Pharmacokinetic (Part-02) Distribution of Drug | Drug Distribution | General Pharmacology | ADME

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Pharmacokinetics is currently defined as the study of the time course of drug absorption, distribution, metabolism, and excretion. Clinical pharmacokinetics is the application of pharmacokinetic principles to the safe and effective therapeutic management of drugs in an
individual patient. Pharmacokinetics influences the decided route of administration for a specific medication, the amount and frequency of each dose and its dosing intervals.
Pharmacokinetics of a drug depends on patient-related factors as well as on the drug’s chemical properties. Some patient-related factors (eg, renal function, genetic makeup, sex, age) can be used to predict the pharmacokinetic parameters in populations. For example, the half-life of some drugs, especially those that require both metabolism and excretion, may be remarkably long in the elderly
In pharmacology (and more specifically pharmacokinetics), absorption is the movement of a drug from the site of administration to the bloodstream.
Absorption involves several phases. First, the drug needs to be introduced via some route of administration (oral, topical-dermal, etc.) and in a specific dosage form such as a tablet, capsule, solution and so on. Drug absorption is determined by the drug’s physicochemical properties, formulation, and route of administration. The drug distribution is usually varied and depends on several factors such as:
(1) Blood perfusion
(2) Tissue binding (since drug binding is linked to the lipid content)
(3) Regional pH
(4) Cell membrane permeability
Pharmacokinetic- “What does BODY 1 do to the DRUG 2” we have simple interchanged the BODY and DRUG to make a definition. And as per the definition, our body responds to any drug by giving ADME effects.
1. A Stands for - Absorption
2. D stands for - Distribution
3. M stands for - Metabolism
4. E stands for- Elimination
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Most easy way to learn. Thanks for your teaching. Plz the writing on the board is unclear. Have problems to make notes 📝🥰

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Now i have improved. It was an old video

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Sir I'm a BSC nursing student
And ur video is so much helpful for pharmacology..😊

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Sir mene pharmacist exam ki puri teyari apke videos se ki h

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Sir great

[@manojtr4183]

Sir please upload these topics in english.... please.

[@solutionpharmacy]

Our pharmacology lectures in English (Started From 01/12/2020). Link- Complete Pharmacology Topics (English)
ua-cam.com/play/PLOsge3l7t_CTpZW0qDKEHoYyYBTYPozex.html
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Bahut bahut dhanyawaad. I am so happy that my effort is creating a smile in your face. Stay happy. All the best.

[@mahamoodpasha9872]

Its very helpful to us.....Good sir.......but English me b simply definition smjaoo.........tnk q

[@solutionpharmacy]

mahamood pasha ok i will try

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your lectures are very helpful........ May ALLAH bless you.......

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@@solutionpharmacy English main weak ho AAP 😁😁

[@solutionpharmacy]

@Cricket motivation That was because of voice assistance. Please have a look to these lecture and then let me know how i am - Our pharmacology lectures in English (Started From 01/12/2020). Link- Complete Pharmacology Topics (English)
ua-cam.com/play/PLOsge3l7t_CTpZW0qDKEHoYyYBTYPozex.html
Channel list - ua-cam.com/users/PharmacyDictionaryBySolutionPharmacy

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Rj Rocks most welcome

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Really It's too good explanation 😍 Keep going sir...and please do more and more videos❤

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Really u r good explain sir tqq u so much

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love from bangladesh..
try to add more 4/5 mints for our satisfaction.. 😍

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AMITAV SEN Thank you. Ok

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All my concepts are clear ...thank u so much sir 😊

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Very helpful sir thanks a lot sir
Very nicely explained 🙌

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Pawan Yadav Thank you

[@atifchannar]

Good 👍 work sir but speaking 🗣️ study should slowly

[@quainatsaleem163]

Thank you so much sir for you're lectures... They helped me alot and still helping me...
Sir can you tell me what is meant by reversible distribution and when it occurs? It's different from redistribution?

[@solutionpharmacy]

Yes its different. Redistribution means again distribution from 01 highly perfused tissue to the orher (lower) but sometime reverse that means from
It has originally came. (Some time seems same as redistribution)

[@quainatsaleem163]

@@solutionpharmacy OK sir got it... Thank you so much sir!!

[@growmore3656]

Thank you sir very halpful knowledge

[@solutionpharmacy]

Thank you so much for your feedback and support.

[@mnhyi]

Wow...Super nice explanation with proper basic information..Thank you sir for uploading this..Please do a lecture on diuretic and anti diuretic..

[@solutionpharmacy]

Thank you so much. Sure i will upload those topics too.

[@manishatanan8508]

I m new on this channel. May u let me know that is it similar for 2nd year MBBS k d Tripathi ???
But it is not same as 8th edition of KDT.
Please let me know that it really helpful to me. 🙂

[@solutionpharmacy]

Firstly welcome to your own channel. Sorry i did not get your question. All of our lectures are rqually useful for MBBS and we follow 12 book which is followed by MBBS students

[@manishatanan8508]

@@solutionpharmacy okay sir.
I started reading pharmacology from your channel.
It is really helpful sir. Thank u 😊

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[@solutionpharmacy]

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[@pinky9609]

I m sorry sir .. but I think there is a little error 5.0 .. lungs is highly perfused organ than brain .. please do reply sir ..

[@solutionpharmacy]

Amisha Pandey Blood flow and tissue perfusion are 2 different things. And yes lungs is highly perfused then brain. In our videos we have just given example of high and low perfusion organ.

[@pinky9609]

@@solutionpharmacy got it . Sorry for inconvenient Sir.

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Its ok. No issue.

[@bhanupratapsingh8875]

Tnks sir for helping us..😊🙏

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Its my pleasure. Students are my strength. I love my students.

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Thank you so much sir for these videos...it was very helpful...superb lectures...keep making videos sir..🙏 God bless you..

[@solutionpharmacy]

Thanks aot

[@madhurakayara5533]

Awesome sir!
May I please know on which book your lectures are based ?
I am willing to follow the same book as it would be easier comprehending( I am MBBS student)

[@solutionpharmacy]

I use diff books - KDT, Lippincott, Text book of pharmacology by P Jagdeesh prasad

[@madhurakayara5533]

Solution- Pharmacy Which one book would you PERSONALLY suggest me( MBBS student) for maximum understanding?
Please let me know your opinion!

[@solutionpharmacy]

Madhura Kayara KDT and Lippincott together. 1 st read from Lippincott qnd then repeat it from KDT.

[@madhurakayara5533]

Solution- Pharmacy Thank you sir!

[@amjadabbas1522]

@@madhurakayara5533
Lippincott is the best

[@medicalschoolguidelines]

Dear sir, Thankyou very much for making this subject interesting for us. You have very well explained this chapter.

[@officialgauravverse9434]

Very nice or very easy sir apne kafi easy or acche se samghya❤🎉😊

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Thank you so much

[@kaynatfarheen3736]

Your videos are very good for concept build up sir

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[@mahirakhan774]

Sir...m beginner plz suggest me which book i should prefer.
And i'm watching ur videos serially ...i loved it
But sir u speak lil bit fast🙄 .

[@solutionpharmacy]

Sorry for the speed. Have a look to our channel we have just uploaded review on books

[@vaishnavidesai4852]

Hello sir ..I recently started watching your lec they are so good ..no doubt..I just want to tell that in this lec you not explained the chemical nature of drug point in capillary permiability

[@solutionpharmacy]

These was our initial videos so we could not cover all points. Sorry for that

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I am searching for distribution for drugs

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हमे ये समझ नही आता ये जो कुछ 10-15 लोग वीडियो को dislike किए है कौन , मतलब की हमने आज तक इतने अच्छे teacher को नही देखा जो ऑनलाइन भी पढ़ते है तो ऐसा लगता है कि ऑफलाइन पढ़ रहे है और यदि इन सर के वीडियो को अच्छे से देखे तो हमको नहीं लगता की कोई टॉपिक छूटता हो ..... thanku so much sir full support from UP

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[@syedakiran6027]

Sir , drugs which have capability yo bind with plasma proteins, mean they will stay in blood stream so their distribution to the target sites will be less?? What will be the effect of theraputic effect?? Please answer i am confused here

[@solutionpharmacy]

Syeda Kiran Those drug which are binded with PP will not be able to distribute in many tissue as you have said (Its correct) and there will be cumlation of the drug which may cause toxicity. After some time (Depends on drug to drug) they will be dissociate and binding will be leleased and then drug will start its usual action.

[@vamanrathodvaman230]

Sir, main BHMS student hu.
Pharmacology ka konsa book best hai????

[@solutionpharmacy]

Textbook of pharmacology by Jagdish prasad

[@kuberpatidar6388]

शर आप बहुत अच्छे से टाॅपिक क्लियर करते हे

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I am future ayush Dr. & Following you sirr 🥰 tussi great love uhh sirr may allah guide you 😊✌️

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Thank you so much. God bless you too dear

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Your videos are very helpful sir ...please aise hi videos banate rahiye...apka explanation deneka tarika bhot acha he ...

[@solutionpharmacy]

Sure. I will

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Thank you so much sir 🙏🙏🙏🙏🙏

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My pleasure

[@intelligenceguidline8698]

Sir ap topic bohat good method se explain karte hay ...lekin sir 1...speed tora kam kare please. Bohat jalti se ap batha raheho ...aur 2..writing thora large size may kare specialy in diagram ...thank u so much sir

[@solutionpharmacy]

Thank you. Ye hanare sabse pahle ke videos hai aur aaj ki date me sab video uploaded hai to aage ke parts me sahi ho gaya hai

[@PharmaPrepcom]

Sir here any lacture on anticancer drug?

[@solutionpharmacy]

Favourite gaana Really sorry but we have not reached that chapter yet. But it will be available soon

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Very helpful lecture dearest sir and very important your lecture for clearing concept

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Really helpful thnku sir... Ap k lec ki waja se mujhe pharmacology easy lg rhi h.... 🙂

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Saliha Khan Thank you so much for giving your feedback. All the best.

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Must try these fantastic lectures:
Dr Junaid Asghar

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Really helpful explanation thanks.....plz upload drug metabolism as well I have exams soon and ur way of explanation answer my all questions ... thanks again

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P K Thank you so much. We have uploaded 1 part of metabolism and today 2 part will be uploaded at 6PM. Thank you for your support.

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You're doing an amazing job sir!! Your lectures are so helpful. Please keep making them!!!

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[@Kittupatel089]

Which book you prefer sir for pharmacology?

[@solutionpharmacy]

Pharmacology books which we use to make lectures
ua-cam.com/video/4qjLQqfwGog/v-deo.html

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❣🤗Cology ko easy bana diya apne

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Thank you so much

[@chandravamsich]

Good and informative video uploaded by you sir, thank you.
More information is required about mechanism of drug action by considering volume of distribution as a factor.
Other: Difference between potency and efficacy.

[@solutionpharmacy]

Thank you. I will look on these

[@TheKaleemullah12345]

Sir, your videos are super, i am commerce student but I love these videos.

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Really,it too good explanation...thank you sir...😇

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Thank you

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Really awesome and .. understandable explanation sir ... thank you so much

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Alfiya Biradar Thanks alot for your feedback

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Sir I watched this video today & ur voice & way of teaching is ❤️

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Your lectures are very helpful and good explanation sir

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really amazing sir......

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Sir making a video sympathomimetic drug and sympathetic blocking drug

[@solutionpharmacy]

Sure.

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good explanation sir, thankyou 🙏

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Thank you so much

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It's a very helpful video for all pharmacy students and medical students 👍👍 thank you so much sir ❤️🙏🏻

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I'm so lucky that my senior told me about your channel tnx sir ❤❤❤

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Mashallah very nice explanation sir😊.....

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Shukriya

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Really your work is highly appreciated. I am very happy to revise my pharmacology in quick way by listening your videos😃

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Thanks sir aap ne video upload kri ise he jaldi jaldi krye

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Naim Akhtar ok

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Very helpful to the us ..thankuu sir❤🔥🔥

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Thank you so much sir....🙏😘

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Aakash Patil my pleasure

[@docdoc8069]

very well dear. one thing please make it in sequence by giving number and playlist.thanks dear

[@solutionpharmacy]

MBBS stuff Thank you so much. Sir we have created a playlist. Please do find in our channel.

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@@solutionpharmacy yea but it's mix up. anyhow it's so nice

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It is very useful.....for all of us.🔥❤️
We really thankful to you for this vedio......

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Thank you

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Superb teaching sir ...best teacher ever seen ... keep smiling always

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Thank you sir ❤️❤️

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My pleasure

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Vry hlpful lecture sir. Thank u soo mucxh

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Thank you

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Love your videos sir 😄

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Wow sir please clear all the topics like this u are very nice explainer

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Thank you

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Thanks sir..... Great videos....easy to understand

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Thank you so much for valuable feedback

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Effective lecture.. Thank you Sir!

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Thank you so much

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Thank u so much sir for this amazing lecture

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My pleasure. Thank you

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Sir allergy topic bhi prha dyn or B catagory k exam dene hn next month please allergy ka btayn or medical importance of carbs glucose wagaira is me plant uski class name use wagaira hota hai sir ye do topics mjhy yad nhe ho rahy next month exam hn please iski bhi video dalein

[@solutionpharmacy]

mano khan sir syllabus ke according sari video dalne ki kosis karenge. Thank you

[@durgeshwaridevi5185]

Bhut acha tha sir... But screen short k liye kuch kuch word dikhai nhi dete

[@solutionpharmacy]

Durgeshwari Devi Thank you. Sorry ye purane vidoe hai. Ab hum har video ke last me screenshot ke liye time de rahe hai.

[@dr.sakshitomar6943]

Very very good explanation. U r good teacher

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Thanks alot for your valuable feedback madam

[@pharmacystudycenter1958]

Followed you from Kailali District, Sudurpashchim Province, Nepal.
I am Diploma in Pharmacy degree holder and am working as Assistant Pharmacist at Mahakali Provincial Hospital, Kanchanpur District, Sudurpashchim Province, Nepal.

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Such a nice explanation! Thank you sir

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Thank you

[@lalimohapatra8460]

Thank you sir... Best video for quick revision in 15 minutes

[@solutionpharmacy]

LALI MOHAPATRA my pleasure. Thank you for feedback.

[@saifkalim]

Sir in case of redistribution of drugs, how can it’s effect last long if the target is highly perfused organ bcz redistribution terminates drug action in such organs?

[@solutionpharmacy]

Saif Kalim you are right but when the same drug is given repeatedly or continuously over long periods, the low-perfusion and high-capacity sites are progressively filled up and the drug becomes longer-acting.

[@saifkalim]

Solution- Pharmacy got it sir. Thank you.

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Very helpful and time saving

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Thank you

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Thnku soo much for this vedio❤

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Welcome

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I love your all videos Sir and never feel borious with you . Thank you so much dear sir for brightening future of us . Thank you so much again dear sir .....

[@solutionpharmacy]

My pleasure. Thank you so much for your kind support.

[@manoharkokani8835]

Thank you Sir

[@solutionpharmacy]

Manohar kokani My pleasure

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Good lecture sir👍👍

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Please provide all syllabus of pharmacy

[@solutionpharmacy]

Will try

[@tejpratapbanjara7512]

Sir Please upload video for dose adjustment in hepatic and renal failure

[@Dentalsurgeon152]

Volume of distribution.
Sir in case of Vd (volume of distribution) what is means by "amounts drugs in body " ??..
..

[@noorr9637]

Really helpful kindly tell about Effect of toxicant on target molecules .i dnt hv lectures

[@AbdullahAhmed-zh8yz]

Mashallah

[@mr_musician6954]

sir aapke videos bohot acche h kaafi sahuliyat h videos m but aapse guzarish y h ki app thoda videos chote banaye or usi video m koshish kare explain karne ki,matlab point to point padaye,time kaafi lagta h itna hum samjh jaate because we are in MED school.Baaki taareef karunga, explaination bohot accha h.

[@solutionpharmacy]

Thank you so much sir.

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@@solutionpharmacy no sir....zyaada explain kita krein plzzzz

[@saroshsaroshali9654]

Kiya*

[@nupurkumari8498]

newly developed drug has log P value 2, pKa- 4.8 and intrinsic solubility 0.14 gm/liter.
Does this drug exhibit any absorption related issue? If yes, how this issue can be addressed? Sir iska answer bta degeye plz

[@swagatikamishra8191]

Words are not enough to describe your teaching🙏.......
Best you tube channel for medicos

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Thank you so much for your feedback. Your trust and satisfaction is very vital

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Great very nicely explained thanks

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Thank you for feedback