An absolute boon to us med students. My professor taught this once and took an hour for this. I can revise the same pathway in less than 15 mins, with diagrams, mnemonics, concepts and clinical correlations as well. Thank you, good sir!!!
Time will come when education will b like this....its actually interesting, its simple, very logical, fun to watch, keeps attention and without noticing u just learned everything till the ending of the video!! Great stuff, Thanks man, You are really awesome!!.... hitting something that 99,9% of the professors r unable to do....
After 2 days of digging in the COX mode of action, none of the article was easy to read....found this video that made my life easy...Amazing job done boy
@@MedicosisPerfectionalis I have only one question if you please. In 5:39 you said, now you know why inhaled steroids are used to treat asthmatics. This is because they block the pathway leading to production of Thromboxane A2 and so no vasoconstriction?
No, it’s because inhaled steroids block the PLA2 and therefore decrease the level of arachidonic acid. This will, subsequently, decrease the level of leukotriens which make the life of an asthma patient hell!
I never comment on UA-cam videos, but your channel is one of the best things I've ever found on the Internet. Everything is so well explained and you're so damn funny. A huuuge thank you ❤️
You are absolutely the best at explaining things in a way I understand! And you're so funny, my 14 year old watches you with me just to hear you're jokes
When you linked it to real clinical scenarios, it felt like it clicked! Thank you! Also, I am from Australia and I am worried there are differences in the naming of certain things. Should I be worried about any differences that you know of?
Hey 👋 Emily...Thank you so much for your kind words...Brand names differ between countries, but what really helps is knowing the generic name by heart.
great video...just curious about how does the NSAID drug inhibits the cyclocygenase? like the functional groups present within the binding site etc....
One might have tought: maybe if you inhibit COX1, since COX2 still works and can't make TXA2, it can make more PGI2 when not racing against COX1 for PGH2 thus decreasing the risk of clotting more than non-selective COX inhibitors?
I like the "just kidding" at the end, implying that there's so much spite he wouldn't tell Merck & Co. about the biopathway even for a billion dollars. That's the kind of top-tier spite I can get behind.
Got curious about cox 1 and cox 2 because celebrex only inhibits the latter and I'm wondering why I'm still in pain compared from when I took ibuprofen before getting prescribed celebrex. I have otitis externa. From what I understood, I shouldn't be in pain. This is coming from a non-pharmacy student. Thank you very much by the way for having this lecture free for everyone to learn. :)
hello, have an pharmacology text book "pharmacology for health professionals 5th ed, by B, Byrant & K, Knights, and it says that it is PGI2 with COX1 inhibition that causes gastric ulcers, not Thromboxane A2 and now im confused to know which is right. Could you please be able to explain why the text book may be saying this and why you have said otherwise? Thank you :)
@@MedicosisPerfectionalisoops my bad, then what causes gastric ulcers more specifically other than just saying COX 1? I just want to learn thank you :)
There are some prostaglandins that protect the stomach...These prostaglandins are produced thanks to COX-1...When a drug inhibits COX-1 and COX-2, the protective mechanism is destroyed. However, when a drug selectively inhibits COX-2 only, the stomach is in good shape because COX-1 is uninhibited...Hope it helps!
So does this pathway, work differently in different cells. So the membrane phospholipids of platelets dont produce leukotrines do they. So its not really at multiple choice pathway but a single choice depending on what cell you are?
You are great! I am beside myself angry with uneducated nurses shaming me for managing pain after a surgery without NSAID’s (asthmatic). I don’t know why in the hell I have to do all of this research myself as a patient. I have learned a lot but this is aggravating. Anesthesiologist understands it. What do I tell these people? Please help
Thank you 🙏 I appreciate your comment! I really admire your perseverance and the fact that you are doing all of this research even though you’re not a doctor! Hats off to you!
@@MedicosisPerfectionalis well my friend, I’ve always had interest in the medical field…. being a seasoned IT veteran, many of those whom which I’ve helped have called me a doctor anyway, lol. Being an analytical thinker to begin with, they have some alignment. Anyway if anybody would be kind enough to provide their two cents I would love to hear it. Obviously it’s not going to be taken as any sort of medical advice I promise! More or less,, direction,, would be nice or references to material that I can study. Just trying to feel better as all. And I’m in such a small group of people apparently. Asthma exacerbation caused by classical NSAID’s with persistent nasal polyps and contact dermatologist. I’ve been called lucky in the past by several people. Evidently as my life continues I realize I am always gaining on that forefront LOL…
Hi, very informative video thanks for it. I have a question for you, my diet was high ( now realized) in Salicylates & histamine for few months. After all I am now suffering from Chronic Sinusitis & hypersensitivity to salicylates in food. As COX is blocked. My question is how you unblock COX. Even a tiny amount in food gives me bloating. Can salicylates free diet for long term will help? Or reducing omega 6 & boosting? omega 3 will help. Thanks
how is PGI2 decreasing in COX 2 inhibition? It should be promoted with TXA2 right? and there can be balance. Isnt PGI2 coming under COX1 control? please help thanks :)))
What happens if you combine classical (COX-1 + COX-2) and new NSAIDs (COX-2 only)? Could you mix these in a way which balances out the bleeding vs clotting risks to make the medicine not impact this aspect at all?
Don't miss my 50 hematology 💉 cases, limited availability, go to www.patreon.com/medicosis/
where is microbiology.cardio-diseases,respiratory disease
On their way
Medicosis Perfectionalis
Where can I get COX2? I’m going to have a surgery in October. Don’t want to take NSAIDS .
Thank you you !
i guess Im kind of off topic but do anybody know of a good place to watch newly released movies online?
@Alexis Ernesto Lately I have been using FlixZone. Just google for it =)
An absolute boon to us med students. My professor taught this once and took an hour for this. I can revise the same pathway in less than 15 mins, with diagrams, mnemonics, concepts and clinical correlations as well. Thank you, good sir!!!
I am honored!
Kindly help me by sharing my videos with others!
Time will come when education will b like this....its actually interesting, its simple, very logical, fun to watch, keeps attention and without noticing u just learned everything till the ending of the video!!
Great stuff, Thanks man, You are really awesome!!.... hitting something that 99,9% of the professors r unable to do....
Thank you ☺️
i didn't know that i can laugh so hard watching a pharmacology video....
😂😂
Learning should be fun!
Me neither!!!!!! 🥰🥰🥰🥰🤣🤣🤣🤣🤣🤣🤣
You made pharmacology fun to me !! Thanks
I'm so glad!
your sarcasm and gansta talk is golden but your knowledge is just priceless, keep it up brother, PT student greetings from Peru.
Thanks a million!
Damn, this video is funnier than most of the stand up comedies🤣
Thank you so much 😊
I'll never understand how you can teach complex things, that even professors find difficult, so easily. Thank you so much sirrr❤
Thank u for saving those of us struggling in biochem
My pleasure!
💊 Pharmacology Playlist: ua-cam.com/play/PLYcLrRDaR8_d5RzuEJprW-NWXTK22ByVC.html&si=MGlX4_a2LlLOo6Ed
After 2 days of digging in the COX mode of action, none of the article was easy to read....found this video that made my life easy...Amazing job done boy
Thank you so much 😊
@@MedicosisPerfectionalis I have only one question if you please. In 5:39 you said, now you know why inhaled steroids are used to treat asthmatics. This is because they block the pathway leading to production of Thromboxane A2 and so no vasoconstriction?
No, it’s because inhaled steroids block the PLA2 and therefore decrease the level of arachidonic acid. This will, subsequently, decrease the level of leukotriens which make the life of an asthma patient hell!
Medicosis Perfectionalis u r awesome..thanks a lot
You're definitely the best 😩😩how can one ever forget the concept 🥰🥰
Thanks a million! I am honored!
the BEST teacher ever, I wish you could teach all of my lectures.... these videos are pure gold.
Thanks a million, dear!
I am speechless.
Can you please help me by sharing?
@@MedicosisPerfectionalis shared with my classmates!!
Bro love the video, the sarcasm is great. It's funny, the way you talk is the same way I talk to myself when I'm studying. Thanks for making this!
You're very welcome 😊
El mejor video de quimica que he visto sobre la ciclooxigenasa :D
🙏🙏🙏
These are the best videos! Man, I am just a regular person with no medical education just an interest. You make it understandable and entertaining.
Thank you 😊
spent hours looking up this stuff online, this video couldnt have been more helpful !!!
You make it a point to respond to every comment. You’re a great teacher❤
I am honored!
Hi sir 🥰 you are saving me every time I have an exam..
Sending gratitude and love for you 🥰🥰🥰
You are a great human being
Thank you so much 😊
I appreciate you!
Thank u thank u thank u. Honestly love people who are make sure to help others by education and other things they can offer the society with
Thank you 🙏
Sir u have great sense of humor
Thank you ☺️
This video is pure gold. Funny and informative!! Concepts well explained
Sometimes I think you know me better than I do, because as soon as I have a question, you immediately answer it!
Haha 😂
i really love your sarcasm and funny jokes, this is my first video and i cant help but to subscribe. thank you very much !!
Thank you so much 😊
This video is great! Thank you! I understood everything! 🎉
My pleasure!
great presentation thank you from a non academic studying herbs!
Thank you!
man, I fucking love you and your sense of humor
Thank you so much!
iv never heard an into this insanely cooooll
Thank you so much!
I'm subscribing purely for your laugh. The personality in this video makes me actually enjoy pharmacology
I am honored! Thank you 🙏
first video i saw, you already earned my loyal subscription
Thank you so much 😊
oh how I wish you were my pharmacology professor. This makes so much more sense now!
Awesome 👏
Informative and humorous.... as always... a winning combo.
Thank you so much 😊
Can you please help me by sharing?
what an explanation man😍😍😍.....thank you for making it easier and funny👍🏻👍🏻
My pleasure 😇
Very creative ways of nomenclature,doctors are geniuses...🤣🤣🤣
Haha 😂
I never comment on UA-cam videos, but your channel is one of the best things I've ever found on the Internet. Everything is so well explained and you're so damn funny. A huuuge thank you ❤️
Thank you so much 😊
I am honored!
Thank you very much
I always love watching your video
Your video help me alot ❤
I am honored, Mary!
you are better than my uni teacher
Thank you so much ☺️
You are absolutely the best at explaining things in a way I understand! And you're so funny, my 14 year old watches you with me just to hear you're jokes
The best lectures!
Thank you so much 😊
U got a nice way of teaching...keep it up...good job man...i like ur style
Thanks a million!
Thanks for this, I'm working on a article. This gave me a great insight.
Yay 😃
This was really helpful
I am glad 😃
thank you u got a new follower , im pharmacy student and this is way better thanhow my professor explain
Thanks 😊
Can you please help me by sharing it with your colleagues?
I love the prostacyclins keep the blood "cyclin" that helps me actually recall PGI2 function!
Thank you 😊
I was not bored for a single miN lol thanku! really helpful
Wow 🤩
Thank you so much 😊
I didn't know when clicking on this video I'd laugh, let alone how much I did. Amazing work ahahhaa
Thank you so much 😊
Why was only Rofecoxib removed and not other COX 2 selective NSAIDs? Don't they all increase the risk of blood clotting because like you said at 9:44?
Theoretically you are correct, but in the real world, there seem to be a difference.
YOU ARE FREAKIN FUNNY. I love it. Learned so much.
Thank you so much 😊
THIS HELPED ME SO MUCH!
Awesome 👏
Awesome video. I am currently writing an article about this subject, and it was really informative and entertaining. Keep it up.
Thank you 🙏
should be called sassy science. loved it tho
😂
It was great. So simple and easy to remember way of teaching
Thank you so much 😊
@@MedicosisPerfectionalis may you make a lecture about antipsychotics?
When you linked it to real clinical scenarios, it felt like it clicked! Thank you! Also, I am from Australia and I am worried there are differences in the naming of certain things. Should I be worried about any differences that you know of?
Hey 👋 Emily...Thank you so much for your kind words...Brand names differ between countries, but what really helps is knowing the generic name by heart.
I wish i could shake my hand with you..just awesome man., 💜💜💜💜
🤝🤝🤝
@@MedicosisPerfectionalis 😂😂 handshake in online is like this
😁😁
@@MedicosisPerfectionalis 💚💙💚💙
👍😍😍
I found you just before our exam! I feel so lucky. Sending love! Thank you for the fun-niest learning💚
Thanks a million, dear :)
I truly appreciate it.
If you have time, can you please help me by sharing?
Can't thank you enough for this content.
My pleasure 😇
great video...just curious about how does the NSAID drug inhibits the cyclocygenase? like the functional groups present within the binding site etc....
thank you! you just saved my LIFE
My pleasure 😇
Thankyou so much🙌
My pleasure!
One might have tought: maybe if you inhibit COX1, since COX2 still works and can't make TXA2, it can make more PGI2 when not racing against COX1 for PGH2 thus decreasing the risk of clotting more than non-selective COX inhibitors?
You are amazing. Thank you for your videos♡♡♡
My pleasure 😇
Brilliant video!!
Thank you so much 😊
Can you please help me by sharing?
Thank you soo much sir ❤
Most welcome!
Thanks alot for your easy simple entertaining Explanation 💜💜.. really appreciate it !! You are awesome
Thank you 😊
2:31 in the name of God The most merciful
بسم الله الرحمن الرحيم
💜
Great teaching..... Bless up
Thanks 🙏
Can you please help me by sharing?
You are amazing , I’m in love with your lectures
Thank you so much 😊
I am honored!
Soo professional 👌😎
Thanks, dear :)
Please share my videos with others...It really helps!
@@MedicosisPerfectionalis already did👍
Thanks a ton!
WOW... Just WOW :)
Thank you so much 😊
I like the "just kidding" at the end, implying that there's so much spite he wouldn't tell Merck & Co. about the biopathway even for a billion dollars. That's the kind of top-tier spite I can get behind.
Thank you ❤😘
My pleasure 😇
I really love this teaching yo perfect 👍🏼
Thanks a million!
I couldn't thank you enough !
Amazing Video, Thank You for sharing your Knowledge with us.
This is amazing, thank you so much!
My pleasure 😇
That was really gud , thank you
My pleasure 😇
Got curious about cox 1 and cox 2 because celebrex only inhibits the latter and I'm wondering why I'm still in pain compared from when I took ibuprofen before getting prescribed celebrex. I have otitis externa. From what I understood, I shouldn't be in pain. This is coming from a non-pharmacy student.
Thank you very much by the way for having this lecture free for everyone to learn. :)
My pleasure 😇
I am sorry for your pain, but I really don’t know...Please talk to your doctor.
Thanks for the video. I love it. 🙆🏻♀️❤️
My pleasure 😇
THANK YOU VERY MUCH! YOU ARE JUST AMAZING!!
Thanks a million 😎
hello, have an pharmacology text book "pharmacology for health professionals 5th ed, by B, Byrant & K, Knights, and it says that it is PGI2 with COX1 inhibition that causes gastric ulcers, not Thromboxane A2 and now im confused to know which is right. Could you please be able to explain why the text book may be saying this and why you have said otherwise?
Thank you :)
I never said that inhibition of thromboxane A2 causes gastric ulcers.
@@MedicosisPerfectionalisoops my bad, then what causes gastric ulcers more specifically other than just saying COX 1? I just want to learn thank you :)
There are some prostaglandins that protect the stomach...These prostaglandins are produced thanks to COX-1...When a drug inhibits COX-1 and COX-2, the protective mechanism is destroyed. However, when a drug selectively inhibits COX-2 only, the stomach is in good shape because COX-1 is uninhibited...Hope it helps!
@@MedicosisPerfectionalis thank you very much :)
My pleasure 😇
You’re the BEST
Thank you 🙏
Everithing looks clear now! Awesome vid, thanks...
You’re very welcome, bro!
Amazing but i have one question so cox-1 is responsible for stomach protection by which prostaglandins is it PGE2 but its also responsible for pain
So does this pathway, work differently in different cells. So the membrane phospholipids of platelets dont produce leukotrines do they. So its not really at multiple choice pathway but a single choice depending on what cell you are?
awesome video .got solid concepts!
Great 👍
Very helpful and fun in learning.
Thanks a ton!
You are great! I am beside myself angry with uneducated nurses shaming me for managing pain after a surgery without NSAID’s (asthmatic). I don’t know why in the hell I have to do all of this research myself as a patient. I have learned a lot but this is aggravating. Anesthesiologist understands it. What do I tell these people? Please help
Thank you 🙏
I appreciate your comment! I really admire your perseverance and the fact that you are doing all of this research even though you’re not a doctor! Hats off to you!
@@MedicosisPerfectionalis well my friend, I’ve always had interest in the medical field…. being a seasoned IT veteran, many of those whom which I’ve helped have called me a doctor anyway, lol. Being an analytical thinker to begin with, they have some alignment.
Anyway if anybody would be kind enough to provide their two cents I would love to hear it. Obviously it’s not going to be taken as any sort of medical advice I promise! More or less,, direction,, would be nice or references to material that I can study. Just trying to feel better as all. And I’m in such a small group of people apparently. Asthma exacerbation caused by classical NSAID’s with persistent nasal polyps and contact dermatologist. I’ve been called lucky in the past by several people. Evidently as my life continues I realize I am always gaining on that forefront LOL…
Hi, very informative video thanks for it. I have a question for you, my diet was high ( now realized) in Salicylates & histamine for few months. After all I am now suffering from Chronic Sinusitis & hypersensitivity to salicylates in food. As COX is blocked.
My question is how you unblock COX. Even a tiny amount in food gives me bloating. Can salicylates free diet for long term will help?
Or reducing omega 6 & boosting? omega 3 will help. Thanks
Greate.. Bro
Thank you so much 😊
how is PGI2 decreasing in COX 2 inhibition? It should be promoted with TXA2 right? and there can be balance. Isnt PGI2 coming under COX1 control? please help thanks :)))
PGI2 is via COX-2
I assumed PGI2 comes under COX 1 coz COX2 selective inhibition allows COX1 function to occur unopposed..
My GOAT🐐
Thank you so much!
Ahahha never enjoyed studying before thank you
My pleasure 😇
YOU ARE AMAAAAAAAAAZING...THANK YOOOOOU
My pleasure 😇
What happens if you combine classical (COX-1 + COX-2) and new NSAIDs (COX-2 only)? Could you mix these in a way which balances out the bleeding vs clotting risks to make the medicine not impact this aspect at all?
Cyclooxygenase 1 and 2 begins at 6:15 for those that only need that information.
Hello sir, can you please do a general pharmacology videos
I have an entire series of videos (course) about general pharmacology here: www.medicosisperfectionalis.com/products/p/general-pharmacology-course/
You are very much inspiring.i want to be cool like u
I am humbled ☺️
Thank you for the video! Which one makes PGI - COX1 or COX2?
PGI2 is by COX-2...Mnemonic: 2 by 2
جزاكم الله خيرا
You too
precious explanation1
Thanks 🙏