You will have to take a drug holiday and allow B-cell reconstitution if you want to maximise your chances of a B-cell response. However, people on anti-CD20 therapy can make antibody responses and they probably do make cellular immune responses to vaccines. I suspect it will all depend on the vaccine.
What if you are already on an anti-CD20 and are lacking some vaccine immunity?
You will have to take a drug holiday and allow B-cell reconstitution if you want to maximise your chances of a B-cell response. However, people on anti-CD20 therapy can make antibody responses and they probably do make cellular immune responses to vaccines. I suspect it will all depend on the vaccine.