It takes 3.3 half lives to reach 90% of the steady state, so by that formula it will take around 4.95 hrs to cross 90%, option d is also correct in first ques.
I wish I discovered all your videos a long time ago, now I'm close to my exam I hope I'll have time to thru most of them... You're incredible, I can really see a difference in my Uworld scores in subjects I had trouble with.
You have no idea how your videos helped me and made it possible for me to study for my exam, I am a family medicine specialist in my country, I came 2 years ago and I was surprised that I have to pass all these exams to be able to work as a doctor in the USA, step one was so difficult for me. I graduated in 2002 and I no longer remember most of the basics so I just gave up, but now I am back studding with passion I really appreciate your effort thank you so much
Nisreen, Keep studying hard...STEP 1 is biggest hurdle... I'm glad you found the videos helpful. Stay STRONG, Stay positive... Thank you for taking time to comment.
I usually never comment on UA-cam videos. This is probably my first time. You are doing a great job Dr. Neil!! Covering all my weak areas☺️ soo thankful!! God bless you always😇
Hey Dr Randy, by any chance do U have a video of beta blocker tracings ( those crazy graphs asking what was drug X or the one That compares Epi, Nepi, isopropanol etc) if not, can u make one please with NBME questions? I learn so Many things from u because of your questions. Please and thanks for The awesome videos
Dear Randy Neil MD I think you will never respond to my comment but I think you are one of the most powerful teacher your make difficult concept easy to understand like Hussain Sattar does.I respect you and want to meet you in real life thank you vry much.
You Have been doing a wonderful job on Behavioral Science Reviewing. Now following your on pharmacology. It makes my reviewing both subjects more interesting/fun/quickly. Highly appreciate!
The vancomycin example is not correct because half-life is 6 hours while the frequency of dosing is 12 hours. So two half-lifes occur with one dose given. If 1000mg is given, 12 hours later, 250mg is present (2 half-lives have occurred), then another 1000mg is given (1250mg goes through two half lives), it will be 312.5 -> Another 1000 would be 1312.5, and after two half-lives, it will be 328.15. It would take much more than 36 hours to reach steady state at this dosing frequency. Please correct me if I'm wrong here, but 24 hours (option D) only holds true if the dosing frequency and half-life are the same duration.
@@RandyNeilMD doctor had my exam yesterday and it it was heavily focused on ethics, biology experiments questions and respiratory system. I don’t know if that could help with future videos
Awesome vids! Quick clarifying question ...I remember hearing that Vd technically IS effected by liver disease, since albumin can alter drug binding, so liver failure can produce higher Vd. Or does it depend on medication?
PLEASE make a video on all the fractions and basic math stuff that can save time on the day of the exam. Some of us suck at math...asking for a friend...lmao
@@RandyNeilMD Dr Neil please update more videos on pharmacology... In which I am not confident enough to do questions... Eagerly waiting for next update...😊😊😊😊
Hiiii… thanks so much Neil… ur videos r superb… can u make video on ANS and most of pharma? It’s just my suggestion….and can u post the pdf of pharma in ur website ….
i am currrently preparing for my step 1 exam . your videos are alot to me . infact a very different approach . please make more videos with must know concepts along with classic questions .
well the drug is administered every 12hrs and the half life is 6 hours so but the time you load more medication your initial dose would have gone to 25% not 50%
Thanks for the video, Doc! But I am unclear on loading dose and its relation to liver impairment. Wont it be affected if synthetic liver function is affected since Vd( which is affected by albumin levels) is one of the variables for calculating it?
Dr Neil , volume of distribution is affected by the amount of proteins in the body ( liver and kidney disease increase Vd) as mentioned in your previous videos. So my question is why is is not affecting our loading dose say if a person has kidney dysfunction ?
Місяць тому
first question reasoning only applies to First order kinetics?
u said loading dose doesnt change with liver and kidney disease. As loading dose depend on volume of distribution,which changes with protein concentration.so loading dose should theoratically change with disease
Your videos amazing but I beg your pardon if you can answer me about Vd in loading dose,is it affected in liver disease because of protein affected as you mentioned in 1st pharm video,will this affect loading does or not?
I dont understand how loading dose isnt affected by liver disease or lets say nephrotic syndrome- both cases of decreased plasma protein. Wouldn't a drug that is highly protein-bound have its Vd be affected by cases of low plasma protein, therefore, affecting the loading dose? Love the videos btw. I saw the old biostats videos and was over the moon when I found out you were back!
I wish I could explain your question better... I only memorize/present in the simplistic format that I hope can get us through STEP 1... If I am incorrect in anything, please let me know so we can help everyone watching.
@@RandyNeilMD No worries Dr.Neil, I know your correct as I saw a question which presented a similar concept. Was wondering why is all but Imma just accept it and put it with the rest of 5000 facts for step 1 haha. Cheers!!
STEP 1 tomorrow! And I am binge watching your videos! THANK YOU SO MUCH!
Ala, Hope it went well. Keep me posted.
It takes 3.3 half lives to reach 90% of the steady state, so by that formula it will take around 4.95 hrs to cross 90%, option d is also correct in first ques.
exactly
Dr Randy Neil you are an Angel not just an Angel i would say Archangel for all of us .waiting for more n more videos :)
Chetan, I always appreciate you taking time to leave a comment Thank you.
The series is full of information and now basic pharma is much easier and interesting. I really appreciate you.
Thank you Musawair, Keep studying HARD and MOVING FORWARD!!
Couldn't have said it better myself! Thank you big time!
I think im going to cry! thank you Dr Randy Neil!
Thank you Celene... I guess... Feel free to cry after you get your MATCH notice...
I wish I discovered all your videos a long time ago, now I'm close to my exam I hope I'll have time to thru most of them... You're incredible, I can really see a difference in my Uworld scores in subjects I had trouble with.
Hors, I am glad to hear you are gaining confidence before your exam. FINISH STRONG!!
@@RandyNeilMD Thank you!! ☺️
your videos are more like come study with me than lectures, you have done an amazing work
love you from Syria
You have no idea how your videos helped me and made it possible for me to study for my exam, I am a family medicine specialist in my country, I came 2 years ago and I was surprised that I have to pass all these exams to be able to work as a doctor in the USA, step one was so difficult for me. I graduated in 2002 and I no longer remember most of the basics so I just gave up, but now I am back studding with passion
I really appreciate your effort thank you so much
Nisreen, Keep studying hard...STEP 1 is biggest hurdle... I'm glad you found the videos helpful. Stay STRONG, Stay positive... Thank you for taking time to comment.
@@RandyNeilMD thank you so much
I usually never comment on UA-cam videos. This is probably my first time. You are doing a great job Dr. Neil!! Covering all my weak areas☺️ soo thankful!! God bless you always😇
Kimani, I am humbled by your comment. I do appreciate the feedback. let me know of any weak areas and if I have the material... I will post.
Randy Neil, MD maybe Hardy Weinberg problems😁
Thanks a lot😇
Dr. Neil, I literally have your videos on repeat when I’m on UA-cam.
How do you get so good at what you do?? ❤️
Jolie, We just may have the cure for insomnia... be careful. Don't watch too many at once.
Thank you for the comment. I am humbled.
Dr. Neil, you’re funny 😆
And always so inspiring ❣️
Thank you so much Dr. Neil
Dr.Neil ,I just started to watch your videos and can say you have super power in teaching pharm,can't thank you enough
Thank you Pardis for the kind words. I'm glad the video was helpful.
there is no enough words to thank you for all that effort , really simple ways
Thank you Yehia. Glad it was helpful.
Best videos on pharmacokinetics
Thank you Akshay.
Hey Dr Randy, by any chance do U have a video of beta blocker tracings ( those crazy graphs asking what was drug X or the one
That compares Epi, Nepi, isopropanol etc) if not, can u make one please with NBME questions? I learn so
Many things from u because of your questions. Please and thanks for
The awesome videos
Thank you so much for all the videos and the explanations Dr. Neil. They've been very helpful. God Bless you
Marisabel, Thank you for commenting.
I can’t thank you enough sir, you helpd me ALOT!
Yousif, As long as you tell me it is helping... I will continue making...
Thank you so much Dr. Neil!
God bless you!
You are most welcome Nimra.
SO grateful for these videos Dr Neil !
You are most welcome.
Dear Randy Neil MD I think you will never respond to my comment but I think you are one of the most powerful teacher your make difficult concept easy to understand like Hussain Sattar does.I respect you and want to meet you in real life thank you vry much.
Thank you for the kind comment... Yes, we will cross paths one day. Until that time... KEEP STUDYING HARD!!
Your systematic method is amazing.
Thank you!!
your method of teaching is great because its all problem based!!!!
Teach towards the EXAM... I agree. Glad it was helpful.
You Have been doing a wonderful job on Behavioral Science Reviewing. Now following your on pharmacology. It makes my reviewing both subjects more interesting/fun/quickly. Highly appreciate!
Princess Z, Thank you for leaving a comment. I always appreciate you giving feedback.
Wouldnt the minimum of hours needed to hit 90 percent be 5 hrs instead of 6 hrs??
yes
This doc is the best for usmle hands down man 👋👋👏
Thank you for the kind words
I was very much worried about pharmacology for step 1 prep...U made all these so much palatable...Thank you so much for all that you do.
It's very doable... :)
You're an amazing teacher 🙏🙏🙏
Tej, Thank you for commenting. Keep studying HARD!!
Was lovely. Reinforced all concepts nicely . Thank You.
Thank you for taking time to comment.
You are amazing!! God bless you
Thanks for the kind words Ahmad
The vancomycin example is not correct because half-life is 6 hours while the frequency of dosing is 12 hours. So two half-lifes occur with one dose given. If 1000mg is given, 12 hours later, 250mg is present (2 half-lives have occurred), then another 1000mg is given (1250mg goes through two half lives), it will be 312.5 -> Another 1000 would be 1312.5, and after two half-lives, it will be 328.15. It would take much more than 36 hours to reach steady state at this dosing frequency.
Please correct me if I'm wrong here, but 24 hours (option D) only holds true if the dosing frequency and half-life are the same duration.
Exam is tomorrow and watching your videos to get a quick review
CRUSH IT!!!
@@RandyNeilMD I hope to do so sir
@@RandyNeilMD doctor had my exam yesterday and it it was heavily focused on ethics, biology experiments questions and respiratory system. I don’t know if that could help with future videos
You make our life easy🥹 Thank you
You are most welcome Deepa
Sir thanks a lot for making these tricky topics much clear ad easier for us. More power to you.
Moseeb, You are most welcome.
Sir, you are requested to add content about ethics, as exam is having more and more questions on ethics.
Thanks in anticipation.
Please keep making these videos....much appreciated.
Abhishek, Thank you for taking time to comment.
This is an art
Thank you so much ❤️
Amir, You are most welcome.
Great job keep going.
Thanke you
Thank you Haitham, Glad it was helpful.
Just awesome.. Thank you Doc
Lukash, Glad it was helpful.
@@RandyNeilMD Its great to learn from your channel. Hope you will keep adding new videos... Thank you- From Nepal
Keep making more videos please
So helpful 💯💯💯
I will try.... thank you for taking time to comment.
@@RandyNeilMD Sir I was hoping for videos on Autonomic nervous system in pharma series 🙊 like for last minute revision before exam if possible
Love your videos. They are so helpful
Berkie, Glad they are helpful.
Thanks for this
Yosira, You are most welcome. Keep studying HARD!!
Outstanding teacher
Thank you Salam
Awesome vids! Quick clarifying question ...I remember hearing that Vd technically IS effected by liver disease, since albumin can alter drug binding, so liver failure can produce higher Vd. Or does it depend on medication?
Was reading comments to find this. 💯
PLEASE make a video on all the fractions and basic math stuff that can save time on the day of the exam. Some of us suck at math...asking for a friend...lmao
love these videos so much.
Reina, I am glad they are helpful.
thank you dr. neil
Rasish, You are most welcome.
Great Video Dr Randy
Could you also upload a copy of your Laminated Notes ??
It is really compact and high yeild.
I will upload as soon as the website guy completes the website update...
You are amazing, thank you so much!
You are most welcome.
Hello Sir thank you so much 😊. Sir can you please make vedios on substance abuse. Like downers, uppers and hallucinants. Thanks 👍
I think I touched on that with the "drugs of abuse" video... but let me know if I didn't cover it. I appreciate your feedback.
Omg really worried about pharmacology but simply well explained thank you Dr Neil... Hope to watch more videos..😊😊
Rewathy, You are most welcome.
@@RandyNeilMD Dr Neil please update more videos on pharmacology... In which I am not confident enough to do questions... Eagerly waiting for next update...😊😊😊😊
These videos are so helpful. You are an amazing teacher!
Thank you Racquille
👍🏼👍🏼👍🏼 ...awsm . Phenomenal .. thanks for your time and effort
USMLE_Goal, Thank you for the comment. Glad it was helpful.
Hiiii… thanks so much Neil… ur videos r superb… can u make video on ANS and most of pharma? It’s just my suggestion….and can u post the pdf of pharma in ur website ….
i am currrently preparing for my step 1 exam . your videos are alot to me . infact a very different approach . please make more videos with must know concepts along with classic questions .
Tarfa, As long as the feedback says it helps. I will continue to try and help...
u said loading dose can be given without any taking care of liver kidney problem etc but vd changes when we have problem with liver kidney etc
Was really hoping to see some zero-order kinetic questions
I love you randy Neil
:)
well the drug is administered every 12hrs and the half life is 6 hours so but the time you load more medication your initial dose would have gone to 25% not 50%
Thanks for the video, Doc! But I am unclear on loading dose and its relation to liver impairment. Wont it be affected if synthetic liver function is affected since Vd( which is affected by albumin levels) is one of the variables for calculating it?
Thanks again!!!
You are welcome.
Dr Neil , volume of distribution is affected by the amount of proteins in the body ( liver and kidney disease increase Vd) as mentioned in your previous videos. So my question is why is is not affecting our loading dose say if a person has kidney dysfunction ?
first question reasoning only applies to First order kinetics?
if the Q at 17:30 asked about the maintenance dose.. then what would be the answer?
you are perfect!!!
Hoang, Thank you!
u said loading dose doesnt change with liver and kidney disease. As loading dose depend on volume of distribution,which changes with protein concentration.so loading dose should theoratically change with disease
Not sure if I mis-spoke but loading dose (based on formula) is independent of impairment... That would be the take-home concept. I hope this helps.
Your videos amazing but I beg your pardon if you can answer me about Vd in loading dose,is it affected in liver disease because of protein affected as you mentioned in 1st pharm video,will this affect loading does or not?
thankyouuu
You are most welcome.
Where can I get those pharma notes, not available on the website? :/
God bless u Sir!!!
Umair, Thank you for the feedback.
🎉🎉
Thanks a tonnnn 🙏🙏🙏
Sangay, Keep studying HARD... Always appreciate your comment.
Doctor please how can i register with you? Please sir i need to register
I dont understand how loading dose isnt affected by liver disease or lets say nephrotic syndrome- both cases of decreased plasma protein. Wouldn't a drug that is highly protein-bound have its Vd be affected by cases of low plasma protein, therefore, affecting the loading dose?
Love the videos btw. I saw the old biostats videos and was over the moon when I found out you were back!
I wish I could explain your question better... I only memorize/present in the simplistic format that I hope can get us through STEP 1... If I am incorrect in anything, please let me know so we can help everyone watching.
@@RandyNeilMD No worries Dr.Neil, I know your correct as I saw a question which presented a similar concept. Was wondering why is all but Imma just accept it and put it with the rest of 5000 facts for step 1 haha. Cheers!!
Thanks! ❤️💕
You are most welcome
👏👏👏👏👏👏👏
Thanks for the feedback... :)
👏👏👏👏
Mish, You are welcome.
yes
Appreciate the "yes"... Thanks