Clearance and Rate of Elimination - Pharmacokinetics - Pharmacology Lect 12

This lecture covers clearance and rate of elimination. View the other videos on pharmacology below.
(1) Pharmacokinetics & ADME: • Pharmacokinetics for S...
DRUG ABSORPTION Videos:
(2) Drug Absorption Overview: • Absorption of Drugs - ...
(3) Bioavailability: • Drug Bioavailability O...
DRUG DISTRIBUTION Videos:
(4) Drug Distribution Overview: • Distribution - Pharmac...
(5) Volume of Distribution: • Volume of Distribution...
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DRUG METABOLISM Videos:
(6) First Pass Metabolism: • First Pass Metabolism ...
(7) Phase I Metabolism: • Phase I Metabolism - P...
(8) Phase II Metabolism: • Phase II Metabolism - ...
(9) First Order and Zero Order Kinetics: • First Order & Zero Ord...
(10) Drug Half-life: • Drug Half-life | An Ov...
(11) First-order elimination rate constant and half-life-details: • First Order Eliminatio...
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DRUG ELIMINATION / EXCRETION
(12) Drug Clearance: • Clearance and Rate of ...
(13) Renal Excretion of Drugs: • Renal Excretion of Dru...
(14) Ion Trapping: [not yet posted]
(15) Dosage Regimens: [not yet posted]
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Factors That Affect Drug Metabolism:
(16) Enzyme Induction: • Enzyme Induction - Pha...
(17) Competitive Inhibition Overview: • Competitive Inhibition...
(18) Competitive Inhibition of Statins: • Competitive Inhibition...
(19) Acetaminophen toxicity (Clinical Correlate): [Not yet posted]
(20) Pharmacogenomics Overview: • Pharmacogenomics | Asi...
(21) Slow Acetylators - Pharmacogenomics: [not yet posted]
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[@redak679]

Wow, I just discovered your channel now and I'm surprised how I didn't come across it earlier. Thank you so much for the videos, all of them are extremely helpful. Please keep making more.

[@phoenixhelicase98]

" I want to be clear here " ... haha ! what a perfect line for the video.

[@kim-dannguyen2332]

I'd like to thank you for doing these videos. They are helping me so much. I've had a hard time trying to understand the concepts in my textbook but now it's ALOT clearer!!!!!

[@damarisgarcia87]

Thank you soo much for posting this. It makes so much more sense.

[@citadel7925]

I really loved your lectures - my request is I could found anything amongst your lectures, which would cover subjects regarding - Achieving Steady State, Therapeutic window, Plateau Principle, Rate of infusion and Effect of loading dose as a logic continuation of drug elimination part of Pharmacokinetics. Anyway, thanks much, keep it going, bright clear lectures! Well Done.

[@KP-zh8fn]

Thank you so much for this video! It was so clear and I’m grateful for all the effort you’ve put in. It helped me a lot :)

[@marianaribeiro9593]

Thank you, thank you, thank you!

[@henamadi3175]

Thanks for these videos, really helpful. Please keeping producing new videos

[@chappahx]

really great job explaining these concepts, thanks

[@pohsstudio7769]

Hello, thanks so much for the videos, I love them. I have one question though. Is the elimination rate constant the same as the rate of elimination in this video? How are the 2 related? Really confused.

[@antonioluparelli5509]

From an Italian medical student: THANK YOU

[@77amams]

Many Thanks, was waiting it

[@thahirahussain3796]

awesome!

[@TheHobopower]

Amazing!

[@Nadasistschoen]

Fantastic video!!!!!

[@loveqw023]

Thank you so much for the videos!! :)

[@ksenianaturalova2152]

Thank you!!!!

[@aniqabano1582]

Wonderful teaching. Thanks a lot. Can you please tell Which soft ware are you using to make teaching videos like this. Hiw do you make it

[@amryounes1286]

cant thank you enough

[@shruthiracharla4922]

Thank u so much

[@pokerater4463]

According to goodman gilmans " clearance is the volume of plasma cleared of drugs per min per kg of body" so unit will be ml/min/kg. But u are saying it is ml/min.....im confused now

[@oushea]

Thank you for your efforts :)

[@TheZna7a]

Thank you

[@HafizahHoshni]

thanks

[@minah549]

What happens with CL when we are in 0 order kinetics?
When you look at the graph, CL is constant at 1st (green slope or 1st order kinectics). But does the CL go to zero when we're in 0 order kinetics?
When I think of it logically, it doesn't make sense. Our bodies won't stop filtering just because we've maxed out our kidney's capacity... right?
Someone help!

[@idontknowmyname1033]

The "no pun intended" at 7:38 cracked me up

[@Illuminateur]

Does hepatic metabolism not play a role in drug clearance?

[@CharisAlleng]

u r awesome...

[@debra-rosewilliams184]

This is great! Btw what book do you use?

[@khaliqzahid6686]

great

[@pokerater4463]

Plus what is CL in zero order kinetics??? N how half life affects CL???

[@pharmacystudent7036]

why havnt i discover this before

[@sobiasarfraz8789]

Plz upload more 😞

[@dr.soumyasworld1177]

👏🏻👌🏻👍🏼

[@Stupidity_iNk_Tattoo]

14999 thankful ppls :)

[@JawadAli-nd2kk]

Thank you soo much for posting this. It makes so much more sense