Hypersensitivity types in 4 minutes

Hypersensitivity reactions
When our immune system gets mad
There are 4 types of hypersensitivity reactions, usually labelled in Latin numbers.
In type 1, the antigen, which is usually external allergens such as pollens or certain food molecules, binds to IgE antibodies attached to the surface of mast cells or basophils.
This antigen-antibody binding induces cascade of intracellular reactions resulted in release of large amount of histamine from the storage vesicles.
The released histamine induces various degrees of allergic reactions.
In hypersensitivity type 2, the antigen is not external allergen floating in the blood, but rather certain molecules attached to external surface of the patient cells.
Binding of IgG or IgM antibodies stimulate cascade of immune reactions result in activations of complement system, natural killers, and macrophages.
Which induce further damage to affected tissues.
In hypersensitivity type 3 the small antigen-antibody complexes float through the blood ad accumulate in various tissues such as joints, glomeruli and blood vessels.
This accumulation triggers the complement system to attack the hot tissues.
Unlike other types, the hypersensitivity reaction type 4 is not antibody mediated but mainly cell mediated immunity.
In this type the T helper cells especially CD4 cells recognise the intracellular antigens such as fungi or mycobacterium tuberculosis.
The stimulated CD4 cells release certain cytokines which activates various immune system components such as phagocytes
The activated phagocytes attack and engulf the affected body-cells.
This table summarize the main differences between the 4 types of hypersensitivity reactions.
Now we have comprehensive overview of the hypersensitivity reactions
At the end of this video me and Dr jehad hammad wish you very happy reading
the narration is read by
Alexandra Daniele
Kings College London KCL University

[@calpolyca]

You just taught me in 4 minutes what I needed to know. I spent 3 hours of lecture and a 70 slide PowerPoint trying to learn this in class to no avail. Thank you for making this so simple and easy to understand! I appreciate it!

[@PharmacologyAnimation]

I am very happy because you find it helpful

[@farookchintu9463]

Yes these are very helpful for our exams

[@lupemojarro5920]

I spent 4 lectures (8 hours) learning this and i bet I spent over another 4 hours trying to understand my notes at home hahahaha

[@adeyemibabatunde1814]

​@@PharmacologyAnimationKindly make available the enlarged summary table for downloading

[@hauwakabir7777]

This is the first time I'm experiencing that "spending hours on a lecture and learning the content in minutes" situation. Thank you so much, it was really helpful

[@PharmacologyAnimation]

Thank you so much

[@socialgrowthclub]

Educative video and very interesting as well. Especially the last part when they say this is not Dr....
Watching you all the way from Kenya
You saved my degree

[@magzywazir6526]

This was a really good video. Helped me alot in understanding.

[@PharmacologyAnimation]

I am happy you find it useful

[@brandig4970]

Thank you for making something so complicated so simple! Ive been trying to understand this for hours!

[@PharmacologyAnimation]

You are welcome

[@user-kj2zm5pc3o]

My exam tomorrow and you are a Savior

[@Vendzor]

Lol mine too
How did you do?

[@emekao7512]

One of the best videos i have watched on youtube got everything I needed

[@PharmacologyAnimation]

Thank you so much. Glad you found it useful

[@janstrakos9827]

Great job! These are the moments I am very happy to be able to understand English! :)

[@Stunna_XD]

I was serious in thought and the end of your video snapped me into a laugh when I read, "This man is not Dr jehad Hammad" and at the same time I wondered why capitalize only his last name but at the same time, who cares about spelling when you are so busy understanding and spreading the words of science to us who aren't on the field able to understand it ourselves. Thank you for all your videos, they have helped me for years and I appreciate your work 💪

[@jayariesgianan3160]

one of the best presentation of hypersensitivity I saw.

[@PharmacologyAnimation]

Thank you so much

[@aafreenimtiaz901]

10 marks answer only in 3 mins 26 second love to watch.thanks for making it

[@sneshhtaeshh]

Gawd u saved me sir!!! I have my mains in few hours and wanted to quickly learn this topic. Ahhh never thought i could finish this soon. Thank u😭💜

[@samuelgitau5352]

Made the whole subtopic easy so quickly.....lots of loves

[@Ryana42m]

Big up yuhself, short, spicy and has the info needed. Thank you👍🏾

[@007010700]

lol jamaicans everywhere 🙂

[@kritikashekhawat5052]

I must say this is the best ever video to understand hypersensitivity types❤❤❤❤ loads of blessings to you

[@XxElectricRainbowsxX]

Short direct summary, great for review and test prep. Thank you!

[@PharmacologyAnimation]

Thank you so much.

[@nams9298]

best explanation for parent with multi allergies kids! i wish i could print out the notes 😂 it's okay i will jot down thanks again 🥰

[@Elif-vv7sn]

Thank you, this was great summary before i study colorless slides

[@aamirhussain.]

First 2 min... believe me ..what u taught in 3..4 hours💛.
Thanks

[@PharmacologyAnimation]

Thank you so much

[@amitnaik630]

Really helpful, ❤️❤️❤️we need teaching skills like this unlike modern poppets

[@DocTraderPH]

Very helpful

[@Jaxispi]

Saving me in Physical Therapy School! Thank you!

[@elishaodum7638]

You got this!

[@ollur2257]

This was awsome thank you so much..... I love to have a global view of the subject before going into the details 💕💕💕💕

[@ghaziturki9756]

Really 💞💞💞good

[@ManpreetSingh-dv5vs]

Nice video ... Explanation

[@dr.shamia]

Thank you very much Dr. Jihad 🌹

[@nabilahmad4863]

thank you so much , very useful , lots of contents which i had read , spent lots of time and hadnt got any point but here just in minutes. now i know this topic better than my teachers. THANKS A LOT

[@PharmacologyAnimation]

I am happy you find it useful

[@shahabuddin6149]

Really great video thanks

[@AshmiShakyawar]

Simple and good explanation

[@ethansalazar4920]

Precise and easy to understand. Thank you and God bless 🙏🏻

[@jamilcruz4732]

This is such a simple explanation! Thank you, great video.

[@bkkarthi5016]

👌super

[@veemon9280]

Thank you for this review...this was one of the harder concepts to stick during meds school for some reason.

[@PharmacologyAnimation]

Glad you found it useful. I designed this video after I had felt how much the students suffer to understand the differences between the 4 types of the hypersensitivity reactions

[@amnaalnour9918]

the most perfect video i have ever watched

[@PreciousMaria.]

Thank you so much. This is straight to the point

[@BJPdarkhistoryINDIA]

Great, crisp and concise

[@muntahabajwa8572]

awesome . thankyou soooo much

[@somebody5126]

خير الكلام ما قل و دل
Thank you

[@ayafouda8133]

This is very clear☺️ brilliant 🤗

[@christianbrunsgaard3256]

It is not the CD4+ T cells that are relevant in the type 4 reaction as you say in the beginning. It is the CD8+ T cells, which is shown in the very last overview picture.

[@fahedthefahed]

Excellent work made it easy. May Allah bless you. Thank you again to you all i am now a subscriber 😊

[@withsk4471]

This was a special treat, thank u so much, u just save my time❤

[@Stunna_XD]

I like how most these comments are repetitive.

[@Ghaidaa-vn7ru]

رائع

[@hashansenavirathna8070]

Welldone. Good explanation

[@iamdanyboy1]

Great video. Best for a rapid recap.

[@compleekated]

a very good video indeed. please correct the heading of fourth table saying "Type lll", as it is "Type lV" .... Dr. Syed M. Junaid , Resident derma, Pakistan

[@hayderjawad2466]

Very amazing and valuable presentations. Thnks.

[@Dr.Emmanuelthomas]

Great Job.. Keep up the good work

[@yatharathsingh7649]

really good video. very helpful to summarize in a few minutes and to the point information

[@PharmacologyAnimation]

Glad you found it useful

[@Snigdha2409]

Thank you. It was quite helpful as an overview.

[@PharmacologyAnimation]

Glad you found it useful

[@infundibulum723]

I wish if I got to college that have a professor explain like this way 😢😢😢

[@PharmacologyAnimation]

Thank you so much. I spent 12 year teaching in Gaza Strip, but I am a lecturer in Kings College London KCL University in UK now.

[@Dr_Sudeep_jha]

I loved it... Plzz make more short video's like this ❤❤

[@ifrahsiddiqui8319]

Very good explanation

[@cc-calipusanfranzryanmarga1004]

very helpful. am so grateful for you guys..

[@tkmkuzhali5198]

Amazing revision!

[@medicalknowledge7950]

Thank u...

[@djiatro]

The last column is Type IV, but named as Type III by mistake.

[@joebug8984]

Thanks so helpful. Also, i love the meme in the beginning😂

[@madhushree5410]

Osum... Easily understood the concept!

[@therock7055]

Thanks alot….you earned sub! ❤❤❤❤

[@starry-eyed_68]

you are angels, thank you

[@shwetadhavale3047]

Tooo good.... Keep it up 😊 and thank you 🙏

[@43.prachirathore18]

Efforts appreciated 👍

[@Fatema_Fa]

love that it's very useful for reviewing , Thank you

[@nirajgupta9257]

The BEST!!!❤️

[@katef7848]

thank youuu .the best

[@fahadnadeem7599]

Good vedio ...help me upto some extent

[@Rahul_5801]

very much helpful .. thankyou 😊

[@hmirza2879]

Exactly what I wanted thankyou

[@nobrainer4771]

THANKYOU SO MUCH!!

[@muath7962]

Thank you so much, this is Very helpful 🤍

[@maxh1964]

in the photo you show at the end it is suddenly a cd8+ lymphocyte in hypersensitivity type 4

[@PharmacologyAnimation]

You are right Maximalian. Indeed both CD4+ and CD8+ can be involved in hypersensitivity reaction type 4.

[@arbitrarylib]

Thank you so much.

[@rajkumarm9829]

Explain is super mam

[@vijinakoovva3291]

Thank you 🎉It helpful

[@msara5589]

Thanks a lot ♥️♥️

[@favourobasi5012]

Thank you

[@Ogechic]

great video

[@ellios5734]

What I needed

[@narendravermakabir9448]

very good time saving 👍

[@PharmacologyAnimation]

Glad you found it helpful

[@abdullah0506637]

Thank you so much!

[@LifeLens00]

THANK YOU

[@fatimasuleman1980]

Thank you so much 🥰

[@alexispichardo]

Thanks

[@alagagaming1659]

V.good

[@mohsinfareed1797]

Great video.Well explained and clear.Thanks very much for your effort.

[@PharmacologyAnimation]

Glad you found it useful

[@luanamirandamonteiro]

Great explanation, thanks!!

[@sayandutta9893]

This was really good

[@user-bl3yi6fr2d]

Thank you ❤❤

[@kadijajammaz582]

Thank you 💚

[@dilkushathanzeel4662]

thank you so much 👍👍

[@soulijm1757]

Thank you so much

[@PharmacologyAnimation]

You are welcome

[@MK-zg5ib]

Wow this is really good, thank you :)

[@ArthurMorganOoO]

i really love u
it is very simple
thaaaaaaaaaaaaaaaaaaaaaank uuuuuu doctor i m so glad

[@Roblox-Japan-]

good!!

[@mileto1924]

@3:09 you showed Type III twice. Is the last collum supposed to be Type IV?

[@Emyousef663]

That was amazing 👍🏻✨

[@ecologie4948]

What is the fate of the immune complex of mast cells and IgE In the body After an immune response ?

[@stanzinlzaooth21]

Thank you mam