Thank you very much Areo. I searched for this topic to get clear on the mechanism of action of Zolpidem to prepare my board exam to become a pharmacist. Your video is very effective because the diagrams gave me multiple viewpoints of the receptor--from a close up of a receptor, to how it fits in neuronal action. It's comprehensive and organized, and that's why I'll be able to pay it forward by telling my future patients about their Zolpidem! Thanks again and please continue doing what you're doing.
hello im a nursing student and this short 9 minute video helped me understand and connect the dots for CNS depressants, receptor binding, GABA, and differences between drugs, so thank you :)
In spanish there aren't many videos about pharmacology as well explained as this one. Despite the language, i understood everything and clarified my doubts. Thanks!!!
You sir, have a nice project here. You manage to explain everything perfectly, the slides are good, the pictures are explained and your voice doesn't sound like every other person on youtube explaining interesting stuff (yes we all know what it mostly sounds like... Tandooooori) I normally don't subscribe to people but you really earned it!
I just wanted to comment on the GABA(B) receptor discussion. GABA(B) receptors are g-protein coupled; however, they are able to open Potassium channels. A special type of Potassium channel known as a g-protein activated inwardly rectifying K+ (Potassium) Channel or GIRK channel will open in response to GABA(B) receptor "activation." Great, informative video. Thank you for posting.
I recently began taking Baclofen. Life-changing. I would love to see an explanation of how it works. Please consider a more detailed lecture. Your presentations are helpful.
Also, Benzo are metabolized by the hepatic CYP, a alkaline place, up the acidosis in the body for a faster metabolism. Slow metabolite transforms the original drug throughout its metabolism process. Where you could have only taken one drug but labs will show you have taken several from the same family/class in your system, such as Benzo.
06:11 I think the Barbiturates bind to the Beta-subunit only and not the Beta-Gamma-subunit-connection. Otherwise your 3D picture of the GABAA-channel wouldn't make sense.
hey thanks for the video! You summarized (in 10 minutes) what my lecturer couldnt' do in 2 hours. ... that or maybe i just wasn't paying attention. Thanks for clearing things up :D
very good and on and off alcohol is something that is well explained in your lecture as involves gaga and so people are surprised with spice breath and un opposed to breath tests as a result of all you had made clear thank you sir from dan ragan
I just want to add some information as to what @TheAncientScholar has commented about GABA(B) receptor discussion: -the GIRK or G-protein activated Inwardly Rectifying K+ Channel is composed of G beta & gamma subunits and has a slow response to GABA NT Thank you for this video..
You forgot the best part. After you use Benzos or "Z" drugs for more than two weeks, the GABA receptors down regulate. Then you need to take more of your Benzo or "Z" drug to have the same effect. The longer you use them, the more they down regulate your GABA receptors. And if you decide you want to stop taking them? It can take months or years for your GABA receptors to up regulate back to normal. Meanwhile, you will be in a special kind of hell while you wait for your GABA recptors to up regulate back to normal. Benzos are extremely effective, but be very careful. Once you are on them, they can be extremely difficult to get off of for a significant percentage of the population.
The problem is that in US you'll be always given the strongest benzos. E.g. Alprazolam. Only if people would understand to take something less effective.
Why I'm here is benzo issues, 10 years on them I decided to go cold, was a very fast hospital trip, 2 months later back on it and higher dose and there not doing shit, I'm stuck in a hell, was never warned on benzos
it is really nice to watch your videos, they make pharmacology so much easier to understand. please make more videos if you can and especially on cns. thank you
Great tutorial, just one slight correction that I am sure you are aware of but at 8:03 GABA-B receptors are G-protein coupled receptors not ion channels.
I suffer from Idiopathic Hypersomnia (or Major Somnolence Disorder). I have a GABA hypersensitivity that is caused by a chemical in my CSF. The effect is similar to being on a constant IV of benzodiazepines therefore things like caffeine & amphetamines do not reverse the effects of this chemical like flumazenil can. However flumazenil is only in the early stages of being compounded so that we can use it effectively so I'm looking for something else that will work the same way Flumazenil does.
Great video, thanks a lot for the explanation. Taken as you've done multiple such videos, it's safe to assume you work as a pharmacologists or somewhere within the sphere?
Nice! And thank you. But of course VESICLES do not traverse across the synaptic cleft, it's the GABA from INSIDE the vesicles, released upon their fusing with the neuronal membrane, which diffuse across.
+Lighto Yagami Voltage gated Ca(2+) ion channels lie at the end of an axon and open when an action potential reaches the presynaptic terminal. This causes the vesicles filled with neurotransmitters (could be GABA, glutamate, glycine, norepinephrine, or countless others) (I believe the vesicles are just made of phospholipids like the cell membrane) to fuse with the cell membrane which releases the neurotransmitters into the synapse to interact with the receptors on the post synaptic neuron.
It's crazy to think that those neurons are individual organisms who are dependent on their community relationship with the rest of the organisms (cells) to keep everyone alive. Commonly referred to as the human body.
can you explain what taurine will do? if this is a like GABA which fixes on GABAa or b? And how glucuronolactone and inositol are acting on GABA and dopamine releaser?
Excellent presentation. However, at 7:39, the speaker says "you get more hypnotic effect with less sedative effect" I think this is a contradiction, since hypnosis is the same thing as sedation. Perhaps the speaker meant anxiolytic effect rather than sedative effect? :)
Sedative removes the excitement (he spoke about) and irritability; making one calm that leads to the promotion of sleep. Hypnotic is a instability in producing sleep. Hypnotic can be done without the use of anesthetic/drugs where sedation cannot. Similar, but not the same.
@Areo staffarzadeh - peace bro My question is, does GABA and Glutamine compete for the same binding site? If they do - would it decrease its use/processes for muscle recovery and rest? Thanx in advance
so does this mean i will be more relaxed and sleep better taking gaba supplements, also i get the (uneducated) feeling my migraines can be connected to an excitable brain, ive takin Gaba and feel calmer and sleep better, i don't use anything else.
you just explanined to me in ten minutes what my teacher could not make me understand in two months - thanks a lot!
Thank you very much Areo. I searched for this topic to get clear on the mechanism of action of Zolpidem to prepare my board exam to become a pharmacist. Your video is very effective because the diagrams gave me multiple viewpoints of the receptor--from a close up of a receptor, to how it fits in neuronal action. It's comprehensive and organized, and that's why I'll be able to pay it forward by telling my future patients about their Zolpidem! Thanks again and please continue doing what you're doing.
hello im a nursing student and this short 9 minute video helped me understand and connect the dots for CNS depressants, receptor binding, GABA, and differences between drugs, so thank you :)
Amazing how great the colors look! ;)
Man its crazy how good these colors look!
I mean: Man, it's crazy how nice these colors look! Hehe eauhhhhhh
Canada0609 3:26
In spanish there aren't many videos about pharmacology as well explained as this one. Despite the language, i understood everything and clarified my doubts. Thanks!!!
Excellent presentation! I wish you had been my instructor in Pharm school! Thanks!
You sir, have a nice project here. You manage to explain everything perfectly, the slides are good, the pictures are explained and your voice doesn't sound like every other person on youtube explaining interesting stuff (yes we all know what it mostly sounds like... Tandooooori)
I normally don't subscribe to people but you really earned it!
Great video! I just had to start taking Lorazepam and its nice to find such a clear description of whats going on.
I just wanted to comment on the GABA(B) receptor discussion. GABA(B) receptors are g-protein coupled; however, they are able to open Potassium channels. A special type of Potassium channel known as a g-protein activated inwardly rectifying K+ (Potassium) Channel or GIRK channel will open in response to GABA(B) receptor "activation." Great, informative video. Thank you for posting.
Does an imbalance of these above contribute to rigidity in muscles?
does anyone here know?
Lorrinda Mills too little GABA can do that. synapticmhz.blogspot.com/2015/03/learning-to-write-again.html is one page from my blog.
That was so great and informative, I have an exam two days later and I finally understand sedative-hypnotic drugs
thank you
I recently began taking Baclofen. Life-changing. I would love to see an explanation of how it works. Please consider a more detailed lecture. Your presentations are helpful.
Hi, update ?
really helpful video! just a note that the GABA B receptor isn't a potassium channel, it's a GPCR that activates other potassium channels
just "ouaouuu" now I love GABA receptors.Thank you so much, you are an excellent teacher!
The post-synaptic potential is not an action potential but a graded potential. Apart from that, a good explanation.
Thank you for making this stuff fun to learn and review. You certainly have a gift for making complicated stuff understandable. Great Job!
Also, Benzo are metabolized by the hepatic CYP, a alkaline place, up the acidosis in the body for a faster metabolism. Slow metabolite transforms the original drug throughout its metabolism process. Where you could have only taken one drug but labs will show you have taken several from the same family/class in your system, such as Benzo.
He has just diluted this topic well done
06:11 I think the Barbiturates bind to the Beta-subunit only and not the Beta-Gamma-subunit-connection. Otherwise your 3D picture of the GABAA-channel wouldn't make sense.
hey thanks for the video! You summarized (in 10 minutes) what my lecturer couldnt' do in 2 hours.
... that or maybe i just wasn't paying attention. Thanks for clearing things up :D
i think he's good.i'm not sleepy at all.*i just learnt about gaba today,so this is kinda to refresh my memory* =)) thank you for uploading.
very good and on and off alcohol is something that is well explained in your lecture as involves gaga and so people are surprised with spice breath and un opposed to breath tests as a result of all you had made clear thank you sir from dan ragan
I just want to add some information as to what @TheAncientScholar has commented about GABA(B) receptor discussion:
-the GIRK or G-protein activated Inwardly Rectifying K+ Channel is composed of G beta & gamma subunits and has a slow response to GABA NT
Thank you for this video..
You forgot the best part. After you use Benzos or "Z" drugs for more than two weeks, the GABA receptors down regulate. Then you need to take more of your Benzo or "Z" drug to have the same effect. The longer you use them, the more they down regulate your GABA receptors.
And if you decide you want to stop taking them? It can take months or years for your GABA receptors to up regulate back to normal. Meanwhile, you will be in a special kind of hell while you wait for your GABA recptors to up regulate back to normal.
Benzos are extremely effective, but be very careful. Once you are on them, they can be extremely difficult to get off of for a significant percentage of the population.
The problem is that in US you'll be always given the strongest benzos. E.g. Alprazolam. Only if people would understand to take something less effective.
lol really?,the "Z"! drug 😂
Why I'm here is benzo issues, 10 years on them I decided to go cold, was a very fast hospital trip, 2 months later back on it and higher dose and there not doing shit, I'm stuck in a hell, was never warned on benzos
@FUBAR well said buddy
Exactly. Took me 3 years to get off 1mg micro tapering at 2-5% every 2-4 week's. Brutal.
Doctor's and these guys clueless and pro's with gaslighting.
Is there a bigger pool of video's i'm missing? You've got a good teaching style
it is really nice to watch your videos, they make pharmacology so much easier to understand. please make more videos if you can and especially on cns. thank you
Really like this. Since i am on medication. Using benzodiazepines.
Timeless and invalueable information. Thank you good sir.
Great tutorial, just one slight correction that I am sure you are aware of but at 8:03 GABA-B receptors are G-protein coupled receptors not ion channels.
..yes that's correct
Thank you very much , you made it very easy. I was having a hard time in getting the concept of the Mechanism of action
liked the explanations, helpful stuff and i want to watch the other videos on GABA
Are you single? Well at least I have your science. Great stuff. Helps us to understand what we r doing. Keep it up! Just found this site.
Love this presentation style, thank you for helping me study for my exam!
I suffer from Idiopathic Hypersomnia (or Major Somnolence Disorder). I have a GABA hypersensitivity that is caused by a chemical in my CSF. The effect is similar to being on a constant IV of benzodiazepines therefore things like caffeine & amphetamines do not reverse the effects of this chemical like flumazenil can. However flumazenil is only in the early stages of being compounded so that we can use it effectively so I'm looking for something else that will work the same way Flumazenil does.
The colors are amazing! It wasn't a silly comment. Thanks!
Amaying colors, dude... and completely beside the point, also a great intro to GABA, thanks ;)
you are an awesome teacher ty
also; the colors duke the colors! (anyone remember that popsicle commercial with the dog? "I'm color blind kid")
i wish you had been my instractor in cilinical pharmacy school!!!!! tanks mor!!!!!!!!!!!!!!!
Finally get it. Bless you, sir.
These videos are awesome - thanks so much for doing them and I hope more are to come.
Beautifully explained ... many thanks 🙏
Great video, thanks a lot for the explanation. Taken as you've done multiple such videos, it's safe to assume you work as a pharmacologists or somewhere within the sphere?
Omg! I love this!!!
You save my seminar!!!
Absolutely PHENOMINAL! Thanks for that!
Nice! And thank you. But of course VESICLES do not traverse across the synaptic cleft, it's the GABA from INSIDE the vesicles, released upon their fusing with the neuronal membrane, which diffuse across.
hahaha "man its crazy how the colours look, hehehe"
also, thanks for the video :)
wow. thanks, it really makes more sense now. are you in pharmacy school?
please someone ...does glutamate also use calcium for vesicles or onkly GABA ????
+Lighto Yagami Voltage gated Ca(2+) ion channels lie at the end of an axon and open when an action potential reaches the presynaptic terminal. This causes the vesicles filled with neurotransmitters (could be GABA, glutamate, glycine, norepinephrine, or countless others) (I believe the vesicles are just made of phospholipids like the cell membrane) to fuse with the cell membrane which releases the neurotransmitters into the synapse to interact with the receptors on the post synaptic neuron.
How would different subunits mediate anxiolytics vs hypnotic effects?
Lost my shit at "that was a silly comment.." LMFAO. Concepts were really well explained too.
Sir.. Where is part 1 and 2 that precced this video?? Also I can't seem to find video on GABAa receptors.. Kindly reupload them
It's crazy to think that those neurons are individual organisms who are dependent on their community relationship with the rest of the organisms (cells) to keep everyone alive. Commonly referred to as the human body.
thank you for your clear and excellent explanation..
GREAT video!! Thank you for the concise explanation.
Excellent video.
Which software did you use to make this presentation?
wow how u did this video? thinking to do the same so that i able to help others.. by the way, this video is really helpful!
is flumazenil similar to Dogmatil and Solian?
great explanation
can you explain what taurine will do? if this is a like GABA which fixes on GABAa or b? And how glucuronolactone and inositol are acting on GABA and dopamine releaser?
What software are you using to draw?
Really wasn't a silly comment to say colours look so much better, I'm feeling that, colours DO look much better 6 months after detox.
Excellent presentation. However, at 7:39, the speaker says "you get more hypnotic effect with less sedative effect" I think this is a contradiction, since hypnosis is the same thing as sedation. Perhaps the speaker meant anxiolytic effect rather than sedative effect? :)
Sedative removes the excitement (he spoke about) and irritability; making one calm that leads to the promotion of sleep.
Hypnotic is a instability in producing sleep. Hypnotic can be done without the use of anesthetic/drugs where sedation cannot. Similar, but not the same.
@Areo staffarzadeh - peace bro
My question is, does GABA and Glutamine compete for the same binding site?
If they do - would it decrease its use/processes for muscle recovery and rest?
Thanx in advance
This is outstanding.
It was really informative Sir. Thankyou !
Amazing video, thank you!
Dude, you are a bad ass!!! Thank you very much!!!
very simpley put and educational thanks
Hi guys, do anyone know what kind of software/s does he using? (other then the graphic tablet). Thanks.
Excellent explanation. 😉
so does this mean i will be more relaxed and sleep better taking gaba supplements, also i get the (uneducated) feeling my migraines can be connected to an excitable brain, ive takin Gaba and feel calmer and sleep better, i don't use anything else.
Areo, you are amazing. Thanks for the video!!!
which software are you using?
Omgoodness, that cleared things up so much! Thank you!
Depends upon where you're trying...
that`s reeeeeeally helped me .. thanks you A LOT
Thank you very much.
You are amazing! thank you for the great lecture!
how does he draw so well with a mouse
gracias compare
How many GABA-A receptors are in the human body?
Brotizolam + Etizolam stacked !
No Cigarete by products. Brotizolam + Etizolam stacked with a touch of vodka!!
A GABA receptor and a glutamate receptor is not the same thing??
I respect this guy. He dope
the problem is if you burn the bz out with overuse they can get damaged
Dose alcohol affect your gaba?
The GABA receptor is a heteropentamer??
Hello!! Very informational and nicely teached! I liked!
thank you so much! I really appreciate it
Nice one!!! Thanks
great video! thanks a lot!
gAY IS THE ONE WHO IS LECTURING
Gaba B is a metabotropic receptor. Is it not?
SagaOfEquilibre yes
AMAZING THANK U SOOOOOOOOOOOOOOOOOOOOOOO MUCH ITS REALY HELPFUL
Not all heros wear capes!
great video
thanks a lot :)
Irani hastin?
great video, Thank you. Subbed!