Somatic hypermutation : Generating antibody diversity

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  • Опубліковано 1 січ 2025

КОМЕНТАРІ • 81

  • @swatimavinkurve2305
    @swatimavinkurve2305 Рік тому +11

    honestly the best videos that teach such concepts to great details I have found on youtube!! Thank you, you are the reason for my good score in immunology.

  • @sxbear9988
    @sxbear9988 2 роки тому +3

    Thanks for this wonderful explanation of somatic hypermutation which confused me for a very long time. Well done!

    • @animatedbiologywitharpan
      @animatedbiologywitharpan  2 роки тому +1

      Please share my channel link with your friends and help me to reach big audience

  • @UmmUmarHamzah
    @UmmUmarHamzah 4 роки тому +12

    I love the animations and the content. Great as a study aid!

  • @dmitrybaer5873
    @dmitrybaer5873 3 роки тому +3

    THANK YOU SO MUCH FOR WHAT YOU ARE DOING! Big Immune Exam in Few weeks

    • @animatedbiologywitharpan
      @animatedbiologywitharpan  3 роки тому +1

      Watch my entire immunology playlist and it would be useful for you....also share with friends

  • @prevenaselvaraj2677
    @prevenaselvaraj2677 4 роки тому +2

    Very clear explanation. Please do more videos like this!!!

  • @amritpalkaur3301
    @amritpalkaur3301 Рік тому +1

    Very beautifully explained. Thanks!

  • @nerddocnextdoor1378
    @nerddocnextdoor1378 2 роки тому +5

    Correction- Somatic hypermutation is for generation of antibody specificity which is antigen dependent.

    • @animatedbiologywitharpan
      @animatedbiologywitharpan  2 роки тому +3

      Indeed this is important. Thanks for pointing out . At the 4.00-4.30 timestamp of the video it is mentioned that T cell dependent activation is kind of prerequisite for somatic hypermutation. But I agree, it should be stated clearly that it's a process to create highly specific antibodies.

  • @arinarakhteenko579
    @arinarakhteenko579 4 роки тому +1

    Thank you for awesome video and explanations! Very good drawn and prepared

  • @ramchandrasuthar2848
    @ramchandrasuthar2848 4 роки тому +2

    GREAT analysis sir

  • @Pulaobiryani95
    @Pulaobiryani95 3 роки тому +1

    I love the animations and content and I've shared your videos with my friends. But I have one advice: please increase the volume of the videos.
    Thank you so much! 🇵🇰

  • @kvnkvn9191
    @kvnkvn9191 3 роки тому +1

    Why prokeryotic replication diagram there 7:50

  • @anushabhat4135
    @anushabhat4135 4 роки тому

    Too good explanation.. my saviour.. thank u

  • @lenaeospeixinhos
    @lenaeospeixinhos 2 роки тому +1

    Awesome video, thank you

    • @animatedbiologywitharpan
      @animatedbiologywitharpan  2 роки тому +1

      You can support the channel by clicking on the super like icon below the video ( a heart sign with $ in it ) . You can support using paytm/ phone pe/ gPay / paypal. Your small contribution means a lot for me

  • @arbitrarylib
    @arbitrarylib 3 роки тому +2

    Thank you sir for that overview of WHY this somatic hypermutation must happen in the first place. I guess you can think about it like two defenses chaing their strategies (their DNA or their biological makeup ) to have an advantage over the other side because they (the host antibodies or the antigen (bacteria, viruses)) keep changing to adapt to their environment.

    • @animatedbiologywitharpan
      @animatedbiologywitharpan  3 роки тому +2

      See now you understand the topic so well...not only you have the info but also you have understood the concepts.

    • @animatedbiologywitharpan
      @animatedbiologywitharpan  3 роки тому +2

      Please share my channel link with your friends and help me to reach big audience....feel free to connect via social media

  • @shwetapandey1194
    @shwetapandey1194 3 роки тому +1

    This is helpful.. thank you so much.

    • @animatedbiologywitharpan
      @animatedbiologywitharpan  3 роки тому +1

      Please share my channel link with your friends and help me to reach big audience

  • @Freak.pharma1
    @Freak.pharma1 3 роки тому +1

    Thank you very much
    Your channel is very useful 👍

  • @toufikfrioua6786
    @toufikfrioua6786 3 роки тому +4

    i love how this indien explain immunology

    • @animatedbiologywitharpan
      @animatedbiologywitharpan  3 роки тому +1

      Please share my channel link with your friends and help me to reach out big audience

  • @anishchauhan2723
    @anishchauhan2723 10 місяців тому +1

    After watching the video, I must say the way of explaining is outstanding. I have a doubt: in somatic hypermutation, mutations occur at the genetic level with the assistance of AID mainly. Still, the entire process is being considered a somatic process. why so?

    • @animatedbiologywitharpan
      @animatedbiologywitharpan  10 місяців тому

      Good point. They name this kind of mutations somatic mutation because these are not inherited. Germline mutations are changes to your DNA that you inherit from the egg and sperm cells during conception. Somatic mutations are changes to your DNA that happen after conception to cells other than the egg and sperm.

    • @anishchauhan2723
      @anishchauhan2723 10 місяців тому +1

      @@animatedbiologywitharpan agreed.

    • @animatedbiologywitharpan
      @animatedbiologywitharpan  10 місяців тому

      please share my videos with friends@@anishchauhan2723

  • @ajayreddy2434
    @ajayreddy2434 4 роки тому +2

    Awesome👏👏👏 sir

  • @iiateeqii
    @iiateeqii 4 роки тому +1

    Very well explained!

  • @saddamalgafsi6721
    @saddamalgafsi6721 Рік тому

    thanks for the video, I have a question though: in 4:11, you showed the interaction of B cell / Th in the paracortex region, are you sure this is where it happens? because as far as I know, B cells don't enter the paracortex region, they stay in the outer cortex and they move to its edge and stay there waiting for passing-by Th cells to recognize their MHC-II. To sum up, I think all of this occurs on the edge where the Th in the paracortex facing the B cell in the cortex exchanging signals.

    • @knowinfo1893
      @knowinfo1893 Рік тому +1

      The T cells are in the parafollicular/paracortical region. B cell can go to parafollicular region but they cant go inside the mantle zone of follicle (until activated by any antigen , either self or foreign) and can't go inside germinal centre of follicle (unless gets activated by foreign pathogen and gets permission from t cell)
      If you want cd markers then - cd 5 and cd23 .
      If you still haven't understood anything you can ask again

  • @KuchNaaya
    @KuchNaaya Рік тому +1

    Sir what was the reference book for this content

  • @nidhisolanki4993
    @nidhisolanki4993 Рік тому +1

    Sir please make video on junctional and insertional diversification. There are no vidoes on you tube on you tube

  • @quickbiology5159
    @quickbiology5159 2 роки тому +1

    I always get confused between affinity maturation somatic hypermuation and class switching

    • @animatedbiologywitharpan
      @animatedbiologywitharpan  2 роки тому

      Follow me on instagram and facebook
      My social media handle is @animatedbiologywitharpan

  • @samarthkumar5198
    @samarthkumar5198 4 роки тому +2

    Is there class switching video available on your channel?

  • @priyadarshinighosh6461
    @priyadarshinighosh6461 4 роки тому +1

    Very helpful, thanks

  • @tohela7588
    @tohela7588 3 роки тому +1

    Thanks a lot!

  • @samarthkumar5198
    @samarthkumar5198 4 роки тому

    Do one plasma cell produce different classes of antibodies?

  • @niki2993-c1y
    @niki2993-c1y 4 роки тому +1

    Your videos are really helpful .keep up the work ,also would you try to make videos on TIFR 2020 biology exam solutions ?

  • @EdT.-xt6yv
    @EdT.-xt6yv Рік тому

    8:09 rate, affinity

  • @samarthkumar5198
    @samarthkumar5198 4 роки тому +1

    Can u share this presentation?

  • @incrediblemedoconcepts
    @incrediblemedoconcepts 4 роки тому +1

    Hi bro... beautifully explained...i luv ur content...I want to learn how to make these kind of videos, diagrams? I am using adobe illustrator (cracked version)..but i don't know how to use it....do u create each and every diagram by modifying the basic shapes?

    • @animatedbiologywitharpan
      @animatedbiologywitharpan  4 роки тому +1

      Yup it’s all about using the fundamental geometric shapes.....I also hand draw in my iPad

    • @animatedbiologywitharpan
      @animatedbiologywitharpan  4 роки тому +1

      Soon in my patron page I will show how to make this kind of graphics using power point only......be my patreon

    • @animatedbiologywitharpan
      @animatedbiologywitharpan  4 роки тому

      www.patreon.com/arpan_parichha

    • @animatedbiologywitharpan
      @animatedbiologywitharpan  4 роки тому +1

      I will also share that using what tools i make these graphics.....my set up ,different styles etc all at $5 per month ( 350 rs only )

    • @incrediblemedoconcepts
      @incrediblemedoconcepts 4 роки тому +2

      @@animatedbiologywitharpan
      thanks brother

  • @geminra
    @geminra 4 роки тому

    activate window :D

    • @animatedbiologywitharpan
      @animatedbiologywitharpan  4 роки тому

      ha ha ha.....did it

    • @animatedbiologywitharpan
      @animatedbiologywitharpan  4 роки тому

      please share with your friends .....it would help the channel to grow

    • @geminra
      @geminra 4 роки тому +1

      Definitely. Love the graphical presentation you put thought out the video. 👍

    • @animatedbiologywitharpan
      @animatedbiologywitharpan  4 роки тому +1

      I have another channel as well .....subscribe it as well ua-cam.com/channels/4IpyopsGWSjaPACNTZLuqg.html thanks for the support

  • @clementmonnier9318
    @clementmonnier9318 2 роки тому +1

    THANKS a lot !

    • @animatedbiologywitharpan
      @animatedbiologywitharpan  2 роки тому

      In order to make high quality content consistently, we need support from you. Please support us by using super thanks option. Super thanks icon is present below the video ( a heart sign with $ in it ) . You can support using paytm/ phone pe/ gPay / paypal. Your small contribution means a lot for us.

  • @EdT.-xt6yv
    @EdT.-xt6yv Рік тому

    8:09 rate, affinity