Bioavailability and Bioavailability Curve | General Pharmacology | Bioavailability Definition

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Bioavailability and factors affecting bioavailability- • Bioavailability | Fact...
Bioavailability refers to the extent and rate at which the active moiety (drug or metabolite) enters systemic circulation, thereby accessing the site of action.
Bioavailability of a drug is largely determined by the properties of the dosage form, which depend partly on its design and manufacture. Differences in bioavailability among formulations of a given drug can have clinical significance; thus, knowing whether drug formulations are equivalent is essential. Bioavailability is usually assessed by determining the area under the plasma concentration-time curve The most reliable measure of a drug’s bioavailability is AUC. AUC is directly proportional to the total amount of unchanged drug that reaches systemic circulation. Drug products may be considered bioequivalent in extent and rate of absorption if their plasma concentration curves are essentially superimposable. Plasma drug concentration increases with the extent of absorption; the maximum (peak) plasma concentration is reached when the drug elimination rate equals the absorption rate.
The physicochemical properties of the drug and its excipients determine its dissolution in the intestinal lumen and its absorption across the intestinal wall.
Decomposition of the drug in the lumen.
pH and perfusion of the small intestine.
Surface and time were available for absorption.
Competing reactions in the lumen (such as the drug with food).
Hepatic first-pass effect.
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[@lakeshkd1067]

Types of bioavailability
1. Absolute bioavailability
2. Relative bioavailability
And measurement of bioavailability-
1. Pharmacokinetic method
(a) urine data
(b) plasma data
2. Pharmacodynamic method
(A) acute pharmacologic effect
(B) clinical response

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Thanks for your feedback. Its my pleasure to serve students

[@ronakrd2717]

I am really appreciate to you. This is very good learning experience 👍
I want to understand some more point:
1) AUC 0-T, 0- infinity,
2) what is power?
3) Why 80-125% criterion in bio?
4) intersubject and intra subject variability?
5) highly variable drug challenging in bio point of view?
6) which parameters should i focus during the bio study?
If you explain in deeply with example it would be great help to me.🙏

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1

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Shahab Uddin Thank you so much for your feedback

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I am in 3 year b. Pharm student

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It's very helpful video to understand bioavailability..👌👍

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Most welcome. Thank you for your feedback

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We can say minimum tocxic concentration to maximum safe concentration as at minimum toxic concentration the unwanted effects are toleratable but above that the unwanted effects can not be tolerated

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sanjivani udasi most welcome. All the best

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Thank you

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Sir aap ki videos boht achi hoti hain..please factors influencing the bioavailability pe b video bnayein....

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Sarosh Sarosh Ali Thank you. Already uploaded. Please watch Bioavailability and Factors Affecting Bioavailability- Simple Explanation in HINDI
ua-cam.com/video/FZQ5WCiUEKE/v-deo.html

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Thank you so much. Biochem will start after some time

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sir Bioavailability k types bhi hote to Bahut Achha..... Like absolute bioavailability and relative bioavailability

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Sultan mirza yes. This was just an intro. I will upload detail one.

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[@drsachindeshmukh6924]

Thank You Sir for Nice Work 🙏
One Q
Bioavailability of IV drug is Always 100%and that of Oral is never 100% then
Why we give drug in same dose for IV and Orally
e.g1).Inj Ondem 2ml contains 4mg
Tab Ondem 4mg
2) IV Levoflox 500.
Tab Levoflox
3)Inj Voveran 75 mg /3ml
Tab Voveran 50mg

[@solutionpharmacy]

Dr Sachin Deshmukh This is a nice qus. Its BA is not a general it for drug specific. Yes BA of IV is 100% but its duration of action will not be prolonged

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[@solutionpharmacy]

@@roublearora4817 in short. The 1st pass metabolism is not same for all oral drug. Their extent may warry. I have uploaded a video - on 1st pass metabolism. Extent of First- Pass Metabolism of Certain Drugs (HINDI) GPAT, NIPER, Pharmacist Exam Exclusive

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Thanks

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