the right answer.

  • @inksandbrushes7813
    @inksandbrushes7813 Рік тому

    Crazy how I wanted to escape mathematics through medicine

  • @pattymitre3580
    @pattymitre3580 4 місяці тому

    But isn't first-order kinetics called linear, and zero-order non-linear?

  • @luispineres3212
    @luispineres3212 11 місяців тому

    ily

  • @BadBad-i7m
    @BadBad-i7m Місяць тому

    لا إله إلا الله وحده لا شريك له

  • @雅子人見
    @雅子人見 2 роки тому +1

    Why You never gets angry,whatever a student does?😘