Personally I just want to thank you for making these videos, I am predominantly a visual learner and though I love studying biomedical science, the lectures have been hard to follow. It's important to note that I'm not replacing all of my revision with these videos but you are very good at illustrating the main points, you create a clear context on which to work from. Thanks so much!
@@Splendiferousofficial i feel most med school students end up getting save by youtube or some sort of video lecture site, cause im in med school now, and my friends, my group members, and I all rely on online lectures to make sense of our school lectures.
@@muyezhang343 Not in med school but most of my undergrad education was mostly based on UA-cam. I would read the textbook and then youtube for clarification.
Omg, I dont understand how it takes my proffessor 2 weeks, 120 slides and an entire chapter of her own textbook to TRY to explain what you can clearly get across in 15 minutes.... mind boggling... thank you sooo much :)
I used to watch your videos during my high school, also during my college and even today during my postgraduate degree. Thank you so much for being my constant, incredible tutor and getting me through tough exams.
u r such an amazing teacher and doctor ...i can't tell u how i feel now after i saw this video ..i was so confused and so afraid that i can't understand the complements for the exam ..but now i get it well ..really really i won't forget ur help forever .....iam just so happy ..thxxxxxx so much ..
Hélène Bouwmeester I'm a vet student as well. I understand things much better and faster here than any lecture ever taught haha! He's a true life saver :)
I was reading my immunology book and notes and was trying very hard to visualize what was happening, but I couldn't because the plethora of C's and numbers and other letters really distracted me. This video was so SO helpful! Thank you!
I've been subbed to you for about a year when I was taking biology and chemistry. Never expected you to have anything on immunology. Thank you so much for this video.
Ur lectures are really straight forward. . N understanding. . Really explained well.. I understood it in 14mins than spending 50mins in class yet confused me..
I'm in microbiology right now and have a test over the complement system. When I start nursing school, you will be one of my go-to sources for enrichment.
@@marianadeau8632 he became a doctor look at his website, I used to watch him while studying nursing, now I am studying medicine and watching him again lol :D
I lost touch in Immunology which I studied 4 years ago, now I wanted to brush up and this video is SPOT ON!!! Thank you so much for this brilliant stuff!!! :)
Oh.. My.. God! This is VERY GOOD! Thank you so much for taking time doing it, I imagine it must have taken a lot of work, and also for sharing it with us! All the best! :D
i have been banging my head with two immunology books to understand this you have made it a lot more easier thank you so much. you should definitely be a professor or a lecturer.
Your videos are the best! Watching your biochem videos helped me a lot and made get an A on my biochem exam and now I'm watching your immunology videos for my immunology exam! You're amazing. Thank you soooo much. Getting through pharmacy with your videos!! Greetings from sweden!!
Awesome video! It really helped me visualize the three pathways and the overall actions. One thing though: the alternative pathway actually technically activates first because of something called tickover: some spontaneous breakdown of C3 into C3a and C3b
Took me a while to understand what you meant by checks. If you would understand the teaching method, it makes much more sense to see how the alternative pathway is related to the rest in this way. Its a wiser idea also not to give your address to the public. Thanks Armando
Thank you so much I literally spent so much time trying to understand this because my textbook explains it in the most convoluted way possible and you explained it perfectly in 15 minutes
I just realized you already have it ore drawn out behind the paper I've been over here like "he writes so perfectly, so quickly with no mess ups!" Lol. Smart. Thanks so much for the videos. This is definitely helping me with this class compressed into 4 weeks for summer classes!
Armando, I want to thank you for the video and for the graphic. It really helped me to sort out the various parts of the complementary proteins. It was getting too much when I was reading my notes, but your video laid it out very nicely.
very well structured video, explains VERY complicated concepts in simple ways and illustrations. Definitely worth a watch is you're studying the complement system in Immuno
very good armando ..i take many days to understand this complicated topic in patho book but when i watch this it makes my concept and am clear on this topic thankyu keep it up
i just wanted to take a minute and appreciate your hard work and your dedication. you are simply amazing- you make really informative and yet understandable content videos. I can see how much effort you put in your videos- thank you
Great video. Thank you so much for making this! Something I don't think you mentioned, which may be obvious to some but not all, is that the C1q,C1r,C1s complex will bind to antibodies IgG and IgM via the C1q subunit of the complex (the site of the complex that associates with the Fc region of the antibody).
Btw, C1qr2s2 complex doesn't just bind to C4b2a. It gets activated when it binds to an antigen-antibody complex causing it to activate C1s and cleave it away. The activated C1s will cause C4 to cleave to C4a and C4b. The C4b now has a small part missing, to which attached C2 and cleaves itself to C2a and C2b...and removes the C2b part. There we form the C4b2a complex
I wanted to point out that there has been a nomenclature change: C4bC2a has been changed to C4bC2b. Its kind of meditative to watch your video, hear the sound of the sharpies and learn the topic. Valueable precious content!!! thank you so much.
@@manishchandrayadav7202 Zipfel, P., Skerka, C. Complement regulators and inhibitory proteins. Nat Rev Immunol 9, 729-740 (2009). doi.org/10.1038/nri2620 or here en.wikipedia.org/wiki/C3-convertase
This guy is my adaptive immunity against a bad GPA thanks man
lol I second that
He is a master at "convertasing" complex topics into simple ones
you clearly were not paying attention. adaptive immunity is 1/3 of the pathways
I third that 😂😂😂😂
😆
Personally I just want to thank you for making these videos, I am predominantly a visual learner and though I love studying biomedical science, the lectures have been hard to follow. It's important to note that I'm not replacing all of my revision with these videos but you are very good at illustrating the main points, you create a clear context on which to work from. Thanks so much!
sammmeeeeee!!!
sigh... getting through medschool via UA-cam once again. But yolo, this video saves lives!
So did u survived med school? I just entered and now can't wait to graduate asap 😫
@@Splendiferousofficial i feel most med school students end up getting save by youtube or some sort of video lecture site, cause im in med school now, and my friends, my group members, and I all rely on online lectures to make sense of our school lectures.
@@muyezhang343 same here :(
@@muyezhang343 Not in med school but most of my undergrad education was mostly based on UA-cam. I would read the textbook and then youtube for clarification.
I love the time you spend filling in the arrows :) awesome video!
Dhruv Adawal 😂
Dhruv Adawal I hate it
Omg, I dont understand how it takes my proffessor 2 weeks, 120 slides and an entire chapter of her own textbook to TRY to explain what you can clearly get across in 15 minutes.... mind boggling... thank you sooo much :)
I love you man... You have no idea how happy you've made me
I used to watch your videos during my high school, also during my college and even today during my postgraduate degree. Thank you so much for being my constant, incredible tutor and getting me through tough exams.
You are genius to explain this good! 5 hours spent for studying those systems and I got everything for 15 min. Thank you man!!!!!!!
I love the time we live in, where amazing people like yourself provide the public with free knowledge!
u r such an amazing teacher and doctor ...i can't tell u how i feel now after i saw this video ..i was so confused and so afraid that i can't understand the complements for the exam ..but now i get it well ..really really i won't forget ur help forever .....iam just so happy ..thxxxxxx so much ..
My complements to the author!
spelling!!!!
It's a joke! You must be immune to humour.
***** lol
AYYYYYY!!! Immunology jokes!
"Everything should be made as simple as possible, but not simpler." You've done just that; well explained and concise, thanks so much!
Honestly you are saving my life!
I swear, if I pass my Immunology exam on wednesday, you have earned yourself a new patreon supporter.
No matter how much my prof explained this concept it was never truly clear. This video is exceptional!!
As a veterinary student I have to know this stuff, but it is really difficult. This video really helped me study for my test!
Hélène Bouwmeester I'm a vet student as well. I understand things much better and faster here than any lecture ever taught haha! He's a true life saver :)
+Hélène Bouwmeester I'm a Vet and my teachers never taught me this :C
Hélène Bouwmeester i
Armando, you're a force of knowledge. Thanks for your generosity and help with a challenging, complex topic.
Literally a 2 hour lecture of scratching my head, condensed into 15mins of knowledge. Thankyou so much!
I was reading my immunology book and notes and was trying very hard to visualize what was happening, but I couldn't because the plethora of C's and numbers and other letters really distracted me. This video was so SO helpful! Thank you!
This guy needs an award.. makes it look simple.. thanks 🙏🏽 Armando
I've been subbed to you for about a year when I was taking biology and chemistry. Never expected you to have anything on immunology. Thank you so much for this video.
Timeless video. This video is helping me 8 years after your initial post. Thank you!
Ur lectures are really straight forward. . N understanding. . Really explained well.. I understood it in 14mins than spending 50mins in class yet confused me..
Learnt more in this 14min video than I did in the one hour lecture. You’re a life saver!
Likewise😅
I'm in microbiology right now and have a test over the complement system. When I start nursing school, you will be one of my go-to sources for enrichment.
Hey,
No I am not, I am a biomedical student. I amtrying to get into med next year
thanks!
Did you get into medical school? Where are you now?
@@marianadeau8632 he became a doctor look at his website, I used to watch him while studying nursing, now I am studying medicine and watching him again lol :D
@@gorgioarmanioso151 Hell yea that's awesome, thanks for telling me! And congrats, Armando!
I have my final exam of Immuno tmrw at 8, and you just saved my year.. Thank you so much. Plz, never stop to do this
you are the best. Love from a current medical student
i cant thank you enough on how much your videos helped me with my exams you are really awesome at what you do thanks again and again.
I lost touch in Immunology which I studied 4 years ago, now I wanted to brush up and this video is SPOT ON!!! Thank you so much for this brilliant stuff!!! :)
Legend has it the comment section is still complimenting him on this fantastic break down of the compliment pathways. THANK YOU SO MUCH OMG!!!!!!!!!!
Oh.. My.. God! This is VERY GOOD! Thank you so much for taking time doing it, I imagine it must have taken a lot of work, and also for sharing it with us! All the best! :D
i have been banging my head with two immunology books to understand this you have made it a lot more easier thank you so much. you should definitely be a professor or a lecturer.
Your videos are the best! Watching your biochem videos helped me a lot and made get an A on my biochem exam and now I'm watching your immunology videos for my immunology exam! You're amazing. Thank you soooo much. Getting through pharmacy with your videos!! Greetings from sweden!!
Watching these videos instead of re-reading lecture notes while studying for exams>>>>>>>
Literally no one has explained it as clearly as this
How tf did they discover all this
My question too😂
this is my question everyday as im studying medicine LOL
🤣🤣🤣
Just conspiracy
Amazing video, never seen anybody else showing the connection between the different pathways in such a clear way, or at all. Thank you!
This hard subject could not be explained better than this. Thank X100
i 've been learning from your lessons for 3 years
your way is so impressive for me
i really like your accent
nobody can beat this! This video is a key to success;)
All the very best Armando.
Awesome video! It really helped me visualize the three pathways and the overall actions.
One thing though: the alternative pathway actually technically activates first because of something called tickover: some spontaneous breakdown of C3 into C3a and C3b
Words can't justify how useful that file is 👏
Took me a while to understand what you meant by checks. If you would understand the teaching method, it makes much more sense to see how the alternative pathway is related to the rest in this way. Its a wiser idea also not to give your address to the public.
Thanks
Armando
Thank you so much I literally spent so much time trying to understand this because my textbook explains it in the most convoluted way possible and you explained it perfectly in 15 minutes
hands down, one of the best complement system learning videos out there. thank you!
Three thumbs up! Thank you very much. Having illustrations and doing a flow chart (ONE STEP AT A TIME) is extremely effective.
Starting a PhD that requires previous immunology concepts that i don’t have but thanks to you I’m getting there :) thank you Bro
Many thanks! This was so helpful for me as a chemist to get a first undertstanding what the C-system is.
u r intellegent enough,u make my medical life easy,GOD bless u
Wow! Simplified! Beautifully explained! Unique style of teaching! Keep it up!
This is the fourth time I have heard this, but the first I understood. Thank you for the great explanation!
Thank you sooooooooooo much!!!! I didnt understand Complement Pathway for ages! You are the best tutor! 👍🏻
Wow I just realized how long ago this was posted, yet still VERY helpful! God Bless You
The best overview of the complement system that I have ever seen. Thanks you!
So grateful for you right now! Sending you good karma and virtual hugs! Thank you!
I just realized you already have it ore drawn out behind the paper I've been over here like "he writes so perfectly, so quickly with no mess ups!" Lol. Smart. Thanks so much for the videos. This is definitely helping me with this class compressed into 4 weeks for summer classes!
Armando, I want to thank you for the video and for the graphic. It really helped me to sort out the various parts of the complementary proteins. It was getting too much when I was reading my notes, but your video laid it out very nicely.
Armando, thank you so much, you saved my life, I didn't get any of this before I saw your video!
You have no idea how helpful this was! thank you
You managed to explain 4 hours worth of lectures in 15 minutes. Well done! Also, lovely drawings. ((:
This video was so incredibly helpful. Thank you so much for spending the time to make and share this.
Armando, you're a legend. This is a very clear and concise summary!
this is honestly the best video on the complement system. Thank you so much!
Studying for SBB exam, this was great!
your videos need more views. This is brilliant, just made me understand it much better and easier
Great video! I've used these so much for studying for immunology - both in class and for a refresher for Step 1 studying. Thanks!
very well structured video, explains VERY complicated concepts in simple ways and illustrations. Definitely worth a watch is you're studying the complement system in Immuno
Thank you for making this video. Your video saves my biochemistry exam.
A heads up for the more recent viewers: the c3 convertase for the Classical and Lectin pathway is no longer C4b2a; it is now C4b2b
Thank you
Thanks dude, this is very helpful! No unnecessary info and great illustrations!
You are amazing for taking the time to help all of us!!
If i ever meet you, I'll sing "you're beautiful" by james blunt for making us all understand such a difficult topic with this much ease.
Thank you! I find complement difficult to remember but seeing how it all comes about makes it easier
Increíbles tus dibujos y explicaciones, a pesar de no saber inglés e inmunología al 100% pude retener absolutamente todo. Sigue así !
very good armando ..i take many days to understand this complicated topic in patho book but when i watch this it makes my concept and am clear on this topic thankyu keep it up
Many thanks for helping out a med student in need.
You really make this so understandable. I can't thank you enough!
From a very very grateful First Year biomedical science student.
i just wanted to take a minute and appreciate your hard work and your dedication.
you are simply amazing- you make really informative and yet understandable content videos. I can see how much effort you put in your videos- thank you
before this video i used to hate immunology and allison cameron
haha, great comment
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haha ! House reference on point
Best comment 😂
Unbelievably helpful. I am a big fan of what you are doing.
It's easy to understand. thank you
yesterday, I learned conplement system in my class but I didn't understand what my teacher said.
yeah
Thank you so much for the video! It really helped made complement pathways a lot easier for me.
Thank you! These videos are incredible! Thank you for getting me through medical school
Great video. Thank you so much for making this!
Something I don't think you mentioned, which may be obvious to some but not all, is that the C1q,C1r,C1s complex will bind to antibodies IgG and IgM via the C1q subunit of the complex (the site of the complex that associates with the Fc region of the antibody).
the best explanation i ever heard about complement system... you are awesome Armando! 😍
Hi Armando. Can you please include a video on cytokines as a part of the immunology series?
yes pleaseee make one !!!
we honestly cant thank you enough Armando :)
You're a great teacher. Thanks for sharing your knowledge.
Thank you for the nice illustrations to understand a very complicated subject.
Thanks to you i may just pass my Immunology exam.
مبدع هالرجّال،
شكراً أرماندو : )
Thanx Armando
Wish you all the best and we waiting for your new project
you are the hope of many medical students
FC Prof Armandoh!!!!
This is so unbelievably helpful. THANK. YOU !
u make concept very easy to understand..god bless u
Btw, C1qr2s2 complex doesn't just bind to C4b2a. It gets activated when it binds to an antigen-antibody complex causing it to activate C1s and cleave it away. The activated C1s will cause C4 to cleave to C4a and C4b. The C4b now has a small part missing, to which attached C2 and cleaves itself to C2a and C2b...and removes the C2b part. There we form the C4b2a complex
you truly have been sent, to teach us in a way that we understand ! Thank you !
So clear... you really shine a light on things.
You're vids will be the reason I pass my exams. Thanks so much. Good luck with getting into med. :)
Been watching his videos since highschool. Didn’t know you could have such a huge crush on faceless man’s hand
I wanted to point out that there has been a nomenclature change: C4bC2a has been changed to C4bC2b.
Its kind of meditative to watch your video, hear the sound of the sharpies and learn the topic.
Valueable precious content!!! thank you so much.
SOURCE PLZ
@@manishchandrayadav7202
Zipfel, P., Skerka, C. Complement regulators and inhibitory proteins. Nat Rev Immunol 9, 729-740 (2009). doi.org/10.1038/nri2620
or here
en.wikipedia.org/wiki/C3-convertase
wow i like ur way of explanation it makes things look simple