Mitochondria in GCase-Linked Neurodegeneration - Drs. Behrouz, Deleidi, and Klein

At this week's Fireside Chat, Dr. Spring Behrouz, CEO and Co-Founder of Vincere Biosciences discusses GBA's role in mitochondria with experts Drs. Michela Deleidi and Andres Klein.
Dr. Michela Deleidi, Assistant Professor at University of Tübingen, in Germany, discusses her team's recent publication, "Glucocerebrosidase is imported into mitochondria and preserves complex I integrity and energy metabolism," published in Nature Communications on 06 April 2023.
Dr. Andres Klein, Associate Professor at Universidad del Desarrollo, in Chile, provides his thoughts on the topic and shares his view points from his comment article in response to Dr. Deleidi's publication.
Link to full articles:
www.nature.com/articles/s4146...
www.nature.com/articles/s4146...
#discussion #research #science #mitochondria #biology #openscience #vincere #tübingen #desarrollo #naturepublication #parkinsons #gaucher #aging
Dr. Deleidi's Profile and Social Media:
Profile: www.scent.uni-tuebingen.de/?t...
LinkedIn: / michela-deleidi-a5a52914
Twitter: micheladeleidi?la...
Dr. Klein's Profile and Social Media:
Profile: www.udd.cl/persona/andres-d-k...
LinkedIn: / andresklein
Dr. Spring Behrouz Social:
LinkedIn: / bahareh
Twitter: / dr_behrouz
Chapters:
00:00-01:04 Introduction: Dr. Deleidi
01:05-09:19 Background and Research
09:20-10:39 Dr. Behrouz- Comments
10:40-11:08 Introduction: Dr. Klein
11:09-15:37 Dr. Klein- Comments
15:38-22:22 Q&A: Translational and Physiological Relevance
22:23-25:02 Q&A: Compensation and Relationship with Golgi Burden
25:03-35:55 Q&A: Choice of GBA Mutations and Relationship Between Parkinson's and Gaucher
35:55-38:13 Q&A: GCase Import Mechanism into Mitochondria
38:14-45:14 Q&A: Potential Mitochondrial Marker of Mechanism
45:15-51:10 Q&A: Translation for Patients and Therapeutics
51:11-53:36 Rapid Fire Questions
53:37-54:43 Conclusion