Tools and methods for CRISPR-Cas9 screening for functional genomics and drug discovery

Presented By:
Louise Baskin, M.S. Molecular Biology and Genetics
Senior Product Manager for Functional Genomics, Thermo Fisher Scientific
Speaker Biography:
Louise has 15 years of experience in product management, marketing, and technical sales of reagents and tools for gene modulation, encompassing primarily RNA interference and CRISPR-Cas9.
She received her Masters Degree in Molecular Biology & Genetics from Northwestern University.
Webinar:
Tools and methods for CRISPR-Cas9 screening for functional genomics and drug discovery
Webinar Abstract:
Loss-of-function studies are an established method for uncovering a gene’s role in a biological pathway or disease state. The advent of CRISPR-Cas9 for gene knockout has given researchers a powerful tool for single-gene studies as well as high-throughput screening applications. Some experimental systems and assays demand solutions that enable long-term phenotypic readout, delivery into difficult-to-transfect cells, and the ability to easily move from pooled to arrayed screening reagents. The Invitrogen™ lentiviral guide RNA portfolio offers a toolset to achieve these goals. We will additionally present a recent case study of how a screen with LentiArray™ gRNA reagents has led to a potential human cancer therapeutic.
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