Vitamin D and the Immune system
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- Опубліковано 5 чер 2024
- Vitamin D and the immune system work together. You might be surprised that vitamin D can boost and suppress the immune system. Vitamin D can boost primitive defenses of macrophages (Cathlecidin, LL-37, and Beta Defensins. However it reduces classic inflammatory cytokines like IL-1beta, Il-6, and TNF-a. Vitamin D also suppresses the adaptive immune system, B and T cells. This means that high levels of vitamin D (10,000 IU) can be prescribed by a doctor to treat autoimmune diseases like lupus, MS, and psoriasis.
Sources:
www.ncbi.nlm.nih.gov/pmc/arti...
www.ncbi.nlm.nih.gov/pmc/arti...
www.ncbi.nlm.nih.gov/pmc/arti...
pubmed.ncbi.nlm.nih.gov/8394351/ - Наука та технологія
This video is pure gold. Thanks Dr to dedicate your time to teach us these valuable concepts.
Great video, someone told me that when taking vitamin D you also need vitamin K2 to stop the calcium deposits on the inside of blood vessels 👍
correct make sure you're taking D3. K2 helps D3 absorb into your system completely.
Take natto for K2. Its sold in Asian stores
even better, Thorne has a Vit D3 + K2 all-in-one liquid drop with 600 servings. been taking it for months now
True.
Everyone should take K2, regardless of D supplementation status. D simply increases the calcium uptake from food; it doesn't inherently 'try' to calcify tissue. Eating a few Tums a day probably does more to increase calcium than even a large daily dose of D3.
stunning presentation - intriguing observations - thanks
Wow! Wonderful presentation 👏👏👏.
thank you sooo much for your work and kind sharing your precious knowledge!!!
I like the drawing, with the description over it. And your giant brain!♥️🧠
I really appreciate your diagrams. Thank you.
I think that you are very clever, I have liked and I have subscribed.
LOve your videos.....Thank You!
Great and easy to understand explanation. Are you familiar with the research PhD. Bruce Hollis has done on the dosage of Vitamin D? He recommends higher doses and has even explained how researchers at Washington University in the 1970’s got the dosage wrong by a factor of 10.
Was wondering, as a video request, can you make a video on learning the immune system and all the cells and pathophysiology involved for people
starting out, I'm a 1st year med student and kinda struggling and you seem to explain things in such a simple way, especially with the diagrams.
Very interesting, I wish this info lasted more than a few minutes in my memory banks. Thank you
Great information, thank you!
*Timestamps:*
0:01 Intro
0:23 Vitamin D = 1,25 dihydroxy
(⁉️ I don't like this at all! You should differentiate between D3, its passiv form 25(OH)D3 and its active form 1,25(OH)D3 )
0:49 Classic Mechanism
1:52 Immune System
1:58 Macrophage is an inate immune cell, VDR
2:26
3:17 (⁉️What about the sun?)
3:23 It's a Hormone
3:49 it can boost and supress macrophages
4:06 cytokines
8:14 Cathelcidin, LL-37, Beta-Defensin
9:55
11:45 T-Cells and B-Cells
At (rachitism ) rickets low muscular tonus are seen.
If vitD enhance basal muscular tonus, theoreticaly , IT enhance thermogenesis especially in sleep.
If SARS COV2 better replicate at low mucoseal temperature,(see at TWiV Nr 659 at min29 when Christian Drosten indicate that a year ago) high level of vitD can , theoreticaly, prevent high SARS COV2 replication.I presume.
0:23 - She does this later in the video
3:17 - Even the layman knows Vit D3 is created via UV-B irradiation of exposed skin; however, in the context of this video (simplicity) that would then lead on to how cholesterol present in the skin (7-dehydrocholesterol) is photolyzed, etc. If someone with no knowledge of what a hydroxyl group even is were to stumble upon this video and then hear her go on about the aforementioned points, the message would go right over their head.
Context is everything.
🙏🏾 thanks for sharing your knowledge🙏🏾
Glad it was helpful!
Hi Professor 👋. Always amazing
Thank you both for your efforts in explaning all the details!
Learning something every time.
Thanks Doc 👍.can you more more videos on how vitamins affect the immune system ?
I am completely impressed by this outstanding video. You show great passion and share your vast knowledge in easy to understand language.
You are a blessing to humanity and the world is a better place with people like you in it.
Wishing you every success and God's eternal blessings.
Thank you!
Thank you so much! Comments like these mean a lot to me.
Thanks! You are good teacher.
Thank you
So nice and interesting explanation, thank you very much 👍🏼❤️
So far the best video about vitamin d. Thank you
perfect explanation thankyou
Great video. Thank you 💜
Nice information
Thanks! That's very helpful!
great video!
Interesting video..this is late reply can you provide information or a link to beta defensins given as a antibiotic
Thanks!!!!!💯💥💯
What a wonderful explanation ♥️
Thank you.
WOW! The best ever Vit D video. Now I understand.
Brilliant presentation, thank you! Your videos are like "smart pills".
Thank you so much!
@@friendlyneighborhoodimmuno7192 can you do one on the new virus this omricon?
@@friendlyneighborhoodimmuno7192 Can you do one about restore Mitochondrion?
More like dumb pills
Dear FNI, Please tell me which of these is the best book: “Infectious” by Tregoning; “Immune” by Dettmer; or “The Secret Body” by Davis. Thank you.
Q: How did I manage to develop an allergy to cats as an adult having spent so much time around them as a child with no apparent problems? Thanks in advance. Love the channel!
That can happen if you spent a long time away from cats. Did you go off to college and not have pets for many years?
In my experience allergies are pretty fluid things that change as we age. When I was a kid I never had any allergies. in my 20's and 30's I got hit twice a year pretty hard. Ragweed in Sep, and cedar/juniper pollen in Jan & Feb. But sometime in my late 40's I stopped having those seasonal allergies, if not completely, much less severely.
I had the opposite experience. I was allergic to cats and horses as a child. As a young adult I got both and my allergies improved a huge amount. Conversely when I moved from the Southern hemisphere to the Northern hemisphere I got adult asthma
Based on this, is it possible that maintaining a high level of vitamin D can help me with my seasonal pollen allergy? (I've devoloped a little intolerance to some fruits too, like eating apples makes my throat slightly inflamed for a short time after it. Thanks in advance for your answer.
There are some studies showing high levels of Vitamin D3 can help reduce severe allergies.
Quercetin is your friend when it comes to allergies. Now Foods sells a Quercetin & Bromelain combo. Bromelain helps with the absorption of Quercetin (as does Vitamin C). Zinc plays a very close roll with Quercetin so you may end up supplementing a little with zinc as well. But do look into Quercetin.
FWIW, my seasonal mesquite eye and sinus allergy significantly improved after I started 8K D3 a day back in early 2020. I can't quite comfortably walk out into the Az desert on a breezy day, but I'm vastly improved over the pre-D situation of being stuck indoors with "Terminator-Eye" allergic conjunctivitis.
thank u mam
I wish you can talk about the new Medicago plant-based covid vaccine from Canada. And the ingredients it use for its GSK adjuvant. They are silent about components of the adjuvant used. Thank you.
It appears they are using GSK's AS03 adjuvant, based on a press release I found in 2020 if that is still accurate. AS03 is squalene-based that can be sourced from shark liver or plants. Medicago is also in partnership with Japan's Mitsubishi Pharma.
What about the other 3 fat-soluable vitamins K2, A and E and their *synergies* with Vitamin D3?
You forgot the Liver and Kidneys - key to get the hormone D3 into the right places
Would vitamin D3 help with alopecia? I live in sunny England and study pharmacology so I don’t get much sun!
does it help with asthma? Cold, damp air definitely causes mine to get worse
Hi, my wife has low LAT results we need to get it higher in preparation for pregnancy, aside from LIT treatment what else can we take like vitamins or foods? Thanks
25 D is also an inactive compound, but is the most reliable measurement of an individual’s vitamin D status.
Most of those immune cells she mentions make the 1-alpha hydroxylase enzyme on site. They can indeed uptake 25-D and produce their own 1,25-D to stimulate the VDR.
You forgot to mention sunshine 🌞 .
Yes, quite right. I understand that sunlight is more important in producing vitamin D than food.
I live in Scotland, and my doctor recommends that we should take vitamin D3 all year, because of our lack of sunlight.
The first time I have ever seen someone write letters the exact same as me. Looks like I wrote it
I also take Magnesium Glycinate and Phosphate and Liposomal Vitamin C so that D3 will work.
My wife suffer from Lupus for the past few years, what is the recommended dosage of Vit D3 per day
Does high dose (20000/d) of vitamin d3 can cause very low lymphocytes ? is it ok ?
Do you have a tweeter account ?
so do you think taking between 5.000 and 10.000 I.U. could be more bad than good relating to covid?
Greetings from Austria
The research for COVID says that having one high does of Vitamin D helps when you first get it or when you are first admitted to the hospital. Not sure if taking that much regularly is a good idea or not. I would recommend running it by your regular doctor.
Thank you as a person diagnosed with RR MS in 1999. I’ve always heard D3 was important now I know why. My last physical I had my dr test me D2 and D3 levels. My D2 was too very low. So I am supplementing D2 2400 ui andD3 5000ui and I take 1500mg Tumeric . Daily. How is D2 different from D3 on the immune system
I'm glad this helped explain why people with autoimmune diseases often take high levels of Vitamin D. It took me a while to figure out the difference between D2 and D3 because most research has been done on Vitamin D3. D2 comes from plants and is not at readily absorbed as D3. I only found one published paper saying Vitamin D3 boosts macrophage function, but D2 does not. It seems like this is an understudied area of the immune system.
It is important to take Vitamin K2 with D3.
so that's why psoriasis situation could be improved by sunshine more to produce vitamin D to suppress the overactive immune system?
You are wonderful, now I have no need to go to college. 🤔
Thank you and sorry?!
@@friendlyneighborhoodimmuno7192 I think the person was saying, "I have no need (now) to go to college" - because "you are so wonderful"- in explaining everything.
I might not have helped any - as it is 2:00am my time, lol. 😄
So vitamin d3 stops inflammation in rheumatoid arthritis? How much would you need to take ?
30.000 IU daily is completely safe.
My vitamin D comes in little gummy bears. I envisioned little gummy bears getting inside the microphage nucleus cave and hibernating! I would've made an A.
That's a great mental image.
Lol that's funny as. I can suggest checking out chubbyemu's channel for the dangers of too many vitamin gummy bears. Its quite entertaining.
@@bobman929, Wasn’t that Zinc gummy bears? I think that guy overdosed on Zinc.
I have a research question. Who kills bacteria and viruses better, acids or bases? Intensity-wise, or, do acids kill more types of bacteria/viruses or do bases kill more bacteria/viruses?
That's a fascinating question. The answer is either works if concentrated enough. For example you can kill either bacteria or viruses with hydrochloric acid which has a pH between 1-2, and you can kill them with bleach pH 11-13. So on either far end of the pH spectrum can kill microbes. Interestingly, fungus is best killed with bleach.
@@friendlyneighborhoodimmuno7192 but the problem is bleach is also an oxidizing agent. You have to compare acids/bases that are not oxidizing agents, or acids/bases that are both oxidizing agents. So nitric acid is a acid that is also a oxidizing agent. And bleach is like 1% NaOH. Don't imagine it's easy to get 1% NaOH, 99% water.
🌻🌻
I have had lupus since 1972
And this has not been given to cure the lupus
When Vitamin D is passed on in breast milk, is it the active or inactive form?
So, since Vit d really only helps an overactive immune system like that in autoimmune diseases- should people with immune deficiency NOT take vit d ?
I got viral load 19000 and my cd4 is ZERO 0 i dont take retrovirals has been 9 years....can i take 50.000 per day? Of D3? Please help me ❤
2:51 I'm not sure, but I don't think the D3 is the active form of vitamin D. What I learned is the Vitamin D3 or D2 need to be transformed to 1,25-dihydroxycholecalciferol by the liver and the kidney to be active.
Interesting. Vitamin D2 and D3 are the two main forms. I do have the active form of Vitamin D3 listed and you have the correct active form of Vitamin D2.
@bibodude, Calcifediol…
Just took some D3 😂
You also should take Vitamin K2 with D3.
I have taken D3 for several years but never have taken K2 . WHY Is k2 needed ?
You can take too much Vitamin D, which can cause problems. Vitamin K2 helps tp resolve those problems so you can take more Vitamin D. Vitamin K2 helps deliver calcium to where it belongs.
So low vitamin D can cause feeling of clogged ears ? Yet my Dr can't see any thing going on ? I still have ear / head / face pressure . Low vitamin D ? My levels are 34ng and yes that's low
Yes, it can cause that. Supplement vitamin until You reach 50-60 ng and then see how You feel
I’ve been taking vitamin D for a couple weeks now, and I see no difference. I have chronic ITP and my antibodies are still attacking my platelets
You have to give it some time. Also, check the vitamin D level in Your blood
🥳🥳🥳
Cool video but no mention of the best source THE SUN lol. Also 400 IU is the minimal need for calcium absorption. The studies I read/watched all state that 2000 IU daily is recommended for adults. You should look up vitamin K2 as well
Calcium metabolism and immune function are two entirely different animals.
It turns out that bone tissue has a 'molecular pump' that helps force D into the cell. Immune cells lack this mechanism and rely on simple diffusion. They thus need a higher blood concentration of D in order to acquire enough.
DR Mark Hyman recommends around 2000iu of vitamin D a day at the minimum.
Great video. I probably got Roasea from taking to much vitamin d. As a healthy person, I would be careful about taking too much vitamin d supplements. I bought into the hype and took 10.000 iu over a few month. I have light skin and shortly after taking the vitamin d, I developed Rosacea. After reading a bit about the topic, it's probably because of the cathelicidins.
Very interesting. I haven’t heard of that connection before, but I agree high dose vitamin D is not for everyone.
Can you explain the role of vitamin K in Vitamin D absorption?
Vitamin K and vitamin D synergize in the bone for maximum calcium absorption. In the bone there is a protein, osteocalcin, that is dependent on Vitamin K. Ostoecalcin needs Vitamin K to work and Vitamin D needs it to help store calcium. www.ncbi.nlm.nih.gov/pmc/articles/PMC5613455/
@@friendlyneighborhoodimmuno7192 Vitamin K2.
vitamin D umbrella term: the actual substrate vitamin D3 cholecalciferol, the circulating metabolite tested for nutrient level calcidiol or calcifediol 25OHD3, the active hormone 1,25OH2D3 calcitriol, names are important because of the ubiquitously used umbrella term 'vitamin d' causes mass unclarities.
you'll be interested in these articles the 2017 is an updated version with newer info based on 2013 version. The Role of the Parent Compound Vitamin D with Respect to Metabolism and Function: Why Clinical Dose Intervals Can Affect Clinical Outcomes 2013, Hollis and Wagner
New insights into the vitamin D requirements during pregnancy 2017, Hollis and wagner,
you'll be interested know that cholecalciferol vitamin d3 is utilized heavily in paracrine/autocrine...
25OHD3 also utilized in innate immune response more specifically, but more limited than cholecalciferol's wide use through all cells. Calcitriol circulating is indeed limited to select cells of calcium/phosphorus regulation feedbacks, and highly upregulated in pregnancy without calcemic effects.
I just starts got 40.000ui perday till my cd4 gets UP
Mention another sources that pesky source outside in the sky also it’s helper K2.
I think you're missing a few minor things. Vit d supplementation actually triggers VDR down regulation, I know you touched on this but what you missed is that the 1,25ohd becomes massively elevated from ridiculous high intakes and and this means it needs somewhere to go (yes half life is 6ish hours)... Itt has a massive affinity for other receptors like TRa1, infact it has more of an affinity for many of these receptors to a greater extent than the receptors designed ligand... And in the case of the thyroid this elevated d3 triggers its dysregulation and inhibition. Also ingested d3 blocks vit A uptake and vit a is required as the other half of the dimer for the VDR receptor. VDR+RXR (lol and magnesium, but wheres that not used) allow the vdr to activate the Antimicrobial peptide and none of us get enough vit A as it is, proper vit A not this fake stuff they fortify stuff with that causes toxicity. There's a few more things but one of the biggies is also that with vit d elevating so too does calcium to match it, thus blood levels of calcium sky rocket and this is mostly being leached from the bones. The elevated calcium causes all sorts of havoc most interestingly (lol obviously to) arteriosclerosis elevations, heart attacks and strokes. Don't get me wrong vit d from the sun is unbelievable but that's a whole diffrent animal. Anyway thank your for your video it was very informative.
Interesting! I didn’t know about the details of up and down regulation of the receptors. Thanks for sharing
@@friendlyneighborhoodimmuno7192 found something else out that's terrifying, d3 sups inhibit GcMAF, this is the protein produced by the live (yer what pro isn't) to carry d from skin to activation points. Frightening part is its required to heal/ wake up dorment/infected macrophages. When I day wake up I mean it allows them to detect aids and cancer, yer and o know how it sounds but feel free to look into it yourself, this has been know since 1990 when a Japanese sc descovered it, they them withheld it so to patent it. Anyway its formation is inhibited as d sups inhibit skin formation and the sups are carried by lipoproteins. I wonder if this is what it felt like for those watching folks get told hydrogenated vegtable oil is the best and butter/tallow will kill you.
What are you talking about? Why would vitamin D leach calcium from the bones? The parathyroid does that when vitamin D is low, so the opposite is true.
@@kali7989 Yes but its not really that straight forward when you start mega dosing a hormone.
@@kali7989 High dose vitamin D without extra calcium supplementation has been associated with increased levels of the active vitamin D metabolite 1, 25(OH)2 vitamin D (calcitriol), and an increase in CTx.
Calcitriol stimulates osteoclastogenesis and differentiation, either through action on osteoblasts or by direct action on osteoclast precursors.
Also high-dose vitamin D may also suppress PTH by direct action on parathyroid cells or indirectly by enhancing intestinal calcium absorption. This might reduce PTH-mediated bone formation, which when combined with a vitamin D-mediated direct effect on osteoclast activity, thus result in the dose-related accelerated decline in bone mass density.
(Effect of High-Dose Vitamin D Supplementation on Volumetric Bone Density and Bone StrengthA Randomized Clinical Trial
Lauren A. Burt, PhD1; Emma O. Billington, MD, FRCPC1; Marianne S. Rose, PhD2; et al)
hypercalcemia occurs as a result of increased calcium absorption from the intestine and increased bone mobilization. The 25(OH)D3 or 25(OH)D2 which are present in increased amounts bind to the vitamin D receptor in sufficient amounts to induce processes that enhance intestinal calcium absorption and enhance bone mobilization (Vitamin D-Mediated Hypercalcemia: Mechanisms, Diagnosis, and Treatment
Peter J. Tebben, Ravinder J. Singh, and Rajiv Kumar)
Nephrectomy prevents completely the bone calcium mobilization response to 25-hydroxycholecalciferol. In contrast it does not prevent this response to 1,25-dihydroxycholecalciferol. Because it is known that the kidney is the site of 1,25-dihydroxycholecalciferol formation, these results provide evidence that 1,25-dihydroxycholecalciferol or a further metabolite thereof and not 25-hydroxycholecalciferol is the metabolically active form of vitamin D(3) responsible for bone calcium mobilization.
(1,25-dihydroxycholecalciferol: metabolite of vitamin D3 active on bone in anephric rats
M F Holick et al. Science. 1972.)
400 IU is laughable. Not even 2000 are enough to raise levels. And if you're obese, you need even more
Half hour in the noon sun, you make 20.000 IU easily. Body can tolerate it.
What happens if I take oral vitamin d and my levels go down … white British female.
Vitamin D needs Magnesium to work. Take it together and make sure to take 4000IU of D3 daily and not the Vegan sourced D2 which absorbs less in our body. I recommend D3 with vitamin K2 combination in one. Calcium supplements avoid it. We get Enough calcium from our foods.
Could you please compare all known vaccines (Pfizer, Novavax, Valneva) in terms of safety? Which one is least likely to cause unwanted side effects? I would not care about the effectiveness.
The side effects are related to the dose. The efficacy is also related to the dose. Moderna is more effective, but also has more side effects than Pfizer because it’s more than 3x the dose. But then Pfizer will require more doses. Other than the dose, Pfizer and Moderna are nearly identical.
The other vaccines will have the same issue. The efficacy and side effects will depend on the dose.
The fact that they targeted only the spike was a bad idea. Honestly I wouldn't get any of them since the spike that is coded is 2 years old and doesn't work anymore. If it was the whole virus on a older platform that would give you a broad immunity to any of the 29 proteins vs only 1 or 2 of spike. It almost like they wanted it to fail. Dr Malone the inventor of the MRNA tech says he wouldn't recommend these to any group of people and he was Vax injured by Modena. But yes if you don't care Novavax at least measures the amount of spike and doesn't make you body produce it so way safer
@@terjeoseberg990 No doctor including Pfizer or Moderna can tell you how much spike is produced because everyone will make different amounts. Nor do they have any studies on the toxicity of the LNPs in people. These shots are Russian roulette and obviously a big fail. Narrow immunity spike was a bad concept.
@@ar2268 Thx But I need a answer from a researcher :-)
Great explanation about the effects of vitamin D3 on the immune system. My take away is that vitamin D3 weakens the immune system with respect to virus attacks. So, in times of corona viruses, vitamin D3 supplements seem to be counterproductive for the immune system. Is this right?
It's actually not true. Let me explain.
1.
Vitamin D is a immunomodulator and it protects from the coronavirus.
Vitamin D exerts immunomodulatory effects both on innate and adaptive immune responses. It enhances the synthesis of anti-microbial peptides, promotes autophagy and increases the production of lysosomic degradation enzymes within macrophages. For adaptive immunity, vitamin D improves CD4+ T lymphocytes, suppresses T helper 17 lymphocytes and promotes the production of virus-specific antibodies by activating T-dependent B lymphocytes. In addition, vitamin D attenuates the cytokine storm, increases the bioavailability and expression of ACE2, inhibits renin expression and enhance type 1 interferon anti-viral replication. All of above mechanisms might contribute to the beneficial effects of vitamin D on COVID-19
2.
The most important studies on vitamin d and Covid are the randomized clinical controlled trials.
In the Entrenas-Castillo trial they gave the patients 106.000 I. U. on day one and 53.000 I. U. on day 3 and 7. That's 212.000 I. U. a week which adds up to 30.000 I. U. a day.
The results are 50% of the control group but only 2% of the vitamin D group required ICU treatment. There were 2 deaths in the control group and none in the vitamin D group. Calcifediol treatment reduced the odds of ICU admission by 98% (P
Ok I can see why it sounds like that. Perhaps I should explain more. The correct amount of Vitamin D helps your immune system function normally. Having too little Vitamin D is bad for you immune system. E has some specific sources related to coronavirus. The sources I have used for this video are in the video description.
@@friendlyneighborhoodimmuno7192 Is it because of that people who have less vit D frequently catch cold n cough ?
The video is definitely misleading and after reading these explanations, I think that the video was created with incomplete information.
Thank you for the explanations. After watching this video, I gave up on giving my mother vitamin D. This video needs to be removed from youtube.
Good grief
I actually dislike the information on this video, specifically the dosage recommendation. If you read the literature, you'll find a large proportion of the human population is either vitamin D deficient or insufficient. Taking 400IU will literally do nothing to bring a person into sufficiency. You also did not even mention the main way we produce vitamin D, that being through healthy sun exposure. It is near impossible for a person to obtain enough vitamin D in their diet to maintain a healthy level, even in the fortified foods. Otherwise healthy individuals should take 5,000IU of vitamin D3 via a supplement everyday and obtain enough healthy sunlight. The reason? Our modern lifestyle of clothing ourselves, being indoors between the hours of 10am through to 2pm (the period UVB rays actually reach out skin) means we are all at huge risk of being either insufficient or deficient. No disrespect, you went to medical school. But so did Dr. Michael Holick, a person who you should look up and watch some of his videos on the topic. He is the expert in Vitamin D.