This video is very wrong.... When digoxin blocks the Na / K+ ATPase pump it causes build up of intracellular Na causing inhibition of Na / Ca+ channel exchanger (which causes extrusion of intracellular Ca+ and influx of Na) so when it's inhibited you won't longer have extrusion of Ca+ so following action potential Ca+ flows in through L-type calcium channel to causes muscle & since the Na/Ca+ channel exchanger has been inhibited by intracellular build up of Na the Ca+ remains trapped in the cell resulting in dia mopping up by sarcoplasmic reticulum increasing the Ca+ store to favour more effective muscle contraction following a subsequent action potential
That's true, but you need to know also that Na+/Ca2+ channel exchanger can work both ways, meaning it can transfer both Na+ and Ca2+ ions in both directions. So it only depends on the way you want to look at it, the effect is the same. www.cvphysiology.com/Cardiac%20Function/CF023
i think there is a mistake here. Increased Na ion inside the cell doesnt activate the Na-Ca exchanger rather it deactivates it .So it cant take out the Ca .It increases the amount of Ca inside the cell overall.
Please take down the video. It's very wrong. 1. Conc. of Ca was initially freely rushing inside the cell, so it's doesn't need the Na to go out in order to go in. 2. with the effect of Digoxin, Na conc. outside is very low (Na cannot go out since ATP pump was blocked), and since Na was low outside, it cannot go back inside for the Ca to go out thru Na/Ca exchange 3. Ca was trapped inside, hence, increase contraction of the heart
This video is incomplete, The increase of sodium inside the cell will make less gradient of sodium between the intracellular and extracellular. Making the calcium sodium exchanger inactive which in turn makes less calcium pumped out of the cell. Digoxin is used to increase the calcium inside the cell by preventing it to be pumped out from the cell
Negative people say this video is wrong 🤬🤬🤬😡😡 Use heart in science not ur brain. Keep on spreading positivity dear positive people 🥰 THIS VIDEO IS ALL GOOD. BE POSITIVE 🥴
This video is very wrong.... When digoxin blocks the Na / K+ ATPase pump it causes build up of intracellular Na causing inhibition of Na / Ca+ channel exchanger (which causes extrusion of intracellular Ca+ and influx of Na) so when it's inhibited you won't longer have extrusion of Ca+ so following action potential Ca+ flows in through L-type calcium channel to causes muscle & since the Na/Ca+ channel exchanger has been inhibited by intracellular build up of Na the Ca+ remains trapped in the cell resulting in dia mopping up by sarcoplasmic reticulum increasing the Ca+ store to favour more effective muscle contraction following a subsequent action potential
That's true, but you need to know also that Na+/Ca2+ channel exchanger can work both ways, meaning it can transfer both Na+ and Ca2+ ions in both directions. So it only depends on the way you want to look at it, the effect is the same. www.cvphysiology.com/Cardiac%20Function/CF023
Thanks brother
Bro can you explain me this na+ _ ca 2+ antiport pump and it's roles on cardiac muscle
Yes, that's right. I got confused. Thank you
They have the Na/Ca exchanger going in the wrong direction
i think there is a mistake here. Increased Na ion inside the cell doesnt activate the Na-Ca exchanger rather it deactivates it .So it cant take out the Ca .It increases the amount of Ca inside the cell overall.
Indeed
I think that too
Nice i agree
Agreed
As simple as that and intracellular calcium would cause contraction 👍🙌
i love your graphics and animation . i love your work
Damn, that was an effective quickie ❣️
Nice. Simple and effective plz make such videos of mechanism of action
Please take down the video. It's very wrong.
1. Conc. of Ca was initially freely rushing inside the cell, so it's doesn't need the Na to go out in order to go in.
2. with the effect of Digoxin, Na conc. outside is very low (Na cannot go out since ATP pump was blocked), and since Na was low outside, it cannot go back inside for the Ca to go out thru Na/Ca exchange
3. Ca was trapped inside, hence, increase contraction of the heart
exactly
Sure💯
Thank you soo much ❤
Simply superb
This video is incomplete, The increase of sodium inside the cell will make less gradient of sodium between the intracellular and extracellular. Making the calcium sodium exchanger inactive which in turn makes less calcium pumped out of the cell. Digoxin is used to increase the calcium inside the cell by preventing it to be pumped out from the cell
Great one..
Good explanation 🙏
Awesome Thanks 😍
Good work 😊
Feel spread goodness
Plzzz make video of every drug.....
So grateful,I learned in feww minutes' amazing
only one minute.
But that was a bit mistaken concept!
It was very helpful ....made the complex thing to easy
Nice
excellent!
Mistake huge mistake
Ca na pump is reversed in this video...
Such a shame!! Good graphics but TOTALLY WRONG INFORMATION! To those who will take their exams, don't even watch this.
This video is totally wrong
Thats wrong!
Negative people say this video is wrong 🤬🤬🤬😡😡 Use heart in science not ur brain.
Keep on spreading positivity dear positive people 🥰 THIS VIDEO IS ALL GOOD. BE POSITIVE 🥴
This vedio is wrong
Wrong concept
It's WRONG
Wrong video ❌❌❌❌❌❌❌
It's wrong