After reading this in Tripathi 4 times over I decided I had enough. Then I stumbled across this video and my, I learned so much! Thank you so much for your work! keep it up!
I’ve been reading about Barbiturates and needed a visual representation of the GABA receptors and I enjoyed your explanations. Learned so much! Thanks.
WOW!! Thank you so much for creating such a lovely video to explain this concept that is difficult to grasp. So simple but so very well organized, paced, and explained. I learned a lot!!! Thanks again and I hope you keep creating more videos like this.
1.) Barbituates and DZD's work on different sites, but this doesn't have any effect on addiction potential. Most GABAergics, including ETOH can cause physiological, and psychological dependence. The binding sites (which have sub receptors) have little to do with the effect and the fact that 2 different sites exist isn't physiologically significant in addiction potential. 2.) Actually 3, as well as sub receptors, this was a good overview though.
Yes, you are correct they act on different sites. Therefore, Flumazenil is the antidote for benzos but not barbituates, because it only antagonizes benzo's binding site.
I was on 3mg of Ativan daily for 5 years and switched over to 2mg of klonopin without tapering off the Ativan. I just stopped the Ativan and went to klonopin. A few weeks after I started having very bizarre symptoms like fully body muscle twitching, cramps, pins and needles feeling and a bunch of other scary symptoms. Could the difference in the benzos cause such things? I've been cleared by my doctors and neuromuscular specialists as its not some type of disease. I still twitch 24/7 and still experience strange symptoms to this day which is a year later. Thanks
Hey man thanks. I just wanted to see how to draw the structure from side view for prof. But I like how you worked hard for this. Nice. Btw can you understand this sentence: MBBS kar rahay ho ya BDS?
I might be wrong, but the negative allosteric modulator (or the benzodiazepine antagonist) is called FLUMAZENIL and not FLUMEZANIL. Please correct me if I'm wrong.
Less specific to more specific, so from system to molecule: Start at the system (nervous) Then part of nervous system (brain) Location in the brain (CNS) Then the neurons (I’m not sure) Then the location on that neuron (I think the neuron terminal?) Then the structure of the terminal membrane (phospholipid bilayer) This is where the receptor is located. Then into more detail from there
After reading this in Tripathi 4 times over I decided I had enough. Then I stumbled across this video and my, I learned so much! Thank you so much for your work! keep it up!
+Justin Chu glad u found this helpful
same story here :)
Tripathi sucks like most other Indian books....Books suck
Justin Chu same here
most doctors prescribe as Anxiolytic drug (BZD's) by anti convulsion and partial amnesia will not have major bearing on health na ?
Short, concise and very well informative. Thank you sir!
I’ve been reading about Barbiturates and needed a visual representation of the GABA receptors and I enjoyed your explanations. Learned so much! Thanks.
In our times, we have youtube, then there's guys like you!! Thanks
+Anything Goes Thank u pal
Great drawing, very clear and easy to understand way of presenting the information. Thank you!
WOW!! Thank you so much for creating such a lovely video to explain this concept that is difficult to grasp. So simple but so very well organized, paced, and explained. I learned a lot!!! Thanks again and I hope you keep creating more videos like this.
Very good explanation. Thanks so much Sir. Regards from Canada
+Simarjot Singh You are welcome simranjot
+Simarjot Singh You are welcome simranjot
Thank you.....your voice is very pleasing to my ears lol sorry had to say it 😁 good explanation tho!!.☺
Very nice, I like the sped up writing/drawing presentation
You r the best man. Continue
I appreciate your hard work! ❤️✨
thank you sir very useful.....
Thanks❤❤❤
OMG this is so informative!
Thank you
THANKS MAN , SIMPLE TO THE POINT , VERY INFORMATIVE
Good explanation!
loved it! Thank you!🙂
Excellent work...really simplified this confusing topic ...thanx!!
thankyou sooooo much it just helped me out so much to study general pharmac
sir plz make a lecture on neuro pharmacology....
Very good presentation. Easy to follow and understand. Thanks!
Very helful video
100 times made easier than tripathi
Very good run on review.
FANSTASTIC LET'S TALK ANALOGUES WITH MULTIPLE BINDING SITES AND PUBLISH THAT THESIS!
Excellent work thank you!!
Thank u so so so much ❤️❤️❤️❤️❤️❤️❤️❤️❤️
Well said Dr♥️♥️♥️
Awesome brother
what is the best way to deal with Xanax withdrawl? can alcohol keep you ok until your next refill?
So fabulously explained sir 😍
Thank you so much 💚💚
Mannnnnn.. thank you❤
nicely done !!!
very nice teaching
1) Barbs and BZs work on two different sites, thats why theyre additive? Or am I wrong?
2) Aren't there 2 GABA binding sites?
1.) Barbituates and DZD's work on different sites, but this doesn't have any effect on addiction potential. Most GABAergics, including ETOH can cause physiological, and psychological dependence. The binding sites (which have sub receptors) have little to do with the effect and the fact that 2 different sites exist isn't physiologically significant in addiction potential.
2.) Actually 3, as well as sub receptors, this was a good overview though.
Video was informative
Helped me to see it broken down that way. Ty.
Thanking you, come again
i liked and subscribed your channel /// nice job
U have beautiful handwriting
Good way of explanation
Thanks for the simplification :)
Nicely done and presented 👍
Even better than college 🤓
Very nice video
super understandable, thank you
thank you ,, this was very informative and organised well
nice explanations and informative
Thank you it's really effective for my exam
Thanks. Very informative.
Very nive job, ty
Exactly what and how much I was looking for
Amazing description. .thankyou-;)
Nice lecture
Genius!!!!!
can you do one on GABAB please?! this was so helpful
Thx too match really really helpfull :)
You are very welcome
Thanks alot!!!
+Alexis Schulman You are most welcome
very good...
Best sir..
Thanks Dr
thank you so much
u da bomb
Nice 👍🏻
Thanks
Please can you make a video on gaba B rc as well...I made notes from your video it was very helpful. Thankyou
Thank you!
thanx dude
I thought barbiturates and benzos act on two different sites.
Yes, you are correct they act on different sites. Therefore, Flumazenil is the antidote for benzos but not barbituates, because it only antagonizes benzo's binding site.
Yes you are right though. I was wondering if Thiopental is the only druk to have effects on both sides.
@@tobiasmuller2499 can a barbiturate stop benzo withdrawal? Or can alcohol stop benzo withdrawl?
Erik Guidry bet alcohol would help cuz of receptors are same
Erik Guidry alcohol works on same receptor
Great,,,, awesome,,,
Great video! What is the function of muscimol as a drug? Is it positive or negative effect?
thank you
👍 thanks
Good
Make vdo on NMDA receptor
Am I the only here that is watching for fun?
sebastian cuello. Could there be any other reason? :)
I was on 3mg of Ativan daily for 5 years and switched over to 2mg of klonopin without tapering off the Ativan. I just stopped the Ativan and went to klonopin. A few weeks after I started having very bizarre symptoms like fully body muscle twitching, cramps, pins and needles feeling and a bunch of other scary symptoms. Could the difference in the benzos cause such things? I've been cleared by my doctors and neuromuscular specialists as its not some type of disease. I still twitch 24/7 and still experience strange symptoms to this day which is a year later. Thanks
Pen1980IM how are you feeling now? I’ve been switched from Ativan to clonazepam also. Trying to taper off clonazepam now
Pen1980IM been clear from drs what do thay know about anything
thanks sir
I must say "medsimplified"😀
thank you :)
helpful.
what will bind in third binding site
No entiendo inglés pero entendí Perfecto todo lo que decía acá jajajaja thanks for all !
Bring a bit of confidence in your voice. Nice video by the way !!!
+Souvik Goswami thank u for ur feedback souvik
Souvik Goswami
I disagree. I think his voice is most pleasant. Such a refreshing change from the usual monotonous drone in these information videos.
Hey man thanks. I just wanted to see how to draw the structure from side view for prof. But I like how you worked hard for this. Nice. Btw can you understand this sentence: MBBS kar rahay ho ya BDS?
+Hassaan Huda Abbasi thank you hassan for ur appreciation. I have completed my M.B.B.S.
Ah nice nice. Best of luck for the future. And keep making for videos. You're good at explaining things
+Hassaan Huda Abbasi For Sure. same to you
Liked ☺
Cheers from Greece
hello, where can I find the 3D model you made?
where is the third site
I might be wrong, but the negative allosteric modulator (or the benzodiazepine antagonist) is called FLUMAZENIL and not FLUMEZANIL.
Please correct me if I'm wrong.
Ur wrong
*Is GABA a neuroleptic?*
Please tell about dcmc drug ie. ,benzodiazepine inverse agonist?
🔥🔥✨✨
I am lost in this subject... Where should i start???
Less specific to more specific, so from system to molecule:
Start at the system (nervous)
Then part of nervous system (brain)
Location in the brain (CNS)
Then the neurons (I’m not sure)
Then the location on that neuron (I think the neuron terminal?)
Then the structure of the terminal membrane (phospholipid bilayer)
This is where the receptor is located.
Then into more detail from there
what about GABBA C?
how thiocolchicoside act on the ...if it gaba competitive antagonist....
please answer me as fast as you can, it is for a school project
osm
What is action in cNS
CNS stands for Central Nervous System
BDZ act on different receptors than barbiturets and other anaesthetics
I tore many ligaments and tendons due to benzos induced muscle weakness. I’m bedridden. 😣