You are sooooo good. Thank you for helping me cover 2 big chapters in less than 5minutes. Something my teacher did four hours but none could understand, you just made it so simple for me
How does that make sense ? Acetylcholine is the primary neurotransmitter of the parasympathetic nervous system.... During a time of fight or flight ( sympathetic nervous system) acetylcholine leaks from the neuromuscular junction and acetylcholinesterase is inhibited. Does the system need more acetylcholine or less ?
Is a chronical cholinergic crisis a possible thing? I'm asking because after just three doses of choline alfoscerate at 400 mg, I developed a bunch of torturous symptoms. For more than six weeks I have been constantly in a depressed, anxious, desperate mood. I have no appetite at all (I hardly can eat), I have ringing in the ears, bradycardia, thready pulse, impaired circulation, increased intestinal peristalsis, fatigue, chills, sweating, slight fever, weakness and other crazy parasympathetic effects. Is it theoretically possible that, for some unknown reason, my acetylcholine level does not decrease and even gradually accumulates, which leads to such symptoms? This hypothesis came to my mind for the following reasons: 1) The antidepressants prescribed to me only affect my mood but have no effect on the "muscarinic" symptoms, like bradycardia. It looks like a mood disorder is one of the manifestations of the disease, and not the disease itself. 2) Atropine temporarily relieves my condition 3) A dose not exceeding 1 mg of atropine does not even raise my pulse 4) Over time, the effectiveness of atropine decreases. Since I use it only in extreme cases, my body's adaptation to it is doubtful. 5) If acetylcholine does not accumulate in my body, then the disease would go away by itself, since cholinesterase would quickly remove excess acetylcholine So how to reduce the level of acetylcholine in my body or, if this is not possible, how to block excess acetylcholine? What medications are best for this?
Watching this, I'm wondering why recent Alzheimer's/general Dementia drugs have been targeting mAChR3, even though it's primarily involved in smooth muscles. I used be interested in drug addiction, but damn, I'm growing more addicted to helping with dementia than ever before, and this video doesn't help at all
why does acetylcholine (parasympathetic) cause WAKEFULLNESS. Shouldn't it make you sleepy instead?? Instead, it is the ANTI-cholinergics (like diphenhydramine) that make you sleepy. Counter-intuitive?
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You are sooooo good. Thank you for helping me cover 2 big chapters in less than 5minutes. Something my teacher did four hours but none could understand, you just made it so simple for me
the best youtube channel for medical students. Thank you so much!!!!!!!!!!!!!
👍This is an excellent summary. I particularly enjoyed watching the animation. Thank you very much for sharing.
Short and contentful video
Thanks. I hope you will cover other core pharmacology concepts soon.
Marvelous and too much good this summary . Thanku so much for making this video🙏🙏🙏
Most welcome and thanks 😊
Thank you ❤
Very clear and simple thank you
Thank you
Please make a video on adrenergic drugs
Coming up next indeed!
@@Alilamedicalmedia That's awesome....Thank you very much
Thank you so much for sharing ❤❤
Thank you for sharing
wonderful video. thank you.
Thank you so much
Superrrrrrrrrrrrr.......... NO COMMENTS
Thank you!
Thank you soo much ❤️✨
Thank you
How does that make sense ? Acetylcholine is the primary neurotransmitter of the parasympathetic nervous system....
During a time of fight or flight ( sympathetic nervous system) acetylcholine leaks from the neuromuscular junction and acetylcholinesterase is inhibited.
Does the system need more acetylcholine or less ?
Great video, very helpful!!
thanks
Just perfect
Excellent
Amazing 😍 iam a neet aspirant
awesome
Amazing explanation
Is a chronical cholinergic crisis a possible thing? I'm asking because after just three doses of choline alfoscerate at 400 mg, I developed a bunch of torturous symptoms. For more than six weeks I have been constantly in a depressed, anxious, desperate mood. I have no appetite at all (I hardly can eat), I have ringing in the ears, bradycardia, thready pulse, impaired circulation, increased intestinal peristalsis, fatigue, chills, sweating, slight fever, weakness and other crazy parasympathetic effects. Is it theoretically possible that, for some unknown reason, my acetylcholine level does not decrease and even gradually accumulates, which leads to such symptoms?
This hypothesis came to my mind for the following reasons:
1) The antidepressants prescribed to me only affect my mood but have no effect on the "muscarinic" symptoms, like bradycardia. It looks like a mood disorder is one of the manifestations of the disease, and not the disease itself.
2) Atropine temporarily relieves my condition
3) A dose not exceeding 1 mg of atropine does not even raise my pulse
4) Over time, the effectiveness of atropine decreases. Since I use it only in extreme cases, my body's adaptation to it is doubtful.
5) If acetylcholine does not accumulate in my body, then the disease would go away by itself, since cholinesterase would quickly remove excess acetylcholine
So how to reduce the level of acetylcholine in my body or, if this is not possible, how to block excess acetylcholine? What medications are best for this?
Thank you sir
Nice
Please do more videos
Thank you mam 🙏
great
Thank you :D
Classification of Drugs Pharmacology eg Anti cogulant s , Anti histamine
Good very good ❤
Watching this, I'm wondering why recent Alzheimer's/general Dementia drugs have been targeting mAChR3, even though it's primarily involved in smooth muscles. I used be interested in drug addiction, but damn, I'm growing more addicted to helping with dementia than ever before, and this video doesn't help at all
🙏🏿🙏🏿 gods work
Lovely
Mam.. Plsss upload more videos for 4th sem b. Pharmacy
Omg these are strong,,,
why does acetylcholine (parasympathetic) cause WAKEFULLNESS. Shouldn't it make you sleepy instead?? Instead, it is the ANTI-cholinergics (like diphenhydramine) that make you sleepy. Counter-intuitive?
This has me thinking, depending on the drug and what it is trying to treat, the cholinergic medication acts as a stimulant does it not?
from where come from thrse drugs
Sir make adrenergic drugs sir video si
You are wonderful 🌸
Please translate to Arabic, 💙💙
🙏
❤️
It would have been better if u have mentioned name of drugs too.
They are written on the screen :)
Animation
Excellent
Excellent