Exposed! The Vicious Hype Cycle of Supplements
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- Опубліковано 27 вер 2024
- You’re being sold false hope in a bottle, and the evidence they’re using to convince you is nothing but smoke and mirrors.
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As a physician who has a patient population of young adults with fatty liver disease, I find the C15:0 story compelling. Specifically the pathophysiology of the cellular fragility syndrome makes sense. Low levels of sturdy fatty acids like C15:0 in our cell membranes leads to weakened cells, leading to lipid peroxidation, ROS, iron deposition, iron overload and cell death by ferroptosis, leading to accelerated NAFLD/NASH. Further, the clinical trial you mentioned was performed by Dr. Schwimmer, a leader in pediatric fatty liver disease. The way I read his findings is that if you increase your C15:0 levels above 5ug/mL, patients with increased liver enzymes had significant improvements in ALT and AST, which to me means that there is a safe, low risk way to address a condition (fatty liver disease) that has very few treatment options. Exciting (but early) findings.
You are either incorrect or have little evidence that supplements that are antioxidants generally blunt the effect of exercise. You should stop saying this. Some antioxidants do this but not all. We know that there are human studies suggesting that astaxanthin increases muscle strength and endurance. There are mouse studies on curcumin and olive leaf extract that show that each improved muscle mass, strength and /or endurance.
I will give you one example, but there are several
This human clinical trial on Natural Astaxanthin in 2011 was funded by Gatorade Sports Science Institute. For this study, Gatorade used competitive cyclists, supplementing them with a placebo or 4 mg of Natural Astaxanthin each day for four weeks. From the endurance athlete’s-or for that matter-from any competitive athlete’s perspective, the results were excellent. In a 20 kilometer (approximately 12.5 mile) cycling time trial, the performance of the subjects taking Astaxanthin significantly improved, while the subjects taking placebo showed no improvement. Natural Astaxanthin made these competitive cyclists on average 5% faster in only 28 days. Also, the cyclists taking Astaxanthin demonstrated significant improvement in their power output, which increased by 15% on average over the same 28 day period.
As far as I know, Gatorade does not sell, and has not sold, a product containing astaxanthin
@DrBradStanfield I get the impression that the shill selling snake oil is felling threatened by Fatty 15, a product that was going through the pharma route to market, but was withdrawn and released as a supplement because it is a natural product, not needing the approval required for drugs. It is interesting that so many specialists in their fields are doing their own research on C15. And the fact you ignored evidence from populations that naturally consume large quantities of C15 in their diets and have higher health and longevity markers than the rest of the European and American population’s.
Man that C15 TED talk has been all over my UA-cam feed lately too.
Odd, it never came up on mine. I subscribe to at least 19 health and aging channels.
And if it IS found to be effective, guess what? A pharmaceutical company will say that it is extremely beneficial for a particular ailment and will apply with the FDA for it to be sold by prescription only.
It depends. Astaxanthin from BioAstin got FDA-approved but can still readily be bought without prescription.
Seems like some supplements companies are just as bad for the public as pharmaceutical companies.
I heard that some idiot at Harvard tried that with NMN, a variant of niacin.
bullshit, there are plenty of supplements with proven efficacy that are still cheap and available (Creatine, Taurine, Glycine, NAC and many other)
Vit C was helpful in lab rats with CMT neuropathy but didn't work in humans with CMT
Definition of vitamin is?
Most Vitamin C supplements are unstable. Unless they use a stabilized slow release version I don't think anyone knows what it's capable of.
Which is sad. No one does the leg work on anything.
@@darkhorseman8263 Simply get real V-C ! Pine needles are loaded with real C and makes for a excellent tea and saves you money!
I wish doctors were as careful about prescribing medications.
I've been critical of your videos in the past due to what I believed were overly negative statements towards some supplements & health interventions that had both positive and negative data supporting their use. In this case, you have redeemed some of my criticism by providing solid information and an educational public service. Thank you for this.
thanks Brad, an excellent investigation and illustration of the supplement hype cycle
Actually many ingredients that make a cake taste better also make a stew taste better... Adding black chocolate to the sauce of a beef stew like Daube or Boeuf Bourgignon is an old trick of french cooks, cinnamon also adds flavor. More general, adding sugar to savory dishes in general makes them better, as does adding a bit of salt to many sweet desserts and cakes. Adding butter to both will also make them simultaneously tastier and unhealthier...
Do two teaspoons of Ghee per day (very tasty). It has the same amount of C 15 as the Fatty 15 supplement.
Right... or put a little cream in your coffee, or have a little cream cheese. "Deficiency" cured.
I do one ounce of cheddar cheese in my salad. It has the same amount of C15 plus it is high in spermidine.
I have a few grams of butter on a slice of seed bread fron trader joes for lunch and dinner. A total of 22 carbs and some protein too.
Cream in coffee or tea blocks absorbion of beneficial polyphenols
awaiting more research. early days but are getting some good results after 2 months.
Thx for covering Fatty 15, haven't been able to find an objective review since it's release a while back. It's super expensive as well.
Listen to latest Dave Asprey podcast. The person behind it is on it and mentions where you can get links to research. Up to you to decide then.
Don't forget that Dr Brad was pro resvératrol just a few years ago after he'd drunk the David Sinclair Koolaid (as had many of us, admittedly). Even at that time there was research around which dissed it.
"All of this is complete bollocks" 🤣
Love it.
@@phaedrusalt You have to have the intelligence to know the difference between the two.
If you're studying C15, you should be studying it in relation to age related organ iron overload.
Particularly, expression of IL-11 driven inflammation and P21 expression in stem cells.
Thank you Dr. Stanfield for the insightful, well organized analysis.
Excellent information 👍
I’m in my 50’s and most of my family has died from Alzheimer’s. Because of this and my age, I started taking neuro hacking supplements a few years ago. I had a full physical about 5 months ago and was told my liver enzymes were spot on for good health. 4 months ago, I added the supplement uridine after watching some videos on it. A month ago I ended up spending several days in the hospital with fatty liver disease. They said one of my numbers is supposed to be under 100, but was now over 2100. I started reading about each supplement I take and found that in some, uridine can cause this. I stopped taking all supplements completely. I feel more clear minded now than I have in years. I’m going to steer clear of supplements for the foreseeable future.
Apolipoprotein E4 is associated with improved cognitive function in Amazonian forager-horticulturalists with a high parasite burden
www.ncbi.nlm.nih.gov/pmc/articles/PMC5349792/
Contrary to observations in industrial populations, older adult E4 carriers with high parasite burdens either maintained or showed slight improvements in cognitive performance, whereas non-E4 carriers with a high parasite burden showed reduced cognitive performance. Being an E4 carrier is the strongest risk factor to date of AD and cognitive decline in industrial populations
Nice one Dr Brad, I reached a similar conclusion.
I was looking forward to this from you. Thank you ❤
Fantastic, we need much more like that! Thank you!
thank you so much for this really informative video🤗
Please do a video on reversing hair loss and greying
And reversing hypothyroidism!
Excellent review. Thank you for making a video about this. This supplement seemed "fishy" to me because of the lack of controlled human evidence.
Having taken Fatty 15 for 5 months now my HDL is the highest it has ever been, my before & after blood test prove it. This was the reason I started it. Also fasting Insulin went from 15 to 6.6. I will keep on taking it and will test again at the end of the year. For now my biomarkers are moving in the right direction if that changes then I will change my supplements.
Maybe you’ve changed something else too ??
I believe his job is to deter you from something that may work. He does this all the time.
@@MegaWandak Oh? And why would he do that?
I’m taking it to. I am seeing and feeling much better. 59 and getting morning erections again. How’s that for a scam? I’ll take the scam.
@@MegaWandak True, I feel this way about Brad. Only focuses on single facts about substances that have been studied vastly in many areas like resveratrol.
Thank you Dr. Stanfield! I almost purchased their product :( It has been touted on so many podcasts! Honesty and understanding are thoroughly lacking on so many other podcasts!
me too
I did and it’s making a big difference in my health.
love your analogy re sub group analysis : if you torture the data enough you can get the result you want to hear
Ozempic is a good example of what will happen if someone comes out with something that actually works as well as its advertised. You're gonna hear about it very quickly
Ozempic also calls bowel obstruction. And you're not hearing about that yet, are you?
I am glad I waited. I was one of the people that took the information about C15 to heart. But I never bought any. I was thinking a bit in the direction of eating those types of fish those dolphins ate. But I have a question, on your video. You showed white compressed pills, but how can those contain fats?
Dr. Brad will you please do a video on hyperbaric oxygen therapy.
Best video yet Brad. Your videos are becoming sharper and sharper. Keep u the good work.
I hear you Dr Brad, never heard you angry like this saying “bollocks” love it 😊
I'm so glad you go against the mainstream health-UA-cam-channel trend with pushing supplements by sowing fear and instead stick to medical research on humans.
creatine is just about the only supplement that matches the hype and I’ve been around for 60 years so few really pan out to your point don’t chase every new thing doctor oz was the biggest offender every week a new miracle, food or pill for me this is a particularly good video thank you
There’s a few others.
I appreciate the information. I had taken this product before and it did nothing for me. I even put that on a post of this product on facebook. Some had even taken this for a year and it did nothing for them as well. I hope this video makes it around so others know not to take this product.
Timely video, brother - time to put a spotlight on Urolithin-A, if you haven't already.
Yes, supplements must be research science based and have pharmaceutical level quality control, even then they dont work for everyone in the same way, just as drugs don't always too .
Thanks for a great overview and presentation. We should probably always be careful with new molecules and wait for good human double blind placebo controlled studies.
Great video. I bought into the hype because of the interview with Stephanie Venn Watson. She seemed so sincere and the dolphin story and the Sardinian (humans) story. She may be sincere and the marketing people took over and over hyped the product. The fatty 15 people say they have a double blind placebo human trial of 20 people taking their pills and 10 control people taking placebos with good results on the 20 people. I wish Brad had talked some about the Sardinians and the human trials, otherwise it was a great video.
I have obtained a letter from the National Archives that Stephanie Venn-Watson wrote back in 1977 when she was just 5 years old. She wrote to the United States Congress demanding they modify the dietary guidelines to exclude dairy fat. AND THEY DID JUST THAT! The same exact year, her future husband wrote to Sardian sheep farmers in broken-Italian and asked them to consume adundant amounts of their pecorino cheese to obtain high levels of C15:0. Their plan? 45 years later compare Sardians with high levels of pentadecanoic acid to Americans with almost none, pen some wild story and publish it in a peer-reviewed journal, then create a supplement. And it worked...ALMOST. If it hadn’t been for the New Zealand medical Magnum P.I. (you just need to grow a crumb catcher, Brad) they would have gotten away with it! Thanks for the cracking the case! By the way, I would love to try the supplement you're pushing on your website (the Dr. Brad Stanfield Micro Vitamin for a cool $39.99) in order to reep the "18% smoother skin" benefit. Would you recommend I have my rough skin tested prior to taking it and then again after 3 months? What would that test be, exactly? Thanks, Julian
What I did after reading all the "C15 papers" I could find - simply make a more concerted daily effort to getting grass-fed dairy products, goat/sheep milk products, and/or grass-fed beef. Near as I can tell, about 2 ounces a day of such cheese or butter, 4 oz of such beef, or a couple cups a day of such whole milk meets the "RDA" (assuming/if such a thing truly exists for C15). Any one of those in nominal amounts each day should do the trick, and since all of those are all healthy unprocessed foods with beneficial Omega 3 profiles as well - as long as I keep it all within daily calorie thresholds there is no downside risk if the whole thing turns out to be bullocks. :)
What about the saturated and trans fat content? What about the associations of animal protein with cancer and autoimmune diseases (established with strong statistical significance in epidemiological studies documented in the China Study?)
What about them? Sure, there are people with allergies or vegan that may wish to avoid. I would suggest anyone that believes proper health maintenance must include 100% avoidance of any level of saturated fat consumption is not fully or properly informed. For example; C15 itself - to any extent it truly is essential - is a saturated fat. And somehow, if the research is to be believed, that saturated fat became “essential” to proper cellular health over the course of at least a few hundred thousand years of evolution (if not millions), despite the absence of a magic pill…
I see that you take psyllium husk for digestive health. Could you comment on recent research that says beta glucans (found in mushrooms, seaweed, barley and oat husks) are even better for gut nutrition than insoluble fiber like psyllium?
Still waiting on your HUMAN Rapamycin study doc.
Maybe you could start supplying us with it , and the profit can go towards the funding.
I heard AG1 was a scam as well.
Check some videos about the owner. A professional scammer
Thank you for this review.
Would your grandma need to do resistance training to get the health benefits from creatine?
This remind me of all the hype around the immune suppressant rapamycin and the over priced multivitamin supplements on the market
Thanks a lot for this video. Just in time, as I was on the point of ordering some C15
I believe the same thing happened with CoQ10
If I had a nickel for every time something called "fatty" tried to scam me I'd have two nickels this year, which isnt a lot but its weird that it happened twice.
Aaawww tell me you didn't buy the coin
Lmao
Interesting report. What about Urolithin A ?
Thank you very much for this.
Everyone loves dolphins. I’m going to find the secret component in bamboo shoots because everyone gushes over panda bears.
Execellent video, Dr Brad. Cutting through the wellness BS is important work. I’d be interested to know your opinion of naturopathy, a practice that seems to rely on prescribing any number of supplements to treat patients.
Brad, I listen to you, and I do listen.
Excellent video! 👏👏👏
Turns out I'm not a dolphin. Glad to get that sorted.
I dunno... check out the Aquatic Ape Hypothesis...
Thank you Brad
This video was very helpful. I've been subscribed to Fatty15 for over a year. Cancelled my subscription today. I had not noticed any differences.
Great video!
Both Brian Johnson and Dave Pasco both take it as far I can see.
It's just Dave Pasco... Sorry...
Thank you as I saw this add and was wondering because I have high cholesterol.
Could you let us know your view on hydrogen water and hydrogen generating effervescent tablets .
Can you do a video on octacosanol? It's a fatty alcohol that supposedly improves endurance. Also does this fat occur in other seafood as well? Or is it exclusively in dolphins?
Also while what makes a cake taste good may make a stew taste better it also may make it worse. Similarly, the supplement may worsen our health. So literally no reason to take it, it gives hope but also risks.
Best breakdown update on C15
👍👍
Well it may be my so called placebo effect trait from Ancestry, but on day 32 the hair on my arms is getting thick, sex changes - more ejaculate, slightly better sleep. Better mood. I am 70. Also started taking astragalus though as well. I have looked hard for the papers from 2012, nada. It does make me suspicious about a scientific journey vs. greed. But if it can lower mTor which is unproven, it might escape all those patents and just be added back into milk.🎉 My hearing loss may be improving due to that new form of autophagy. But there are other variables that may be involved.
Well for NMN and other NAD+ booster there have been results for people with very low NAD+ levels, like glaucoma patients with very low NAD+. It very well could be same for C15:0 that it is beneficial in cases were levels are very low. But we would need a longer trial with a lot of people with initial and further levels measured.
Oh no!! I just bought this supplement because it was promoted many times on the podcasts. Will not buy this again!
Don't throw it out. Take a blood test before and after, it may work!
@@jaimearaque8503 ok. I will that
I wouldn't underestimate the effect vanilla can have on a stew
Wow buen video, excelente para tener criterio con la industria de la publicidad ( en realidad criterio con todo 😮). Espero que pronto esté excelente canal tenga su versión en español.
mice dolphins humans --- all mammals --- but very different metabolisms and diets- thanks Dr.Brad Stanfield ... you are treasure imho
Hello Doctor - looked at your brand for psyllium husk - is not organic. Some brands indicate organic and third party tested. Is to costly? Or really not needed or benefit if organic brand?
💯Thanks!
Thank you
Hi doc,can you please make video on heme iron intake and risk of CVD and T2D diabetes?T2D heme iron intake study is latest one.
Well, the highest level of c15 in humans are those who live in Sardinia.
Hi brad, don't you offer any discount code from your supplements? I am thinking of switching and putting my trust in you. I usually buy them separately from do not age.
Are the compounds from natural foods or plants?
we are confused by everybody claiming the best proven supplement and at the end it is an ad for a company greedy for money but does not care about health of humans and they get the shady approvals anyway
Counterpoint to dolphins... wasn't Ozempic created by synthesizing a chemical in Gila monsters? 🐬
"Cellular Fragility Syndrome" being a member of the disease of the month club I will forward that to our committee.
We need a public shaming platform and call these scientists out by name. Thanks for having the guts to call out Sinclair and now Venn-Watson along with her husband, military physician Dr. Eric Venn-Watson, co-founders of Seraphina Therapeutics
Would creatine benefit an over 50 person that does not work out?
Great video with analysis of Fatty 15. I canceled my subscription with them after watching this. Thank you for great insight! It’s hard to get a meaningful information in an ocean of articles and publications and reviews. Maybe you could do a video about Novos Core and Novos NMN supplements if they are worthy of taking? Thank you 🙏 very much, Brad! Greatly appreciate all the work you do!👍🤗
Thank you
Thank you for a great video. Can you do one on spirulina and sea moss pls. Thank you ❤
man i haven't finished c14 yet and they already released c15 smh
How the hell they manage to skirt the FDA approval and form a company and sell a product????! Wtf? 😅
Its unfortunately alot easier than u think
I dono ask Brad he sells one lol
I bought a 3 month supply of Fatty15. Still on month 1. Not sure I noticed anything yet. But curious what you say about it.
Do you feel a greater sense of porpoise?
@stevenh109 🤣
Come on dude you made 235 videos on this subject, also remember that what didn't work now may start work in 1y
His closing remarks about trust made me wonder if he is talking about Moderna and fauci.
Sinclair
I cancelled my Ancestral Supplements order lol.
I have a question. Some researchers claim, that C15 is essential. Is there really evidence for that?
So you mean this snake oil I've been drinking won't give me the reflexes of a viper? 😞
They selling us dolphin's supplements...
Ah yes the Resveratrol playbook.
thanks Dr Brad. I bought that crap. It is useless.
They got your boy. Save yourselves. (Still feel kinda good though)
Dr Brad's argument , to me, sounds like because he has not yet seen human trial results, that the product is ineffective and automatically assumes the company is devious...Lack of human trial results should not give anyone, especially a famous online doctor, an excuse to vilify a company
think you've missed the overall point of my video, particularly the last part. My main gripe with this is the overhyping and overselling. From the Fatty15 website, the potential benefits appear proven when in reality they are not
As is all "Test Boosters" Be smart with your money people!
dude, they need to fund their research somehow lol
Absolutely, and I address this later in the video. My gripe is the overhyping
Very important video -> eye opening that supplements companies have been infiltrated by the big pharma methods -> are they the same people from big pharma starting these companies???
i bought the hype, and started adding butter to my coffee, i get the same amount of C:15 that's in the pills and a creamer coffee...i have no idea what this does to my body but my coffee tastes better
How do you know you vet 100mg of c15 in a tablespoon of butter?
@@pattersonellen i googled food sources for Pentadecylic acid or C15...it works out to about 13-14 grams of butter (1/2 ounce)