Extrinsic Pathway of Apoptosis | FAS Ligand Mediated

In this video the second pathway for extrinsic apoptosis have been discussed. This pathway is mediated via FAS Ligand and FAS Receptor.
The fas receptor (First apoptosis signal) - (also known as Apo-1 or CD95) is a transmembrane protein of the TNF family which binds the Fas ligand (FasL). The interaction between Fas and FasL results in the formation of the death-inducing signaling complex (DISC), which contains the FADD, caspase-8 and caspase-10. In some types of cells (type I), processed caspase-8 directly activates other members of the caspase family, and triggers the execution of apoptosis of the cell. In other types of cells (type II), the Fas-DISC starts a feedback loop that spirals into increasing release of proapoptotic factors from mitochondria and the amplified activation of caspase-8.

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A fantastic, clear and concise introduction to this topic - thank you!!

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[@Ashnaasweetgirl]

Correction: CAD stands for Caspase Activated DNAse.
Awesome tutorial by the way.

[@LaloboJDavid]

ANY REFERENCE BOOK ?

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you have ceased my caspase cascade, and I will now survive...

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Thanks Alice for appreciation...... Glad to know that it helps.....
And i always try to keep my videos short and precise.

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[@hussainbiology]

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[@hussainbiology]

You are welcome...

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Thank you

[@hussainbiology]

You're welcome

[@shivasf4019]

It would really really help if you could include your sources in the description. Thank you for this video though. Amazingly explained.

[@hussainbiology]

okay i will consider

[@tatsumiogawa1107]

Just one little thing, I think the ligand and receptors are of 3 units (not 4) according to several sources, because they are involved in a step called trimerization. Other than that, it was a very nice video!! :D

[@hussainbiology]

Yeah they are 3 units , the picture depicted here is only to show the interaction otherwise it should have been trimeric structure ....Thanks for taking this into consideration

[@tatsumiogawa1107]

Still a very good video, thank you!@@hussainbiology

[@hussainbiology]

Thanks....Keep sharing and supporting

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Ek No.
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Most welcome...

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Nice explanation 🌷

[@hussainbiology]

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[@cassiacorrea9112]

Muito bom! 😍

[@hussainbiology]

Thanks for appreciation.....
Muito bom means??

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@@hussainbiology It means *Very Good* in Portuguese

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#Medschooldiscussion

[@hussainbiology]

Thanks for appreciation....

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Supbbb explanations

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[@LaloboJDavid]

HELP ME WITH THE REFFERENCE BOOK.YOU ARE THE BEST

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[@LaloboJDavid]

@@hussainbiology NO REFFERENCE BOOK?

[@hussainbiology]

@@LaloboJDavid Lodish Molecular Biology ( Chapter 21 ) Eight Edition

[@LaloboJDavid]

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[@thaovungocphuong5544]

Hello, somebody can tell me what is the different between MHC I and FasR?

[@xrcc202]

Ya That's a good question

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this is tough to remember than TNF

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But u will remember it...✌️✌️✌️

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Can't understand single thing you are saying