This is the best video about mechanism I ever watched. I take my hat off, now I understand everything. Thank you for this verry informational videolesson!
I’ve been searching it from my notes and textbooks but still I was confused !! This video just cleared the concept like hair extracted from butter , you know !!
Can anyone please explain if it block Na*/K* atpase pump than how contration of K* is restored after each cardiac cycle back to normal, as K* was leaving the cell during phase 1 to 3.
In the absence of digoxin, the concentration of Na inside the cell is low compare to outside the cell, but when digoxin acts, it blocked Na/K pump which inhibit transfer of Na to the outside as well as K to the inside. Therefore the amount of Na inside the cell will consequently be higher which will prevents the cell from getting rid of Ca which leads to increase in Ca conc. in the cell and its subsequent storage in the endoplasmic reticulum. So now when action potential transfers one Ca ion into the cell through L tupe calcium channel the calcium ion will trigger massive release of more calcium which could produce much powerful contraction.
In the presence of digoxin,Na ion conc is Higher inside.Shouldn’t Na go outside in exchange of Ca ion coming inside via NCX rather NCX become completely disable?
Na concentration gets higher compared to before Digoxin inhibits the Na/K-ATPase. Not higer than extracellular (in average dose of Digoxin). So the driving force for Natrium to get IN the cell gets lower. Thats why the NCX "throttles down" > less Calcium is eliminated via the NXC > more Calcium accumlate in cell > Ca ATPase of SR undertake Calcium-elimination > More Ca in SR in the case Natrium-concentration gets higher than extracellular NXC will transport Na and Ca reversed > so thats what you meant
Even I have gone through two mechanisms of digoxin related to NCX.. One mechanism States that digoxin inhibits nakatpase , so na accumulates inside the cell which leads to blockade of NCX also n thereby ca also accumulates inside... Other mechanism States that digoxin inhibits nakatpase, so na accumulates inside the cell.. Since NCX is a na ca exchanger, so it can transport na n ca in both directions depending upon concentration,..in case of digoxin, na accumulates more inside, so NCX will throw this na out of cell in exchange of ca which will result in increase intracellular ca... I am going with the second mechanism however bcz NCX is an exchanger n it should work according to concentration gradient..
Even I have gone through two mechanisms of digoxin related to NCX.. One mechanism States that digoxin inhibits nakatpase , so na accumulates inside the cell which leads to blockade of NCX also n thereby ca also accumulates inside... Other mechanism States that digoxin inhibits nakatpase, so na accumulates inside the cell.. Since NCX is a na ca exchanger, so it can transport na n ca in both directions depending upon concentration,..in case of digoxin, na accumulates more inside, so NCX will throw this na out of cell in exchange of ca which will result in increase intracellular ca... I am going with the second mechanism however bcz NCX is an exchanger n it should work according to concentration gradient..
Why do cell use sodium calcium exchanger pump because due to depolarization already there is much sodium inside the cell so why do cell increases sodium level?
In another video that i have watched,increasing sodium activates sodium calcium channel that leads to increasing calcium intracelluler,which one is legit?
Why is your Na/Ca exchanger in opposite direction? Pretty sure the MOA is the increased Na in the cell from digoxin causes increased activity of the Na/Ca to pump the Na out of the cell, which brings more Ca into the cell. It doesn't stop the Na/Ca from working...
more clear than this? impossible! Thank you so much for making it easy to visualize!
This is the best video about mechanism I ever watched. I take my hat off, now I understand everything.
Thank you for this verry informational videolesson!
Best explanation ever! Thank you so much for this, it is the first time I properly understand the mechanism. Thank you, thank you, thank you!!!
Best video of digoxin out of all i have seen so far .. V well explained! Thanks.
this is the best video out there for this!
OMG Thank you. This is so simple to understand.
Precise and to the point.. thanks for this short review
have to say a very useful video. helped my understanding a lot thanks.
You made it so simple to understand!! Thank you
The best video on this. Thank you 😩
Simple and clear - thank you !
yeah 😊
Thank you so much ! that was very useful and simple, god bless you
Thanks a lot, complex made easy to understand, doing a great job!!
Bro! Hours of research in a few minutes! Gr8 & Thanks
Utterly clear...thank you!!
Well explained and concise. Thank you
Thank you. You explained it clearly.
Very helpful. Thank you !
Wow ,,
Never could understand this better.
Thank you very much
This was much needed
Thank you for the video. Very helpful!
Thanks a lot
Simplified and to the point
great video. Thank you
Perfectly explained. Nice
Thanks for making it easier for us👍💛
Absolutely accurate, thx for this
Great Explanation, Thank You!
Excellent explanation! Thank you so so so much
Thanks for that pretty video 🙏🏻
You r great teacher!..Thank you for high yield video
Excellent video!!!!
Amazingly explained 👍
short and easy to revise. Thank u ☺️
amazing video, thank you
Wow I lost hope understanding this until I saw your video Thanks 🥺🥺
U just made my day😍
Thanks for the explanation.
Thank you for the video. I'm learning for my medicine-examen and never understood this mechanism completely til now. Hospital I'm coming :-)
Very clear explanation... thanks soo much..
Amazing!
Very helpful, thank you very much
God bless you🙏🏻
I’ve been searching it from my notes and textbooks but still I was confused !!
This video just cleared the concept like hair extracted from butter , you know !!
Wonderful!
U helped me so much. Thanks:)
simple & useful thank you
Thank you.
Very nice explained
Alhamdulillah
thanks team work
Beautiful 🤩
Amazing! Thx
Thank you
Amazing
Thank you. This will be the last vid on my playlist as I go in for my Viva..
Same😃
Thanks
Helpful!💫
thank you
Very nice explain
Well explained 👍🏻
Simple to understand. Thanks.. can u also explain digoxin toxicity
thank you sir
V well explained
Thank youuuuuuu so much
Thanks a lot
Thanks dear
Thanks man
Thank u
understande it totally
thnks
THANKS Buddy🤓
Best best supper best video.
Great
So the muscle relaxes when Ca is exchanged for Na , how is it able to relax when the exchanger is blocked?
Thanks a ton 👌🏻
Ok Boomer 😂😂
🗿good video
Thanku
What becomes the resting membrane potential of this cell then if it has such a high Na+ content?
Can anyone please explain if it block Na*/K* atpase pump than how contration of K* is restored after each cardiac cycle back to normal, as K* was leaving the cell during phase 1 to 3.
Good
To the point & very useful! Thank you & please work on your visuals. Do it like osmosis. You've got great content don't let trivial things ruin that.
Venkatesh Sawant the visuals are good enough bruh
However, what would happen to potassium? and what are the side effects if a person is already taking a diuretic that is non-spearing potassium?
I dobt understand. To begin with isnt there more Na outside the cell and mre K inside the cell??
In the absence of digoxin, the concentration of Na inside the cell is low compare to outside the cell, but when digoxin acts, it blocked Na/K pump which inhibit transfer of Na to the outside as well as K to the inside. Therefore the amount of Na inside the cell will consequently be higher which will prevents the cell from getting rid of Ca which leads to increase in Ca conc. in the cell and its subsequent storage in the endoplasmic reticulum. So now when action potential transfers one Ca ion into the cell through L tupe calcium channel the calcium ion will trigger massive release of more calcium which could produce much powerful contraction.
In the presence of digoxin,Na ion conc is Higher inside.Shouldn’t Na go outside in exchange of Ca ion coming inside via NCX rather NCX become completely disable?
Na concentration gets higher compared to before Digoxin inhibits the Na/K-ATPase. Not higer than extracellular (in average dose of Digoxin). So the driving force for Natrium to get IN the cell gets lower. Thats why the NCX "throttles down" > less Calcium is eliminated via the NXC > more Calcium accumlate in cell > Ca ATPase of SR undertake Calcium-elimination > More Ca in SR
in the case Natrium-concentration gets higher than extracellular NXC will transport Na and Ca reversed > so thats what you meant
@@515silas thanks,,, its enough to understand 💓
Even I have gone through two mechanisms of digoxin related to NCX.. One mechanism States that digoxin inhibits nakatpase , so na accumulates inside the cell which leads to blockade of NCX also n thereby ca also accumulates inside... Other mechanism States that digoxin inhibits nakatpase, so na accumulates inside the cell.. Since NCX is a na ca exchanger, so it can transport na n ca in both directions depending upon concentration,..in case of digoxin, na accumulates more inside, so NCX will throw this na out of cell in exchange of ca which will result in increase intracellular ca... I am going with the second mechanism however bcz NCX is an exchanger n it should work according to concentration gradient..
Even I have gone through two mechanisms of digoxin related to NCX.. One mechanism States that digoxin inhibits nakatpase , so na accumulates inside the cell which leads to blockade of NCX also n thereby ca also accumulates inside... Other mechanism States that digoxin inhibits nakatpase, so na accumulates inside the cell.. Since NCX is a na ca exchanger, so it can transport na n ca in both directions depending upon concentration,..in case of digoxin, na accumulates more inside, so NCX will throw this na out of cell in exchange of ca which will result in increase intracellular ca... I am going with the second mechanism however bcz NCX is an exchanger n it should work according to concentration gradient..
@@mrrock3162 is it possible that both Na & Ca concentration is higher inside,,,but Ca is going outside via NCX and Na is influxed??
👏🏻👏🏻👏🏻👍🏻❤️
Why do cell use sodium calcium exchanger pump because due to depolarization already there is much sodium inside the cell so why do cell increases sodium level?
👾💛
👍
Glad to see pharm D
In another video that i have watched,increasing sodium activates sodium calcium channel that leads to increasing calcium intracelluler,which one is legit?
The mechanism you are talking about is of cardiac action potential.
This one is different. It is effect of Digitalis on cardiac myocyte.
Why can't people explain it like this? Man, life would be so much easier. Thanks.
Please lecture at my uni haha
Anyone can get it.
Why is your Na/Ca exchanger in opposite direction? Pretty sure the MOA is the increased Na in the cell from digoxin causes increased activity of the Na/Ca to pump the Na out of the cell, which brings more Ca into the cell. It doesn't stop the Na/Ca from working...
I'm pretty sure that the NCLX allows 2 Na+ ions in (not 3) in exchange for 1 Ca ion
Shit!!
Thank you
Thanks
Thank u
Thank you
Thank you