AGGGHHHH! I KNEW there was a really good reason I had no desire to become a doctor or anything requiring similar course study....for me it would be absolutely torture ....there literally could not be a reward great enough in the end to make it worthwhile to me ...SO? All you medical nerds are personal heros to me, SO HAPPY so many people are able to slough through stuff like in this video and worse
Really easy!! I have been hearing both sides of the argument and the final truth is actually not difficult it's real simple. The high death rates in Hypertension and Diabetes can be separated by those who are taking ACE2 and ARBS and those who are not taking ACE@ and ARBS. Simple if 2000 people died with COVID19 that had high blood pressure similar age and males and the ARBS and ACE2 death rate was 1500 vs 500 who did not take the medication then you would have an actual number to go off of either way. this could be repeated in China, Italy etc etc
Yeah, I had to slow way down to 1.9x. I usually watch most stuff at 2.7 speed. Admittedly, I did watch the drbeen RAS hypercoagulability video, circa 5-1-2020 like 9 times. I was mainly looking for a simple, targeted explanation of the difference between the drugs, in relation to covid. Bradykinin hypothesis, in mind.
Now I know why a majority of elderly diabetic are dying from Covid-19 because many of them are placed on Ace inhibitors. I am 72; so called pre diabetic; and am on a beta blocker for my status post open heart surgery in 2018. I also take a good multiple vitamin with vitamins D as well as Q-10. In addition I take Lipitor and a baby aspirin daily. I am glad I refused the ACE inhibitor the doctor wanted me to take for my diabetes to protect my kidney. Cheers I know my best bet to beat this virus from hell is social distancing; but having seen your class; I now think I might stand a better chance should I get the devil inside my body. Cheers and Thank you.
Wildman Samurai yes you are 100 percent correct in your statement and there is some evidence that ACE inhibitors may save the kidneys of a diabetic. So anyone on their ACE inhibitors should never stop taking it without the advice of their doctor.
@@thomasfraser9072 I'm right that taking an Ace inhibitor or doesn't increase your chances of dying from this virus... There is absolutely no scientific data to back that statement.. This virus attacks old, young, middle aged, Ace inhibitors, no inhibitors, blood pressure problems, no blood pressure problems, healthy people, sick people.. It doesn't discriminate and it doesn't have a specific class of people that it goes after.. As a species we humans have never seen anything like this.
Wtf did i just read. Why does this samurai feel like hes being attacked personally by OP? TWICE. Even when the OPs agreeing with the fact that theres no evidence omg I wonder if samurai’s response was motivated by some politically aligned view about the disease or the vaccines. Nvm. Dead thread. Gg
This is extremely relevant now that the supercomputer has hypothesized that the bradykinin storm is at root cause of the cytokine storm and Covid19 deaths!!! I am not a doctor, but I play one in the movies. Nor do I have any health issues. I do have aging parents over 74. I have a fair grasp of the RAS. However, I am still struggling to get a really good visual diagram that brings home the difference in mechanism of action between Ace inhibitors and ARBs. Especially, in relation to covid. I get ARBs block at1 and Ace inhibitors do something else to block Ace from making angiotensin 2... I am guessing we are hoping for angiotensin 1,7, which cannot be made if ace1 is blocked. So, we would rather just block the at1 with arbs , which is causing the problems. This distinction is still being elusive in my mind, easily forgotten as an amateur who does not use this information daily, or even weekly or monthly.... Yet the distinction seems like it is life or death, right now.... I will re-watch this video a few more times. But I hope you can revive and drive home the point, the distinction, and hopefully steer people for better choices and save a few lives in the next few months.
Antagonist is the technical pharmacological term. A “blocker” usually means antagonist. An inhibitor…well, it depends on what you’re inhibiting. Only if you’re inhibiting the receptor of the agonist do we call you an antagonist. Otherwise, you’re an inhibitor, but not an antagonist. Example, Zileuton is an inhibitor. It inhibits the 5-LOX enzyme. However, Zileuton is NOT a leukotriene receptor antagonist. Hope it helps!
@@MedicosisPerfectionalis Thank you. But I'd like to know is it because ACE inhibitors would cause increase in renal perfusion hence resulting in changes in starling's forces and ultimately leading to less albuminuria..? Is that how its mechanism of action is?
Medicosis Perfectionalis in my opinion Doctors are rushing all their diabetic patients on Ace inhibitors way too early. And now with Covid19 they are quickening their death by doing it. What say you.
Theses two topics were discussed in details in previous videos...This video was just a quick comparison. Also, you can click on the gear ⚙️ icon and decrease the playback speed.
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AGGGHHHH! I KNEW there was a really good reason I had no desire to become a doctor or anything requiring similar course study....for me it would be absolutely torture ....there literally could not be a reward great enough in the end to make it worthwhile to me ...SO? All you medical nerds are personal heros to me, SO HAPPY so many people are able to slough through stuff like in this video and worse
Thank you so much 😊
You haven’t had near enough credit this video is great
Thank you so much, dear!
Would you please help me by sharing?
Super awesome! Thank you!
My pleasure!
Can't imagine there is a better explanation! Very good!
Thank you so much 😊
I love you man ❤❤
Thanks!
BRILLIANT !
Thank you 🙏
Why isn’t there orthostatic hypotension with ACE inhibitors?
Playback 0.75 is perfect
Ok
Agree!
BD yes, I played it 0.75 too otherwise it’s hard to catch. But I like how easy ace inhibitors are explained here
What about the higher risk of lung cancer?
Angioedema with ARBs as been reported in small proportion
Nothing is 0%.
Really easy!! I have been hearing both sides of the argument and the final truth is actually not difficult it's real simple. The high death rates in Hypertension and Diabetes can be separated by those who are taking ACE2 and ARBS and those who are not taking ACE@ and ARBS. Simple if 2000 people died with COVID19 that had high blood pressure similar age and males and the ARBS and ACE2 death rate was 1500 vs 500 who did not take the medication then you would have an actual number to go off of either way. this could be repeated in China, Italy etc etc
Thanks 🌺
My pleasure 😇
You talk way too fast. Had to lower the playback speed
Thank you so much for your feedback!
Yeah, I had to slow way down to 1.9x. I usually watch most stuff at 2.7 speed. Admittedly, I did watch the drbeen RAS hypercoagulability video, circa 5-1-2020 like 9 times. I was mainly looking for a simple, targeted explanation of the difference between the drugs, in relation to covid. Bradykinin hypothesis, in mind.
Now I know why a majority of elderly diabetic are dying from Covid-19 because many of them are placed on Ace inhibitors.
I am 72; so called pre diabetic; and am on a beta blocker for my status post open heart surgery in 2018. I also take a good multiple vitamin with vitamins D as well as Q-10. In addition I take Lipitor and a baby aspirin daily.
I am glad I refused the ACE inhibitor the doctor wanted me to take for my diabetes to protect my kidney. Cheers
I know my best bet to beat this virus from hell is social distancing; but having seen your class; I now think I might stand a better chance should I get the devil inside my body. Cheers and Thank you.
There is no evidence that taking an Ace inhibitor is killing more people with this virus.
Wildman Samurai yes you are 100 percent correct in your statement and there is some evidence that ACE inhibitors may save the kidneys of a diabetic. So anyone on their ACE inhibitors should never stop taking it without the advice of their doctor.
@@thomasfraser9072 I'm right that taking an Ace inhibitor or doesn't increase your chances of dying from this virus... There is absolutely no scientific data to back that statement.. This virus attacks old, young, middle aged, Ace inhibitors, no inhibitors, blood pressure problems, no blood pressure problems, healthy people, sick people.. It doesn't discriminate and it doesn't have a specific class of people that it goes after.. As a species we humans have never seen anything like this.
Wildman Samurai no argument otherwise
Wtf did i just read. Why does this samurai feel like hes being attacked personally by OP?
TWICE. Even when the OPs agreeing with the fact that theres no evidence omg
I wonder if samurai’s response was motivated by some politically aligned view about the disease or the vaccines.
Nvm. Dead thread. Gg
Sir if Ace2 resptor will destroy of cell the covid 19cannot enter into cell and can,t make their copies
Sir ...kindly make videos on hards or complex topics these are easy topics everyone can understand it easily...
Thanks for your feedback
This is very good except on1.. ARBs can produce dry cough after a while... 2..you did not mention the effect of them about lipido and erection
🙏🏼
This is extremely relevant now that the supercomputer has hypothesized that the bradykinin storm is at root cause of the cytokine storm and Covid19 deaths!!! I am not a doctor, but I play one in the movies. Nor do I have any health issues. I do have aging parents over 74. I have a fair grasp of the RAS. However, I am still struggling to get a really good visual diagram that brings home the difference in mechanism of action between Ace inhibitors and ARBs. Especially, in relation to covid. I get ARBs block at1 and Ace inhibitors do something else to block Ace from making angiotensin 2... I am guessing we are hoping for angiotensin 1,7, which cannot be made if ace1 is blocked. So, we would rather just block the at1 with arbs , which is causing the problems. This distinction is still being elusive in my mind, easily forgotten as an amateur who does not use this information daily, or even weekly or monthly.... Yet the distinction seems like it is life or death, right now.... I will re-watch this video a few more times. But I hope you can revive and drive home the point, the distinction, and hopefully steer people for better choices and save a few lives in the next few months.
Good article Sir.
Can switch from Coveram (10mg+10mg) to Azoren (20mg+5mg) ?
Theorectically, ARBs is better than CCB, to" prevent " covid?
Is there a difference between inhibitors, blockers and antagonsits?
Antagonist is the technical pharmacological term. A “blocker” usually means antagonist.
An inhibitor…well, it depends on what you’re inhibiting. Only if you’re inhibiting the receptor of the agonist do we call you an antagonist. Otherwise, you’re an inhibitor, but not an antagonist.
Example, Zileuton is an inhibitor. It inhibits the 5-LOX enzyme. However, Zileuton is NOT a leukotriene receptor antagonist.
Hope it helps!
@@MedicosisPerfectionalis Thank soo much 🙏 It cleared all the confusion!
Will you please make this video in hindi.
Talking too fast
Thank you for your honest feedback!
@@MedicosisPerfectionalis you’re welcome. I was very interested but had a hard time following you
They say the Corona virus enters the host cell using ace receptors. Would prescribing ace inhibitors be helpful or catastrophic for treatment ?
@@robertjohnson3549 No.
Nope.
Would an ACE work for stage fright?
Never heard of that.
Beta blockers will help with that.
Since ACE Inhibitors & ARBs cause renal impairment then why do we use them incase of diabetic nephropathy?
ACE inhibitors are bad for kidneys except in 2 situations:
1. Diabetic nephropathy.
2. Scleroderma nephrosis.
Hope it helps!
@@MedicosisPerfectionalis Thank you. But I'd like to know is it because ACE inhibitors would cause increase in renal perfusion hence resulting in changes in starling's forces and ultimately leading to less albuminuria..? Is that how its mechanism of action is?
Medicosis Perfectionalis in my opinion Doctors are rushing all their diabetic patients on Ace inhibitors way too early. And now with Covid19 they are quickening their death by doing it. What say you.
@@thomasfraser9072 No.
is it wise to implement these during an running infection and howto revert this - is EPO a substance of interest ?
Hi gudafternoon. I just want to ask if wat theory DOES Captopril ACE Inhibitors followed?
Thankyou
What do you mean by “what theory”?
@@MedicosisPerfectionalis I mean.. Like for example
Induced fit theory, rate theory, occupancy theory etc
I don’t know 🤷♂️
@@MedicosisPerfectionalis OK thanks
@@maciaschristene9318 -> you refer to citokine storm ?
you are literally so hilarious
Thanks a million!
It’s an honor!
Can you please help me by sharing my videos with others?
Slooooooooow dowwwwwwwn
I like ur videos, thank you
My pleasure 😇
cool
Thanks 🙏
Where is info about covid-19?
It should have been a good explanation.. You talk way too fast!
Theses two topics were discussed in details in previous videos...This video was just a quick comparison.
Also, you can click on the gear ⚙️ icon and decrease the playback speed.
Too fast ..man.
Greetings from La Paz, Bolivia (3600 m o s l) city
too fast mate, you speak far too quickly to be an effective teacher.
You can slow down the video yourself in your own settings
Thanks ❤️
My pleasure 😇