So glad i found all your lectures, i think you may have saved me. I was looking for study material for my clinical pharmacology exam and all you lectures are just perfect, you make everything so easy to understand, just wish i found these earlier... only 2 weeks left to study for finals.... thx so much
Thank you so much for your help. The pharmacology professor at my med school is awful and I can't "absorb" what he teaches. I will subscribe to your channel and please post if you ever build upon something which is ran through donations or payment. I would love to further support you!
Oh gosh u are a savior!!!Man!! # legend of pharm..!!Doc u just made these stuffs so meaning full !!! This has to be imbibed by every med graduate... Now we could imply these things in our future as pharm is an very important part of all the treatment strategy As u said now u made pharm more palatable!!!! U indeed did that doc!! Thank u to tons!! 🤩🤩🤩🤩🤩🤩and tonssssss!!!!!!I never felt pharm this way... Looking forward for upadates.. Of ur upcoming vedios.. Thank u..
amazing! I have got all of my questions those confused me in the class while i have taken PK and PD units in the class. thank you very much! keep it up!
Thank you sir it’s really helping me a lot I just entered into pharmacology my md3 semester it’s making me to go more interesting towards the subject I am understanding a lot thanks for your videos I’m a subscriber
I will owe my medical degree to you if I pass end of block.......but question, why you no make more videos? Struggling with pharmacodynamics and pharmacotherapy of the nervous sytem
What if I say 50mg of iv dose in this case is the AUC p.o, bioavailability is 0.5 and what we are looking for here is AUC I.v(total amount of drug to be administered) F po= AUC po/ AUC I.v In this case what we are looking for is AUC I.v. AUC I.v = AUC po/ F po AUC I.v = 50mg/0.5 =100mg Won't that be a bit easier?
I don't like how Concentration is said to be equal to Mass / Volume. That's Density, not concentration. Why isn't the equation for (molar) concentration Moles of solute / Volume of solution instead?
If a drug is 100% absorbed that means its 100% present in blood not in plasma .. Drugs tend to bind with plasma reversibly in a balanced form .. That means u still have free drug present in your blood which is unbounded to plasma .. So you cant measure the concentration of the drug in the plasma directly as you did in your first example
? I don't understand this; he differentiated between fluid containing RBCs, (blood) and the very same fluid w/o RBCs. Since I guess drugs are usually not binding on RBCs I think he's right; I think you are talking about plasma proteins; and why can't you measure it? Is it only possible to measure the unbound fraction or what's your point?
You counted 2,5 mg in the stomach, 2 mg in the intestines and 2,5 mg in the liver...doesn't this make a total of 7 mg lost? You said only 5 mg instead of 7 mg
Look closely and you'll know that the drug loss at last stage (from the liver) has been labeled as 0.5mg. Also, for the first time he pointed it out as 0.5 mg which by the second time was described as 2.5mg. So this must've been an error; I hope you don't have the doubt anymore.
This idea that area under the curve tells us how much drug was absorbed really bothers me. To get the total quantity of drug, we would need to integrate the _flux_ of drug through the plasma. Integrating the volume of a section of river over time does not tell us the quantity of water that has flowed through. The river could be flowing fast or standing still. We would need to integrate flow through a cross-section over time. The ratio of two concentration integrals, e.g. oral over intravenous, comes closer to telling us something, but still only describes reality for identical, constant rates of excretion. Because rates of excretion usually depend on concentration, we have to be careful here too and acknowledge that these are very rough approximations.
Your lecture & its representation was like an 17.14mg i.v dose, 100% absorbed.
Hats off man.
I am planning to study MSc Toxicology and feeling very lucky that found your lectures even though it's
not new but helped me a lot, many thanks.
So glad i found all your lectures, i think you may have saved me. I was looking for study material for my clinical pharmacology exam and all you lectures are just perfect, you make everything so easy to understand, just wish i found these earlier... only 2 weeks left to study for finals.... thx so much
Thank you so much for your help. The pharmacology professor at my med school is awful and I can't "absorb" what he teaches. I will subscribe to your channel and please post if you ever build upon something which is ran through donations or payment. I would love to further support you!
ThereWasMore TWM Can I put you into the garbage?
I have an exam on this very soon. You are a life saver. Very clear explanations. Thank youuuu!!
Happy you enjoyed it!
I don't understand where 8 came from?
are you not uploading videos anymore?
Please keep on making videos Sir . They are easily understandable and perfect.
Please don’t stop making wonderful videos like this
Perfect quality, good teaching , tech well used. Clear. Video, voice and content.
Oh gosh u are a savior!!!Man!! # legend of pharm..!!Doc u just made these stuffs so meaning full !!! This has to be imbibed by every med graduate... Now we could imply these things in our future as pharm is an very important part of all the treatment strategy
As u said now u made pharm more palatable!!!! U indeed did that doc!! Thank u to tons!! 🤩🤩🤩🤩🤩🤩and tonssssss!!!!!!I never felt pharm this way... Looking forward for upadates.. Of ur upcoming vedios.. Thank u..
amazing! I have got all of my questions those confused me in the class while i have taken PK and PD units in the class. thank you very much! keep it up!
Thank you for the throughout explanation of this. I truly admire your ways of teaching, especially the use of repetition.
Thank you sir it’s really helping me a lot I just entered into pharmacology my md3 semester it’s making me to go more interesting towards the subject I am understanding a lot thanks for your videos I’m a subscriber
Fantastic, really useful, everything perfectly explained. Would be amazing if you could include some pharmacodynamics too? Thanks
Fantastic series well done! Is the Bateman equation of drug absorption covered here?
Well done video. Crystal clear thank you
I will owe my medical degree to you if I pass end of block.......but question, why you no make more videos? Struggling with pharmacodynamics and pharmacotherapy of the nervous sytem
Did you get ?!
THANK YOU VERY MUCH NFOR YOUR ELOQUENCY AND CLARITY..YOU'RE A MARVEL
wow! u easily explained the most difficult thing... thank you
Thanks, this is awesome. Really appreciate all of your videos ! keep the hard work !! :DD
Is there are more specific clinical term used to describe the "drug loss" or "drug being lost" as it passes through each compartment?
Sir which textbooks are you using as your source of information.
Thank you very much for sharing your knowledge! You are a great tutor!
your voice is magic
aaayyyyyeeeee!!!!🙌 You keep me motivated 💪 Yourvideos are amazing 🙌
What if I say 50mg of iv dose in this case is the AUC p.o, bioavailability is 0.5 and what we are looking for here is AUC I.v(total amount of drug to be administered)
F po= AUC po/ AUC I.v
In this case what we are looking for is AUC I.v.
AUC I.v = AUC po/ F po
AUC I.v = 50mg/0.5 =100mg
Won't that be a bit easier?
Thanks professor your lectuere are really helpful
Thanks for uploading.. this is a great help in my Nursing Studies... :))
hi you said the is no distribution for the IV case , so how then does the drug in plasma reaches the desired site of action
it is just Scenario as he said it is one
compartment >
Very useful ,thnx , continue making more👍
What kind of software do you used? and could you save the drawings in the presentation?
By the way nice lecture.
I don't like how Concentration is said to be equal to Mass / Volume. That's Density, not concentration. Why isn't the equation for (molar) concentration Moles of solute / Volume of solution instead?
scottseptember1992 The purpose was to just make it easier. There are more simple terms to say directly: mass and volume. That's all :)
well explained topic
really clear out my doubts.THX.
Thank you! I learn a lot!
If a drug is 100% absorbed that means its 100% present in blood not in plasma ..
Drugs tend to bind with plasma reversibly in a balanced form .. That means u still have free drug present in your blood which is unbounded to plasma ..
So you cant measure the concentration of the drug in the plasma directly as you did in your first example
? I don't understand this; he differentiated between fluid containing RBCs,
(blood) and the very same fluid w/o RBCs. Since I guess drugs are usually not binding on RBCs I think he's right; I think you are talking about plasma proteins; and why can't you measure it? Is it only possible to measure the unbound fraction or what's your point?
thank you so much. you are very talented!
thank you so much dr ^^
Those 20 dislikes must be for Jamaicans who confuse dislike with dis I like.
Good information.
Must be the first video ever... on YT... to have zero dislikes... maybe the content is a troll repellent. LOL
how to download all..?
your explanation was Wonderful.Thanks
AMAZING!!!!
Elimination = The dissolution of Egos of the Professors discussed in the comments below.
very useful thank you
Nice video but the subtitles get in the way so much that it's hard to make out what you're writing.
you can turn off the subtitles: problem solved
This is all in the book, why others find it hard to understand this mathematical formula.
Because I guess it just becomes easier when someone else dictates it to us.. That's how most people have been trained since childhood
Brilliant video! (y)
sir u r awesome
Thanks you
You counted 2,5 mg in the stomach, 2 mg in the intestines and 2,5 mg in the liver...doesn't this make a total of 7 mg lost? You said only 5 mg instead of 7 mg
Look closely and you'll know that the drug loss at last stage (from the liver) has been labeled as 0.5mg. Also, for the first time he pointed it out as 0.5 mg which by the second time was described as 2.5mg. So this must've been an error; I hope you don't have the doubt anymore.
Thanks
This idea that area under the curve tells us how much drug was absorbed really bothers me. To get the total quantity of drug, we would need to integrate the _flux_ of drug through the plasma. Integrating the volume of a section of river over time does not tell us the quantity of water that has flowed through. The river could be flowing fast or standing still. We would need to integrate flow through a cross-section over time.
The ratio of two concentration integrals, e.g. oral over intravenous, comes closer to telling us something, but still only describes reality for identical, constant rates of excretion. Because rates of excretion usually depend on concentration, we have to be careful here too and acknowledge that these are very rough approximations.
thank you :)
is good
I get it
i love u haha thanks a lot
Books suck... you Rock!!
Wow! :)
Thanks a lot! But please pronounce "route" differently, it confuses ^_^
sir u r awesome