Metabolism | Fatty Acid Oxidation: Part 2
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- Опубліковано 18 чер 2017
- Official Ninja Nerd Website: ninjanerd.org
You can find the NOTES and ILLUSTRATIONS for this lecture on our website at:
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@1:52 ATP is Broken into AMP and Pi,
as a result
@13:52 We subtract 2 ATP
Energy balance when 1 NADH yields 3 ATP and 1 FADH2 yields 2 ATP, the Net Gain from 1 Palmitoleic Acid (16C) molecule is 129 ATP
and
Energy balance when 1 NADH yields 2,5 ATP and 1 FADH2 yields 1,5 ATP, the Net Gain from 1 Palmitoleic Acid (16C) molecule is 106 ATP
Ninja Nerds!
In this lecture Professor Zach Murphy will present on part 2 of this two part series on fatty acid oxidation. During this lecture we will continue our discussion on fatty acid oxidation and conclude this mini series, helping you to understand this complex process. We hope you enjoy this lecture and be sure to support us below!
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Can't even imagine my grade in mbbs without ur lectures
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In the activation step, ATP is converted into AMP not ADP. That's why when calculating the energetics you've to subtract 2 ATPs from the final tally. Then you would either get 129 or 106 ATPs as the final amount.
106 is more logical . 1 FADH2 = 1.5 ATP & 1NADH = 2.5 ATP
True.. The NET is 129 or 106(if we get so particular)
How is it 2 ATP , wasn't the pyrophosphate taken from 1 ATP ??
@@someone-yj2im it's because ATP(tri phosphate) is converted to AMP(Mono phosphate) and NOT ADP ( di phosphate) in the activation step. So, we consider it as 2 molecules of ATP.
@@abhinavshankar414
Ohh so we consider that for each phosphoanhydride bond broken is like using 1 ATP.
I got it now, thank you so much!
today i had my metabolism test results- i got 70% - im soooo happy. Thank You!
I can't express in words how much I love you! Makes so much sense and your explanations are so logical!
+Simonel awesome I'm so happy we were able to help!
complete oxidation of 16 carbon fatty acid yield total ATP (108) then 2 ATP were used in activation of fatty acid (-2) so net ATP is 106.....,,;refrence book ; satyanarayana medical biochemistry book@ninja nerd
I had biochemistry exam today, i watched this video and the one of ETC the previous night, lo and behold, most of the things he explained came out in the exams and i answered them with ease,thank you zack, you're a saviour ❤
People like me would read some research here and there, but these basics require drilling through numerous med text books.
You offering it with awesome concise explanation and simple visuals is a very generous and great service for lots of people. Especially those seeking knowledge in the sea of confusing guidelines and information backed and funded by different contradicting parties.
Your explanation of odd-chain FA is so good! Simplified it immediately. Also awesome that you sprinkle medical correlations throughout!
You make an impact on the lives of the students BY YOUR LECTURE VIDEOS JUST THANX
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@@gabrielmensah6113 Could always tag him in a few years.
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Also another mistake in the first reaction ATP will be broken to AMP and 2 Pi in two steps ATP to AMP and PPi then PPi will be broken by the same enzyme to get the reaction completed, so effectively it is like using 2 ATP not one ATP because you broke the hell out of it and now you will need twice the energy of phosphate bond to produce it roughly -60k Joule/mole
Oh, no wonder my textbook says 106 ATP, thanks for pointing that out.
the net = 129 ATP as written in lippincott
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thank you for your great videos, they helped me to get more grades .... but I took in my lecture and I found on other sources that we will minus 2 ATP for FA activation and the total net energy will be 129 ATP ??
+Heba Sayed yes you are correct it requires 2 ATP to activate the fatty acid before transporting into mitochondria.
I learned the same thing. 2 ATP for activation
yes we get total 129 ATPs. Dear Sir Zack you are splendid thank you for your vedioes.STAT BLESSED.
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Amazing videos and reviews of such complex topics. Would it be possible if you can add in the future also some words for the oxidation of unsaturated fatty acids?
good contents. Reminds me of how Lorenzo's oil was made.
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Amazing Explanation
Almost as good as Dr Najeeb
Hi! Thankyou for the amazing lectures.
Just wanted to know that when will you post beta oxidation of unsaturated fatty acids and alternative pathways of fatty acid oxidation including omega and alpha oxidation.
Btw keep going , you are doing a great job .
The fatty acid synthesis mnemonic AC RDR (A for attachment of both acetyl and malonyl coAs, C for their condensation, R for their reduction, D for their Dehydration and R for reduction again) Fatty acid oxidation follows a LITERAL reverse of this mnemonic from the back ie OHOT as well as the product names in reverse! YOU ARE WELCOME
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wouldn't you subtract -2ATP from the net total because 1ATP is utilized for the free fatty acid activation and 1ATP is utilized for the glycerol activation?
Just a big fan ❤❤of you and your lectures,Sir.
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Just a heads up, when you draw a fatty acyl CoA, the CoA is connected to the carbonyl C atom via the -S- bond.
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Ps, can you add the reaction for odd Fatty acid chain ?
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From University of Nigeria Enugu.
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Oommgg
I remember it as O HOT as well
And I also remember the first oxidation with the F so it’s Fad dependent !
I’m happy u do that too 😂!!❤️❤️❤️❤️❤️❤️
Edit : I started this lecture and commented the above comment.. when I ended it now and went to the comments I found my this comment 2 hours ago 😅😅 when the lecture is about 40 min😅😅 .. I went and had a Nescafé and had a break as well through the lecture 😂💙
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However i would like to request you to please make a video on glyoxylate cycle. It will be really helpful sir
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