Esters & Amides -Local anesthetics

Classified as Esters or Amides based on their Chemical structure
Esters
-Cocaine
-Benzocaine (ALL HAVE 1 ''i'' in the word )
-Tetracaine
-Procaine
-Chloroprocaine
Amides
-Lidocaine
-Prilocaine
-Bupivacaine
-3 Main components of LA
1.Lipophillic group
2.Hydrophillic group
3.Linker group
Functional group in LA
The chemical formula of Esters & Amides
-Water solubility of Esters due to presence of hydrogen bonding
-Metabolism of Amide & Esters in the human body
-Pseudocholinesterase & True cholinesterase
-Terminal AMINE in primary secondary & tertiary form & its significance in LA
Difference between ESTERS & AMIDES
-About COCAINE-origin & history
Properties & uses of:-
-Cocaine
-Procaine
-Chloroprocaine
-Benzocaine
AMIDES as drug of choice for LA
-Lignocaine used for all BIT-Block, Infiltration & Topical
-Prilocaine -safest, but contraindicated in methemoglobinemia
-Procainamide
-Bupivacaine
-Articaine
Difference between esters & amides-
1.Their molecular structure that makes a compound ester or amide
2. The chemical behavior that makes them local anesthetics
3.How they break down in our body
4.The advantages & disadvantages of esters and amides.
5.Brief notes on a few types of LA.

[@AmandaHermida]

this covered so many topics in addition to the amide ester breakdown. I Loved the depth of detail you went into to make this understandable. thank you!

[@dentalbasics7122]

😊 thank you for your feedback that u understood & loved the depth n detail👍

[@khaledasd1000]

toxicity of bupivacaine is more than lidocaine ....19:29 min

[@dentalbasics7122]

Yes if given intravenously.