I'm one of Dr Green first 500 patients and stood in that same office and talked to him 3 years ago for over 2 hours on this topic. He's an amazing man. I believe his protocol has made my life better.
My parents, 87&84, no meds, 10 pin bowl several times a week, dads in a band, they take care of peoples dogs when they go away, live in their own house, without outside help. My mammy lived to 102.5, and had all her faculties. I want to be like them when I grow up. Presently 61, weight train five days a week, walk my pups two hours everyday, each a meat heavy diet. Think I’m well on my way😊
Meat heavy diets are contraindicated for longevity. They improve sports performance in the short run, but high protein diets (especially high methionine diets) cause accelerated aging.
I will be age 84 in May and yesterday evening I began my monthly 4 to 7 day fast. In about 1 hour I will take 1 mg of rapamycin (I can't afford the full dose). I take the small dose in hope of kick-starting autophagy. I don't really know if all this is helping but as far as I know I'm in pretty good health.
Around age 81, but monthly only since the middle of age 83. I'll be 85 in May of 2024. I may have to switch back to fasting once a quarter because it's taking longer for me to regain my strength after each fast.@@mnkwazi
The same applies to me. Having said that, I can't see the BIG benefits of taking supplements, but take them because research/science suggests that it is more or less correct. The only thing I can say with my hand on my heart that has HELPED me is fasting, multi-day fasting.
@@orjanbern4766agree, fasting is incredibly powerful. I need to figure out how it fits into a life on a rapamycin protocol since it hits different pathways (with some overlaps). Fasting is more broadly healing to my understanding. While rapa has more targeted effects.
It’s refreshing to hear from someone who has actually experienced aging and who understands these drugs. I’m getting tired of hearing from ripped 30 year old men on the “effects of aging”. Thank you for this insightful interview.
mTor is an interesting subject. mTor is the signaling mechanism for protein synthesis. It’s role in growth of muscle is important. The problem is it’s growth properties for everything, including cancer. I wonder if consistent strength training will channel mTor into muscle growth and away from negative tissue growth. It’s a thought.
@@anonymissed3611 Yes, suppressing MTOR will inhibit muscle protein synthesis. I think that is why the rapamycin is not dosed all the time. .... I would like more clarification on: is resistance work still beneficial when approximately alternated with rapamycin?
rapa is not dosed all the time because it’ll start surprising mtor2 instead of mtor1. if mtor1 is suppressed long enough. Check out Peter attiya interview with Matt kaberline and David sabatini on it, they go deeep. Building muscle and strength training is complex and it will be impaired to an extent temporarily but the tests done on it are done at peak blood levels 2hrs post ingestion, so worse case scenario. Rapamycin news forums have some good threads on building muscle while on a rapamycin protocol.
Thoroughly enjoyed this Mike. That last few minutes especially...research extensively, take back responsibility for our own health... grass roots indeed! 👏💕
Not easy to find a 79 years old men that seems a centenarian. I feel sorry for him. I would like to take rapamycine (I’m 44), but looking at him many doubts.
Hello dear brother I thank you soo much for your efforts Could you please enlighten us in your next videos about resistance training for type two diabetes and overall cure for diabetes please. ?
Alan, I think you would bennefit greatly from high dose psylocybin, really increase neurogenesis and chock the body with oxygen so it breath more life/energy into you. I think psylocybin is a MUST as we age post 40y
ok, dear guys , i have a little problem, and maybe here someone explain me that, have 30 years old , really fit guy, maybe will take rapamycin but probably around 50 or sth, but i read that probably you can couse some inhibition of mTOR using supplement called caAKG. And i have a problem with that, from one point of view i read about promoting protein synthesis and anticatabolic effect of AKG , from other i read about inhibiting of mTOR, isn't it conflicting, can someone understand this , it is possible that inhibition of mTOR can be in some parts and in other i mean muscles when you practice bodybuilding not? , really try to figure out mechanism of working of caAKG
20:11 which proves that everything had to be designed to work the correct way, instantly, because if things didn't work, everything would have died and no code could be passed on. If something isn't designed to survive, it will die and you will never see it again. This is insane to think that one person didn't have everything it needed with its brain gut and organs but it was able to passcode all by itself to become something that could reproduce. Miss me with this nonsense. Google tells me to imagine the shoulder evolved from the oblique muscle but how in the world would humans have fed themselves without the shoulder muscles so that they had the energy to reproduce and then feed themselves again without shoulder muscles to go out and provide so that child has a chance to grow up and reproduce. It's impossible for something to not work and reproduce if it wasn't designed to work and reproduce at the start
Explain to me sir how the Lord says he pulled man out of the soil and all of the minerals found in soil are found in each of my cells in my body, but evolution says I came from a fish that somehow developed the ability to breathe on land before it died so that it could pass on code. Honestly if that fish came on land and died, it's dead, and it can't reproduce something that can breathe on land. It died! You people have been sold a lie and everyone is still trying their hardest to validate something that requires blind imagination. I'm sorry, Mike, you got to 👍, I will fast forward so you get a complete view, and you got multiple comments, but I can't listen to this mumbo-jumbo no more
I seem to have found some interesting info about Rapamycin, both great and not-so-good. V. interesting info here, ideal to build up on many levels and try to maintain as we get past 60 or so. Good practical functionality in out elder years. Pfizer has the patent on Rapamune and it seems to relate both to health and a possible future gold mine. Bottom line~ Enjoyed the talk!
From Britanica: Immune suppression by rapamycin has been associated with potentially serious side effects, including increased risk of infection and lymphoma. Other side effects include fever, diarrhea, joint pain, headache, and vomiting." Um...no thanks!
Well think back to one of the women that you interviewed before that talked about not mixing fat with carbs in each meal, but separating them and then another you interviewed that said if you start your day with carbohydrates, you will be craving them all day long so I like to start my day with meat and something fatty and mixing carbs later in the day, if I even need them
Same!! Did strict keto for two years and I’ve found now that I’m fat adapted I can cycle my carbs and do my keto coffee in the morning and have carbs later in the day especially when my cycle is coming!! I can actually stop/start my cycle if I don’t have enough carbs or forget to eat (momlife) it’s amazing how powerful the use of fat and carbs can be especially in a Womans body!
@@Freyasmom13 leg days and plyo torso days get carbs. I will lightly sea salt water/Gatorade and have a teaspoon of honey before a run, to keep my throat from drying, otherwise only on Wednesday will I have potatoes with my steaks in the first meal
@@Freyasmom13 sometimes on Fridays to kick-start my longest fast of the week bible have sticky rice with my morning salmon that I have every single Friday all year long but again that's just to help me finish the work day before I start a much more extended fast into Saturday
@@drip369 nice! I feel like I felt like carbs were evil for so long but I’m realizing that I don’t have to be so dogmatic in my thinking! I feel like as humans who are tribal we tend to be all out, one team or the other- vegan, keto etc but in reality we can just eat what’s healthy and that’s different for everyone and their needs
Metformin also slows MTor which is why every podcaster stopped taking it. So Which is it, slow mTor or increase it? And wouldn't metformin that has been more tested and tried and easier and cheaper to get do the same/very similar thing?
Dinosaurs are like todays AI ... lolz but then Dinosaurs are questionable of their existence. Excellent interview. I learn so much from your channel for so many years!
In cell studies, treatment with rapamycin reduced follistatin levels and follistatin is touted as an anti aging, muscle anti muscle wasting protein and is contraindicated with rapamycin. Again, too much contradictory advice for how expensive and potential side effects at the moment.
@@laraross2701 i agree, I honestly, wholeheartedly thought he was going to say something like 95 years old, when asked how old he is... but guess it depends what medical condition(s) he's had to contend with.
@@anthonyeves2005 You have to take account he had health issues before he started , they resolved with rapamycin. Plus he doesnt lift weights. Muscle loss is real if you dont lift weights no matter what you take
@High Intensity Health, do you think Rapamycin is being used by cyclists at the World Tour level? It doesn't seem to be on the banned list. Also I'm interested as a 45 yr old competitive masters road cyclist. Cheers.
Im a couple years older than you, honestly, I’m not ready to buy that we don’t need mTOR at our age. I think until we are 50, 55 or so, taking it less frequently than once per week is a better idea. But hey, I have no f’ing idea in reality lol
I don't think any do but from experience I can say it won't hurt. I increased my FTP by 24W this winter whilst taking rapamycin (doses varuimg from 2mg to 16mg with grapefruit juice but on average 6mg with grapefruit juice fortnightly) but my FTP isn't that high (254->278 @75kg 48y/o) but still 24W is 24W
As a Cylinggeek with 53 years I would interested where to buy the RapaStuff😄 which should be a trusted Source and Shipping to France...(or to my MyUS Postbox).. Thank, you very much and greetings from Andreas in Alsace /France
When Dr. Green says taking rapamycin once weekly makes you burn “cleaner fuel”. What the heck is he talking about? Personally i dose rapamycin much less frequently than once per week, so i can keep some mTOR going for my muscles. But do I need to take it weekly to tap into this “cleaner fuel” he speaks of? Either he was speaking way down to the layman, or he doesn’t know what he’s talking about? I honestly can’t tell.. no disrespect intended here!
Why this horrible music?? I want to hear what this man is telling us…😢 This music is way too loud and makes it impossible for me to hear him 😟 Could you please remove the music? 🙏🏻
Wow I don’t know if it’s certain ethnicity, but my pops os 80 and he literally looks and is like a healthy 40 yr old and agile. And my grandmothers are both almost 100 and bouncing around. This guy look Older and sound’s older than them. Proofs in pudding so I think I’ma gonna stick to what my parents and grandparents are doing. Some is due to our DNA, but the most part is lifestyle and our culture eating style. 🤷🏻♀️
This one gets really juicy around 37:00! Thanks for having patience, hope you enjoy this conversation.
👍 👍 👍 👍 👍👍 👍 👍 👍
Tip: when using a lav mic, put on side of shirt in path of speech. In this scenario, screen left lapel. Have them talk across the mic.
I thought I fell into a time warp ... just then... all the sudden where am I?
and there is a fly on my screen ... I keep wanting to swap it.
THANK YOU for this!
I bet when he was young, he was just like you, Mike ... he just wants to help people.
I'm one of Dr Green first 500 patients and stood in that same office and talked to him 3 years ago for over 2 hours on this topic. He's an amazing man. I believe his protocol has made my life better.
He seems so incredibly sharp for how old he looks.
Listening to an elderly person is always worthwhile.....
Listening to someone running a clinical practice using rapamycin on more humans than anyone else is useful.
My parents, 87&84, no meds, 10 pin bowl several times a week, dads in a band, they take care of peoples dogs when they go away, live in their own house, without outside help. My mammy lived to 102.5, and had all her faculties. I want to be like them when I grow up. Presently 61, weight train five days a week, walk my pups two hours everyday, each a meat heavy diet. Think I’m well on my way😊
Meat heavy diets are contraindicated for longevity. They improve sports performance in the short run, but high protein diets (especially high methionine diets) cause accelerated aging.
I will be age 84 in May and yesterday evening I began my monthly 4 to 7 day fast. In about 1 hour I will take 1 mg of rapamycin (I can't afford the full dose). I take the small dose in hope of kick-starting autophagy. I don't really know if all this is helping but as far as I know I'm in pretty good health.
@IggyDalrymple at what age did you start fasting?
Around age 81, but monthly only since the middle of age 83. I'll be 85 in May of 2024. I may have to switch back to fasting once a quarter because it's taking longer for me to regain my strength after each fast.@@mnkwazi
My supplement dish is starting to look bigger than my dinner 😕
The same applies to me. Having said that, I can't see the BIG benefits of taking supplements, but take them because research/science suggests that it is more or less correct. The only thing I can say with my hand on my heart that has HELPED me is fasting, multi-day fasting.
I can relate. I'm an admitted supplement hoe.
Lol, my husband says our kitchen looks like a pharmacy 😂
Same 😂
@@orjanbern4766agree, fasting is incredibly powerful. I need to figure out how it fits into a life on a rapamycin protocol since it hits different pathways (with some overlaps). Fasting is more broadly healing to my understanding. While rapa has more targeted effects.
Mike, I think this is the best interview I have heard on rapamycin, and maybe one of my favorite of your episodes. Keep up the good work.
It’s refreshing to hear from someone who has actually experienced aging and who understands these drugs. I’m getting tired of hearing from ripped 30 year old men on the “effects of aging”. Thank you for this insightful interview.
mTor is an interesting subject. mTor is the signaling mechanism for protein synthesis. It’s role in growth of muscle is important. The problem is it’s growth properties for everything, including cancer. I wonder if consistent strength training will channel mTor into muscle growth and away from negative tissue growth. It’s a thought.
Conversely, will suppressing motor inhibit muscle mass
@@anonymissed3611 Yes, suppressing MTOR will inhibit muscle protein synthesis. I think that is why the rapamycin is not dosed all the time. .... I would like more clarification on: is resistance work still beneficial when approximately alternated with rapamycin?
rapa is not dosed all the time because it’ll start surprising mtor2 instead of mtor1. if mtor1 is suppressed long enough. Check out Peter attiya interview with Matt kaberline and David sabatini on it, they go deeep.
Building muscle and strength training is complex and it will be impaired to an extent temporarily but the tests done on it are done at peak blood levels 2hrs post ingestion, so worse case scenario.
Rapamycin news forums have some good threads on building muscle while on a rapamycin protocol.
Thoroughly enjoyed this Mike. That last few minutes especially...research extensively, take back responsibility for our own health... grass roots indeed! 👏💕
Very interesting info & your a great interviewer as you let your guest speak.
Thanks Mike
Not easy to find a 79 years old men that seems a centenarian. I feel sorry for him. I would like to take rapamycine (I’m 44), but looking at him many doubts.
I thought he was much older too
He was falling apart physically at age 72 due to congenital issues. Most likely still is. He looks bad, but for 79 I think he's very lucid and sharp.
@@jamesbowen2258Thank you.
Consider that he had a serious heart problem that probably would have killed him by now if he hadn't started Rapamyacin.
THANK YOU for this.!
I bet when he was young, he was just like you, Mike ... he just wants to help people.
57:11 mtor in young vs old. Building muscle vs maintaining muscle. (Sounds like you better build up before beginning regimen)
No offense to Dr. Green in anyway. I know many folks who are in their 80's who look, act, and appear much younger.
He is in a terrible shape, he seems a centenarian to me.
He has only been taking rapamycin for around 5 yrs and was already sick when he started.
If this helps preclinical cardiac issues. recent..err..events..may suggest a deep dive into this....
I don't think it slowed his aging but it did relieve his heart myopathy.
He’s still sharp for his age. I think rapamycin does work.
Good for cancer too.
Gonna have to play this on 2x 😅
Thankfully no one will complain I'm talking too fast in this one!!
😂😂
1.25x
Hello dear brother
I thank you soo much for your efforts
Could you please enlighten us in your next videos about resistance training for type two diabetes and overall cure for diabetes please. ?
This is a good start: ua-cam.com/video/61ognDvXsDU/v-deo.html
Berberine by Thorne along with daily walks
Alan, I think you would bennefit greatly from high dose psylocybin, really increase neurogenesis and chock the body with oxygen so it breath more life/energy into you. I think psylocybin is a MUST as we age post 40y
Excellent - thank you. Maybe take down the electric guitar a few dB on the intro mix on the next one?
🤘🏿Sunday podcast day!🤘🏿
Just a wonderful interview Mike.
super interesting thanks !
ok, dear guys , i have a little problem, and maybe here someone explain me that, have 30 years old , really fit guy, maybe will take rapamycin but probably around 50 or sth, but i read that probably you can couse some inhibition of mTOR using supplement called caAKG. And i have a problem with that, from one point of view i read about promoting protein synthesis and anticatabolic effect of AKG , from other i read about inhibiting of mTOR, isn't it conflicting, can someone understand this , it is possible that inhibition of mTOR can be in some parts and in other i mean muscles when you practice bodybuilding not? , really try to figure out mechanism of working of caAKG
Something Dr Green says drives me insane...
Does he keep saying "sort of like?"
Great info, ty!
20:11 which proves that everything had to be designed to work the correct way, instantly, because if things didn't work, everything would have died and no code could be passed on. If something isn't designed to survive, it will die and you will never see it again. This is insane to think that one person didn't have everything it needed with its brain gut and organs but it was able to passcode all by itself to become something that could reproduce. Miss me with this nonsense. Google tells me to imagine the shoulder evolved from the oblique muscle but how in the world would humans have fed themselves without the shoulder muscles so that they had the energy to reproduce and then feed themselves again without shoulder muscles to go out and provide so that child has a chance to grow up and reproduce. It's impossible for something to not work and reproduce if it wasn't designed to work and reproduce at the start
Explain to me sir how the Lord says he pulled man out of the soil and all of the minerals found in soil are found in each of my cells in my body, but evolution says I came from a fish that somehow developed the ability to breathe on land before it died so that it could pass on code. Honestly if that fish came on land and died, it's dead, and it can't reproduce something that can breathe on land. It died! You people have been sold a lie and everyone is still trying their hardest to validate something that requires blind imagination. I'm sorry, Mike, you got to 👍, I will fast forward so you get a complete view, and you got multiple comments, but I can't listen to this mumbo-jumbo no more
I seem to have found some interesting info about Rapamycin, both great and not-so-good. V. interesting info here, ideal to build up on many levels and try to maintain as we get past 60 or so. Good practical functionality in out elder years. Pfizer has the patent on Rapamune and it seems to relate both to health and a possible future gold mine. Bottom line~ Enjoyed the talk!
From Britanica: Immune suppression by rapamycin has been associated with potentially serious side effects, including increased risk of infection and lymphoma. Other side effects include fever, diarrhea, joint pain, headache, and vomiting." Um...no thanks!
@@MusicLovingFool1 that's long term use for lymphoma and serious sides
380$/mo 😂 im going to have to age naturally
@@Michael-wy7om keep movin and healthy lifestyle in order to doge that grim reaper. lol I agree~
Can u check out how Rapamycin reduces testosterone? Apparrently this is a thing.
Well think back to one of the women that you interviewed before that talked about not mixing fat with carbs in each meal, but separating them and then another you interviewed that said if you start your day with carbohydrates, you will be craving them all day long so I like to start my day with meat and something fatty and mixing carbs later in the day, if I even need them
Same!! Did strict keto for two years and I’ve found now that I’m fat adapted I can cycle my carbs and do my keto coffee in the morning and have carbs later in the day especially when my cycle is coming!! I can actually stop/start my cycle if I don’t have enough carbs or forget to eat (momlife) it’s amazing how powerful the use of fat and carbs can be especially in a Womans body!
@@Freyasmom13 leg days and plyo torso days get carbs. I will lightly sea salt water/Gatorade and have a teaspoon of honey before a run, to keep my throat from drying, otherwise only on Wednesday will I have potatoes with my steaks in the first meal
@@Freyasmom13 sometimes on Fridays to kick-start my longest fast of the week bible have sticky rice with my morning salmon that I have every single Friday all year long but again that's just to help me finish the work day before I start a much more extended fast into Saturday
@@drip369 nice! I feel like I felt like carbs were evil for so long but I’m realizing that I don’t have to be so dogmatic in my thinking! I feel like as humans who are tribal we tend to be all out, one team or the other- vegan, keto etc but in reality we can just eat what’s healthy and that’s different for everyone and their needs
Which interview was that? The one with the woman who talked about not mixing fat and carbs in every meal?
Mike, you need to talk with Dr Jerry Mixon in Kirkland.
Metformin also slows MTor which is why every podcaster stopped taking it. So Which is it, slow mTor or increase it? And wouldn't metformin that has been more tested and tried and easier and cheaper to get do the same/very similar thing?
FYI, San Pelligrino has fluoride in it.
Whats the median age or tipping age when someone is condsider young and old person? 40???
Most people notice significant changes after 50, but it depends on diet and lifestyle.
Things definitely change after 50 from my experience.
38:35 recommended age around 40 to start thinking about taking it.
Why It's not avilable all over Nepal
Hey HIH have you seen the red light therapy helmets for Parkinson's disease treatment? As well as general brain health...
Dinosaurs are like todays AI ... lolz but then Dinosaurs are questionable of their existence. Excellent interview. I learn so much from your channel for so many years!
*rubs hands together excitedly*
😆
I kinda, like, may be interested in this, when I, like, get older.
Wait is this an antibiotic?? Why is that good? I’m listening but it’s hard to understand
It’s not an antibiotic, it’s an mTOR inhibitor!
@@Highintensityhealth ohhh!! Ok interesting!! So as you age you need to trigger mtor bc of muscle loss I’m guessing
In cell studies, treatment with rapamycin reduced follistatin levels and follistatin is touted as an anti aging, muscle anti muscle wasting protein and is contraindicated with rapamycin.
Again, too much contradictory advice for how expensive and potential side effects at the moment.
How do you get rapamycin?
Alldaychemist
So, what is the natural version of this drug? Just as Berberine is the ‘natural version’ of metformin.
the natural version of rapamycin is rapamycin, a synthetic version would be everolimus
berberine and metformin are very different.
What is the word that doctor green uses sort of as a adjectives? ... Cirolife?, .... serlion? ...., Maybe before a noun like "HEALTH"? ... Thanks.
"sort of like"
Perhaps sirolimus? Didn't watch yet though but sirolimus is synonymous with rapamycin
I think he's saying "sort of like.". It seems uncharacteristic for someone of his age and education. It drives me insane 😂
How old is Alan Green MD?
81 I believe
@@Highintensityhealth Only? Wow, he is doing something wrong! Sorry!
Remember, Dr. Green had a heart problem! Before starting wrap a micin rapamycin.
@@laraross2701 i agree, I honestly, wholeheartedly thought he was going to say something like 95 years old, when asked how old he is... but guess it depends what medical condition(s) he's had to contend with.
@@anthonyeves2005 You have to take account he had health issues before he started , they resolved with rapamycin. Plus he doesnt lift weights. Muscle loss is real if you dont lift weights no matter what you take
I would have guessed 90 to 95, not 80.
@High Intensity Health, do you think Rapamycin is being used by cyclists at the World Tour level? It doesn't seem to be on the banned list. Also I'm interested as a 45 yr old competitive masters road cyclist. Cheers.
Im a couple years older than you, honestly, I’m not ready to buy that we don’t need mTOR at our age. I think until we are 50, 55 or so, taking it less frequently than once per week is a better idea. But hey, I have no f’ing idea in reality lol
I don't think any do but from experience I can say it won't hurt. I increased my FTP by 24W this winter whilst taking rapamycin (doses varuimg from 2mg to 16mg with grapefruit juice but on average 6mg with grapefruit juice fortnightly) but my FTP isn't that high (254->278 @75kg 48y/o) but still 24W is 24W
As a Cylinggeek with 53 years I would interested where to buy the RapaStuff😄 which should be a trusted Source and Shipping to France...(or to my MyUS Postbox).. Thank, you very much and greetings from Andreas in Alsace /France
@@Viertelfranzose I self-prescribe but I heard there are online european MDs that write prescriptions that are valid in the entire EU
@@arhu74 Thank you... I thought I could buy it like Bromantane or other Nootropic Stuff...without a MD
A time bomb in genetic makeup 🤔. MNRA, that’s all.
This guy is 122 years old
Well being he is the world's oldest man he is looking good
What is Emptur?
Search for mTOR
mTOR
he means MTOR, the target of rapamycin
Just don't eat ice cream. You'll never be able to compensate for the damage you'd be doing to your body.
why because it is cold,, hehe
Background music is distracting.
When Dr. Green says taking rapamycin once weekly makes you burn “cleaner fuel”. What the heck is he talking about? Personally i dose rapamycin much less frequently than once per week, so i can keep some mTOR going for my muscles. But do I need to take it weekly to tap into this “cleaner fuel” he speaks of? Either he was speaking way down to the layman, or he doesn’t know what he’s talking about? I honestly can’t tell.. no disrespect intended here!
How do you dose it, how old are you and where do you get it lol, any benefits?
Umm...innate immune system is involved in managing cancer cells, no?
First to say first!
Obama must have taken speaking lessons from this guy.
Why this horrible music?? I want to hear what this man is telling us…😢
This music is way too loud and makes it impossible for me to hear him 😟
Could you please remove the music? 🙏🏻
Fast forward through the intro :)
Stop winging before you've heard past the intro bro! Too quick to complain!! You know the type!! You!
Wow I don’t know if it’s certain ethnicity, but my pops os 80 and he literally looks and is like a healthy 40 yr old and agile. And my grandmothers are both almost 100 and bouncing around. This guy look Older and sound’s older than them. Proofs in pudding so I think I’ma gonna stick to what my parents and grandparents are doing. Some is due to our DNA, but the most part is lifestyle and our culture eating style. 🤷🏻♀️
80 and looks like healthy 40??
@@vegasallen1212We need more info about this miracle. We need every thing that they do. 😊