When he said that COX 1 inhibition had "highest risk" he should have added "higher GI risk" but less cardiovascular risk. COX 2 inhibition has higher cardiac risk.
"Relative" COX selectivity data presented in this video was obtained from the article published in European Heart Journal (March 2016): academic.oup.com/eurheartj/article/37/13/1015/2398407 Also, although I try to obtain information from reputable journals and medical textbooks keep in mind that it may be outdated at the time you view this video. Furthermore, this is not a therapeutics lecture and it is not meant to provide any treatment advise. Please read the disclaimer for the channel.
Another fantastic lesson, wow...thank you! I can't imagine how long it takes you to find/make all those illustrations and sync them with your narration. This is masterful teaching in my opinion.
I don't like the notion of normal, we're all very different in great ways and we should embrace the yearning for knowledge. Always good to learn new things.
One of the best things you do is start off with the normal pathways and mechanisms of the body these drugs affect. It really helps understanding to start there and not just 'memorise fact A is A because it's A". It makes SENSE this way.
Your videos are best. I have been watching your videos for last one month and i have found them so helpful in better understanding of my pharmacology concepts. Your easy explanation and to the point explanation makes it fun to watch and learn. Hope to see more awesome videos in the future. :)
Yessss I was waiting for a new video ❤️Thank you so much. Can you also please make a video about CNS drugs or anti-microbials? Those topics are so huge and I find them very tough. It would be great if you made a video about that.
in some articles, COX-1 and not COX-2 drives PGI secretion, however, in some books, COX-1 and COX-2 both drive the secretion of PGI-2, that's why Selective COX-2 NSAIDs have been re-instated clinically.
thank you very much for all the well done lectures. it is no easy task and u did a great job. please continue the good work for the greater good. Nobody knows everything and no one can be perfect. your lecture has made work easier for a whole lot of us. thank you again.
Whenever I get a chance I'll refer your channel to all my junior students.. Please upload videos of on every topic of second year pharamacology.. Please I beg you sir... Your videos made me concepts very very easy.. Please sir please do more & more videos
Videos aren't made quickly enough... This channel is my No.1 resource for my Pharm course, and whether or not I ace a topic depends on whether or not videos on that topic were available. Sad, but true. Plz, plz make more videos... in the mean time, I'll be finding other (less thorough) resources to study from, which inevitably means 3-4 other resources besides my lecture notes, at the LEAST.
The list of medications that are selective and non-selective Cox inhibitors is not correct. Celecoxib is the only true Cox-2 inhibitor on the market in the US.
Please check your sources for your lectures, there is a big mistake in classification of NSAIDs according to COX selectivity, as you classified diclofenac, meloxicam, and etodolac as selective COX-2 ?!!! Generally your videos informatics. so thanks for your attempt ❤️❤️ بژي كورد 👌❤️
i know where you getting this, these are preferentially cox 2 inhibitors which mean they have a little cox 1 inhibition too. but due to maximum activity on cox 2 he just simply classified them into selective cox 2 inhibitors. so that's not make any difference...
Diclofenac is one of the most ulcer-making NSAID, so giving him to selective COX-2 drug is quite big mistake (in some country is prescribed as combined with misoprostol). Please revise your materials.
Although I try to obtain information from reputable journals and medical textbooks keep in mind that it may not be always 100% accurate. Furthermore, this is NOT a therapeutics lecture and it is NOT meant to provide ANY medical advise. Please read disclaimer for the channel. Thanks for watching.
Your videos are really informative and useful although once you've been told that you made a mistake, the least you could do is putting a pop-up note regarding the mistakes you've made in the classification! Otherwise its just irresponsible because you knew about it and didn't do anything leading to confusion in many, including myself. Because obviously people are watching the videos regardless of your disclaimer.
So since I'm not allowed opioids for my back pains Diclofenac which is the only one which helps slightly with the pain is more dangerous but not addictive. Which makes sense since you can't be addicted when you're dead.
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your 11 mins lecture is wayy far better then my faculty"s 1 hr lecture
respect from india
Our teachers explain this in 3 hours🤓
When he said that COX 1 inhibition had "highest risk" he should have added "higher GI risk" but less cardiovascular risk. COX 2 inhibition has higher cardiac risk.
Haiwawo
@Tichaona tissangane kuinibhokisi
Thank you sir
Thank you for this information
He mentioned it
"Relative" COX selectivity data presented in this video was obtained from the article published in European Heart Journal (March 2016): academic.oup.com/eurheartj/article/37/13/1015/2398407
Also, although I try to obtain information from reputable journals and medical textbooks keep in mind that it may be outdated at the time you view this video. Furthermore, this is not a therapeutics lecture and it is not meant to provide any treatment advise. Please read the disclaimer for the channel.
Thankful for your efforts.. 😉🙂
thanks for the clarification
We cant see all screen. Half screen seen
Another fantastic lesson, wow...thank you! I can't imagine how long it takes you to find/make all those illustrations and sync them with your narration. This is masterful teaching in my opinion.
I'm just a normal person but i like to study I'm so glad I found this channel!!!
Na, u ain’t normal
I don't like the notion of normal, we're all very different in great ways and we should embrace the yearning for knowledge. Always good to learn new things.
@@RunCmp lmao
Aw I hope you’re having a great life fellow human, science is awesome
You mentioned in the video that aspirin is selective COX 1 inhibitor while it is a non selective COX inhibitor please confirm this
One of the best things you do is start off with the normal pathways and mechanisms of the body these drugs affect. It really helps understanding to start there and not just 'memorise fact A is A because it's A". It makes SENSE this way.
I'm so lucky 😍 my exam on Sunday & on my schedule I have to study this lecture today !!! Thank you so much ❤
Did u pass?
@@23k31 of course I graduated med school too 💃🏻
@@samnoah6019 congratsss
Your videos are best. I have been watching your videos for last one month and i have found them so helpful in better understanding of my pharmacology concepts. Your easy explanation and to the point explanation makes it fun to watch and learn. Hope to see more awesome videos in the future. :)
This explanation was perfect, using images made it more effective and easy to understand thank you
Thank you so much for this!!! Your videos really help me understand pharmacology! Literally right on time for exams next week! God bless you!
thank you so much. It was indeed a great effort to make students understand the basics of PG. It was a beautiful video. Well done !
Yes true
Ur classes are different from others.same every time and very clear.learning is easy with you.
Ketorolak, Flurbiprofen, Ketoprofen, Indomethacin, Diclofenac and Etodolac are non-selective COX inhibitors.
Exactly
Yep
Finally I found the perfect channel for pharmacology 👍
....from India ☺️
Me too
Starting pharmacology this year and this was so informative!
Your Lecture need full attention❤❤❤
Best channel for pharmacology 👍
i wished this video came out earlier before my pharmacology exam :'(
Where are u studying medicine? (from which place)
Great Video. Thanks for simplifying things for me. Now lets hope that I will pass my exam on 7th December 2021
did u pass it
@@alessandrononinosacher Gave exam last Tuesday. Result will come in first week of January. I am sure I will pass.
Yessss I was waiting for a new video ❤️Thank you so much.
Can you also please make a video about CNS drugs or anti-microbials? Those topics are so huge and I find them very tough. It would be great if you made a video about that.
iFenom_z same but I find these two topics kinda tough
I'm just about to take those class next semester. CNS + Antibiotics!
Yeah , especially the antimicrobials... we've recently finished that chapter and it's giving me grey hairs.
in some articles, COX-1 and not COX-2 drives PGI secretion, however, in some books, COX-1 and COX-2 both drive the secretion of PGI-2, that's why Selective COX-2 NSAIDs have been re-instated clinically.
I love your channel. I love your accent. And now I like Pharmacology❤️❤️❤️
Iam glad I found this channel
thank you very much for all the well done lectures. it is no easy task and u did a great job. please continue the good work for the greater good. Nobody knows everything and no one can be perfect. your lecture has made work easier for a whole lot of us. thank you again.
Whenever I get a chance I'll refer your channel to all my junior students.. Please upload videos of on every topic of second year pharamacology.. Please I beg you sir... Your videos made me concepts very very easy.. Please sir please do more & more videos
Indomethacin, sulindac,
meclofenamate, and ibuprofen nonselectively inhibit both COX-1
and COX-2. Please correct that mistake. Refference: Basic & Clinical Pharmacology [Katzung, Trevor] 13th Edition (2015)
Adamsın
Peki ya COX-3?
Indeed
I second👊
What told by sir in video is correct
Ref the following web
www.eurekaselect.com/72639/article
Videos aren't made quickly enough... This channel is my No.1 resource for my Pharm course, and whether or not I ace a topic depends on whether or not videos on that topic were available. Sad, but true. Plz, plz make more videos... in the mean time, I'll be finding other (less thorough) resources to study from, which inevitably means 3-4 other resources besides my lecture notes, at the LEAST.
The list of medications that are selective and non-selective Cox inhibitors is not correct. Celecoxib is the only true Cox-2 inhibitor on the market in the US.
Thank you! Your videos are great, waiting for other topics in pharmacology 👍
Yes I was been searching for that yesterday we studied this lecture and you did a great job 👌👌👌👌👌👌
Please check your sources for your lectures, there is a big mistake in classification of NSAIDs according to COX selectivity, as you classified diclofenac, meloxicam, and etodolac as selective COX-2 ?!!!
Generally your videos informatics.
so thanks for your attempt ❤️❤️
بژي كورد 👌❤️
It's right na! They do belong to selective cox-2 inhibitors...
i know where you getting this, these are preferentially cox 2 inhibitors which mean they have a little cox 1 inhibition too. but due to maximum activity on cox 2 he just simply classified them into selective cox 2 inhibitors. so that's not make any difference...
Very helpful, very well illustrated, very well explained..
God bless u..
Excellent Mode of Teaching
Extremely perfect ,I love your lecture...
Very good video for test. Thank you
your videos are always the best
Thank you
You are amazing! Thank you so much! Please make some more!
LASSIFICATION
(A) Nonselective COX Inhibitors (Traditional NSAIDs)
1. Salicylates: Aspirin, Methyl Salicylate, Sodium salicylate.
2. Propionic acid derivatives: Ibuprofen, Naproxen, Ketoprofen, Flurbiprofen.
3. Anthranilic acid derivative: Mephenamic acid, Enfenamic acid, Flufenamic acid.
4. Aryl-acetic acid derivatives: Diclofenac, Aceclofenac.
5. Oxicam derivatives: Piroxicam, Tenoxicam.
6. Pyrrolo-pyrrole derivative: Ketorolac.
7. Indole derivative: Indomethacin, Sulindac.
8. Pyrazolone derivative: Phenylbutazone, Oxyphenbutazon.
(B) Preferential COX-2 Inhibitors: Nimesulide, Meloxicam, Nabumeton.
(C) Selective COX-2 Inhibitors: Celecoxib, Etor
Love u bro.. u have made my life easy.. plz upload videos on serotonin agonist and antagonist
Ketorolac and indomethacin are non-selective not only work on cox-1 as mentioned in the video
That was great
I memorized my lecture easily after watching your explanation
Can you please make one for corticoids?
thanks for this informative video
I use Ibuprofen when I have a non bareable period cramps. It does reduce the pain on abdomen and down there area
Thank you for the amazing videos! Could you make one about anti-epileptic drugs?
ua-cam.com/video/ATYmaTmh9RE/v-deo.html
What a fantastic explaination
Neither diclofenac, indomethacin nor keterolac are selective.
These three are for sure non selective
Thank you.. I needed a brief review since it's been awhile since taking pharmacology
Really love this chennal ❤️❤️❤️
Hoping to study biomed research next year and this was fun to watch!
There is no selective cox1 inhibiter, only preferential activity on cox1. (Inhibition is more on cox1 but not exclusive)
Diclofenac is one of the most ulcer-making NSAID, so giving him to selective COX-2 drug is quite big mistake (in some country is prescribed as combined with misoprostol). Please revise your materials.
Although I try to obtain information from reputable journals and medical textbooks keep in mind that it may not be always 100% accurate. Furthermore, this is NOT a therapeutics lecture and it is NOT meant to provide ANY medical advise. Please read disclaimer for the channel. Thanks for watching.
Your videos are really informative and useful although once you've been told that you made a mistake, the least you could do is putting a pop-up note regarding the mistakes you've made in the classification! Otherwise its just irresponsible because you knew about it and didn't do anything leading to confusion in many, including myself. Because obviously people are watching the videos regardless of your disclaimer.
Thanks a lot you are the best
So since I'm not allowed opioids for my back pains Diclofenac which is the only one which helps slightly with the pain is more dangerous but not addictive. Which makes sense since you can't be addicted when you're dead.
Thanks for explaining the differences between various NSAID medicines.
WOW! nicely described
I wait for your videos it makes the stuff oversimplified ... always keep it 💖💖💖
diclofenc is non selective
Excelent video, thank you!
Aw man this video is awesome. THANKS YOU SO MUCH!
Diclofenac is not a selective Cox 2 inhibitor. It inhibites Cox 1 and Cox 2 with equipotency
Super helpful!
Thanks a lot Sir!!.. Great explanation..!!!
Please make a video on anti rheumatoid arthritis
Wonderful thank you so much
Thank you teacher
Jazak Allahu khayran❤
Yup PERFECTION sir ☝️💪
You simply the Best 🔥
May Allah give u reward
Thanks
Excellent Presentation
Hello diclofenac is preferential cox -2 inhibitor, and aspirin is non-selective cox-1 and cox- 2 inhibitor
Hello Brother!
Can we classified diclofenac as Cox 2 not Ns-nsaid? If u have references for this please send me. I really need ur help right now.
Thank you sir.... Thnks for a brilliant lecture ... Our requests for u
Plzzzz Sir upload cns drugs video....
Diklofenac is not a Cox-2 inhibitor. Can you please give me your source on that one?
Always helpful video 👌👍
Thanks heaps 🎉
Can you please make a video on anti gout drugs? These are so good, thanks!!!!
Well explained
thanks for the video
good job sir , thanks alot
thank you
THANK YOU
you are incredible. Thumbs up
Diclofenac sodium is a non selective cox1 and cox 2 inhibitor
Thanks. Any chance your slides are available for download somwhere?
Can you please make a video about immunomodulating drugs (only the cytotoxic drugs)
I really need it in 10 days
Isn't Ketorolac a nonselective COX inhibitor?
MARIN JUST MENTIONED THAT
Yaaa ketrolac is an acetic acid derivative
Darwin....interesting name.
Can you elaborate renal effects of nsaids?
but speed sir google is saying that ketorolac is a non-selective cox inhibitor
good work
This is amazing, I'm glad to have found this channel. Can you please make a video on drugs used in parkinsonism and other movement disorders pleeaase
Awesome video
I'm so grateful👏👏thankyou👌
sir could you also do a video on anti-cancer drugs :-)
I'm uploading vedios on anti cancer subscribe my channel
Great 💯
Thanks
Thanku for this video...
Can you pls reference the table @3.08 as other texts say all that mentioned in selective cox 1 inhibitors are actually non selective?