Type 4 Hypersensitivity Made Easy

Type IV Hypersensitivity
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Type IV hypersensitivity is also called delayed-type hypersensitivity (DTH) because the tissue reaction usually occurs 24 to 48 hours after exposure to antigen. Type IV hypersensitivity is a cell-mediated immunoreaction that is dependent on the presence of a significant number of primed, antigen-specific T cells. This type of reaction is typified by the response to poison ivy, which typically reaches its peak 24 to 48 hours after exposure to antigen.
Plant antigens (haptens) react with and modify cellular proteins that are then targeted by the sensitized T cells. Interaction of CD8+ T cells with antigen presented in the context of class I MHC results in the activation of these T cells and induces them to kill target cells displaying these antigens. APCs also display antigen in the context of class II MHC to activate CD4+ T cells to secrete cytokines, including IL-2, which result in the proliferation of CD8+ T cells. The result of these interactions is the amplification of antigen-specific T cells that initiate the hypersensitivity reaction over the course of a few days.

[@ayeshabakhtfahad.4101]

At the end,when u said thanku,I became amazed,y u r thanking us...we all should say thank u to u for such a wonderful video....perfectly explained...thanx Alot....

[@deenakunwar4244]

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[@josephmayol2361]

Thanks for nice lecture

[@vtrendzmedical8763]

Thank you

[@benwearne542]

Wowwwwww. You broke this down and spoon fed this to us. Great job and thank you so much

[@faash8964]

Amaazing! You cleared up my concept so throroughly, bless you!

[@vishwasjoshi3842]

Thank you for explaining in very simple and more understanding manner and now I am perfect with all the 4 types of hypersensitivity reactions..

[@mehakmehak5005]

After seeing many vedios on you tube this is so satisfying to clear my whole concept... Thankyou so much🧡

[@jatinmalhotra8317]

Omg the best video ever. Thank you so much brother ❤️

[@lifence7573]

This video was really helpful...thanku medsimplified

[@priyankasen9868]

Thankyou so much....after watching every video on DTH response, this video is the best explained 🌷 Thanks for clearing my concept

[@poonamthadani605]

Awesome vedios
I understand every rxn
Thanks for helping in my exams and you done great job
I hope you making more like this vedios😊😊

[@patelshalini8549]

Yur teaching style is very smart sir , you explained lengthy topic in a very short time thankuuu so much sir

[@hari8263]

Beautifully explained. Thanks a lot. 😇🙏

[@MEDSimplified]

You are very welcome 😁

[@laracroft4521]

Thank you for making immunology easy for me. ❤❤❤

[@user-nt6lk9ov6n]

Thank you so much for this amazing video 🤯

[@poojachavan4428]

no word to thanking you

[@bayanattal4894]

Thank you so much very beautifully explained

[@prithvirajpurohit3221]

Thank you so much..amazing explaination.

[@madhurarajmane4702]

You made it super easy....thank you ❤

[@dilnapachitiyan5106]

Beautiful class

[@fbbWaddell]

I would love to see the immune process in sarcoidosis and in leprosy. That would be awesome!

[@khawarjutt712]

Keep it up..... Great job

[@meenushrivastava423]

Excellent explaination

[@sumbee5167]

Thankyou for such an informative lecture.Its really helpful

[@purvapatil8562]

Thank u really simplified video 😊😊

[@user-xs8sw5pc5k]

Thank you so much , you helped me alot ,, well explained..

[@ameerpasha4309]

Excellent hats off 👍

[@damilolaomoboriowo5589]

You're wonderful!

[@imranshaik9960]

Wow admin. I became ur fan. How nice explanation

[@MEDSimplified]

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[@Kalyanihealthcare]

Nice explanation

[@RituSharma-os3gi]

amazing explanation

[@Selina-lk5gl]

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Very much helpful 🙂

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Thank you 😍

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[@josephmayol2361]

So interested and understanble

[@GovindKumar-ro8bs]

Excellent sir....
And thank you very much.....

[@jayproleaguei550]

Great video

[@zahramohammedhamedalmahroo1548]

Laterally the best.

[@Asquare369]

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[@iqraakram9140]

Well explained 😇

[@licot739]

Thank you so much sir... God bless you🥰

[@maleeha_anjum___]

thanks a lot

[@aliciakahn6468]

Thankyou!♥️

[@rakshachandayta9276]

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[@tejaswininagaraj5455]

Tq so much sir these vedios helped me a lott 🙏🙏🙏

[@srirambhardwaj2343]

Thank.you.very.much.sir.

[@perksofbeingprakriti1259]

Amazing ..

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Life and time saver ❤

[@amie_-eu8fn]

bless you

[@shaiklathifmunnisha1426]

Tq so much sir

[@amnabatool7533]

Thankuu soo much

[@monanaveed7894]

Contact dermatitis to poison ivy is an example of CD8 TYPE according to levinson. Please check

[@drmon4665]

Thanks so much,,
From Egypt ♥️♥️♥️

[@xyzabv8403]

Awesome ❤❤❤❤❤❤

[@chiaramariablando8235]

Perfect video! Thank you so much! I have some questions. So does this mean that in the tuberculosis mycobacteria infection, we have T cells that activate at the lung level after 48 hours at the most? And then we have the manifestation of the disease?
Moreover, in these hypersensitivity reactions there is always a need for a first sensitization?
Is contact hypersensitivity also delayed?

[@shaleemkhurshid5857]

Thank you so much i was a wonderful experience to learn from you but I guess Rheumatoid Arthritis is the example of type 3 hypersensitivity in which IgM-IgG complexes are deposited in joints

[@nystagmus]

Good
But what happened to TH2?
TH1 is for intracellular infection
TH2 is for anti helmith and allergic
TH17: for extracellular pathogens and fungi
(Also there is Tregs and TFH and TH22)

[@varunakumarh196]

Thankyou sir

[@abdulsannan3711]

Love your accent❤

[@tejbahadursinghsidar4518]

Awesome yrr

[@meenushrivastava423]

NC explaination 👍

[@MEDSimplified]

Thank you 😃

[@amanshandilya6723]

What softwares did you used to make this video...Pls tell us🙏🤌🤌

[@noorinshadar4779]

Thnk you thnk you thank you thank you thank you thank you🥺🥺🥺🥺🥺🥺

[@vineetmourya2297]

Sir please make a video on cytokines

[@alexentertainer7496]

plz make a video on salivary glands

[@alyiasabir9626]

I m confuse in few books contact dermatitis is example of cytotoxic t cells reaction in levinson book

[@innovation2733]

Can u please make videos ncert topics biology it is useful for many people...

[@honeyherminigildo2728]

Confusing. RA is considered type III hypersensitivity disorder. Immune complexes cause the inflammation in the joints.

[@74shobikadevendran37]

Sprb 👍👍👍👏👏

[@drabbasi9948]

Plz post ent lectures

[@riamali6995]

But type 4 does not show ADCC right?

[@ayat4522]

Isn't rheumatoid arthritis example of type 3 hypersensitivity?

[@petrbatek9501]

It can actually be both, more commonly it is type III, but some cases are defined as type IV.

[@saranoor1007]

👍🏻

[@belizejuliette7223]

Is dress syndrome this type of allergy

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Vary 👍

[@drsavirgupta]

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[@MEDSimplified]

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[@alexentertainer7496]

please

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In tamil explain plz

[@mytalk1897]

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[@LUXURY69GAMING]

neutrophils are not involved in type 4 hypersensitivity reaction 😂😂🤬