APOE4 | APOE4 versus APOE3
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- Опубліковано 15 лип 2024
- APOE4 versus APOE3: APOE4 is a protein that carries lipids or fats in your brain. APOE4 does not work as well as APOE3. I will tell you why people with Alzheimer's disease are more likely to have APOE4 genetics than APOE3 or APOE2. I have researched Alzheimer's disease for 9 years studying the immune response to amyloid plaques and APOE. Please let me know if you have any questions or future video ideas in the comments section. Stay healthy, and eat salmon!
#APOE4 #APOE3versusAPOE4 #Nigerianparadox
Sources:
www.nature.com/articles/nrneu...
www.ncbi.nlm.nih.gov/pmc/arti...
Nigerian paradox:
www.ncbi.nlm.nih.gov/pmc/arti... - Наука та технологія
To be clear, APOE4 likely makes Alzheimer's disease worse because it can't take amyloid beta out of the brain or bring it to immune cells of the brain like microglia to be broken down. The Nigerian paradox is a little different. The theory here is that a lifetime of inflammation from heart disease and high cholesterol in the body, can cross over into the brain. Inflammation in the brain leads to more amyloid beta and more plaques which disrupt brain function. It is hypothesized that since Nigerians have a diet lower in fat and exercise more (on average) than an average American, that they have a lifetime of less body inflammation so APOE4 can do it's job just fine. If you lead a less inflammatory life with reduced consumption of things like fast food, then even if you have APOE4 it can clean up the smaller amount of amyloid in your brain. Let me know if you have more questions!
Interesting article……I’ve heard that BCG especially, but maybe other vaccines as well, may stimulate parts of our immune system that we really don’t understand yet….
www.wsj.com/articles/covid-19-coronavirus-vaccine-prevent-alzheimers-dementia-neurodegenerative-11628196831?st=qn32pbdhr7n9wo8&reflink=article_copyURL_share
You're my favorite Immunity Influencer. Can we have a booster video please? 2nd shot 💉 ?
What Nigerians die sooner than their European counterparts. So they wouldn't even develop the condition of Alzheimer's full stop the Alzheimer's apoe4 usually develops after the age of 60 however the average life expectancy in Nigeria is 54 years
Cholesterol causes inflammation to the body? 😂😂 my brain hurts and you are entirely responsible for that
Do you mean oxidative stress in microglia or astrocytes will be the culprits in AD cascade? Does accumation of the cholesterol inside tissues causing the the APOE inactivation? Or cholesterol syntesis accelerate the potential of APOE function??? Mmm interesting!
Great presentation. I am 72 and APOE4 +/+. I have a coronary calcium score of zero. I exercise madly and am vegan. My LDL IS 35 mg/dL. I am still getting my manuscripts accepted and am receiving NIH funding, measures of intact cognition. Although I am a WASP, I seem to be a beneficiary of the Nigerian paradox. There is hope for folks who are homozygous E4! Thanks again.
Lol bozo I am APOE-ε2 +/+
I'm APOE4 +/+ too and I'm 24 years old and from sweden, thanks for the advice.
As you no doubt know there's a school of thought that insulin, not cholesterol, is the cause of cardiovascular risk and Alzheimer's. I'd love to hear your thoughts about that.
Insulin and IGF1 are counter-longevity. If you wanted to increase your life and especially quality of life at the end-phase of your life and older years, you would want to keep IGF1 and insulin as low as possible over the long-term, as possible. Insulin and IGF1 contribute to all cause mortality: heart-disease, cancer, diabetes, stroke, respiratory disease, etc.
cholesterol is not bad for you, it is actually good and is the building block for brain function and testosterone. However, cholesterol is bad when combined with refined carbohydrates, can increase chronic inflammation which inflammation is the driver of the aging process, and increase risk of all/cause mortality as well.
Insulin is worse than Cholesterol on its own, but cholesterol combined with refined carbohydrates is the worst.
I am an undergrad doing immunology research who also has APOE E4! It gives me hope to know that I am not alone. Keep up the great work!
Very good presentation, clear and concise.
I am sure you are aware of Dr. Dale Bredesen's work on Alzheimers particularly his book called "The First Survivors of Alzheimers." My mother had early onset so I've been fine tuned into Alzheimers for several decades now. Your video, though nicely illustrative, may scare people with APOE 4 as it did me. Dr. Bredesen and others such as Dr. Lisa Mosconi (for women in particular) are neurologists who have dedicated decades of work in the area. I completely respect your work in the immune response side, but getting Alzheimers is so much more than APOE4 and the immune response. I hope those who might be concerned can find hope and positive methods of prevention and reversal by looking into Dr. Bredesen's and Dr. Mosconi's work.
I've been doing Carnivore for 434 day's, about a month ago I had to, EAT VEGIES AGAIN, not by choice, and SINCE re introduction to vegies I'm noticing my leg aching again, not nice...so I'm not eating vegies again now for 2 days...hoping aching will eventually go...I eat meat, fat, Celtic sea salt and water...my deduction of leg pain again is an auto immune response to whatever's in the cruciferous vegetables, GMO foods/ glyphosate s causing this to happen???
Wish I could remember the study that shows amyloid plaque in the brain can be protective to the brain from the assault of insulin resistance…
I really enjoyed your explanation- thank you so much!
Just couldn't understand the difference and this vid described beautifully, Thanks a lot.
Thanks for sharing this
Thank you for this video with the drawings. I didn’t previously understand why others recommended APO4s go on a low fat diet, but you helped me understand it. Cheers
Glad I could help!
Low fat?
Why not keto?
@@krosh8982because keto is generally moderate to high fat, depending on which version you’re referring to
Very nice - there’s more to the story than this of course. I’ll try to do a review and reference your excellent video here.
Thank you ma'am ❤
Thanks so much for your videos! If I can make a suggestion, a video editing tip, if you have a Mac, use iMovie to remove background noise/buzzing from your video files. It’s very easy to do.
Thank you so much! I just got a blue yeti microphone and I don't think I have the setting right. All I have is my super slow work PC. Do you know any tricks that would work in Adobe premier pro? I will try and improve the sound.
@@friendlyneighborhoodimmuno7192 I’m sorry I don’t know how to do it with Adobe. But thank you for the reply 😃 Good luck. I’m sure your channel will be a huge success
Thx u for spelling this out. Now I understand it!!! Can you do one on having 2 Apoe4 genes?
Glad to help. Some people in my family had two APOE genes, so I think about that often. I could go over some research papers, but it is not good news in general. Diet and exercise can help though.
Hi thank you so much for making this video and explaining in detail. I just subscribed and liked this video! ... I got my 23&me results and it says I have the APOE4 gene. It's a pretty scary thing and i wasn't expecting to have it as I didn't know of anyone in my family to have a history of Alzheimer's. I'm pretty familiar with Alzheimer's disease because of research projects I've done in nursing school. And Alzheimer's is something i definitely want to try to avoid in the future . I would like to know more about the correlation between the Nigerian lifestyle that doesn't make them at increased risk for Alzheimer's even with the variant
Nigerians are not on Standard American Diet (SAD).
Thank you for your video. I’m a visual learner so I appreciate the coloring book approach!😂 my mom just died from Alzheimer’s December and was also on cholesterol meds. I am 57 and have already had open heart surgery despite not being a smoker or overweight individual. They now have me on a cholesterol lowering shot because mine is so high. My question is if you have the APOE4 gene, would being on a cholesterol med make things even worse as it’s starving the brain of much needed cholesterol. Thanks!
Wow !
You just made my questions since 4 years into easy answers with these distinguishes.
Have you heard about Dr. Pamela McDonald who wrote a book on "Apo E diet" ?
Subscribed !
All the best and wishes from India 🇮🇳
The drawings helped and were enjoyable to watch! Can a person have one APOE4 gene and APOE2 at the same time?
If you were to make an indepth video about APOE2 it would be the only one on youtube. At least in English.
Wow I didn’t know that! It’s in the works. I’m on taking some family time this week, but I’ll get to it next week.
Thank you for this clear explanation. Am I correct in thinking that a ketogenic diet would be a terrible idea for a person carrying at least one copy of the APOE4 gene?
I would like to hear your thoughts on a link (if any) between IBS/IBD/Whipples/other GI diseases and the cognitive decline.
Anyway you can explain further when you talk about E2 and E3 being able to dump the Amyloid beta outside of the brain? What does that actually mean? Can you fully elaborate? That would be amazing :D I'm selling a diagnostic relating to Amyloid beta 42/40 along with AOE genetic testing. This would really help me give doctors a better insight!
APOE4 can not carry as much lipid as APE2, 3. Is lipid membrane in APOE4 individual not good as APOE2 or 3?
I've also as a baby had twisted bowel, food related too I believe from mother...mum was diabetic/alcoholism, ate ALL the wrong foods!! Processed and refined foods' sugar's, as I know I can't eat these they're rubbish!!! I had Mercuy amalgam fillings wall to wall when 11, govts policy world wide. I developed PSORIASIS gut microbiome stuffed as soon as mercury amalgams poisoned my gut! But after watching my mum die I knew I had that APOE 2 Gene so years ago I asked to be tested for it, came back heterozygous APOE 2....but I still didn't stick to a good diet....mercury amalgams were removed not by a biological dentist and it has poisoned me SO BADLY!! As mercury has a half life....but eating vegies again is not good for me....I have 2-3 cups salt in hot water a day... Celtic sea salt...I eat dripping, meat , salt and water...nothing else ....any help appreciated. Mum had her leg off, diabetes vascular neuropathy..and bad heart disease...
Hi I'm heterozygous APOE 2 gene, I do know that there is a specific group of people in world who have this APOE 2 gene, it's like a village somewhere?? Have you heard of them please??
I'm
a 3/4. If the 4 side has a hard time carrying cholesterol to the brain why would it be beneficial to lower you cholesterol in your body and give your apo less resources to pull from?
If I do not like eating fish, avocados, olive oil, and lean meat but have ApoE4, what can I eat to reduce my risk of heart disease and Alzheimer's because of ApoE4?
I wonder if keto and intermittent fasting could help with EPA DHA D3
Also lactobacillus Reuters and gasseri
I read about choline
My boyfriend has APOE4/4, so he’s very likely to get AD. However, he’s been vegan and low fat for about a year now with no intention of ever stopping. He also takes 480mg of DHA a day. Thankfully I’m 3/3, but do you think there’s enough evidence that DHA reduces risk?
If he makes sure he stays away from contact sports and lives a healthy lifestyle, he’s ok
Absolutely nothing to worry about
Also his ethnicity is a factor, if he’s african or hispanic, he’s even less likely to get AD
My uncle who is a doctor has 2 Apoe4 allels and he is 70 years old now. He has no alzheimers yet. He exercises a lot and avoids saturated fats.
high intellectual level prevents from getting alzheimer's disease
Won't statins prevent Alzheimer's in people with APOE4? Do APOE4 people on high dose prednisone have low levels of Alzheimer's? In theory at least, they should.
Statins lower b12 and disturb methylation (and lower q10), also can rise homocysteine...so what is worse for this gene ;/
I am apoe3
Is there a correlation between right hemispheric spatial navigational strategies, dyslexia, and Apoe2 individuals?
That's a great question. I'm not an expert on dyslexia and spatial navigation. Sorry. However, I will have the APOE2 video up this week.
I would like to know how you can test for apoe type. The genetic test says that there's 1 apoe4, but no indication as to whether the other would be apoe3 or apoe2.
@@thebestofenergy Many labs will test for both copies. I just had mine done with a result of 3/4.
Can intermittent fasting and keto help with APOE4 or can I get Nigerian citizenship and live there ?
So keto diet was just discovered to increase the risk of Alzheimer’s disease, but there’s some data that intermittent fasting could reduce the risk of Alzheimer’s disease.
@@friendlyneighborhoodimmuno7192 it makes sense because keto means eating quite a lot of saturated fats. Intermittent fasting is more like making sugar levels lower. Sugars tends to oxidize the molecules, so I guess it's not good for plaques in the brain. Thank you for your answer ❤️
how on earth diet that improves insulin sensitivity could be bad for brain health overall? Stop making those videos please as you literally know ZERO about the root cause of Neurodegenerative diseases
I’m so upset I tested positive for APOE4 😞
I’m so sorry. Me too. It’s a risk factor but you can do other things like eat right and exercise to reduce the risk. Take care
When I got my test back I got so scared that I didn't open my results again or made any research for next 2 years... Now I realise I am lucky to know this so I can do something...
I got a 23and me test a few years back, and found out that I'm apoe3/4. I wish that I hadn't had that test because now I'm scared to death. My parents are both dead.now, but I wish.that I could present the results If they test and tell them how angry I am with whichever one of them saddled me with this curse.
When you say you “have apoe4” does that mean 3/4 or 4/4?
I meant either one. Even one copy of apoe4 is a risk factor for AD.
@@friendlyneighborhoodimmuno7192 I just got my results back. I’m 2/4. Which is confusing because they say 2 protects against Alzheimer’s but apparently not if you have 4. According to published studies I read last night. The 4 is stronger than and overshadows the 2.
Low carb or zero carb? You really think the Nigerians were eating that sort of diet? Best of luck to you.
I don’t understand. APOE4 is bad because it carries less cholesterol, or less amyloid beta? At the end you mention the “Nigerian Paradox” and that they have lower cholesterol which makes it so that APOE4 can do its job better.
Do they have a suspected mechanism for this? How can APOE4 do it’s job better if there’s less cholesterol? What about Alzheimer’s in people who lower their cholesterol with statins? Do statins reduce instances of Alzheimer’s?
And if the brain needs cholesterol, how could less cholesterol possibly be good for the brain? That makes no sense.
Oh I see how that is confusing. I will likely have to address this in another video. Alzheimer's disease is very complicated, and involves many systems of the body. Perhaps I made the video too short. The brain's cholesterol and the body's cholesterol are separate. APOE4 has many functions. The main issue is that APOE4 cannot remove amyloid beta from the brain, nor can it bring amyloid to immune cells of the brain (microglia or astrocytes).
The second issue has to do with the Nigerian paradox, and I can see how I did not make it clear. The brain makes more amyloid when people have inflammation in their blood stream. The brain and body are connected. A lifetime of inflammation in the blood stream increases amyloid production in the brain. So if you keep your lifetime incident of cholesterol low (which decreases whole body inflammation), then the smaller amount of amyloid in the brain can be removed by APOE4 even though its a little slow.
@@friendlyneighborhoodimmuno7192, Does lowering cholesterol actually reduce inflammation, or does reducing inflammation decrease cholesterol? Has this been proven?
In other words, isn’t increased cholesterol just our body’s response to inflammation? What if increased cholesterol is needed for our body to deal with inflammation, and reducing cholesterol while we are experiencing inflammation makes it so our bodies can’t properly deal with that inflammation?
Wouldn’t that be like taking immunosuppressive drugs while we have an infection because increased immune response is associated with infections? We’re then preventing the body from responding to a threat in the way it needs to. This would be a very bad thing.
Therefore it’s very important to know for certain whether high cholesterol causes inflammation, or inflammation causes high cholesterol. Have they tried continuously injecting cholesterol into someone to see if that increases inflammation?
@@terjeoseberg990 I’m not by my laptop. I can send you some papers addressing your questions. There’s different types of cholesterol that are strongly linked with inflammation and AD.
@@friendlyneighborhoodimmuno7192 Is this the inflammation that is measured by hsCRP? If this is so, then if you are APOE4 positive but have low hsCRP are you at pretty low AD risk? Thanks for the video!
I think i got Alzheimer in my 19 yrs
Please speak up, it’s hard to hear you. Thank you.
Homozygot apoe4 here här in i sweden Sverige 🎉
I mean more than half of US is overweight and relatively unhealthy. Most nigerians can't afford overeating and probably eat more natural so maybe lifestyle can trigger this stuff. Having to walk a couple of miles just to get water helps
Walking every day is a good habit, but yes the health issues are based on economic disparities.
I find it very strange that you didn’t mention you have two APOE which inherit one APoE gene type from each of your parents. So you can be, APOE2/APOE2, APOE2/APOE3, APOE2/SPOE4, then APOE3/APOE3, APOE3/APOE4 and APOE4/APOE4.
APEO3/APOE4 has 3 to 4x the occurrence of developing of Alzheimer’s while APOE4/APOE4 has a 9 to 12 X the occurrence of developing Alzheimer’s.
And the good news as she said is Alzheimer’s is triggered by diet lifestyle and environmental factors.
Avoiding the negative effects of gene triggering simply by adopting a Low Carb, even Zero Carb lifestyle, avoiding processed foods, sugars in all forms and vegetable seed oils could help avoid triggering Alzheimer’s altogether in APOE4’s.
Also the 23&me health test, only identifies APOE4/? or APOE4/APOE4. If you have only one APOE4 gene it won’t identify the other genotype. Of course 75% of time it’ll be APOE3!😃👍❤️