EX: Fasting on Organ Regeneration, Fatness, Autophagy, & Bone Health
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- Опубліковано 29 тра 2019
- Fasting on Cancer, Stem Cells, and Immunity: • EX: Fasting on Cancer,...
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#fastmimickingdiet #fastmimicking #fasting
Thank you for discussing the effect of fasting on organs.Most people on here are focused on weight loss.I'm a tiny person that is fasting to strengthen my heart and kidneys.I actually need to be careful not to lose too much weight.
My pleasure, Jolisan. I appreciate you commenting. If you find it useful to others in your life, I’d appreciate it if you shared the content. I wish you the best with your fasting and organ health!
what is your ailment y u need to strengthen heart and kidneys? I too am small and have already lost almost 20lbs the last 4 months. having what seems to be systemic inflammation affecting my organ function so im unable to digest or absorb nutrients properly anymore. suddenly erupted on me 5 months ago. one day i was seemingly fine then the next i was not and have been fighting since 😞
I fast for health reasons, and you also save money 💰. Win win
@@troyrodgers9790oping you’re ok now as this was some time ago and I’ve just seen this video. No doubt long fasts help to reignite your body’s healing mechanisms and hoping you’ve got the help of a great holistic doctor and health coach.
@@troyrodgers9790= you may have a poor,weak ph in your stomach,so half an hour before you eat special meat you have to drink cider vinegar diluted in a glas of water,to increase the acidity of stomach to break the protein at that level already,then once the food arived into the gut,it will be more digestible without the inflamation over the gut.You may reduce your fiber intake,the fiber caused over some person the inflamation,standing too long time in the gut,anyway you try aplecider vinegar,and can try to consume sourkraut for you gut bacteria,the same natural yogurt helps.Succes😃🤚
Finally! Really interesting findings, thank you Nicolas for review of this study.
I really looking forward for another part!
Such a a great job!!!
Thanks, as always, SnakeY. You’re extremely kind and curious as a person - I deeply appreciate that about you.
Great presentation!! Thank you for your work!! I have fasted a lot throughout my life and know it has healed me significantly. I will subscribe to see the future videos you spoke about. I like your style and speaking so clear I was able to follow without having to go back over. God Bless your work!!
Thank you very much, terrieann; I've been really pleased to see so many people enjoying that video series. I appreciate the support!
I really enjoy your paper analyses and discussions. Thank You! Great Video!
I'm really glad, Chris. I put a lot of time into these Examine pieces, and they're fun to make, so I'm happy to hear you enjoy them!
Absolutely excellent! This is a well thought out analysis.
Thank you for the precious information, that's fantastic!
Nicolas, great input. Invaluable in restoring health. God bless you forever.
Thanks, Thomas!
Thank you, Nicolas!
I just stumbled on your Chanel.
Love it! This video is inspiring me to do fasting again. I am sixty, and didn’t wanted to loose the muscles 😁.
Well, 4 days of fasting!… starting tomorrow!!
Please keep on doing this vlog. It saved my health.
I still cover research - glad it helps, Martijn.
Thank you for the scientific paper discussion of fasting.
Love the west coast gangsta music in the background. I can just imagine a '64 bouncing up and down, bending a corner on 3 wheels.
Hahaha, I’ve since worked on my music choices, but I appreciate it, Sergio. :)
@@Physionic 🤣🤣 i felt like was about to play san andreas.
😂
Wow…packed with great information, many questions answered so thank you very much for this video!
Thank you, Eve.
Wow brilliant the human body is amazing 🥰 thankyou for sharing all your knowledge Nicolas ☺️
Could organ shrinkage and rapid regrowth be better explained by mostly glycogen loss and replacement than cell destruction and regrowth, which would probably take longer?
Potentially. However, if you look at the histological stains at 9:17 it appears like the nuclei of the cells are denser in 4 than 3, suggesting smaller, potentially new cells (Looking into the paper (Figure 1 O) they used an H&E stain, so the dark spots should be nuclei.). So this would suggest to me that this growth in mass could actually at least partially the result of rapid cell division.
Thankyou so much for this video. Amazing 😍
My pleasure, Liezel.
Watching your channel grow over the years has been an absolute treat
Thank you so much, Jeremy. It’s been a long journey, but ever forward we march.
And now at nearly 100k subs. 🎉
Props y'all brought it back as requested. Y'all are awesome. Go Blue Jays 💙
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Discussion/Conclusion: 12:47
Fasting on Brain Health: ua-cam.com/video/rDTdUNuQ-0s/v-deo.html
Fasting on Fasting on Cancer, Stem Cells, and Immunity: ua-cam.com/video/8RNvFvxFI2c/v-deo.html
Fasting on Lifespan and Healthspan: ua-cam.com/video/e9s--UX7C4Q/v-deo.html
Can you link the other 3 here, or put them into the video comments?
I loved the music in this video! Very original 😊
Thank you, Desiree.
Perhaps by now you have information on intermittent fasting ( OMAD ) and bone density ?? Thanks
Love the video! Have you studied Tryptase levels and what they mean?
Thank you, very interesting
My pleasure, Russell - Im glad I could help.
Thank you, I was worried about fasting!Now,not so much.
At the very least, observations look promising for treating connective tissue disorders with fasting regimens improving quality of collagen tissues. I could see refeeds using controlled amounts of highly accessible, or bioavailable, aminos being wonderful for enhancing collagen lattice and other connective tissues. I'd love to see the mechanism quantified.
Definitely, Jacob.
I'm currently doing a 7 day water fast, I've done a few before as well. I lift weights usually and continue to do so while doing these longer fast. It's just that the workouts are not as intense. I only go to stimulate the muscles to further prevent muscle tissue catabolism. The pituitary gland increases the amount of HGH produced to preserve muscles as well.
@RashanNejad the longest I've done was a 3 day hard dry fast. I'll probably attempt 7 days in the future. Thanks
@@MrRay8830Please, stop doing dry fast that exceed 24hours. Dehydration can cause a lot of toxicity to the body system.
Well done. Thanks
Thank you DD
A good one. Thanks 👍
No problem 👍
the organ regeneration is amazing!
Very interesting to see what you said there about scar tissue and fibrosis. I have myleofibrosis and have been feeling drawn to fasting...
Interesting, I'm a t1d with a continuous glucose monitor. I am profoundly interested in nutritional science, endocrinology and energy systems.
I have done many fasts 24-36 hours, the odd 72 but just finished a 5day water only. Much of your ascertions in mice studies I concur with myself.
After day 4 I found weakness in muscle and strength plus shortness of breath. No lack of energy or tiredness, hunger wasnt an issue tbh. At refeed day 5 I could have continued.
Most Interesting I found was Initially I felt that going over 4 days for me was perhaps detrimental to my muscle protein and catabolism of muscle BUT regrowth of muscle in the subsequent days after refeed concurs with the study and actually a substantial improvement in muscle strength over usual pre fast training (my exercise regime was unaffected by the fast)
Weight loss was 7lbs but the mirror suggests it was visceral, again suggest similarity to mice study.
It's difficult to find extended fasts in humans and more so in diabetics and people of my age (over 50). So I did it myself. Very very glad I did.
You'll have to keep up with Physionic, then. I'm releasing a lot more fasting videos in the next 2 months or so. I'm glad some of your outcomes have been consistent with this data, even as an n=1 situation. Thanks for chiming in, Jason's Family & Friends.
@@Physionic tbh human biology to others is similar but results are so different not only from one another but ones self. People use that "we are all different" as an answer to cognitive dissonance and in fasting there is plenty...nobody wants to conceive not eating, especially in todays tasty treats world. N1 is my best study for me lol
If I do 1 3-4 day fast I actually get a little stronger in my workout before I break the fast. Probably adrenaline. Yeah I feel the muscle growing when I eat afterwards, though, so I think your total muscle is going to go up this way!
A video on bone mass and IF would be helpful and rarely covered. Thanks. Hard to find truly objective unbiased sources. Hopefully you’ll stay this way. I stopped watching others who didn’t. New subb.
Love the tunes, lol, this video is flame
Moin :) aufschlussreiches Video! Gut gemacht. ☺
Hast du eigentlich dieses Wasserstoffwasser aus einem Wasserionisierer schon mal recherchiert?
Dieses Getränk ist wirklich mega genial! :)
Wir trinken es vor allem arbeiten !! 🌱
Nein, habe ich nicht. Danke, Meister.
I know this is an old video but I just stumbled upon you channel. I also just watched a newer video regarding how keto affects the heart. So I have following questions: 1. Does fasting also supposedly damage the heart? Fasts are time restricted whereas a diet is a constant thing but still… 2. What happens to the heart when fasting? Does it also shrink (and regenerate)? From I have read/watched it is one of the organs that almost don’t regenerate at all. TIA
Not true the heart does indeed regenerate when autophagy and mitophagy are induced especially via fasting. I suggest you watch Dr. Pradip Jamnadas videos on fasting and autophagy he is a Cardiologist.
Would be great to know what happened to the lifespan of these mice and how long did they subjected them to Fast Mimicking Cycling?
Thanks!
Thank you - just saw this.
Episode should be called Organ and Bone Regeneration, Fatness and Autophagy after Cycling between Severe Calorie Restricted Diet or Fast Mimicking Diet and Refeeding which is strictly speaking still not Fasting in a true sense on Water which has no Food to impact extra Calories, Glucose Rising, Insulin Rising. Would be interesting to know the number of days for people (60-100 Years life) versus mice (2-13? Years) which would have this incredible Autophagy effect.
I love your videos! Thanks a lot! Based on your research what is the best way to reduce subcutaneous fat while maintaining or increasing muscle mass, being someone who lift weights regularly?
Not fasting, haha. You would want to eat multiple times a day with protein rich foods, while maintaining a steady caloric deficit.
maximise the fasted state, nice walk, maximise the fed state, either train fasted or a couple of meals with cold/retrograded white rice + fish/lean meats + half an avo, 3-4 hours apart, train, smash food then organic cottage cheese or casein + berries before bed, 4~ meals a day easy as you like and most importantly work a labour job, freight handling, construction, something like that will keep you fit whilst being able to keep making gains
@@Physionic
Belated comment but newer ZOE video (w/nutrition researcher) on protein and newer studies on protein and muscle actually don’t support the idea of eating protein for muscle gain. A 2023 study on sarcopenia showed the opposite. Maybe good video subject.
@@jmc8076 Dumbest comment ever on protein and muscle gain
It sounds like fasting for 4 days followed by 3 days of refeeding is optimal for organ “shrinking/growing” (wasn’t sure how to word the refeed stem cell phenomenon 😊).
Edit : sorry about asking questions on old videos
Seems evolutionarily sensible for our bodies to boost stem cells at refeeding after significant (deep) fasting. That would be a cool mechanism to know (more) about.
Found one related video headed in that direction:
EX: Fasting on Cancer, Stem Cells, and Immunity
//ua-cam.com/video/8RNvFvxFI2c/v-deo.html
I've done prolonged water fasts for as long as 2 weeks and noticed that my strength remains constant when I exercise during the fast while my muscles seem denser likely because they are. Doctors often warn about losing muscle tissue when doing a water fast. They may not know and repeat what seems to make sense.
Those changes make lots of sense in lab animals
Thanks Nicholas for an interesting video. 4 days extrapolated to humans would be about about 15 days.
I have attempted to maximize Autophagy and noticed that feast and famine has positive outcomes. Have the cells only in Grow Mode or Repair Mode. Intentionally gained 30 pound last August to October (Vitamin D???) and in mid January started to lose it all, and then some. My right shoulder, top of my head, and then neck, down the back is now shedding massive amounts of skin. Not pretty, but the new cells seem baby fresh, and because they are staring to tan, gaining pigment, they can not be scar tissue.
Interesting! What type of fasting periods are you doing in the 'famine' stage?
Any research on autophagy and CKD?
Do you know the duration (days / hours) required for a water fast for humans to experience a non-trivial loss of visceral fat?
So, I have minimal knowledge about epigenetic processes. One of the main concepts that I remember is that it is sensitive to environmental factors. I now wonder if individual cells within the same tissue have variances in their epigenetic settings. If so, I surmise that fasting may result in certain cells surviving based on epigenetic supremacy while others die off. It would be akin to natural selection on a microscopic scale. This would contribute to that rapid regrowth you see during refeeding.
In a sense, the modern environment of plentiful food (much of which is not healthful) creates a low stress environment at the microbiological level which sustains weaker epigenetic traits.
A macro scale analogy would be the domestication of the grey wolf. Dogs regress, genetically, due to the more comfortable existence (generally speaking) they have been accustomed to coevolving with humans.
Ultimately, stress builds strength by killing off the weak to make room for the strong, but humans stopped evolving (progressively) because physical evolution is driven by limited resources in a wild environment that pits trait against trait until one fails, and the other propagates.
Humans have entered a new kind of evolution that is mnemtic instead of genetic because the physical environment that drove genetic evolution has been conquered with intellect. The wild environment that drives mnemetic evolution is the free market.
Ideas that are free to compete with each other creates higher quality and lower costs. Environments where one idea is artificially sustained through subsidy or regulation negates the inherent value of competitive struggle, and better ideas are unable to supplant older and obsolete ideas.
Anyway. Sorry I went all over the place there. Thanks for the video.
+1 Like
+1 Subscribe
And I will be sharing.
how many days are recommended for the organ registration benefits?
My colon was surgically removed (colitis) over 30 years ago. Is it possible to regenerate a new one through fasting?
How much of organ rebound is water weight?
is the autophagy making organs smaller
Any mention of FMD / fasting messing up metabolism?
When does fasting start to catabolise lean tissue
Does autophagy only occur during a dry fast? Or can it also occur during a water fast? I only do water fasting...I drink water during my fast.
Hey Ellen, autophagy happens all the time, even without fasting. However, all forms of fasting increase its activity.
Does body organs shrink in first 24hrs of water fasting. Will it be same in dry fasting too.
Was this Valter Longo's study?
hehehhe, cool dancing cell 😊 love the information you provide and the way you re doing it, nice done. Thank you!
What is the 4 day equivalent in humans, since mouse metabolism is so much faster?
I wonder how this would compare to eating a small low carb meal of 500 calories in humans, or to doing some 'fat fasting'. Too bad they don't have more human studies with fasting-like diets.
Schön das du da bist :) spannende Erklärung! Danke! 🌱
Hast du schon mal zufällig vielleicht das Jungbrunnenwasser aus einem Wasserionisierer jemals kennenlernen können?
Dieses Wasser ist echt beeindruckend! ☘
und Wasserstoff kann helfen Schmerzen zu reduzieren
I haven't looked into it, in what ways does it help alleviate ailments?
Timestamps would help your nice videos! 🙂
Hi, I had a hysterectomy in 09, after seeing several specialist i was told the
surgery was not only barbaric and unnecessary.
After 4 surgeries to try to correct the mistakes, im riddled with scar tissue internally, any suggestions?
Thank you.
Does this include brain organ?
"fastmimicking"
I've probably improved my health and fitness knowledge enormously since subscribing to this channel.
Thank you, Bradley - that's really kind of you.
What about hair loss? I'm a 43 year old male who has been intermittent fasting for years so hard to tell the wood through the trees, but I've been experiencing unusual heavy hair fall (mild Telogen Effluvium). Any chance fasting is causing it?
Machiet --Yes,by fasting,the brain reduced the some functions of the body,those that are considered by the brain as nonessentiales,to survival,for the body,example hair growt mentenance or skin management,or periferic temperature,etc.who are not realy prime important for survival as heart,other organs,muscle,bones.But hair los is compensate by your general healt,and special by your glands and organs,who are more rejuvenated,and regenerated,i think that it worst.Try moderate keto diet coming along with fasting. Success.Hope it helps.😃👍
@@jakobdekim6458 great reply 🙂. For the record, i weight-train so make sure to get my calories so don't think it's a nutritional deficiency thing. Perhaps eating breakfast at midday everyday is still too much? 🤔
Get a vitamin d with k2 supplement. D+k2 has massive improvement in hair health.
Also be sure your basic electrolytes are met every day, sodium,potassium, magnesium, calcium, etc along with water.
@@Vincent_Beers doing all that already 💁. Currently experimenting with omitting creatine. Fingers 🤞
G-funk background music?
I'm thinking metal core next video...
@@Physionic Metal dub step. Make it happen.
Nicholas, I do prolong fasting while working out. Do you know of any studies that need humans?
I would contact Dr. Longo, since he does the research on the topic. I imagine he has a website.
@Anonymous Panacea I do regular fasted cardiovascular, and strength training. It IS a long and difficult transition for the body to adjust to metabolically use fat for fuel, but it can work. I just finished a 2 day backpacking trip in a fasted state, and I had energy for the whole time, over some pretty strenuous terrain. So I think for endurance/stamina/cardiovascular activities its efficacy is proven for me. I also do strongman training, and this is where I'm not convinced that you can perform as well in sheer strength and power exercises, using fat for fuel vs carbs. So far I am doing ok, but not rocking it like I did when I was a carb eater.
Can fasting help me heal a damaged tendon?
Yep. And torn muscles. I've tested it.
Reason for not showing that fasting helps with fat loss that we want to lose in order to get ripped, its not long enough fast, showing that it helps with fat around organs, its because thats where body starts to look for calories once that is used then goes into fat that is around your body and finally belly fat, its long process but thats how it works
Body does not use muscles for energy not until you have enough fat around you.
Liver does well with fasting
What about kidneys?
It showed size increase.
Bad or good?gfr up or down?
Some timestamps would have been nice tbh....
Every time I heard “fast mimicking” I imagined Task Master and heightened mirror neurons.
Monkey See. Monkey Do. SSJ4.
I just want to know how to lose weight, but get all of the essential nutrients. Can humans maintain excellent health on a whole food plant based diet? And what about water? What is the ideal diet for humans? I'm so confused.
Yes, they can. Water isn't too difficult - just look at your pee and make sure it is light yellow. Ideal diet for humans is the one that is most sustainable for you, so there are many choices.
Just came off of a 5-day fast ... 😏👌
fasting saved my kidneys
What about dry fasting (no food or water)? I did DF for 3 days (1 day DF = 3 days WF supposedly) but wondering if the few Russian studies on this is inconclusive
Yep, fasting has no benefit in terms of health to simple caloric restriction.
*****
Scientist high five.
Congrats! You were clear to my Darwinian layman monkey brain.
This is very informative, but the horrendous background music is too distracting
Noted. Thanks for the feedback.
17:00
Regeneration seems like a good idea
damn u looked like a baby 4 years ago....
I don’t really like this guy, he’s really boring as hell and he is monotone
But
He has good logic and although his presentation could be better: i can trust what he says
Hahaha, I appreciate the directness, Barry. I admit, I could me more lively in my older videos. Thanks for stopping by.
@@Physionic no , I love your unique way of talking and your personality , don’t change ever , you don’t need to be more lively we are not having a party