MAPK/ERK Signaling Pathway

The MAPK/ERK pathway (also known as the Ras-Raf-MEK-ERK pathway) is a chain of proteins in the cell that communicates a signal from a receptor on the surface of the cell to the DNA in the nucleus of the cell.
MAPK Pathway in C.elegans : • LET 23/RAS/MAPK Signal...

[@DebateEnjoyer666]

I've watched a few of your videos now. They are so much better than our revision slides... Thank you! Keep up the good work

[@hussainbiology]

Thanks Emmanuel for appreciation.... Glad to know that it helps

[@vishk123]

All your videos are phosphorylating my work!

[@hussainbiology]

that is what how feedback should be.....
thanks

[@AlteraLin]

Just what I needed. Concise, accurate, and clear. Thanks for the vid. :)

[@hussainbiology]

Thanks brother for appreciation..... Really Glad to know that it helps.😊😊

[@jogeshkumarsharma2969]

Damn🔥🔥there is so much information in just less than 7 mins ...amazing thankyou🙏

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[@xrcc202]

I'm getting so much help by watching your video lectures for the preparation of my college studies. Thank you so much Sir for all these because it not only makes us feel interested towards the topic but also makes it way easier.

[@hussainbiology]

thanks for appreciation..Glad it helps ✌️

[@KILIMANJARO3010]

Now I don't have to read through a boring chapter. Thank you!!!

[@hussainbiology]

thanks Madsen for appreciation...Glad to know that it helps

[@arah2368]

It's hard to find niche channels like this for medical sciences. You are filling the biochemical niche very well ❤️😁

[@hussainbiology]

thanks for appreciation ✌️✌️

[@eyadbazmawi8005]

you're keeping me alive in medical school. Thank you so much ♥️

[@hussainbiology]

thanks Eyad for appreciation.... Gald it helps....
Do share it

[@reneesilva8308]

It's amazing how I was reading about Polycystic Kidney Disease, and how this pathway produced the entire physiopathology, or at least part of it. You save my life men, u are amazing.

[@hussainbiology]

thanks dear for appreciation...Glad to know that it helps

[@l.fsader6021]

Everything is connected

[@samuelboatengtakyi7070]

Every detail and interchangeable word used in publications that make them confusing to follow is excellently captured and explained in the video. This lecture is more than 5-⭐rating. Thank you so much!

[@hussainbiology]

Thanks for appreciation...Glad it helps

[@SorrowFullGaming]

thank you so much, this helped me so much for my exam tomorrow! I would've failed without you

[@hussainbiology]

You are welcome Jose....Keep sharing and supporting and thanks for appreciation...

[@SorrowFullGaming]

Hussain Biology definitely will share and support!

[@willj4ck]

thanks for the explanation.
I've seen Neurofibromatosis disease mechanism today and learned about the neurofibromin protein (NF1 gene) but couldn't understand its function at first...now I see that neurofibromin is GAP that stops MAPK/ERK signaling pathway.
thanks a lot

[@hussainbiology]

Thanks Will for appreciation....Glad to know that it helps

[@malvikabisht9288]

THANK YOU SO MUCH . THIS WAS EXPLAINED BETTER THAN IN MY LECTURE

[@hussainbiology]

Thanks for appreciation.. Glad to know that it helps

[@emmanuelappiahtawiah9261]

Thanks a lot, Sir. This couldn't be taught any easier!

[@ankansarkarnjs9750]

You make such pathways so easy. Thanks a lot hussain.

[@hussainbiology]

My pleasure 😊

[@xrcc202]

All the videos by Sabbir Sir regarding cell and molecular biology are just world-class 💯✅

[@sushicat1666]

Thank you very much! helping me through my masters

[@hussainbiology]

Happy to help!

[@JitenderKumar-tm2kb]

Ur smart and hard work make things easy for us .. thank u so much

[@hussainbiology]

thanks for appreciation

[@aswanirael5255]

Thank you sir, may almighty God add you more knowledge

[@hussainbiology]

Thanks for appreciation...Keep sharing and supporting ✌️

[@milenasarkowicz3080]

Great video that puts everything into place! Thank you!

[@hussainbiology]

thanks for appreciation..Glad it helps ✌️

[@sanakausar3229]

Just by seeing ur video for few minutes one can understand whole concept easily... Thank u..🙂make more videos on csir ugc base hot topics

[@hussainbiology]

thanks Sana for appreciation..Glad to know that it helps ✌️

[@koreanshots6716]

You are simply awesome..thank u

[@hussainbiology]

Thanks Sobia for appreciation.... Really Glad to know that....Keep sharing and supporting

[@Vspxaditt]

شكرا على هذا الفيديو الجميل بارك بك الله

[@hussainbiology]

Alhamdulillah......✌️✌️

[@anchalthakur8668]

Thanksu so much sir to make video on this topic. I can readily understand this mapk pathway.

[@hussainbiology]

most welcome... thanks for appreciation....

[@aimnhaqim]

thanks a lot u really help me understand this topic very well 😊

[@hussainbiology]

thanks for appreciation..Glad it helps

[@TheAlcoholicNun]

THANK YOU. only clear and detailed video out there on this process

[@hussainbiology]

Thanks Daniel for appreciation...Glad to know that it helps...

[@ranimealtaweel3732]

Just woww
But I would like to give a note :
The Ras is active only when it is attached to the membrane. When Ras is in a free formule in the cytosol, then it is inactive.
It is just a remarque. Thanks for all from France 😁✌🏻

[@hussainbiology]

thanks for ur feedback ..
✌️✌️✌️ would love this add it on my new signalling pathways...

[@ranimealtaweel3732]

@@hussainbiology yes and just keep doing more videos.
Ihave a question, would you make some video on optical physic ? It seems complicated and it is in medical program for the first year
Any way thank you for all that you do !

[@anjanasaji6557]

Very nyz class...👍 everything is clear,and easy to study.. Thank you

[@hussainbiology]

most welcome

[@nil7425]

🔥Excellently expressed sir. Thank you so much.

[@minaltaunk8888]

You are a true gem keep it up

[@palshah3509]

Great video completely cleared my concept thank you 🙏

[@pesmoboyt777]

Wow amazing.. Just I wanted things.. Are you a medical student? Keep going man.. Iam a biotechnology students.. It's really helpful..New subscriber ❤️

[@hussainbiology]

thanks buddy for appreciation..Glad it helps

[@ek3451]

This pathway seemed dauntingly complicated until I watched this video... Great explanation, even comprehensible to a high schooler like me haha

[@hussainbiology]

thanks Erik for appreciation...Glad it helps

[@hodophile1999]

Nice video sir it helped me a lot

[@hussainbiology]

thanks for appreciation

[@Kelly-jh6dy]

God bless you!

[@hussainbiology]

thanks

[@harunpatel]

GReat ..its excellent video

[@hussainbiology]

thanks for appreciation

[@olaleyeolutunde]

Thank you.

[@zainababdelaal8397]

Thank u soo much for all ur effort ... ❤

[@tanusharma9271]

Tnk u sir for such a perfect video lecture..

[@hussainbiology]

Thanks Tanu for appreciation.... glad to know that it helps

[@sreenivasshenoy729]

Hi, Sir!
Its really very good video and clearly understandable.
So thankyou very much...
I have a suggestion that the subtitles should be error free.

[@hussainbiology]

Thanks for appreciation...Glad to know that it helps... And surely i will be adding accurate subtitles Shortly

[@skyedad9711]

Just wondering if the dimerisation of the receptor is due to cross-phosphorylation or auto-phosphorylation ?

[@gayatridas4896]

Thank you so much 🥺

[@hussainbiology]

You’re welcome 😊

[@yasinyildirim97]

Amazing explanation. Couldn’t thank you enough!

[@sidipyrex7861]

جزاك الله خيراً ❤

[@oculosify]

hello, there is something I dind't understand... does this pathway, just like AKT pathway and STAT pathway, happen in all immune cells, such as tissue-resident cytotoxic T cells (IE-CTL)?

[@زهرهالكاردنيا-ز2غ]

Perfect video 🌹🌹thank you

[@hussainbiology]

thanks for appreciation... Glad to know that it helps ✌️

[@yuktasansare7535]

Ras protein binds to GTP and ERK binds to ATP, what is reason for this difference?

[@blackbeard3285]

I'd like to thank you for your excellent explanation! I've a question though, is this pathway similar to the RAS map kinase pathway? Or is it different? Thanks a bunch 😃

[@hussainbiology]

yeah very much similar

[@blackbeard3285]

@@hussainbiology thanks. Got the clear idea 😃

[@shafatfarooq6903]

Very well explained 👍

[@hussainbiology]

thanks for appreciation...Glad to know that it helps ✌️

[@ashb6136]

I really liked it man.thanks

[@milesofdavis28]

I like this video, but Ras does not phosphorylate Raf. Instead, it binds it, and that is what activates it. Most cell biology textbooks like Molecular Biology of the Cell or Lodish Molecular Cell Biology explain it this way with cited experimental assays as evidence.

[@l.fsader6021]

milesofdavis28 hace you gone into the lab and tested yourself?

[@marianaelisaramirezmitre6858]

ERK does not traslocates to the nucleus?

[@olivia6204]

Thank you soooo much !

[@hussainbiology]

thanks for appreciation..Glad to know that it helps

[@pianomelody3312]

thank u sir....itz very helpful...keep making such awsome videos..

[@hussainbiology]

Thanks buddy....

[@biologicalresearch5836]

No words hussain shab. Panun kashur boiy 😜

[@hussainbiology]

barabar boi.....❤️❤️

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After reading 4 tym. ...wz nt able to get it....Sir u made it 8 once....👌👌👌👌thnx a lot

[@hussainbiology]

thanks Nifat for appreciation...Glad to know that it helps....

[@paramitadas1756]

u know , you r GOD. amazingly nice. u saved me .

[@hussainbiology]

too much for me...☺️☺️ overwhelmed really....
Thank God He created me to make these lectures and make ur work easier...✌️✌️

[@godofallgodswithnoothernam920]

Key to consist is medial-OFC and ACC and vStriatim reward network - this is true❤

[@matskessel5463]

Perfect man!!

[@hussainbiology]

thanks buddy for appreciation

[@bhatjas1820]

thanku sir... nice video... great efforts.. sir have a confusion that raf is not phosphorylated... it is only kinase which is not phosphorylated, recruted by Ras..

[@pirate2255]

You are correct. Recruitment of RAF by RAS actually facilitates the dephosporylation of ser259 which results in the disruption of the interaction between RAF and inhibitory 14-3-3 proteins, therefore activating RAF. RAS also facilitates RAF activation by driving RAF dimerizaiton.

[@l.fsader6021]

Damien Rasmussen no bro. You literally just said the recruitment of raf activates raf. Look at your reasoning

[@vandnakapil889]

Thnkuuu sir ... beautifully explained...

[@hussainbiology]

Thanks Vandna for appreciation.... Glad to know that it helps

[@samirawani8427]

Are u a kashmiri by any chance

[@hussainbiology]

Yes sir .. I am

[@asap000]

Thanks alot..

[@suzuka9654]

Very good representation 👌👌

[@jawadnawaznawaz8793]

Very good

[@adilanessi7248]

Thank you sir

[@hussainbiology]

You are welcome....Gald to know that it helps

[@zainiiBee]

cleared my concepts.. thank you

[@hussainbiology]

Thanks Zainab for appreciation..Glad to know that it helps.

[@نرجسعبدو]

Who is STAT stimulate oct4

[@ramchandrasuthar2848]

Nice analysis bhai

[@surendrasaini9057]

How to erk phosphorylat RTK

[@papiyabiswas3477]

hmm,,onk valo poriskar holo ebr byapar ta

[@hussainbiology]

Couldn't understand???

[@papiyabiswas3477]

No no,I really understand this pathway clearly by your video

[@hussainbiology]

@@papiyabiswas3477 Thanks Papiya for appreciation...Dhan'yabāda

[@villevilkki3625]

KInda of topic, but if you want to be precise with your drawings please draw the nuclear membrane with four layers of phospholipids, not like cell membrane that has only two layers.

[@hussainbiology]

Thanks for your feedback..... I will definitely consider making that

[@lj7019]

Good explanation but please slow down

[@hussainbiology]

Surely i will

[@fathmanawaz5025]

Nice sir

[@hussainbiology]

Thanks Fathma for appreciation.....Keep supporting 😊

[@rajeshbhardwaj298]

Excellent video Hussain. I think one only important thing missing from the picture @3:12 is what phosphorylates RAF. From another video (ua-cam.com/video/ql62kMK3BrM/v-deo.html) what I learnt is that a scaffolding protein binds RAF (which is bound to Ras) as well as Src kinase to form a complex. The scaffolding protein increases the local concentration of Src and RAF allowing them to interact. Src then phosphorylates RAF to fully activate it. I just subscribed your channel to learn more basic biology. Many thanks as you are doing a great job!

[@hussainbiology]

thanks for appreciation and ur feedback is noted

[@tanu6464]

😊😊😊😊

[@matskessel5463]

Do you have a video (if not can you make one?) on tor signalling?

[@hussainbiology]

mTOR video will be available very soon.....

[@subhamchowdhury6655]

Need new vedio

[@weesaikim6090]

Muacks ty

[@hussainbiology]

Thanks for appreciation

[@samhemmings1822]

Ras is not a kinase

[@iqrazulfiqar5945]

WOW

[@hussainbiology]

thanks for appreciation..glad to know that it helps

[@aqsahamdani7545]

wariyah asil

[@hussainbiology]

shukr Alhumdulilah,, Tuhe Luguv asil...